LOCUS       NM_053424               3573 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus solute carrier family 4 member 4 (Slc4a4), mRNA.
ACCESSION   NM_053424
VERSION     NM_053424.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3573)
  AUTHORS   Nolly,M.B., Vargas,L.A., Correa,M.V., Lofeudo,J.M., Pinilla,A.O.,
            Rueda,J.O.V., Guerrero-Gimenez,M.E., Swenson,E.R., Damiani,M.T. and
            Alvarez,B.V.
  TITLE     Carbonic anhydrase IX and hypoxia-inducible factor 1 attenuate
            cardiac dysfunction after myocardial infarction
  JOURNAL   Pflugers Arch 473 (8), 1273-1285 (2021)
   PUBMED   34231059
  REMARK    GeneRIF: Carbonic anhydrase IX and hypoxia-inducible factor 1
            attenuate cardiac dysfunction after myocardial infarction.
REFERENCE   2  (bases 1 to 3573)
  AUTHORS   Liu,J., Liu,W., Li,H., Deng,Q., Yang,M., Li,X. and Liang,Z.
  TITLE     Identification of key genes and pathways associated with
            cholangiocarcinoma development based on weighted gene correlation
            network analysis
  JOURNAL   PeerJ 7, e7968 (2019)
   PUBMED   31687280
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3573)
  AUTHORS   Ciocci Pardo,A., Gonzalez Arbelaez,L.F., Fantinelli,J.C.,
            Aiello,E.A. and Mosca,S.M.
  TITLE     Calcineurin/P38MAPK/HSP27-dependent pathways are involved in the
            attenuation of postischemic mitochondrial injury afforded by sodium
            bicarbonate co-transporter (NBCe1) inhibition
  JOURNAL   Biochem Pharmacol 161, 26-36 (2019)
   PUBMED   30615862
  REMARK    GeneRIF: NBCe1 inhibition limits cell death, improves myocardial
            post-ischemic contractility and mitochondrial state through
            calcineurin/P38MAPK/HSP27-dependent pathways.
REFERENCE   4  (bases 1 to 3573)
  AUTHORS   Minocha,E., Chaturvedi,C.P. and Nityanand,S.
  TITLE     Renogenic characterization and in vitro differentiation of rat
            amniotic fluid stem cells into renal proximal tubular- and
            juxtaglomerular-like cells
  JOURNAL   In Vitro Cell Dev Biol Anim 55 (2), 138-147 (2019)
   PUBMED   30645697
REFERENCE   5  (bases 1 to 3573)
  AUTHORS   Virreira,M., Jin,L., Djerbib,S., De Deken,X., Miot,F., Massart,C.,
            Svoboda,M., Van Sande,J., Beauwens,R., Dumont,J.E. and Boom,A.
  TITLE     Expression, Localization, and Regulation of the Sodium Bicarbonate
            Cotransporter NBCe1 in the Thyroid
  JOURNAL   Thyroid 29 (2), 290-301 (2019)
   PUBMED   30526387
  REMARK    GeneRIF: the sodium bicarbonate cotransporter NBCe1-B is expressed
            in rat and human thyroid
REFERENCE   6  (bases 1 to 3573)
  AUTHORS   Thevenod,F., Roussa,E., Schmitt,B.M. and Romero,M.F.
  TITLE     Cloning and immunolocalization of a rat pancreatic Na(+)
            bicarbonate cotransporter
  JOURNAL   Biochem Biophys Res Commun 264 (1), 291-298 (1999)
   PUBMED   10527880
REFERENCE   7  (bases 1 to 3573)
  AUTHORS   Choi,I., Romero,M.F., Khandoudi,N., Bril,A. and Boron,W.F.
  TITLE     Cloning and characterization of a human electrogenic Na+-HCO-3
            cotransporter isoform (hhNBC)
  JOURNAL   Am J Physiol 276 (3), C576-C584 (1999)
   PUBMED   10069984
REFERENCE   8  (bases 1 to 3573)
  AUTHORS   Abuladze,N., Lee,I., Newman,D., Hwang,J., Boorer,K., Pushkin,A. and
            Kurtz,I.
