LOCUS       NM_001107775            3039 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 4 member 11 (Slc4a11),
            mRNA.
ACCESSION   NM_001107775 XM_001081183 XM_230605
VERSION     NM_001107775.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3039)
  AUTHORS   Gee,M.T., Kurtz,I. and Pannabecker,T.L.
  TITLE     Expression of SLC4A11 protein in mouse and rat medulla: a candidate
            transporter involved in outer medullary ammonia recycling
  JOURNAL   Physiol Rep 7 (10), e14089 (2019)
   PUBMED   31124301
  REMARK    GeneRIF: SLC4A11 is expressed relatively more abundantly in
            collecting ducts of the lower inner medulla where it is involved in
            ammonia recycling.
REFERENCE   2  (bases 1 to 3039)
  AUTHORS   Loganathan,S.K., Lukowski,C.M. and Casey,J.R.
  TITLE     The cytoplasmic domain is essential for transport function of the
            integral membrane transport protein SLC4A11
  JOURNAL   Am J Physiol Cell Physiol 310 (2), C161-C174 (2016)
   PUBMED   26582474
  REMARK    GeneRIF: We conclude that SLC4A11 is a rare integral membrane
            protein in which the CD has strong associations with the integral
            MD, which contributes to membrane transport function.
REFERENCE   3  (bases 1 to 3039)
  AUTHORS   Vilas,G.L., Loganathan,S.K., Quon,A., Sundaresan,P., Vithana,E.N.
            and Casey,J.
  TITLE     Oligomerization of SLC4A11 protein and the severity of FECD and
            CHED2 corneal dystrophies caused by SLC4A11 mutations
  JOURNAL   Hum Mutat 33 (2), 419-428 (2012)
   PUBMED   22072594
REFERENCE   4  (bases 1 to 3039)
  AUTHORS   Groger,N., Frohlich,H., Maier,H., Olbrich,A., Kostin,S., Braun,T.
            and Boettger,T.
  TITLE     SLC4A11 prevents osmotic imbalance leading to corneal endothelial
            dystrophy, deafness, and polyuria
  JOURNAL   J Biol Chem 285 (19), 14467-14474 (2010)
   PUBMED   20185830
REFERENCE   5  (bases 1 to 3039)
  AUTHORS   Damkier,H.H., Nielsen,S. and Praetorius,J.
  TITLE     Molecular expression of SLC4-derived Na+-dependent anion
            transporters in selected human tissues
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 293 (5), R2136-R2146 (2007)
   PUBMED   17715183
REFERENCE   6  (bases 1 to 3039)
  AUTHORS   Park,M., Li,Q., Shcheynikov,N., Zeng,W. and Muallem,S.
  TITLE     NaBC1 is a ubiquitous electrogenic Na+ -coupled borate transporter
            essential for cellular boron homeostasis and cell growth and
            proliferation
  JOURNAL   Mol Cell 16 (3), 331-341 (2004)
   PUBMED   15525507
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473949.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001081183.1, XM_230605.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ225785.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3039
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..3039
                     /gene="Slc4a11"
                     /note="solute carrier family 4 member 11"
                     /db_xref="GeneID:311423"
                     /db_xref="RGD:1310188"
     exon            1..116
                     /gene="Slc4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            117..179
                     /gene="Slc4a11"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..2722
                     /gene="Slc4a11"
                     /note="sodium bicarbonate transporter-like protein 11;
                     solute carrier family 4, sodium bicarbonate
