LOCUS       NM_212512               4952 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 4 member 5 (Slc4a5), mRNA.
ACCESSION   NM_212512 XM_232113
VERSION     NM_212512.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4952)
  AUTHORS   Fukuda,H., Hirata,T., Nakamura,N., Kato,A., Kawahara,K.,
            Wakabayashi,S., Chang,M.H., Romero,M.F. and Hirose,S.
  TITLE     Identification and properties of a novel variant of NBC4
            (Na(+)/HCO(3)- co-transporter 4) that is predominantly expressed in
            the choroid plexus
  JOURNAL   Biochem J 450 (1), 179-187 (2013)
   PUBMED   23205667
REFERENCE   2  (bases 1 to 4952)
  AUTHORS   Groger,N., Vitzthum,H., Frohlich,H., Kruger,M., Ehmke,H., Braun,T.
            and Boettger,T.
  TITLE     Targeted mutation of SLC4A5 induces arterial hypertension and renal
            metabolic acidosis
  JOURNAL   Hum Mol Genet 21 (5), 1025-1036 (2012)
   PUBMED   22082831
REFERENCE   3  (bases 1 to 4952)
  AUTHORS   Kao,L., Kurtz,L.M., Shao,X., Papadopoulos,M.C., Liu,L., Bok,D.,
            Nusinowitz,S., Chen,B., Stella,S.L., Andre,M., Weinreb,J.,
            Luong,S.S., Piri,N., Kwong,J.M., Newman,D. and Kurtz,I.
  TITLE     Severe neurologic impairment in mice with targeted disruption of
            the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5
            gene)
  JOURNAL   J Biol Chem 286 (37), 32563-32574 (2011)
   PUBMED   21705333
REFERENCE   4  (bases 1 to 4952)
  AUTHORS   Damkier,H.H., Nielsen,S. and Praetorius,J.
  TITLE     Molecular expression of SLC4-derived Na+-dependent anion
            transporters in selected human tissues
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 293 (5), R2136-R2146 (2007)
   PUBMED   17715183
REFERENCE   5  (bases 1 to 4952)
  AUTHORS   Abuladze,N., Pushkin,A., Tatishchev,S., Newman,D., Sassani,P. and
            Kurtz,I.
  TITLE     Expression and localization of rat NBC4c in liver and renal
            uroepithelium
  JOURNAL   Am J Physiol Cell Physiol 287 (3), C781-C789 (2004)
   PUBMED   15151908
  REMARK    GeneRIF: the cotransporter plays a role in mediating
            Na(+)-HCO(3)(-) cotransport in hepatocytes and intrahepatic
            cholangiocytes. the cotransporter may play an important role in
            protecting the renal parenchyma from alterations in urine pH.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Dec 2, 2020 this sequence version replaced NM_212512.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY496959.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                JAXUCZ010000004.1  117283294-117283386
            94-168              JAXUCZ010000004.1  117287509-117287583
            169-363             JAXUCZ010000004.1  117288967-117289161
            364-493             JAXUCZ010000004.1  117303129-117303258
            494-654             JAXUCZ010000004.1  117319390-117319550
            655-807             JAXUCZ010000004.1  117320317-117320469
            808-903             JAXUCZ010000004.1  117321703-117321798
            904-959             JAXUCZ010000004.1  117324314-117324369
            960-1117            JAXUCZ010000004.1  117325680-117325837
            1118-1205           JAXUCZ010000004.1  117326915-117327002
            1206-1360           JAXUCZ010000004.1  117328600-117328754
            1361-1549           JAXUCZ010000004.1  117329465-117329653
            1550-1724           JAXUCZ010000004.1  117331761-117331935
