LOCUS       NM_001014118            1749 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 47 member 1 (Slc47a1),
            mRNA.
ACCESSION   NM_001014118 XM_340812
VERSION     NM_001014118.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1749)
  AUTHORS   Nishizawa,K., Yoda,N., Morokado,F., Komori,H., Nakanishi,T. and
            Tamai,I.
  TITLE     Changes of drug pharmacokinetics mediated by downregulation of
            kidney organic cation transporters Mate1 and Oct2 in a rat model of
            hyperuricemia
  JOURNAL   PLoS One 14 (4), e0214862 (2019)
   PUBMED   30951542
  REMARK    GeneRIF: Although multiple factors may influence renal handling of
            drugs, these observations can be accounted for, at least in part,
            by downregulation of Mate1-mediated apical efflux from tubular
            cells and Oct2-mediated basolateral uptake. Our results suggest
            that hyperuricemia could alter the disposition of drugs that are
            substrates of Mate1 and/or Oct2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1749)
  AUTHORS   Ferrigno,A., Di Pasqua,L.G., Berardo,C., Siciliano,V., Rizzo,V.,
            Adorini,L., Richelmi,P. and Vairetti,M.
  TITLE     The farnesoid X receptor agonist obeticholic acid upregulates
            biliary excretion of asymmetric dimethylarginine via MATE-1 during
            hepatic ischemia/reperfusion injury
  JOURNAL   PLoS One 13 (1), e0191430 (2018)
   PUBMED   29346429
  REMARK    GeneRIF: mechanism involved in further increasing biliary ADMA
            levels in sham and I/R groups treated with OCA appears to be
            MATE-1-dependent
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1749)
  AUTHORS   Ma,Y.R., Huang,J., Shao,Y.Y., Ma,K., Zhang,G.Q., Zhou,Y., Zhi,R.,
            Qin,H.Y. and Wu,X.A.
  TITLE     Inhibitory effect of atenolol on urinary excretion of metformin via
            down-regulating multidrug and toxin extrusion protein 1 (rMate1)
            expression in the kidney of rats
  JOURNAL   Eur J Pharm Sci 68, 18-26 (2015)
   PUBMED   25486332
  REMARK    GeneRIF: Inhibitory effect of atenolol on urinary excretion of
            metformin via down-regulating MATE1 expression in the kidney of
            rats
REFERENCE   4  (bases 1 to 1749)
  AUTHORS   Tonomura,Y., Morikawa,Y., Takagi,S., Torii,M. and Matsubara,M.
  TITLE     Underestimation of urinary biomarker-to-creatinine ratio resulting
            from age-related gain in muscle mass in rats
  JOURNAL   Toxicology 303, 169-176 (2013)
   PUBMED   23182769
  REMARK    GeneRIF: renal mRNA level of multidrug and toxin extrusions-1 did
            not show an age-related increase; the increase in creatinine
            clearance highly contributed to the age-related increase in urinary
            creatinine excretion compared to mRNA levels of Oct2 and Mate1
REFERENCE   5  (bases 1 to 1749)
  AUTHORS   Ciarimboli,G.
  TITLE     Membrane transporters as mediators of Cisplatin effects and side
            effects
  JOURNAL   Scientifica (Cairo) 2012, 473829 (2012)
   PUBMED   24278698
  REMARK    Review article
REFERENCE   6  (bases 1 to 1749)
  AUTHORS   Kajiwara,M., Terada,T., Asaka,J., Ogasawara,K., Katsura,T.,
            Ogawa,O., Fukatsu,A., Doi,T. and Inui,K.
  TITLE     Critical roles of Sp1 in gene expression of human and rat
            H+/organic cation antiporter MATE1
  JOURNAL   Am J Physiol Renal Physiol 293 (5), F1564-F1570 (2007)
   PUBMED   17855482
  REMARK    GeneRIF: Sp1 functions as basal transcriptional regulator of human
            and rat MATE1 gene through two GC boxes. May be conserved among
            species. We have identified rSNP of hMATE1 gene (G-32A) (belonging
            to Sp1-binding site) that affects promoter activity.
REFERENCE   7  (bases 1 to 1749)
  AUTHORS   Nishihara,K., Masuda,S., Ji,L., Katsura,T. and Inui,K.
