LOCUS       NM_017048               4053 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Rattus norvegicus solute carrier family 4 member 2 (Slc4a2), mRNA.
ACCESSION   NM_017048
VERSION     NM_017048.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4053)
  AUTHORS   Wang,W., Ren,X., Cai,Y., Chen,L., Zhang,W. and Xu,J.
  TITLE     Rifampicin Induces Bicarbonate-Rich Choleresis in Rats: Involvement
            of Anion Exchanger 2
  JOURNAL   Dig Dis Sci 61 (1), 126-136 (2016)
   PUBMED   26319954
  REMARK    GeneRIF: Results indicate that the increase in bile flow induced by
            rifampicin is mainly due to increased HCO3 (-) excretion mediated
            by increased AE2 protein expression and activity.
REFERENCE   2  (bases 1 to 4053)
  AUTHORS   Bernardino,R.L., Martins,A.D., Socorro,S., Alves,M.G. and
            Oliveira,P.F.
  TITLE     Effect of prediabetes on membrane bicarbonate transporters in
            testis and epididymis
  JOURNAL   J Membr Biol 246 (12), 877-883 (2013)
   PUBMED   24105628
REFERENCE   3  (bases 1 to 4053)
  AUTHORS   Loqman,M.Y., Bush,P.G., Farquharson,C. and Hall,A.C.
  TITLE     Suppression of mammalian bone growth by membrane transport
            inhibitors
  JOURNAL   J Cell Biochem 114 (3), 658-668 (2013)
   PUBMED   23059814
  REMARK    GeneRIF: These results demonstrate that NHE1 and AE2 are important
            regulators of bone growth.
REFERENCE   4  (bases 1 to 4053)
  AUTHORS   Xiong,Y., Li,Y., Xiong,Y., Zhao,Y., Tang,F. and Wang,X.
  TITLE     Exhaustive running exercise induce tyrosine phosphorylation of band
            3 in rat erythrocytes
  JOURNAL   Cell Physiol Biochem 32 (4), 1060-1071 (2013)
   PUBMED   24192602
  REMARK    GeneRIF: Results suggest that exhaustive running exercise results
            in elevated band-3 tyrosine phosphorylation and alters band-3
            membrane organization.
REFERENCE   5  (bases 1 to 4053)
  AUTHORS   Schwabe,K. and Cetin,Y.
  TITLE     Guanylin and functional coupling proteins in the hepatobiliary
            system of rat and guinea pig
  JOURNAL   Histochem Cell Biol 137 (5), 589-597 (2012)
   PUBMED   22310983
REFERENCE   6  (bases 1 to 4053)
  AUTHORS   Chow,A., Zhou,W. and Jacobson,R.
  TITLE     Regulation of AE2 Cl-/HCO3- exchanger during intestinal development
  JOURNAL   Am J Physiol 271 (2 Pt 1), G330-G337 (1996)
   PUBMED   8770049
REFERENCE   7  (bases 1 to 4053)
  AUTHORS   Simon,J.S., Deshmukh,G., Couch,F.J., Merajver,S.D., Weber,B.L., Van
            Vooren,P., Tissil,F., Szpirer,J., Szpirer,C., Alper,S.L.,
            Jacob,H.J. and Brosius,F.C. 3rd.
  TITLE     Chromosomal mapping of the rat Slc4a family of anion exchanger
            genes, Ae1, Ae2, and Ae3
  JOURNAL   Mamm Genome 7 (5), 380-382 (1996)
   PUBMED   8661729
REFERENCE   8  (bases 1 to 4053)
  AUTHORS   Wang,Z., Schultheis,P.J. and Shull,G.E.
  TITLE     Three N-terminal variants of the AE2 Cl-/HCO3- exchanger are
            encoded by mRNAs transcribed from alternative promoters
  JOURNAL   J Biol Chem 271 (13), 7835-7843 (1996)
   PUBMED   8631828
REFERENCE   9  (bases 1 to 4053)
  AUTHORS   Lindsey,A.E., Schneider,K., Simmons,D.M., Baron,R., Lee,B.S. and
            Kopito,R.R.
