LOCUS       NM_001109670            2963 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus solute carrier family 52 member 2 (Slc52a2),
            mRNA.
ACCESSION   NM_001109670 XM_001075182 XM_343272
VERSION     NM_001109670.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2963)
  AUTHORS   Kubo,Y., Miki,S., Akanuma,S.I. and Hosoya,K.I.
  TITLE     Riboflavin transport mediated by riboflavin transporters
            (RFVTs/SLC52A) at the rat outer blood-retinal barrier
  JOURNAL   Drug Metab Pharmacokinet 34 (6), 380-386 (2019)
   PUBMED   31601465
  REMARK    GeneRIF: The obtained results suggested the involvement of
            riboflavin transporters (SLC52A/RFVT) at the outer BRB, and this is
            supported by the expression and knockdown analyses of rRFVT2
            (Slc52a2) and rRFVT3 (Slc52a3).
REFERENCE   2  (bases 1 to 2963)
  AUTHORS   Kubo,Y., Yahata,S., Miki,S., Akanuma,S.I. and Hosoya,K.I.
  TITLE     Blood-to-retina transport of riboflavin via RFVTs at the inner
            blood-retinal barrier
  JOURNAL   Drug Metab Pharmacokinet 32 (1), 92-99 (2017)
   PUBMED   27964953
  REMARK    GeneRIF: The function and inhibition profile suggested the
            involvement of riboflavin transporter 2 in riboflavin transport at
            the inner BRB, and this is supported by expression and knockdown
            analysis of rRFVT2 (Slc52a2) and rRFVT3 (Slc52a3) in TR-iBRB2
            cells.
REFERENCE   3  (bases 1 to 2963)
  AUTHORS   Udhayabanu,T., Subramanian,V.S., Teafatiller,T., Gowda,V.K.,
            Raghavan,V.S., Varalakshmi,P., Said,H.M. and Ashokkumar,B.
  TITLE     SLC52A2 [p.P141T] and SLC52A3 [p.N21S] causing Brown-Vialetto-Van
            Laere Syndrome in an Indian patient: First genetically proven case
            with mutations in two riboflavin transporters
  JOURNAL   Clin Chim Acta 462, 210-214 (2016)
   PUBMED   27702554
REFERENCE   4  (bases 1 to 2963)
  AUTHORS   Subramanian,V.S., Ghosal,A., Subramanya,S.B., Lytle,C. and
            Said,H.M.
  TITLE     Differentiation-dependent regulation of intestinal vitamin B(2)
            uptake: studies utilizing human-derived intestinal epithelial
            Caco-2 cells and native rat intestine
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 304 (8), G741-G748 (2013)
   PUBMED   23413253
  REMARK    GeneRIF: Intestinal riboflavin uptake process undergoes
            differentiation-dependent upregulation and suggest that this is
            mediated (at least in part) via transcriptional mechanisms of
            SLC52A1 and SLC52A3.
REFERENCE   5  (bases 1 to 2963)
  AUTHORS   Yao,Y., Yonezawa,A., Yoshimatsu,H., Masuda,S., Katsura,T. and
            Inui,K.
  TITLE     Identification and comparative functional characterization of a new
            human riboflavin transporter hRFT3 expressed in the brain
  JOURNAL   J Nutr 140 (7), 1220-1226 (2010)
   PUBMED   20463145
REFERENCE   6  (bases 1 to 2963)
  AUTHORS   Yamamoto,S., Inoue,K., Ohta,K.Y., Fukatsu,R., Maeda,J.Y.,
            Yoshida,Y. and Yuasa,H.
  TITLE     Identification and functional characterization of rat riboflavin
            transporter 2
  JOURNAL   J Biochem 145 (4), 437-443 (2009)
   PUBMED   19122205
REFERENCE   7  (bases 1 to 2963)
  AUTHORS   Yonezawa,A., Masuda,S., Katsura,T. and Inui,K.
  TITLE     Identification and functional characterization of a novel human and
            rat riboflavin transporter, RFT1
  JOURNAL   Am J Physiol Cell Physiol 295 (3), C632-C641 (2008)
   PUBMED   18632736
  REMARK    GeneRIF: Identification/characterization riboflavin trasporter
            (RFT1) as a novel riboflavin transporter.
REFERENCE   8  (bases 1 to 2963)
  AUTHORS   Andriamampandry,C., Taleb,O., Kemmel,V., Humbert,J.P., Aunis,D. and
            Maitre,M.
