LOCUS       NM_178092               3623 bp    mRNA    linear   ROD 02-FEB-2024
DEFINITION  Rattus norvegicus solute carrier family 4 member 10 (Slc4a10),
            mRNA.
ACCESSION   NM_178092
VERSION     NM_178092.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3623)
  AUTHORS   Wang,J.L., Zhao,L., Zhu,J., Wang,D.K., Ren,M.J., Wang,M., Liu,Y.,
            Boron,W.F. and Chen,L.M.
  TITLE     Expression, Localization, and Effect of High Salt Intake on
            Electroneutral Na+/HCO3- Cotransporter NBCn2 in Rat Small
            Intestine: Implication in Intestinal NaCl Absorption
  JOURNAL   Front Physiol 10, 1334 (2019)
   PUBMED   31736772
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3623)
  AUTHORS   Guo,Y.M., Liu,Y., Liu,M., Wang,J.L., Xie,Z.D., Chen,K.J.,
            Wang,D.K., Occhipinti,R., Boron,W.F. and Chen,L.M.
  TITLE     Na+/HCO3- Cotransporter NBCn2 Mediates HCO3- Reclamation in the
            Apical Membrane of Renal Proximal Tubules
  JOURNAL   J Am Soc Nephrol 28 (8), 2409-2419 (2017)
   PUBMED   28280139
REFERENCE   3  (bases 1 to 3623)
  AUTHORS   Wang,D.K., Liu,Y., Myers,E.J., Guo,Y.M., Xie,Z.D., Jiang,D.Z.,
            Li,J.M., Yang,J., Liu,M., Parker,M.D. and Chen,L.M.
  TITLE     Effects of Nt-truncation and coexpression of isolated Nt domains on
            the membrane trafficking of electroneutral Na+/HCO3- cotransporters
  JOURNAL   Sci Rep 5, 12241 (2015)
   PUBMED   26192895
  REMARK    GeneRIF: a new promoter of Slc4a10 encoding NBCn2 and a novel type
            of Nterminus-truncated NBCn2, were identified.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3623)
  AUTHORS   Sinning,A., Liebmann,L. and Hubner,C.A.
  TITLE     Disruption of Slc4a10 augments neuronal excitability and modulates
            synaptic short-term plasticity
  JOURNAL   Front Cell Neurosci 9, 223 (2015)
   PUBMED   26136660
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3623)
  AUTHORS   Stakisaitis,D., Meilus,V., Juska,A., Matusevicius,P. and
            Didziapetriene,J.
  TITLE     Sodium is not required for chloride efflux via chloride/bicarbonate
            exchanger from rat thymic lymphocytes
  JOURNAL   Biomed Res Int 2014, 569650 (2014)
   PUBMED   25003116
  REMARK    GeneRIF: The study results allow concluding that Na(+) is not
            required for Cl(-) efflux via Cl(-)/HCO3 (-) exchanger.
REFERENCE   6  (bases 1 to 3623)
  AUTHORS   Chen,L.M., Kelly,M.L., Rojas,J.D., Parker,M.D., Gill,H.S.,
            Davis,B.A. and Boron,W.F.
  TITLE     Use of a new polyclonal antibody to study the distribution and
            glycosylation of the sodium-coupled bicarbonate transporter NCBE in
            rodent brain
  JOURNAL   Neuroscience 151 (2), 374-385 (2008)
   PUBMED   18061361
REFERENCE   7  (bases 1 to 3623)
  AUTHORS   Lee,Y.S., Ouyang,Y.B. and Giffard,R.G.
  TITLE     Regulation of the rat brain Na+ -driven Cl-/HCO3 - exchanger
            involves protein kinase A and a multiprotein signaling complex
  JOURNAL   FEBS Lett 580 (20), 4865-4871 (2006)
   PUBMED   16916513
REFERENCE   8  (bases 1 to 3623)
  AUTHORS   Praetorius,J., Nejsum,L.N. and Nielsen,S.
  TITLE     A SCL4A10 gene product maps selectively to the basolateral plasma
            membrane of choroid plexus epithelial cells
  JOURNAL   Am J Physiol Cell Physiol 286 (3), C601-C610 (2004)
   PUBMED   14592810
  REMARK    GeneRIF: SLC4A10 gene product and NBCn1 both function as
            basolateral HCO3- entry pathways and that the SLC4A10 gene product
            may be responsible for the stilbene-sensitive Na+-HCO3- uptake that
            is essential for cerebrospinal fluid production.