            1725-1858           JAXUCZ010000004.1  117332673-117332806
            1859-2130           JAXUCZ010000004.1  117333880-117334151
            2131-2189           JAXUCZ010000004.1  117338287-117338345
            2190-2390           JAXUCZ010000004.1  117340672-117340872
            2391-2504           JAXUCZ010000004.1  117347335-117347448
            2505-2666           JAXUCZ010000004.1  117349743-117349904
            2667-2845           JAXUCZ010000004.1  117350607-117350785
            2846-2918           JAXUCZ010000004.1  117352204-117352276
            2919-2987           JAXUCZ010000004.1  117358118-117358186
            2988-3161           JAXUCZ010000004.1  117358859-117359032
            3162-3314           JAXUCZ010000004.1  117359665-117359817
            3315-3399           JAXUCZ010000004.1  117362333-117362417
            3400-3467           JAXUCZ010000004.1  117363409-117363476
            3468-4952           JAXUCZ010000004.1  117366540-117368024
FEATURES             Location/Qualifiers
     source          1..4952
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..4952
                     /gene="Slc4a5"
                     /gene_synonym="NBC4"
                     /note="solute carrier family 4 member 5"
                     /db_xref="GeneID:297386"
                     /db_xref="RGD:1303009"
     exon            1..93
                     /gene="Slc4a5"
                     /gene_synonym="NBC4"
                     /inference="alignment:Splign:2.1.0"
     exon            94..168
                     /gene="Slc4a5"
                     /gene_synonym="NBC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..3434
                     /gene="Slc4a5"
                     /gene_synonym="NBC4"
                     /note="electrogenic sodium bicarbonate cotransporter
                     NBC4c; sodium bicarbonate transporter 4; solute carrier
                     family 4, sodium bicarbonate cotransporter, member 5"
                     /codon_start=1
                     /product="electrogenic sodium bicarbonate cotransporter 4"
                     /protein_id="NP_997677.1"
                     /db_xref="GeneID:297386"
                     /db_xref="RGD:1303009"
                     /translation="MKVEEKAGVKKLEPTSYRRRHPEQDFPSIHIGFPVPGYSQRKSD
                     SKGHLSGLQRVQWSLQPDKSQQDLAGPDGIKASSLGGSVDFTKRIRSPAAEQLQDILG
                     EEDEAPNPTLFTEMDTLQHDGDQMEWKESARWIKFEEKVEEGGERWSKPHVSTLSLHS
                     LFELRTCLQTGTVLLDLDSGSLPQIIDDVIEKQIEGGLLRPELRERVSYVLLRKHRHQ
                     TKKPIHRSLADIGKSVSTTNRSSARSPSAGPTLHHSTEDLRIRQSTSYGHLCHAQSRS
                     MNDISHTPNTDQRKNKFMKKIPKDSEASNVLVGEVDFLDQPFIAFVRLAQSSMLGGVT
                     EVPVPTRFLFILLGPSGRAKSYNEIGRAIATLMVDDLFSDVAYKARNREDLIAGVDEF
                     LDEVIVLPPGEWDPNIRIEPPKKVPSADKRKSVFSLAELGQMNGSVGRSGASAGGGGS
                     GGGAGGSGAGGGGSGNEAEMPAMHEIGEELIWTGRFFGGLRLDVKRKLPWFPSDFYDG
                     FHIQSISAVLFIYLGCITNAITFGGLLGDATDNYQGVMESFLGTAMAGSLFCLFSGQP
                     LIILSSTGPILIFEKLLFDFSKANGLDYMEFRLWIGLHSAIQCLILVATDASFIIKYI
                     TRFTEEGFSTLISFIFIYDAIKKMIGAFKYYPINTDFKPDSITTYKCECVAPDTVNTT
                     TVNDSALLVPNTNMSVYTPLNLTALDWSLLSKKECLSYGGRLLGSSCQFVPDLALMSF
                     ILFFGTYSMTLTLKKFKFSRYFPTKVRTLVADFSIVFSILLFCGIDACFGLQTPKLHV
                     PNVIKPTRPDRGWFVAPFGKNPWWVYPASILPALLVTILIFMDQQITAVIVNRKENKL