  TITLE     Cloning and functional characterization of a gamma-hydroxybutyrate
            receptor identified in the human brain
  JOURNAL   FASEB J 21 (3), 885-895 (2007)
   PUBMED   17197387
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473950.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_343272.3, XM_001075182.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC133726.1, AB362535.1 [ECO:0000331]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2963
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2963
                     /gene="Slc52a2"
                     /gene_synonym="Gpr172a; Gpr172b; RGD1560410; rRFT1"
                     /note="solute carrier family 52 member 2"
                     /db_xref="GeneID:362942"
                     /db_xref="RGD:1560410"
     exon            1..358
                     /gene="Slc52a2"
                     /gene_synonym="Gpr172a; Gpr172b; RGD1560410; rRFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            359..574
                     /gene="Slc52a2"
                     /gene_synonym="Gpr172a; Gpr172b; RGD1560410; rRFT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             445..1797
                     /gene="Slc52a2"
                     /gene_synonym="Gpr172a; Gpr172b; RGD1560410; rRFT1"
                     /note="riboflavin transporter 1; porcine endogenous
                     retrovirus A receptor 2; G protein-coupled receptor 172B;
                     G protein-coupled receptor 172A"
                     /codon_start=1
                     /product="solute carrier family 52, riboflavin
                     transporter, member 2"
                     /protein_id="NP_001103140.1"
                     /db_xref="GeneID:362942"
                     /db_xref="RGD:1560410"
                     /translation="MAAPPLGRLVLTHLLVALFGMGSWIAVNGIWVELPVVVKELPEG
                     WSLPSYLSVLVALGNLGLLLVTLWRRLAPGKSERIPIQVVQGLSIVGTGLLAPLWSNM
                     ALVAGQLHSVAFLTLAFVLALSCCASNVTFLPFLSHLPPPFLRSFFLGQGLSALLPCV
                     LALAQGVGRLECLHVPANGTTGPPIKVSPINFPERFSAGTFFWVLTALLGTSAAAFQG
                     LLLLLPSPPPEATMGTGLRVETPGTEEEEEEEEASPLQEPPGQVASIVSSPDPKAHRL
                     FSSRSACLLGLLAITNALTNGVLPAVQSFSCLPYGRLAYHLAVVLGSSANPLACFLAM
                     AVLCRSLAGLYGLCLLGMFFGTYLMTLAVLSPCPPLVGTSAGVVLVVLSWVLCAGVFS
                     YIKVATSSMLHSGGRPALLAAGVAIQVGSLLGAIAMFPPTSVYPVFRSGEDCVDQCGP
                     "
     exon            575..1460
                     /gene="Slc52a2"
                     /gene_synonym="Gpr172a; Gpr172b; RGD1560410; rRFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1584
                     /gene="Slc52a2"
                     /gene_synonym="Gpr172a; Gpr172b; RGD1560410; rRFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..2963
                     /gene="Slc52a2"
                     /gene_synonym="Gpr172a; Gpr172b; RGD1560410; rRFT1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcaggagc attagccggc gtcttaatac ggtgcttggg ctggggtttg gctaccttcc
       61 gggcaaagcg gcattctctt ggtgctgggc gggctgctcc ggtcccacgc ccctgatgca
      121 caacacttag cggaggagcc ctgaataaaa tcagccagcc acgcccctcg ccgacccatg
      181 ccggctgcct ggagttcgct gccatccagt ttggtttagc cgtgccgaga cttggtcctc
      241 cacaagcatc aaggactgtt ctttcgttgg tcctcctctc cggaaccacg ctttaggcca