  TITLE     Molecular cloning, chromosomal localization, tissue distribution,
            and functional expression of the human pancreatic sodium
            bicarbonate cotransporter
  JOURNAL   J Biol Chem 273 (28), 17689-17695 (1998)
   PUBMED   9651366
REFERENCE   9  (bases 1 to 3573)
  AUTHORS   Burnham,C.E., Flagella,M., Wang,Z., Amlal,H., Shull,G.E. and
            Soleimani,M.
  TITLE     Cloning, renal distribution, and regulation of the rat Na+-HCO3-
            cotransporter
  JOURNAL   Am J Physiol 274 (6), F1119-F1126 (1998)
   PUBMED   9841505
REFERENCE   10 (bases 1 to 3573)
  AUTHORS   Romero,M.F., Fong,P., Berger,U.V., Hediger,M.A. and Boron,W.F.
  TITLE     Cloning and functional expression of rNBC, an electrogenic
            Na(+)-HCO3- cotransporter from rat kidney
  JOURNAL   Am J Physiol 274 (2), F425-F432 (1998)
   PUBMED   9486238
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF254802.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF254802.1, AF210250.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132306,
                                           SAMEA5756307 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3573
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..3573
                     /gene="Slc4a4"
                     /gene_synonym="HHNMC; HNBC1; KNBC; Nbc1; NBC2; Nbc4; PNBC;
                     SLC4A5"
                     /note="solute carrier family 4 member 4"
                     /db_xref="GeneID:84484"
                     /db_xref="RGD:68936"
     exon            1..52
                     /gene="Slc4a4"
                     /gene_synonym="HHNMC; HNBC1; KNBC; Nbc1; NBC2; Nbc4; PNBC;
                     SLC4A5"
                     /inference="alignment:Splign:2.1.0"
     exon            53..126
                     /gene="Slc4a4"
                     /gene_synonym="HHNMC; HNBC1; KNBC; Nbc1; NBC2; Nbc4; PNBC;
                     SLC4A5"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..3293
                     /gene="Slc4a4"
                     /gene_synonym="HHNMC; HNBC1; KNBC; Nbc1; NBC2; Nbc4; PNBC;
                     SLC4A5"
                     /note="NBC-like protein; sodium bicarbonate cotransporter;
                     Na(+)/HCO3(-) cotransporter; Na+HCO3- cotransporter 4;
                     solute carrier family 4 (anion exchanger), member 4;
                     solute carrier family 4, sodium bicarbonate cotransporter,
                     member 4"
                     /codon_start=1
                     /product="electrogenic sodium bicarbonate cotransporter 1"
                     /protein_id="NP_445876.1"
                     /db_xref="GeneID:84484"
                     /db_xref="RGD:68936"
                     /translation="MEDEAVLDRGASFLKHVCDEEEVEGHHTIYIGVHVPKSYRRRRR
                     HKRKAGHKEKKEKERISENYSDKSDVENADESSSSILKPLISPAAERIRFILGEEDDS
                     PAPPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFE
                     LRTCMEKGSIMLDREASSLPQLVEMIADHQIETGLLKPDLKDKVTYTLLRKHRHQTKK
                     SNLRSLADIGKTVSSASRMFSNPDNGSPAMTHRNLTSSSLNDISDKPEKDQLKNKFMK
                     KLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLFILLGPKGKA
                     KSYHEIGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWDPAIRIE
                     PPKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHGGGGHGDCEELQRTGRFCGGLIKDI
                     KRKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGDATDNMQGVLESFLGT
