LOCUS       NM_001127456            1572 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus solute carrier family 48 member 1 (Slc48a1),
            mRNA.
ACCESSION   NM_001127456 XM_001060567 XM_217033
VERSION     NM_001127456.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1572)
  AUTHORS   White,C., Yuan,X., Schmidt,P.J., Bresciani,E., Samuel,T.K.,
            Campagna,D., Hall,C., Bishop,K., Calicchio,M.L., Lapierre,A.,
            Ward,D.M., Liu,P., Fleming,M.D. and Hamza,I.
  TITLE     HRG1 is essential for heme transport from the phagolysosome of
            macrophages during erythrophagocytosis
  JOURNAL   Cell Metab 17 (2), 261-270 (2013)
   PUBMED   23395172
REFERENCE   2  (bases 1 to 1572)
  AUTHORS   O'Callaghan,K.M., Ayllon,V., O'Keeffe,J., Wang,Y., Cox,O.T.,
            Loughran,G., Forgac,M. and O'Connor,R.
  TITLE     Heme-binding protein HRG-1 is induced by insulin-like growth factor
            I and associates with the vacuolar H+-ATPase to control endosomal
            pH and receptor trafficking
  JOURNAL   J Biol Chem 285 (1), 381-391 (2010)
   PUBMED   19875448
  REMARK    GeneRIF: HRG-1 regulates V-ATPase activity, which is essential for
            endosomal acidification, heme binding, and receptor trafficking in
            mammalian cells.
REFERENCE   3  (bases 1 to 1572)
  AUTHORS   Rajagopal,A., Rao,A.U., Amigo,J., Tian,M., Upadhyay,S.K., Hall,C.,
            Uhm,S., Mathew,M.K., Fleming,M.D., Paw,B.H., Krause,M. and Hamza,I.
  TITLE     Haem homeostasis is regulated by the conserved and concerted
            functions of HRG-1 proteins
  JOURNAL   Nature 453 (7198), 1127-1131 (2008)
   PUBMED   18418376
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC158869.1.
            
            On or before May 21, 2008 this sequence version replaced
            XM_217033.4, XM_001060567.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158869.1, CO394595.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1572
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1572
                     /gene="Slc48a1"
                     /gene_synonym="HRG-1; Hrg1"
                     /note="solute carrier family 48 member 1"
                     /db_xref="GeneID:300191"
                     /db_xref="RGD:1562880"
     exon            1..184
                     /gene="Slc48a1"
                     /gene_synonym="HRG-1; Hrg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..489
                     /gene="Slc48a1"
                     /gene_synonym="HRG-1; Hrg1"
                     /note="Heme-responsive gene 1 protein homolog; solute
                     carrier family 48 (heme transporter), member 1"
                     /codon_start=1
                     /product="heme transporter HRG1"
                     /protein_id="NP_001120928.1"
                     /db_xref="GeneID:300191"
                     /db_xref="RGD:1562880"
                     /translation="MAPTRLQLGVRAAYSGFSSLAGFSIFFVWTVVYRQPGTAAMGGL
                     AGVLALWVLVTHVMYMQDYWRTWLRGLRGFFFVGALFSAVSFSAFCTFLTLAITQHQS
                     FKDPNSYYLSCVWSFISFKWAFLLSLYAHRYRADFADISILSDF"
     exon            185..352
                     /gene="Slc48a1"
                     /gene_synonym="HRG-1; Hrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            353..1550
                     /gene="Slc48a1"
                     /gene_synonym="HRG-1; Hrg1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcgggccct gcacctgtga gtcggtggcg ctgctcctcc gctgccccat ggccccgacc
       61 cggctgcagc tcggcgtccg cgccgcctac tcgggcttca gctcgttggc cggcttctcc
      121 atcttcttcg tctggacggt ggtctaccga caaccgggga ctgcggcgat ggggggtctc
      181 gcaggtgtcc tggccctgtg ggtcttggtg actcacgtga tgtacatgca ggattactgg
      241 aggacctggc tcagaggcct acgtggcttc ttcttcgtgg gtgctctctt ctccgcagtc
      301 tccttttccg ccttctgcac cttcctgacg ttggccatca cccagcacca gagtttcaaa
      361 gacccgaaca gctactacct ctcctgtgtc tggagtttca tttccttcaa gtgggccttt
      421 ctactcagcc tctacgccca ccgctaccgg gctgacttcg ctgacatcag catcctcagt
      481 gatttctaac ccagggaatg aggtcaccac ggcctggggg ccctcaggag ctggactcag
      541 tttctgagtc attaagggag ctcgccccaa cccctgggga ctccagaacc atggcagagt
      601 atatgggtca gttcggtttc ccagaaatct gtctggtccc ctttggggga agacatagag
      661 ctgttaaaga ggaactgcca atatgcccat tagcctggct acagggcagc ttagaccttt
      721 ccaaatggat ctattttctt agcactctga gggatctttg taagcaaggc catgacaatg
      781 aattcaatgg gtaggcttgg atctgtggcc agtggcaggg gctgggacag gtttccttgc
      841 taccccagac ttcattgaag ctgtgtgtgt ggaggcatca aaggtctggt caggtgaggg
      901 acttctagca gagatctcca tcccagctcc ctcaccctgt tgtcctcaag ggtcgggcag
      961 ctaagtccat tggtccttag ggaagtggca gttggctctc ccctgatcag catagttgaa
     1021 caggagccag tgtctgtccc ttctaccttc ccatccagag tttgtttccc atgagggtgc
     1081 tagtgccagt caaccattcc cgtgtgtcac atgtgcacat atgaccacgt acaccagagc
     1141 aggacccctc agatgaggct agactttgag gaccacagga aacacacccc tgcacctaga
     1201 agggctttgg aatagggggc aacctggtgg gggcctcccc atctgtactg aggccccagc
     1261 cttacatctc ctctacccct gactgcacaa aacaaccctg accgtgagga ccttctccct
     1321 gcaccagacc ccacctttga cctttaacct tctctctccc ccgaaggagc tcttctgagt
     1381 ggacatgggc ccaaggcctt acctaagtgg agagggaggg cagggctgct acatgtctcc
     1441 ttctatggta ggtcaccatt ttgcacatct actatcccac ctgggcactg tccccagctc
     1501 tctgccttac ctgtgtcact aacggaaata cagcggccat tttaaccagc aaaaaaaaaa
     1561 aaaaaaaaaa aa
//