                     transporter-like, member 11; solute carrier family 4,
                     sodium borate transporter, member 11"
                     /codon_start=1
                     /product="solute carrier family 4 member 11"
                     /protein_id="NP_001101245.1"
                     /db_xref="GeneID:311423"
                     /db_xref="RGD:1310188"
                     /translation="MSQNEHCQDSGEYFSAATLGYFKNDTDDNPDVREDSLGDEVFDT
                     VNSSIVSGESIRFFVNVNLEVQPSKSDIEAATGGCVLLHTSRKYLKLKNFEEEVRAHR
                     DLDGFLAQASIILNETATSLDDVLRTMLNRFAQDPNHAEPDCDLDLLMAKLFTDAGGP
                     MESKVHLLSDTIQGVTATVRGLQYEQSWLCIVCTMKSLQKRHVCISRLVRPQNWGENS
                     CEVRFVILVLAPPKMKSTKTAMEVARTFATMFSDITFRQKLLKTRTEEEFKEALVHQR
                     QLLTMMMPRAAGHSMSSLHTHRHPRPPKCKDFFPFGKGIWVDIMRRFPVYPLDFTDGI
                     IGKGKTVGKYVTTTLFLYFACLLPTIAFGSLNDENTNGAIDVQKTIAGQSIGGLLYAL
                     FSGQPLVILLTTAPLAIYTQVIRVICDDYNLDFNAFYAWTGLWNSFFLALYAFLNLSL
                     LMNLFKRSTEEIIALFISITFVLDAVKGMVKIFWKYYYGHHYHTKRTSSLASLLGISR
                     SPNTSLHTALNTSFLASPIEMTTASSPISTHSNQATAVLSLLIMLGTLWLGYTLYQFK
                     KSPYLHPCVRETLSDCALPIAVLSFSLISSYGFQEIEMSKFRYNPSESLFEVAQIHSL
                     SFKAISSAMGLGFLLSLLFFIEQNLVAALVNAPENRLVKGTAYHWDLLLLAIINTGLS
                     LFGLPWIHAAYPHSPLHVRALALVEERVENGHIYETIVNVKETRLTALGASVLVGLSL
                     LLLPFPLQWIPKPVLYGLFLYIALTSLDGNQLFSRVALLLKEQTSYPPTHYIRRVPQR
                     KIHYFTGLQILQLLLLCAFGMSSLPYMKMVFPLIMIAMIPIRYNLLPRIIEAKYLDVM
                     DAEHRP"
     exon            180..344
                     /gene="Slc4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            345..394
                     /gene="Slc4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            395..708
                     /gene="Slc4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            709..832
                     /gene="Slc4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1036
                     /gene="Slc4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1130
                     /gene="Slc4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1256
                     /gene="Slc4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1370
                     /gene="Slc4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1503
                     /gene="Slc4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1577
                     /gene="Slc4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1836
                     /gene="Slc4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1943
                     /gene="Slc4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2112
                     /gene="Slc4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2286
                     /gene="Slc4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2482
                     /gene="Slc4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            2483..2652
                     /gene="Slc4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..3039
                     /gene="Slc4a11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggctctgg tgagtggccc tgcactgtgg aactgttccg aaacttccag gccggcaccc
       61 cacgactctc aggcctgcgc acgcgagcag ccgcggatcc agaacagatc tcgcggaaaa
      121 ctgtgcttga gccatgtcac agaatgaaca ctgtcaggac tccggtgaat acttctcagc
      181 cgccactctg ggatacttca agaatgacac agatgataac cctgacgtcc gggaggacag