                     RKAAGYHLDLFWVGILMALCSFMGLPWYVAATVISIAHIDSLKMETETSAPGEQPQFL
                     GVREQRVTGVMVFILTGISVFLAPILKYIPMPVLYGVFLYMGVASLNGIQFWDRCKLF
                     LMPAKHQPDHAFLRHVPLRRIHLFTLVQILCLALLWILKSTMAAIIFPVMILGLIIVR
                     RLLDLIFSQHDLAWIDNILPEKEKKESDRKKRRKEVHENTDKEPQFLPPSVVKIPMEG
                     IPSDPQNGIHCVGRKRSSSWSHSL"
     exon            169..363
                     /gene="Slc4a5"
                     /gene_synonym="NBC4"
                     /inference="alignment:Splign:2.1.0"
     exon            364..493
                     /gene="Slc4a5"
                     /gene_synonym="NBC4"
                     /inference="alignment:Splign:2.1.0"
     exon            494..654
                     /gene="Slc4a5"
                     /gene_synonym="NBC4"
                     /inference="alignment:Splign:2.1.0"
     exon            655..807
                     /gene="Slc4a5"
                     /gene_synonym="NBC4"
                     /inference="alignment:Splign:2.1.0"
     exon            808..903
                     /gene="Slc4a5"
                     /gene_synonym="NBC4"
                     /inference="alignment:Splign:2.1.0"
     exon            904..959
                     /gene="Slc4a5"
                     /gene_synonym="NBC4"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1117
                     /gene="Slc4a5"
                     /gene_synonym="NBC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1205
                     /gene="Slc4a5"
                     /gene_synonym="NBC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1360
                     /gene="Slc4a5"
                     /gene_synonym="NBC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1549
                     /gene="Slc4a5"
                     /gene_synonym="NBC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1724
                     /gene="Slc4a5"
                     /gene_synonym="NBC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1858
                     /gene="Slc4a5"
                     /gene_synonym="NBC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..2130
                     /gene="Slc4a5"
                     /gene_synonym="NBC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2189
                     /gene="Slc4a5"
                     /gene_synonym="NBC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2390
                     /gene="Slc4a5"
                     /gene_synonym="NBC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2504
                     /gene="Slc4a5"
                     /gene_synonym="NBC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2666
                     /gene="Slc4a5"
                     /gene_synonym="NBC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2845
                     /gene="Slc4a5"
                     /gene_synonym="NBC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..2918
                     /gene="Slc4a5"
                     /gene_synonym="NBC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2919..2987
                     /gene="Slc4a5"
                     /gene_synonym="NBC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2988..3161
                     /gene="Slc4a5"
                     /gene_synonym="NBC4"
                     /inference="alignment:Splign:2.1.0"
     exon            3162..3314