REFERENCE   9  (bases 1 to 3623)
  AUTHORS   Giffard,R.G., Lee,Y.S., Ouyang,Y.B., Murphy,S.L. and Monyer,H.
  TITLE     Two variants of the rat brain sodium-driven chloride bicarbonate
            exchanger (NCBE): developmental expression and addition of a PDZ
            motif
  JOURNAL   Eur J Neurosci 18 (11), 2935-2945 (2003)
   PUBMED   14656289
  REMARK    GeneRIF: We identify two novel variants of the sodium-driven
            chloride bicarbonate exchanger from brain. The developmental
            expression pattern seen by in situ hybridization reveals strong
            expression in spinal cord and brain beginning in embryonic
            development.
REFERENCE   10 (bases 1 to 3623)
  AUTHORS   Wang,C.Z., Yano,H., Nagashima,K. and Seino,S.
  TITLE     The Na+-driven Cl-/HCO3- exchanger. Cloning, tissue distribution,
            and functional characterization
  JOURNAL   J Biol Chem 275 (45), 35486-35490 (2000)
   PUBMED   10993873
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF439856.1.
            
            [WARNING] On Apr 29, 2024 this sequence was replaced by
            NM_178092.3.
            
            On Jun 3, 2003 this sequence version replaced NM_178092.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF439856.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3623
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..3623
                     /gene="Slc4a10"
                     /gene_synonym="NCBE"
                     /note="solute carrier family 4 member 10"
                     /db_xref="GeneID:295645"
                     /db_xref="RGD:631407"
     exon            1..106
                     /gene="Slc4a10"
                     /gene_synonym="NCBE"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..3412
                     /gene="Slc4a10"
                     /gene_synonym="NCBE"
                     /note="solute carrier family 4, sodium bicarbonate
                     transporter-like, member 10; solute carrier family 4,
                     sodium bicarbonate transporter, member 10; Na+ bicarbonate
                     transporter NBCn2-G; Na-bicarbonate cotransporter NBCn2-O"
                     /codon_start=1
                     /product="sodium-driven chloride bicarbonate exchanger"
                     /protein_id="NP_835193.1"
                     /db_xref="GeneID:295645"
                     /db_xref="RGD:631407"
                     /translation="MEIKDQGAQMEPLLPTRNDEEAVVDRGGTRSILKTHFEKEDLEG
                     HRTLFIGVHVPLGGRKSHRRHRHRGHKHRKRDRERDSGLEDGGESPSFDTPSQRVQFI
                     LGTEDDDEEHIPHDLFTELDEICWREGEDAEWRETARWLKFEEDVEDGGERWSKPYVA
                     TLSLHSLFELRSCILNGTVLLDMHANTLEEIADMVLDQQVSSGQLNEDVRHRVHEALM
                     KQHHHQSQKKLTNRIPIVRSFADIGKKQSEPNSMDKNGQVVSPQSAPACAENKNDVSR
                     ENSTVDFSKGLGGQQKGHTSPCGMKQRLDKGPPHQQEREVDLHFMKKIPPGAEASNIL
                     VGELEFLDRTVVAFVRLSPAVLLQGLAEVPIPSRFLFILLGPLGKGQQYHEIGRSIAT
                     LMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRK
                     TPSLPNGTAAHGGPEQHGGHSGPELQRTGRIFGGLILDIKRKAPFFWSDFRDAFSLQC
                     LASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFGGQPLTILG
                     STGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSLVCYITRFTE
                     EAFASLICIIFIYEALEKLFELSESYPINMHNDLELLTQYSCNCMEPHSPSNDTLKEW
                     RESNISASDIIWGNLTVSECRSLHGEYVGRACGHGHPYVPDVLFWSVILFFSTVTMSA
                     TLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLIDYAIGIPSPKLQVPSVFKPTRDDR
                     GWFVTPLGPNPWWTIIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLL
                     MVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLM
                     IFILMGSSVFMTSILKFIPMPVLYGVFLYMGASSLKGIQLFDRIKLFWMPAKHQPDFI
                     YLRHVPLRKVHLFTVIQMSCLGLLWIIKVSRAAIVFPMMVLALVFVRKLMDFLFTKRE
                     LSWLDDLMPESKKKKLEDAEKEEEQSMLAMEDEGTVQLPLEGHYRDDPSVINISDEMS
                     KTAMWGNLLVTADNSKEKESRFPSKSSPS"
     exon            107..188
                     /gene="Slc4a10"