  TITLE     Pharmacokinetic significance of luminal multidrug and toxin
            extrusion 1 in chronic renal failure rats
  JOURNAL   Biochem Pharmacol 73 (9), 1482-1490 (2007)
   PUBMED   17296166
REFERENCE   8  (bases 1 to 1749)
  AUTHORS   Tsuda,M., Terada,T., Asaka,J., Ueba,M., Katsura,T. and Inui,K.
  TITLE     Oppositely directed H+ gradient functions as a driving force of rat
            H+/organic cation antiporter MATE1
  JOURNAL   Am J Physiol Renal Physiol 292 (2), F593-F598 (2007)
   PUBMED   17047166
REFERENCE   9  (bases 1 to 1749)
  AUTHORS   Ohta,K.Y., Inoue,K., Hayashi,Y. and Yuasa,H.
  TITLE     Molecular identification and functional characterization of rat
            multidrug and toxin extrusion type transporter 1 as an organic
            cation/H+ antiporter in the kidney
  JOURNAL   Drug Metab Dispos 34 (11), 1868-1874 (2006)
   PUBMED   16928787
REFERENCE   10 (bases 1 to 1749)
  AUTHORS   Terada,T., Masuda,S., Asaka,J., Tsuda,M., Katsura,T. and Inui,K.
  TITLE     Molecular cloning, functional characterization and tissue
            distribution of rat H+/organic cation antiporter MATE1
  JOURNAL   Pharm Res 23 (8), 1696-1701 (2006)
   PUBMED   16850272
  REMARK    GeneRIF: MATE1 is expressed in the renal proximal tubules and can
            mediate the transport of various organic cations and cephalexin
            using an oppositely directed H+ gradient
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB248823.1.
            
            On Jun 10, 2007 this sequence version replaced NM_001014118.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB248823.1, AB248824.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1749
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..1749
                     /gene="Slc47a1"
                     /gene_synonym="MATE1; RGD1311123"
                     /note="solute carrier family 47 member 1"
                     /db_xref="GeneID:360539"
                     /db_xref="RGD:1311123"
     exon            1..135
                     /gene="Slc47a1"
                     /gene_synonym="MATE1; RGD1311123"
                     /inference="alignment:Splign:2.1.0"
     CDS             4..1704
                     /gene="Slc47a1"
                     /gene_synonym="MATE1; RGD1311123"
                     /note="MATE-1; rMATE-1; solute carrier family 47
                     (multidrug and toxin extrusion), member 1"
                     /codon_start=1
                     /product="multidrug and toxin extrusion protein 1"
                     /protein_id="NP_001014140.1"
                     /db_xref="GeneID:360539"
                     /db_xref="RGD:1311123"
                     /translation="MEVLEEPAPGPGGADAAERRGLRRLLLSGFQEELRALLVLAGPA
                     FLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTGISVGHGLSSACDTLISQT
                     YGSQNLKHVGVILQRGTLILLLCCFPCWALFINTEQILLLFRQDPDVSRLTQTYVMVF
                     IPALPAAFLYTLQVKYLLNQGIVLPQVITGIAANLVNALANYLFLHQLHLGVMGSALA
                     NTISQFALAIFLFLYILWRKLHHATWGGWSWECLQDWASFLQLAIPSMLMLCIEWWAY
                     EVGSFLSGILGMVELGAQSITYELAIIVYMIPAGFSVAANVRVGNALGAGNIDQAKKS
                     SAISLIVTELFAVTFCVLLLGCKDLVGYIFTTDWDIVALVAQVVPIYAVSHLFEALAC
                     TCGGVLRGTGNQKVGAIVNAIGYYVIGLPIGISLMFVAKLGVIGLWSGIIICSVCQTS
                     CFLVFIARLNWKLACQQAQVHANLKVNVALNSAVSQEPAHPVGPESHGEIMMTDLEKK
                     DEIQLDQQMNQQQALPVHPKDSNKLSGKQLALRRGLLFLGVVLVLVGGILVRVYIRTE
                     "
     exon            136..237
                     /gene="Slc47a1"
                     /gene_synonym="MATE1; RGD1311123"
                     /inference="alignment:Splign:2.1.0"
     exon            238..306
                     /gene="Slc47a1"
                     /gene_synonym="MATE1; RGD1311123"
                     /inference="alignment:Splign:2.1.0"
     exon            307..455
                     /gene="Slc47a1"