  TITLE     Functional expression and subcellular localization of an anion
            exchanger cloned from choroid plexus
  JOURNAL   Proc Natl Acad Sci U S A 87 (14), 5278-5282 (1990)
   PUBMED   2371270
REFERENCE   10 (bases 1 to 4053)
  AUTHORS   Kudrycki,K.E., Newman,P.R. and Shull,G.E.
  TITLE     cDNA cloning and tissue distribution of mRNAs for two proteins that
            are related to the band 3 Cl-/HCO3- exchanger
  JOURNAL   J Biol Chem 265 (1), 462-471 (1990)
   PUBMED   2294114
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J05166.1.
            
            On Aug 31, 2012 this sequence version replaced NM_017048.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J05166.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4053              J05166.1           5-4057
FEATURES             Location/Qualifiers
     source          1..4053
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..4053
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; Aep2"
                     /note="solute carrier family 4 member 2"
                     /db_xref="GeneID:24780"
                     /db_xref="RGD:3711"
     exon            1..133
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; Aep2"
                     /inference="alignment:Splign:2.1.0"
     exon            134..247
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; Aep2"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..3901
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; Aep2"
                     /note="AE2 Cl-/HCO3-exchanger, variant AE2b; AE 2; solute
                     carrier family 4 (anion exchanger), member 2; B3RP-2;
                     anion exchanger 2; band 3-related protein 2; non-erythroid
                     band 3-like protein; Solute carrier family 4, member 2,
                     anion exchange protein 2"
                     /codon_start=1
                     /product="anion exchange protein 2"
                     /protein_id="NP_058744.1"
                     /db_xref="GeneID:24780"
                     /db_xref="RGD:3711"
                     /translation="MSSAPRRPASGADSLHTPEPESLSPGTPGFPEQEEEDELRTLGV
                     ERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGP
                     GRKPRRRPGASPTGETPTIEEGEEDEDEVGEAEGFRAPPQQPSPASSPSAVQFFLQED
                     EGTDRKAERTSPSPPTQTPHQEAAPRASKGAQTGTLVEEMVAVASGTAGGDDGGAAGR
                     PLTKAQPGHRSYNLQERRRIGSMTGVEQALLPRVPTDESEAQTLATADLDLMKSHRFE
                     DVPGVRRHLVRKNAKGSTQAAREGREPGPTPRARPRAPHKPHEVFVELNELQLDKNQE
                     PQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLP
                     GVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKEFSFPRNISAGSLGSLLGH
                     HHAQGTESDPHVTEPLIGGVPETRLEVDRERELPPPAPPAGITRSKSKHELKLLEKIP
                     ENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDY
                     HEIGRSISTLMSDKQFHEAAYLADERDDLLTAINAFLDCSVVLPPSEVQGEELLRSVA
                     HFQRQMLKKREEQGRLLPPGAGLEPKSAQDKALLQMVEVAGAAEDDPLRRTGRPFGGL
                     IRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSEL
                     IMSTALQGVIFCLLGAQPLLVIGFSGPLLVFEEAFFSFCKSNQLEYLVGRVWIGFWLV
                     LLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLIKIFQEHPLHGCSVSN
                     DSEADSSSNNMTWAATTLAPDNSSASGQERPRGQPNTALLSLVLMAGTFFIAFFLRKF
                     KNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPDKRGWV
                     INPLGEKTPFPVWMMVASLLPAVLVFILIFMETQITTLIISKKERMLQKGSGFHLDLL
                     LIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVTGLL
                     VALLVGLSMVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVT
                     YVKKVRTMRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMVVLTRIFTER
                     EMKCLDANEAEPVFDECEGVDEYNEMPMPV"
     exon            248..413
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; Aep2"