                     AVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDHSFDYLEFRLWIGLWSAFMCL
                     ILVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSDFRVGYNTH
                     FSCACLPPDPVNLSVSNDTTLAPEDLPTVSSTDMYHNATFDWAYLSKKECVKFGGKLV
                     GNNCDFVPDITLMSFILFLGTYTSSMAMKKFKTSRYFPTTARKLISDFAIILSILIFC
                     VIDALVGVDTPKLIVPSEFKPTSPHRGWFVPPFGGNPWWVCLAAAIPALLVTILIFMD
                     QQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVVCSFMALPWYVAATVISIAHIDSLK
                     METETSAPGEQPKFLGVREQRVTGTLVFILTGLSVFMAPILKFIPMPVLYGVFLYMGV
                     ASLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTSLQVLCLALLWILKSTVA
                     AIIFPVMILALVAVRKGMDYLFSQHDLSFLDDVIPEKDKKKKEDEKKKKKKKGSLDSD
                     NDDSDCPYSEKVPSIKIPMDITEQQPFLSDNKPLDRERSSTFLERHTSC"
     exon            127..306
                     /gene="Slc4a4"
                     /gene_synonym="HHNMC; HNBC1; KNBC; Nbc1; NBC2; Nbc4; PNBC;
                     SLC4A5"
                     /inference="alignment:Splign:2.1.0"
     exon            307..442
                     /gene="Slc4a4"
                     /gene_synonym="HHNMC; HNBC1; KNBC; Nbc1; NBC2; Nbc4; PNBC;
                     SLC4A5"
                     /inference="alignment:Splign:2.1.0"
     exon            443..603
                     /gene="Slc4a4"
                     /gene_synonym="HHNMC; HNBC1; KNBC; Nbc1; NBC2; Nbc4; PNBC;
                     SLC4A5"
                     /inference="alignment:Splign:2.1.0"
     exon            604..783
                     /gene="Slc4a4"
                     /gene_synonym="HHNMC; HNBC1; KNBC; Nbc1; NBC2; Nbc4; PNBC;
                     SLC4A5"
                     /inference="alignment:Splign:2.1.0"
     exon            784..860
                     /gene="Slc4a4"
                     /gene_synonym="HHNMC; HNBC1; KNBC; Nbc1; NBC2; Nbc4; PNBC;
                     SLC4A5"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1018
                     /gene="Slc4a4"
                     /gene_synonym="HHNMC; HNBC1; KNBC; Nbc1; NBC2; Nbc4; PNBC;
                     SLC4A5"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1106
                     /gene="Slc4a4"
                     /gene_synonym="HHNMC; HNBC1; KNBC; Nbc1; NBC2; Nbc4; PNBC;
                     SLC4A5"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1261
                     /gene="Slc4a4"
                     /gene_synonym="HHNMC; HNBC1; KNBC; Nbc1; NBC2; Nbc4; PNBC;
                     SLC4A5"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1375
                     /gene="Slc4a4"
                     /gene_synonym="HHNMC; HNBC1; KNBC; Nbc1; NBC2; Nbc4; PNBC;
                     SLC4A5"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1550
                     /gene="Slc4a4"
                     /gene_synonym="HHNMC; HNBC1; KNBC; Nbc1; NBC2; Nbc4; PNBC;
                     SLC4A5"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1684
                     /gene="Slc4a4"
                     /gene_synonym="HHNMC; HNBC1; KNBC; Nbc1; NBC2; Nbc4; PNBC;
                     SLC4A5"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1956
                     /gene="Slc4a4"
                     /gene_synonym="HHNMC; HNBC1; KNBC; Nbc1; NBC2; Nbc4; PNBC;
                     SLC4A5"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2027
                     /gene="Slc4a4"
                     /gene_synonym="HHNMC; HNBC1; KNBC; Nbc1; NBC2; Nbc4; PNBC;