      301 gcttcttgct cctctgcttg ccagtcctgt tctgaggggt cctggtgcag gcttcttgct
      361 agagaagctt tggacctacg tggggaaaag aacgaattgt taccttcgct ttgtcctgga
      421 gggccctctt tgacctttga cctaatggca gcacctccac tgggccgact ggtgctgacc
      481 catctgctgg tggccctttt cggcatgggc tcctggattg cggtcaatgg gatctgggta
      541 gagctacctg tagtggtgaa agagctcccg gagggttgga gcctcccttc ctacctctca
      601 gtgcttgtgg cactggggaa cctgggtctg ctgctggtga ccctgtggag gcgtctggct
      661 cccggcaaga gcgagcggat ccccatccaa gtggttcagg ggctgagcat agtgggcaca
      721 ggcctgctgg cccctctgtg gagcaacatg gccctggtgg caggacagct ccactctgtg
      781 gccttcctaa cgctggcgtt tgtgctggca ttgtcctgct gtgcttccaa tgtcactttc
      841 ctgccctttc tgagccacct accgcctccc tttttacggt ctttcttcct gggccagggc
      901 ctgagtgccc tgctgccctg tgtgctggct ctggcgcagg gggtgggccg cctggagtgc
      961 ctgcatgtgc ctgccaacgg caccaccggg cctccgatca aggtgtctcc catcaatttc
     1021 cctgagcgtt tctctgctgg cacattcttt tgggtgttga cggccctcct gggcacttca
     1081 gccgccgcct tccaaggcct cctgttacta ctgccgtccc caccacctga agccacgatg
     1141 ggtaccgggc ttcgggtaga aacaccagga acagaggagg aagaggaaga ggaagaggcc
     1201 tcaccattgc aggagccacc aggccaggtg gcaagcattg tttccagccc agaccctaag
     1261 gcccatcggc tgttttcttc ccgaagtgcc tgtctactgg ggctgctggc tatcaccaac
     1321 gccctgacca acggtgtgct gcccgctgta cagagctttt cctgcctgcc ctatgggcgc
     1381 ctggcctacc acttggctgt cgtactgggt agctctgcca atccccttgc ctgctttctg
     1441 gccatggcag tgttgtgcag gtctctggca gggctgtatg gcctctgtct gctgggcatg
     1501 ttctttggca cctacctgat gacactggca gtcctaagtc cctgtccccc tctggtgggc
     1561 acctcagcag gtgtggtcct cgtggtgctt tcatgggtac tgtgtgcagg cgtgttctcg
     1621 tacatcaagg tggcgaccag ttccatgtta cacagtggag gccggccagc actgctcgca
     1681 gctggggtag ctattcaggt gggctctctg ctgggcgcca tcgccatgtt ccctcccacc
     1741 agcgtctacc ctgtgtttcg cagtggagag gactgtgtgg atcagtgtgg cccttgaacc
     1801 gggtcgcgta ggagttactt cacacttgtc tccacccgga gggggccaca gcacctgcgt
     1861 cccgtggccc aaggtggcct cctgacgcac agataatatg gatatttcac actccatata
     1921 gagacctggc ttttgaggaa aagaccaggg tgaggaccaa agagcaggcc cagacccagg
     1981 gataggttgg ggctgcagcc tttcccctgg gacctctgtg ggatttgcac aataaaacat
     2041 cttcatccaa tgggttggta atcccacgag cacagctcac tacgccaggc ctccttccct
     2101 cagtaggcat cccctcttcc ccaagatcct agttacagct tctgggcaga tattcctcca
     2161 ctcccagctg gtgttgccgg gccttgggtg gcctcaggac tcctgcgcca ttgcttctct
     2221 ggaactactt tgggagatga aggctgactc ccagggccca cgcgggactg aagcaggaca
     2281 atgcttctgg tcgcctggac aatcggcaga atcactgctc cactgcaggt cttgagggct
     2341 tgagggtctg gcatggttgg gaagtcaatc aacaagggaa cctgggggag gggaggggtt
     2401 tacacacaag accctcttgc caagatcttc atgtcagagt ttggtgcaag gcccaggtgt
     2461 aaaaggagct cggtgaagct ggctttttat ttgtttgctt tgcttttaaa aaaaaaatta
     2521 ctttattcat gtacatgagt acactgtcgc tgtcttcaga cacaccagaa gagggcatca
     2581 gaccccattc cagatggttg tgagctaccg tgtggttgct gggaattgaa ctcaggacct
     2641 ctggaagaac agtcagtgtt cttaacccct aaaccacctc tccagccctt gttttacctt
     2701 tttattttat gtgcatgggt gttttgcttg aggtcacaat tgaatgtctg atcttctgga
     2761 actggagtta gactgttgtg agctgctatg ggggtgctgg gaattgaacc ctggtcctct
     2821 ggaataccag tgagtgattt taaccacaga gccttctctc cagccccagg agctggtttt
     2881 taaggttctg accctctcag gatctttcaa cttgagaaca ttgcttacca gccctggagc
     2941 tcctagtttc caactcctgc agt
//