                     /inference="alignment:Splign:2.1.0"
     exon            414..658
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; Aep2"
                     /inference="alignment:Splign:2.1.0"
     exon            659..777
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; Aep2"
                     /inference="alignment:Splign:2.1.0"
     exon            778..1010
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; Aep2"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1153
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; Aep2"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1334
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; Aep2"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1470
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; Aep2"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1636
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; Aep2"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1751
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; Aep2"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1936
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; Aep2"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2162
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; Aep2"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2378
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; Aep2"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2527
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; Aep2"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2722
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; Aep2"
                     /inference="alignment:Splign:2.1.0"
     exon            2723..2965
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; Aep2"
                     /inference="alignment:Splign:2.1.0"
     exon            2966..3055
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; Aep2"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3222
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; Aep2"
                     /inference="alignment:Splign:2.1.0"
     exon            3223..3476
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; Aep2"
                     /inference="alignment:Splign:2.1.0"
     exon            3477..3646
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; Aep2"
                     /inference="alignment:Splign:2.1.0"
     exon            3647..3820
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; Aep2"
                     /inference="alignment:Splign:2.1.0"
     exon            3821..4053
                     /gene="Slc4a2"
                     /gene_synonym="Ae2; Aep2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagttgggag aagttgggag cggcgggggc gcgccccggg gtgggcaccg ggaaatcgtc
       61 gggagcgcgc gagggttccg gaggatcagg ggagacccgg agacccccgg gacacgaaat
      121 ctagagctag cgggttatgc ctccaccttg ttgccctgaa agccgaagcg acagtgagaa
      181 gggctaagat ttggccatga gcagcgcccc caggcgcccc gcctcgggcg cagattcttt
      241 gcacacgcca gagccagaga gcctgagccc cggaacacct gggttccctg agcaagagga
      301 ggaagatgaa cttcgtacct taggtgtgga gcggttcgag gagatcctcc aggaagctgg
      361 atccagagga ggagaagagc caggccgcag ctatggggag gaagactttg aataccaccg
      421 ccagtcctcc caccatatcc atcatccact ctccacccac ctgcctcctg acgcccgccg
      481 tcgcaagact ccccagggcc caggacggaa acctcggagg cgccctggag cctctcccac
      541 tggagagacc cccactattg aggaagggga ggaagatgag gatgaagtcg gtgaagctga
      601 agggttcaga gctcccccgc aacaaccatc tcctgcctct tcaccctctg cagttcagtt
      661 ttttctccaa gaggatgaag gtacagatag gaaggcagag agaaccagcc catctccccc
      721 tacacagacg ccccaccagg aagcagctcc ccgggccagc aaaggggcac agacaggaac
      781 tctggtggag gagatggtgg ccgtggccag cggcacggct ggaggtgacg acggaggtgc
      841 tgcagggcgc cccctgacca aagcccagcc tggacatcga agttacaacc ttcaggagag
      901 aaggcgaatt ggcagtatga caggggtgga gcaggccctg ctgcccaggg tccctactga