                     /gene_synonym="NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            189..335
                     /gene="Slc4a10"
                     /gene_synonym="NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            336..474
                     /gene="Slc4a10"
                     /gene_synonym="NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            475..635
                     /gene="Slc4a10"
                     /gene_synonym="NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            636..824
                     /gene="Slc4a10"
                     /gene_synonym="NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            825..913
                     /gene="Slc4a10"
                     /gene_synonym="NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1003
                     /gene="Slc4a10"
                     /gene_synonym="NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1161
                     /gene="Slc4a10"
                     /gene_synonym="NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1249
                     /gene="Slc4a10"
                     /gene_synonym="NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1396
                     /gene="Slc4a10"
                     /gene_synonym="NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1497
                     /gene="Slc4a10"
                     /gene_synonym="NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1672
                     /gene="Slc4a10"
                     /gene_synonym="NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1806
                     /gene="Slc4a10"
                     /gene_synonym="NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..2052
                     /gene="Slc4a10"
                     /gene_synonym="NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2158
                     /gene="Slc4a10"
                     /gene_synonym="NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2320
                     /gene="Slc4a10"
                     /gene_synonym="NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2434
                     /gene="Slc4a10"
                     /gene_synonym="NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2596
                     /gene="Slc4a10"
                     /gene_synonym="NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2848
                     /gene="Slc4a10"
                     /gene_synonym="NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            2849..2917
                     /gene="Slc4a10"
                     /gene_synonym="NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..3091
                     /gene="Slc4a10"
                     /gene_synonym="NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            3092..3214
                     /gene="Slc4a10"
                     /gene_synonym="NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            3215..3282
                     /gene="Slc4a10"
                     /gene_synonym="NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            3283..3399
                     /gene="Slc4a10"
                     /gene_synonym="NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            3400..3438
                     /gene="Slc4a10"
                     /gene_synonym="NCBE"
                     /inference="alignment:Splign:2.1.0"
     exon            3439..3623
                     /gene="Slc4a10"
                     /gene_synonym="NCBE"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggaagaca ccgaagacac tgcagagcaa ggtgcttttt ccagaggtgt tacagaacat
       61 ggagattaaa gaccagggag cccaaatgga gccgctgctg ccaacgagaa atgatgaaga
      121 agccgttgtg gatagaggtg gaacacgttc tattctcaaa acacattttg aaaaagaaga
      181 tttagaaggt catcgaacat tatttattgg agttcatgtg ccgcttggtg gaagaaagag
      241 ccatcgtcgt cacaggcatc gaggccataa gcacagaaag cgggacagag agagagattc
      301 aggactagag gatggaggag agtcaccttc ttttgatacc ccatcacaga gggtgcagtt
      361 tattcttgga actgaggacg atgatgagga gcacattcct catgaccttt tcacagaact