                     /gene="Slc4a5"
                     /gene_synonym="NBC4"
                     /inference="alignment:Splign:2.1.0"
     exon            3315..3399
                     /gene="Slc4a5"
                     /gene_synonym="NBC4"
                     /inference="alignment:Splign:2.1.0"
     exon            3400..3467
                     /gene="Slc4a5"
                     /gene_synonym="NBC4"
                     /inference="alignment:Splign:2.1.0"
     exon            3468..4952
                     /gene="Slc4a5"
                     /gene_synonym="NBC4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagaaagcct ttctgcaacc caacgggagt ggagccaggg gctctggtct tcctgagatt
       61 tggagcctgg tgtccactgc taagaacaca cagtgatgaa agtggaagag aaggctgggg
      121 tcaaaaagct ggagcccaca agctacagga ggagacaccc agaacaagat ttcccttcaa
      181 tacatattgg ctttccagtc cccggttact ctcaaagaaa aagtgactca aagggacatc
      241 tttcaggtct gcaaagagtc cagtggtccc tgcaaccgga caaatctcag caggacctgg
      301 ctggtccaga cgggatcaag gccagcagcc tgggaggctc cgtggatttt accaaaagga
      361 ttcggtctcc agctgctgag cagctacagg acatcctggg ggaggaagat gaggctccca
      421 accccaccct cttcacagag atggacactc tacagcatga tggggaccag atggagtgga
      481 aggaatcagc caggtggata aaatttgaag aaaaggtaga ggaaggagga gaacgctgga
      541 gcaagcccca tgtgtccacg ctgtccctgc acagcctctt tgagctccgc acttgcctgc
      601 agacagggac ggtgctgctg gatctggaca gtggctctct accacagatc atagatgatg
      661 tcattgagaa gcagatagag ggtggacttc tgcgaccaga gctccgggaa agggtcagct
      721 acgtgctcct gaggaagcat cgccaccaaa ccaagaagcc catccaccgt tcccttgcag
      781 acattgggaa gtcggtttct actacgaatc gcagctctgc ccggagcccc tcagcaggcc
      841 caactctgca ccactccacc gaggacctga ggattcggca aagcaccagc tatggtcatc
      901 tgtgtcatgc ccagagtaga agcatgaatg acatctccca taccccaaac acagaccagc
      961 ggaaaaacaa attcatgaag aagatcccca aggactcaga agcctccaac gtgcttgtgg
     1021 gcgaggtgga cttcctggac cagccattca ttgcgtttgt tcgtcttgcc cagtcttcca
     1081 tgctgggagg ggtgaccgag gtgcctgtcc ccaccagatt tctgttcata cttctaggac
     1141 cttctggaag agcaaagtcc tacaatgaga ttggccgagc cattgcaacc ctcatggtgg
     1201 atgatctctt cagcgatgtg gcttataaag cacggaatcg agaagatctg atcgcaggag
     1261 ttgatgaatt tctagatgag gtcattgtcc ttccccctgg agagtgggat ccaaacatca
     1321 gaattgagcc gcccaagaaa gttccctcag ccgacaagag gaaatctgtg ttctctctgg
     1381 cagagctggg ccagatgaat ggctctgtgg gcagaagcgg agcctcggcc ggaggaggcg
     1441 gcagtggcgg aggggctgga ggcagcgggg ccggcggagg aggcagtggc aacgaggctg
     1501 agatgccagc tatgcatgaa attggggagg agctgatctg gaccggaagg ttttttggag
     1561 gactgcgtct ggatgtaaag aggaagctgc cctggttccc aagtgacttc tatgatggct
     1621 tccacatcca gtccatctct gctgtcctgt tcatctacct cggctgtatc accaatgcta
     1681 tcaccttcgg tgggcttctg ggggatgcca cagacaatta tcagggagta atggagagct
     1741 tcctgggcac tgccatggct ggcagcttgt tctgcctctt ctcggggcag cctctcatca
     1801 tcctcagcag cacaggaccc atcctcatct ttgaaaagct cctctttgac ttcagcaagg
     1861 ccaatggcct ggactacatg gagttccgcc tctggattgg tcttcactca gccatccaat
     1921 gccttatcct ggtggccaca gatgccagct ttatcatcaa gtatatcacc cgcttcaccg
     1981 aagagggctt ctccaccctc atcagtttca tcttcatcta cgacgccatc aaaaagatga
     2041 ttggtgcctt caaatactat cccattaaca cggacttcaa gcccgactcc atcaccacct
     2101 acaaatgcga gtgcgtcgct cctgacacag tgaatacaac cactgtcaac gactcagccc
     2161 tgctggtgcc aaacaccaac atgtctgtgt acacccccct taacctcaca gcgctggact