      241 cctgggggat gaggtctttg acaccgtcaa ctcctccatt gtgtctggcg agagcatccg
      301 tttttttgtc aatgtcaacc ttgaagtgca gccttccaaa tctgacatag aagctgcaac
      361 tggaggctgc gtgctcttac acacctcccg caagtatctg aaattaaaga acttcgagga
      421 agaggtccgt gcacaccgtg acctggatgg cttcctggcc caggccagca tcatcctgaa
      481 tgagacagct acctcactgg atgatgtgct ccgaactatg ctaaaccgct ttgcccagga
      541 ccccaaccat gcagagcctg attgtgacct ggacctgctc atggctaagc tctttacaga
      601 tgctgggggc cccatggaga gtaaagtcca cctgctgtca gataccatcc agggagtgac
      661 cgccactgtc agaggactgc agtacgagca gtcatggctc tgcatcgtct gtaccatgaa
      721 gtccctacag aagcggcatg tgtgtatcag ccgcctggtt cggccacaga actgggggga
      781 aaactcctgt gaggttcgct ttgtcatcct ggtgctggcc ccacccaaga tgaaaagcac
      841 caagactgcg atggaggtgg cacgcacatt cgccaccatg ttctccgaca tcaccttccg
      901 ccagaagctc ctgaagaccc gcacagagga agagttcaag gaggctttgg tgcaccagag
      961 acagctgctc accatgatga tgccaagagc agccgggcac agcatgagct ccctccatac
     1021 tcacagacac cctcggcccc cgaaatgcaa ggactttttc ccgtttggga aaggcatctg
     1081 ggtggacatc atgcgcaggt tccctgtgta cccgctggac ttcacggacg gcatcattgg
     1141 gaaaggcaag actgtcggca aatatgtcac caccacgctc ttcctctact tcgcctgcct
     1201 cttaccgacc attgcttttg gatccctcaa cgatgagaac acaaacggag ccatcgatgt
     1261 gcagaagacc atagcaggac agagcatcgg aggcctcttg tatgcactgt tctctgggca
     1321 gcccctggtg atcctgttga caaccgcacc cctggccatc tacacccagg tgatccgggt
     1381 catctgtgat gactacaacc tggacttcaa cgccttctat gcgtggacag gcctgtggaa
     1441 cagcttcttc cttgcgcttt atgccttcct caacctcagc ctgcttatga atctctttaa
     1501 gaggtcaaca gaggagatca ttgctctgtt catttccatc acgtttgtgc tggacgctgt
     1561 caagggcatg gtcaaaatct tctggaagta ctactatggt caccactacc acacaaaaag
     1621 gacttcctcc ttggcaagcc tgttgggcat tagcagaagc cccaacacca gtctccacac
     1681 tgcactcaac accagcttct tggccagccc catagagatg actacagcca gcagccccat
     1741 cagtacacac tccaaccagg ctactgcagt gctcagcctc ctcatcatgc tgggcacact
     1801 ctggctgggc tacaccctct accagttcaa gaaaagcccc tacctgcacc catgtgtgcg
     1861 tgagaccctg tctgactgtg ccctgcctat cgccgtgctc tccttctccc tcatcagctc
     1921 ctatggcttc caggaaattg agatgagcaa gttccggtac aaccccagcg agagcctttt
     1981 tgaggtggca cagatccact ctctgtcctt caaggccatc agcagtgcca tgggtcttgg
     2041 cttcctgctc tccttgcttt tcttcattga gcagaacctg gtggccgccc tggtcaatgc
     2101 accagagaac aggctggtga agggcactgc ctatcactgg gacctcctgc tgcttgccat
     2161 catcaatacg gggctgtctc tgtttgggct accctggatc cacgccgcct atccccattc
     2221 ccctctgcat gtgcgggcac tggccttagt ggaggaacgt gtggagaatg ggcacattta
     2281 tgaaacgatt gtgaatgtta aggagactcg gctgactgcg ctgggtgcca gtgtcctggt
     2341 gggtctgtcc ctgctgctgc ttccattccc gctgcagtgg atccccaagc ccgtgctcta
     2401 tggactcttc ctctacattg cgctgacctc cctggacggc aaccagctct tctcacgtgt
     2461 agctctgctg ctcaaggagc aaacgtcata cccacccaca cactacatcc ggagagtgcc
     2521 ccaaaggaag attcactact tcacgggcct gcagattctg cagctgcttc tgctctgtgc
     2581 gttcggcatg agctccctgc cctacatgaa gatggtcttt ccgctcatca tgattgccat
     2641 gatcccaatc cgctataatc tgctaccccg aatcattgaa gccaagtact tggatgtcat
     2701 ggatgccgag cacaggccct gacctgcacc agcctcccca tccttcaggc ctgctccgtg
     2761 gcaatgtgtg gggagtatga tctgctgtgg ctccagcccg tcctcattgc tgtcttgtgg
     2821 cctaaagccc cttggcgttg tggttttcag aggtgtgtga tcacctctcg ccccatcaac
     2881 atttagtttg gggtcagaaa cactgtcggc gtggggctga gaagagtgga tattcttttg
     2941 ataaaagagt tgatgcccag gagagagccc atttccttga ttgtataagg aactcgattg
     3001 tgcacattag tgaataaaag tcttgtttct atgctttaa
//