      421 ggatgaaatt tgctggcgtg aaggggaaga tgccgagtgg cgagaaacag ccaggtggtt
      481 aaaatttgaa gaagatgtgg aagatggagg agaaagatgg agtaaaccct acgtggctac
      541 actttcgttg cacagcttgt ttgagttgag aagctgcatt ctgaacggaa ctgtgctact
      601 ggacatgcat gccaacactt tagaggagat cgcagatatg gtccttgacc agcaggtcag
      661 ctcaggccag ctgaatgagg atgtacgcca cagggtccat gaagccctga tgaagcagca
      721 tcatcaccag agtcagaaaa agctcactaa caggattcct atcgtccgat cttttgctga
      781 tattggcaag aaacaatcag agccaaattc catggataaa aatggtcagg tcgtttctcc
      841 tcagtctgct ccagcctgtg ctgaaaataa aaatgacgtc agcagggaaa acagcaccgt
      901 agacttcagc aagggactgg gaggccagca aaaagggcat actagtccat gtgggatgaa
      961 acaaaggctt gacaaaggac caccacacca gcaggagaga gaggttgatc ttcattttat
     1021 gaaaaagatt cctccgggtg ctgaggcttc aaacatcttg gtaggagaac tggagtttct
     1081 agacagaact gtggttgctt ttgtcaggtt gtctccagcc gtcttgctcc aaggactggc
     1141 tgaagttcca atcccaagca gatttctgtt tatccttctg ggaccactgg gaaagggtca
     1201 acagtaccat gagattggca gatcgattgc aaccttaatg actgatgagg tgtttcatga
     1261 tgttgcttat aaagctaaag accgcaatga cttggtgtca ggaattgatg agtttctgga
     1321 tcaggttacc gttcttcctc ctggagaatg ggacccaagc atacgaatag aacctcccaa
     1381 aaatgttcct tcccaggaga agaggaagac tccttctcta ccaaatggaa cagcggctca
     1441 tggcggacct gagcaacatg gaggacacag tggacctgag ctccagcgga ctgggaggat
     1501 ttttggggga cttatattag atatcaaaag gaaggctccg ttcttctgga gtgacttcag
     1561 ggatgctttc agcctgcagt gcttagcatc attcctgttt ctctactgtg catgtatgtc
     1621 tcctgtcatc acatttggag gactgctggg agaagccacc gaaggtcgta taagtgcaat
     1681 cgaatcactc tttggagcat ctatgaccgg gatagcctat tctctttttg gtggacagcc
     1741 cctgaccata ttaggcagta cgggacctgt tctggtgttt gaaaagatct tgtttaaatt
     1801 ctgcaaagaa tatgggctgt catacttgtc cttacgggcc agcattgggc tctggactgc
     1861 aacactgtgc atcatactcg tggccactga tgcgagttcc cttgtctgct atatcacccg
     1921 gttcactgaa gaagcatttg cttctctcat ttgcatcatt tttatctatg aagccctgga
     1981 gaagttgttt gagctcagtg aatcctatcc aatcaatatg cacaacgact tggaactgct
     2041 gacacagtac tcgtgtaact gtatggagcc acacagtccc agcaatgaca cactgaagga
     2101 gtggcgcgag tccaacattt ctgcctctga cataatttgg gggaacctaa ctgtgtcaga
     2161 gtgcagatca ctccacgggg aatatgtcgg gcgagcctgt ggccatggcc acccgtatgt
     2221 gccggacgtt ctcttctggt cagtgatcct gttcttctcc acagttacta tgtcagccac
     2281 cctgaagcag ttcaagacca gccggtattt ccccactaag gttcgatcca tagtgagtga
     2341 ttttgcggtt tttcttacaa ttctgtgtat ggttttaatt gactatgcca ttgggatccc
     2401 atcgccaaaa ctacaagtac caagtgtttt caagcccacc agagacgacc gtggctggtt
     2461 tgttacacct ttaggtccaa acccatggtg gacaatcatt gctgccatca ttccagcatt
     2521 actctgtact attctgattt tcatggacca gcagattaca gctgttatca tcaacaggaa
     2581 ggagcacaag ctaaagaaag gttgtggcta tcacctggac ctgttgatgg tggcagtcat
     2641 gctgggggta tgctccatta tgggcctgcc atggttcgtg gcagccactg tcctctccat
     2701 cactcatgtg aacagcctca agctggaatc tgagtgctct gctccaggag aacaacccaa
     2761 atttctcggc attagggaac agagggtcac tgggctcatg attttcatcc ttatgggttc
     2821 atcagttttt atgaccagca ttctgaagtt tatccccatg ccagtgttat atggagtgtt
     2881 tctttacatg ggcgcctcgt ctctgaaggg aattcagttg tttgatagaa taaaactctt
     2941 ctggatgcca gccaaacacc aaccagattt catctatcta aggcatgtac ctctccgaaa
     3001 agtccatctc ttcacagtca ttcagatgag ttgtctcggc cttctgtgga taatcaaagt
     3061 ttcgagagct gctattgtct ttcctatgat ggtgttggca ctggtatttg tgagaaagtt
     3121 gatggacttc ttgtttacca aacgggaact tagctggctc gatgatttaa tgcctgagag
     3181 caaaaaaaag aaactggaag atgctgagaa agaagaagaa caaagtatgc tagccatgga
     3241 ggacgagggc acagtacaac tcccactgga gggacactac agagacgacc catctgtgat
     3301 caatatttct gatgaaatgt caaagactgc catgtggggg aaccttctag tcactgctga
     3361 caactcaaaa gaaaaggagt cacgctttcc ttctaaaagc tccccttcct aatcactcta
     3421 gaagctgatt ccccaaagca ttgaaagccg aaaggagaag aaagctgact cagggaaagg
     3481 cgttgacagg gagacttgtc tatgacttga tcttcaattt attttttaca tatatatgag
     3541 aagagtgtca caattattaa taaaactgct ttgatcatgt cattgtaagc cctgtctccc
     3601 atcccaaatc caccttcata agt
//