      961 tgagagtgag gctcagacgc tggccacagc tgacctcgac ctcatgaaaa gtcaccggtt
     1021 tgaggacgtt ccgggggtac ggcgacattt ggtgaggaag aatgccaaag ggtctacaca
     1081 ggctgcccgg gaaggccgag agcctggccc cacacctcgg gcacgaccac gggcccccca
     1141 taagcctcat gaggtgttcg tagagctgaa tgaattgcag ttggacaaaa accaggagcc
     1201 tcagtggcgg gagacagccc ggtggataaa atttgaggag gacgtggaag aggagactga
     1261 gcgctggggc aagcctcacg tggcatcact gtccttccgc agcctcctgg agctccgcag
     1321 gacactggcc catggagctg tgctcttgga cctcgatcag cagaccctgc ctggggtggc
     1381 ccatcaggtg gtcgagcaga tggttatctc tgaccagatc aaagcagagg acagagccaa
     1441 tgtgctacga gcccttctgc tgaaacacag ccacccaagt gatgagaaag aattctcctt
     1501 cccccggaac atctcagcgg gctctctggg ctctctcctg gggcatcacc acgcccaggg
     1561 gactgagagt gatcctcacg tcactgagcc tctcatcggt ggtgttcctg agacccggct
     1621 ggaggtggat agagagcgtg agctgccgcc cccagcccca cctgcaggta ttacccgctc
     1681 caagtccaag catgagctga agctgctgga gaagatccct gagaatgcag aggccacagt
     1741 ggtcctcgtg ggctgtgtgg agttcctctc ccgccccacc atggcctttg tgcgcctgcg
     1801 ggaggctgtg gaactggatg cagtactgga ggtgcctgtg cctgtgcgct tcctcttcct
     1861 gctgctgggg cccagcagcg ccaacatgga ctaccatgag attggccgat ccatctccac
     1921 cctcatgtct gacaagcaat tccacgaggc agcctacctg gcagatgaac gggatgactt
     1981 gctgactgct atcaatgcct tcctggactg cagtgttgtg ctaccgcctt ctgaagtgca
     2041 gggcgaggag ctgctgcgtt ctgttgccca tttccagcgc cagatgctaa agaagcgaga
     2101 ggagcagggc cgcctgctgc cccctggtgc tgggctagag cccaagtctg cccaagataa
     2161 ggcactcctg cagatggtag aggtggcagg tgcagctgaa gatgatcccc ttcggaggac
     2221 aggccggccc tttggggggc tgatccgtga cgtgcggcgg cgctacccgc actacctgag
     2281 tgacttccga gatgcactag acccccagtg cctggctgct gtcattttca tctactttgc
     2341 cgccctgtcg cctgccatca cttttggggg gctactgggg gagaagacac aggacctgat
     2401 aggagtgtca gagctgatca tgtccacagc gctccaggga gtgatcttct gcctgctggg
     2461 cgcccagcca ctgctggtga tcggcttctc ggggcctctg ctggtcttcg aggaggcctt
     2521 cttctcgttc tgcaagagca accagttgga gtacttggtg ggccgagttt ggattggctt
     2581 ctggctggtg ctcctggccc tgctcatggt ggctctggag gggagcttcc tggtccgctt
     2641 tgtctcccga ttcacccagg agatctttgc cttcctcata tcactcatct tcatctatga
     2701 gaccttctat aagctgatca agatctttca ggagcacccc ctccatggct gctcagtctc
     2761 caacgactca gaggcagaca gcagcagtaa caatatgact tgggcagcaa ccacactggc
     2821 accagacaac agcagtgcgt ctgggcagga gaggccccgg ggccagccta acactgcctt
     2881 gctatcactg gtgctgatgg ccggcacttt cttcatcgcc ttcttcctgc gcaaattcaa
     2941 gaacagccgg ttcttccctg gccggatccg gcgggtaatt ggggactttg gggtgcccat
     3001 cgcgatcctc atcatggtgc ttgtggatta cagtattgag gatacctaca cccagaagct
     3061 aagtgtgccc agtgggttct cagtgacagc cccagacaag cggggctggg tcatcaaccc
     3121 ccttggagag aagactcctt tccctgtgtg gatgatggtg gccagcctgt tgcctgccgt
     3181 tctggtgttc atcctcatct tcatggagac acagatcacc acgttgatca tctccaagaa
     3241 agagcggatg cttcagaagg gctctggctt ccaccttgat ctgttgctca ttgtagccat
     3301 gggtggcatc tgtgccctct ttggcctgcc ttggttggct gctgccactg tccgctctgt
     3361 cactcatgcc aatgcactca ctgtcatgag caaggctgtg gcacctggtg acaaacccaa
     3421 gattcaggaa gtcaaggagc agcgggtgac cgggctgctg gtggccctgc ttgtgggact
     3481 ctccatggtc attggggacc tactgcggca gatccccctg gctgtgctct ttggcatttt
     3541 cttatacatg ggagttactt cccttaatgg gatccaattc tacgagcggt tgcacctgct
     3601 actcatgccg cccaaacacc acccagatgt tacctatgtc aagaaggttc ggaccatgcg
     3661 gatgcacctg ttcactgcct tgcagctgct ctgtctggcc ctgctttggg cggtcatgtc
     3721 cacagctgct tccctggcct tccccttcat cctcatcctc acagtgcctt tgcgcatggt
     3781 ggtacttacc cggatcttca ctgagcgaga aatgaaatgt ctggatgcta atgaggcaga
     3841 gccagtgttt gatgagtgtg aaggtgtgga cgagtacaac gagatgccca tgcctgtgta
     3901 gctgctgtcc agaggcatag cagagggact aaggggcagg ggctgggggg ctggggagct
     3961 ggggctcccc tcctcctgtc cctcctcatt tttatttaag tgaataattt aaagccccct
     4021 tgtccccacc ctgcagtaaa gtgcttcaac ccc
//