                     SLC4A5"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2219
                     /gene="Slc4a4"
                     /gene_synonym="HHNMC; HNBC1; KNBC; Nbc1; NBC2; Nbc4; PNBC;
                     SLC4A5"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2333
                     /gene="Slc4a4"
                     /gene_synonym="HHNMC; HNBC1; KNBC; Nbc1; NBC2; Nbc4; PNBC;
                     SLC4A5"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2495
                     /gene="Slc4a4"
                     /gene_synonym="HHNMC; HNBC1; KNBC; Nbc1; NBC2; Nbc4; PNBC;
                     SLC4A5"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2674
                     /gene="Slc4a4"
                     /gene_synonym="HHNMC; HNBC1; KNBC; Nbc1; NBC2; Nbc4; PNBC;
                     SLC4A5"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..2747
                     /gene="Slc4a4"
                     /gene_synonym="HHNMC; HNBC1; KNBC; Nbc1; NBC2; Nbc4; PNBC;
                     SLC4A5"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..2816
                     /gene="Slc4a4"
                     /gene_synonym="HHNMC; HNBC1; KNBC; Nbc1; NBC2; Nbc4; PNBC;
                     SLC4A5"
                     /inference="alignment:Splign:2.1.0"
     exon            2817..2990
                     /gene="Slc4a4"
                     /gene_synonym="HHNMC; HNBC1; KNBC; Nbc1; NBC2; Nbc4; PNBC;
                     SLC4A5"
                     /inference="alignment:Splign:2.1.0"
     exon            2991..3152
                     /gene="Slc4a4"
                     /gene_synonym="HHNMC; HNBC1; KNBC; Nbc1; NBC2; Nbc4; PNBC;
                     SLC4A5"
                     /inference="alignment:Splign:2.1.0"
     exon            3153..3249
                     /gene="Slc4a4"
                     /gene_synonym="HHNMC; HNBC1; KNBC; Nbc1; NBC2; Nbc4; PNBC;
                     SLC4A5"
                     /inference="alignment:Splign:2.1.0"
     exon            3250..3329
                     /gene="Slc4a4"
                     /gene_synonym="HHNMC; HNBC1; KNBC; Nbc1; NBC2; Nbc4; PNBC;
                     SLC4A5"
                     /inference="alignment:Splign:2.1.0"
     exon            3330..3573
                     /gene="Slc4a4"
                     /gene_synonym="HHNMC; HNBC1; KNBC; Nbc1; NBC2; Nbc4; PNBC;
                     SLC4A5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctcacattc ggtcgccaaa ctggaggagc gacggaagcc cgatcccagg aggatggagg
       61 atgaagctgt cctggacaga ggggcttcct tccttaaaca tgtgtgtgac gaagaagaag
      121 tagaaggtca ccacacgatc tacattgggg tccatgtgcc caagagctac cggagaagga
      181 gacgccataa gagaaaggct gggcacaagg aaaagaagga gaaggaaagg atctctgaga
      241 actattccga caaatcagat gtggagaatg cggacgaatc cagcagcagc atcctcaagc
      301 cgctcatctc cccggccgca gaacgtatcc gattcatctt gggagaggaa gatgacagcc
      361 cagcacctcc tcagctcttc acggaactcg atgagctgct ggctgtggat ggacaggaga
      421 tggaatggaa ggagacagcc aggtggatta agtttgaaga gaaagtggaa cagggtgggg
      481 agcgatggag caaaccccat gtggccacct tgtccctgca cagcttgttt gagctgagga
      541 catgtatgga gaaaggatcc atcatgcttg accgggaggc ctcctctctc ccacagctgg
      601 tggagatgat tgcagaccac cagatcgaga caggcctctt gaagcccgac ctcaaggata
      661 aggtcaccta tacgctgctg cggaaacacc gacatcaaac caagaaatcc aaccttcggt
      721 ccctggctga cattgggaag acagtctcca gtgcaagtag gatgttcagc aaccctgata