     2221 ggtctctgct gagcaagaag gaatgtctga gctatggggg gcgcctgctt gggagctcct
     2281 gccagttcgt ccccgacttg gccctcatgt ccttcatcct tttctttggg acttactcca
     2341 tgaccttgac tctgaagaaa ttcaaattca gccgctattt ccccaccaag gtccgaaccc
     2401 tggtggctga cttctccatt gttttctcca tcctgctgtt ctgtggaatc gatgcctgtt
     2461 ttggcctgca aacccccaag ctgcacgtgc ctaatgtcat caagcccaca aggcctgacc
     2521 gaggctggtt cgttgccccc tttgggaaga atccttggtg ggtgtaccct gccagcatcc
     2581 tgccggccct gctggtgacc atcctgatct tcatggacca gcagatcact gctgtcattg
     2641 tcaacaggaa ggagaacaag ctgaggaagg ccgccggcta ccatctggac ctgttctggg
     2701 tgggcatcct catggccctg tgctccttca tggggctccc ctggtatgtg gctgccacgg
     2761 tcatctccat cgctcacatc gacagcctca agatggagac ggagaccagt gccccagggg
     2821 aacagcccca gttcctgggg gtcagggagc agagagttac tggagtcatg gtcttcattc
     2881 tgacaggcat ctccgtcttc ctggctccta tcctgaagta catccccatg ccagtgctct
     2941 atggtgtctt cctctacatg ggtgtggcct ccctgaatgg catccagttc tgggaccgct
     3001 gtaagctttt cctcatgcca gccaagcacc agccggacca tgccttcctg cgccacgtgc
     3061 cccttcgccg gatccacctg ttcaccctgg tgcagatcct ctgcctggcc ctgctctgga
     3121 tccttaagtc aaccatggct gctatcatct tcccggtcat gatcctgggc ctaatcattg
     3181 ttcgaaggct cctggacttg attttctccc agcatgacct ggcctggatt gacaatatcc
     3241 tcccagagaa ggagaaaaag gaatcagaca ggaagaagag gaggaaagag gtccacgaga
     3301 acacggacaa ggagccccag ttccttcctc cctcagttgt aaagatccca atggaaggta
     3361 tcccatctga tccccaaaac ggtatccact gtgttggcag aaaaagatct tccagttgga
     3421 gccactctct ctgactcctc cttcagtgcc tcagaaccag atagaagcat caccctgcat
     3481 ttcaaaatct cttgtccggc ctcacctgct ttcagctact cacggagtcc actcttcatg
     3541 gtgccacagg tgaggataga gatggactct gacctcaacc tcacagatga cgaggaggac
     3601 tatgggagag aggtgggcgg ggagaccacc ctctagtcct acgtggctct tccaggctgg
     3661 gggcagggca aagctggccc tggcttcatc tagagcgtgt gtcaggcctt tcacctgctt
     3721 cctgacccac tgaccagata gacaactgga ggcctttcag ggatgtctga cagagacatg
     3781 aagctccctg cttctctttg cagttcttaa aatacccaaa acacacggct taaaatgcca
     3841 cctggcatag ataggatctt tcttgtgaga agaacaaaaa tgttttccaa agttacaaat
     3901 aagataaagg gccagtggtg agcgcacatt taaaatgtgt actgatgtag tctcttctgc
     3961 tcaaatcaaa ccccggttta gtgtctttcg aaggtttgat ggacgtctaa gtgatggcct
     4021 tgaaggtcta aatgtgttga gcaggtttgc acggcaggac atggctgggt agttatcttt
     4081 ccctccttct gctttaagtc cagtcctcca ttcagtggac ctggctgttt aagtggggct
     4141 gggcctttca cacactgaaa agccagttct aaatcattcc taggagaacc tgtgtatcac
     4201 aggtacacag tgagcaccca cagttttcct ggaactcctg tgtagatcag gctagcctca
     4261 gaattcagag agccacccgt ctggctcaga gtggattgtt tttaaggcaa aatagtatcc
     4321 attaattgaa ctcttgagtc acactagatc aaccaaatga ccctttaaat gtcactggct
     4381 tcataacctg gaattcccct acttgttgat gtatttgaat aggtcccttc tttccctgca
     4441 cctcaatttt gcagtaacta aagcccagat ttccaatctc aagaacactg catgtggggt
     4501 agctaatggt ggtcaggcta gtactctgta caagtggttg gaagaaacac cattcccaac
     4561 tgggtgaaac ggcccagttc ttcactgatc caaaccctgt ccaacacaaa cgtgtttatc
     4621 ttcctcctca ccaatcccgg gagagctaaa agcatccgtc agtctcgccg acctgcaata
     4681 gcattctatc cagactcagc cgtagcatcg tcacagactc ggagagcagt gtgcttcatt
     4741 aaccaaactg gctgggaaac cagttagttt ttaagaggtt gatcacttta tctaattttt
     4801 accttaaata tcatttatat tttgtgtata cacgaacatt tttaccttta atatgctggt
     4861 gtattaactc tccattcact taggaattca tttcctccat ctctaatgta aactgctctt
     4921 caataaaatt taaatcatgt ctgcttacct ta
//