      781 acggtagccc agctatgacc cacaggaatc tgacatcctc cagtctcaat gacatttctg
      841 ataaaccaga gaaggaccag ctgaagaata aattcatgaa aaaactgccc cgtgatgcag
      901 aagcttccaa cgtgctcgtt ggggaggttg acttcttgga cactcccttc attgcctttg
      961 ttcgtctaca gcaggctgtc atgctgggtg ccctgactga ggtgcctgtg cccacaaggt
     1021 tcttgttcat tctcttaggt ccaaagggga aagccaagtc ctaccatgag atcggaagag
     1081 ccatcgccac cttgatgtct gacgaggtgt tccacgatat cgcttacaaa gcgaaagata
     1141 gacacgacct gattgctggc attgacgagt tcttagatga agtcattgtc cttccacctg
     1201 gggaatggga cccggcaatc agaatagaac ctccaaagag cctcccatca tctgacaaaa
     1261 ggaagaatat gtactcaggt ggagagaacg ttcagatgaa tggggacaca cctcatgatg
     1321 gaggccacgg aggaggaggc cacggtgact gtgaagaact acagagaact ggccggttct
     1381 gtggtggatt aattaaggac ataaagagga aagcaccatt ttttgccagt gacttttatg
     1441 acgctttaaa tattcaggct ctctcggcaa ttctcttcat ctatctggcg acggtaacca
     1501 acgccatcac tttcggaggc ctgctcgggg atgccactga caacatgcag ggtgtgttgg
     1561 agagtttcct gggcactgct gtctctggcg ccatcttttg cctttttgcg ggtcaaccgc
     1621 tcaccatctt gagtagcacg ggacctgttc tggtgtttga gaggcttctt ttcaacttca
     1681 gcaaggacca tagttttgac tacttggagt ttcgtctttg gattggcctg tggtcagcct
     1741 tcatgtgtct catcctggtg gccactgatg ccagcttcct ggttcagtac ttcacccgtt
     1801 tcacggaaga aggattctcc tctctgatca gcttcatctt catctatgat gctttcaaga
     1861 agatgatcaa gctggcagat tactatccca tcaactctga cttcagagtg ggctacaaca
     1921 ctcacttctc ctgtgcttgc ctgccacctg acccagttaa tctctcagta tctaatgata
     1981 ccacactagc cccagaggac ctgccaaccg tttcttctac tgacatgtac cacaatgcta
     2041 cctttgactg ggcctacttg tcaaagaaag agtgtgtgaa atttggagga aagctcgtgg
     2101 gaaacaactg tgacttcgtg cctgacatca cactcatgtc cttcatcctc ttcctgggca
     2161 cttacacctc ttctatggcc atgaagaaat tcaaaaccag ccgctatttt ccaaccacag
     2221 caagaaaact gatcagcgat tttgccatca tcctgtccat tctcatattc tgtgtaatag
     2281 acgccctcgt cggtgtggat actccgaagc taattgtgcc aagtgagttc aagccaacaa
     2341 gccctcaccg gggttggttt gtcccaccct ttggaggaaa cccctggtgg gtgtgccttg
     2401 ctgctgctat cccggctttg ctagtcacca tcctgatttt catggaccag caaatcacgg
     2461 ccgtgattgt gaacaggaaa gaacataagc tcaagaaggg agctggctat cacctggacc
     2521 tgttttgggt cgccatcctc atggtggtgt gctccttcat ggctcttccc tggtatgtgg
     2581 ctgctactgt catctccatc gctcacatcg acagtctgaa gatggagaca gagacttctg
     2641 cgcctggaga acaaccaaag tttctgggag tgagagaaca acgagtcact ggaacccttg
     2701 tgtttattct gactggcctg tcagtcttta tggctcccat cttgaagttt atccccatgc
     2761 ctgttctgta tggcgtgttc ttgtatatgg gggtggcctc actgaacggt gtgcagttca
     2821 tggaccgtct taagctgctt ctcatgcccc tgaagcatca acctgacttc atctacctgc
     2881 gccacgtccc cctgcgccga gtccacctgt tcacctccct gcaggtgttg tgcctggctc
     2941 tgctctggat cctcaagtcc acagtggctg cgattatttt tccagttatg atcctggccc
     3001 tggtagctgt cagaaaaggt atggactacc tcttctccca gcacgacctc agcttccttg
     3061 atgatgtcat tccagagaag gacaagaaaa agaaggagga tgagaagaag aagaaaaaga
     3121 agaaaggaag tctggatagc gacaacgacg attctgactg cccatactca gaaaaggtcc
     3181 ccagtattaa aattccaatg gacatcacgg aacagcaacc tttcctaagt gataacaaac
     3241 ccttggacag agaaagatcc tcaacattcc ttgaacgcca cacatcatgc tgataaaatt
     3301 cctttccttg agtcactggg tttacccagt cctccaagat ctccagtgaa agtcgtgcct
     3361 caaattagaa tagaacttga gtctgaagac aacgattatc tttggaggaa caagggaaca
     3421 gaaaccacgt tgtaacctgt tagtcattct caaaactgac agttctgttg ttaactgttc
     3481 taattttttt tttgtctatg tattttaaaa acttttgttt ggtcactgac tgaataatac
     3541 agtcactctc tctgcttctc tcttgcatag gta
//