                     /gene_synonym="MATE1; RGD1311123"
                     /inference="alignment:Splign:2.1.0"
     exon            456..498
                     /gene="Slc47a1"
                     /gene_synonym="MATE1; RGD1311123"
                     /inference="alignment:Splign:2.1.0"
     exon            499..543
                     /gene="Slc47a1"
                     /gene_synonym="MATE1; RGD1311123"
                     /inference="alignment:Splign:2.1.0"
     exon            544..641
                     /gene="Slc47a1"
                     /gene_synonym="MATE1; RGD1311123"
                     /inference="alignment:Splign:2.1.0"
     exon            642..739
                     /gene="Slc47a1"
                     /gene_synonym="MATE1; RGD1311123"
                     /inference="alignment:Splign:2.1.0"
     exon            740..853
                     /gene="Slc47a1"
                     /gene_synonym="MATE1; RGD1311123"
                     /inference="alignment:Splign:2.1.0"
     exon            854..921
                     /gene="Slc47a1"
                     /gene_synonym="MATE1; RGD1311123"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1030
                     /gene="Slc47a1"
                     /gene_synonym="MATE1; RGD1311123"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1106
                     /gene="Slc47a1"
                     /gene_synonym="MATE1; RGD1311123"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1176
                     /gene="Slc47a1"
                     /gene_synonym="MATE1; RGD1311123"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1309
                     /gene="Slc47a1"
                     /gene_synonym="MATE1; RGD1311123"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1404
                     /gene="Slc47a1"
                     /gene_synonym="MATE1; RGD1311123"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1477
                     /gene="Slc47a1"
                     /gene_synonym="MATE1; RGD1311123"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1749
                     /gene="Slc47a1"
                     /gene_synonym="MATE1; RGD1311123"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacatggagg tcttggagga gcctgcgccg ggaccaggag gcgcggacgc agccgagcgc
       61 cgtgggctgc gccgcctgtt gctgtctggc tttcaagagg agctgcgggc tctcttggtc
      121 ctggcgggtc ctgcgttctt ggcccagctc atgatgttct taatcagttt cataagttca
      181 gtgttctgtg gccacttggg caagctggag ctggacgccg tcacactggc aattgcggtt
      241 atcaatgtca caggcatttc agtgggacat ggcctatctt ctgcttgtga caccctcatc
      301 tcccagacat acgggagcca gaacttgaag catgtagggg ttatcctgca gagggggaca
      361 ctcatcctgc tcctctgctg cttcccatgc tgggcactct tcatcaacac cgagcaaatt
      421 ctgctgctct tcagacagga cccagatgta tccaggctca cccagactta cgtcatggtc
      481 ttcattccag cactccctgc agcctttctt tatacgttac aagttaaata cttgctcaac
      541 cagggcatcg ttctgcctca ggttataacg ggcatcgctg ctaaccttgt caacgccctg
      601 gccaactatc tgtttctcca tcagctacat cttggggtga tgggttcagc gttggccaat
      661 accatctccc agtttgctct ggccatcttc ctgttcctct acattctctg gagaaaacta
      721 catcatgcca cctggggagg atggtcctgg gagtgtctgc aggactgggc ctccttcctg
      781 caactggcta tccccagcat gctcatgctg tgcatagagt ggtgggccta tgaggttggc
      841 agcttcctga gtggtatcct tggcatggtg gagttgggag cccagtccat cacctatgaa
      901 ttggctatca ttgtatacat gatccctgca ggcttcagtg tggctgccaa tgtccgggtg
      961 ggaaatgcgt tgggtgcagg aaacattgac caggccaaga agtcttcagc aatttccttg
     1021 atagtcacag agctctttgc tgtgaccttc tgtgtcctgc tgctgggctg taaggatctc
     1081 gtgggctaca ttttcaccac tgactgggat attgtggcct tggtggctca agtggtcccc
     1141 atttacgctg tgtcccacct ctttgaagct cttgcctgta cctgtggtgg cgttctgagg
     1201 ggcactggaa accagaaggt tggagccatc gttaatgcca tcggctatta tgtcatcggc
     1261 ctccccatcg ggatctcact gatgttcgtt gccaagctgg gagtgattgg tctgtggtca
     1321 ggaatcatca tctgctctgt ctgtcagact tcgtgcttcc tggtttttat tgctcggctt
     1381 aattggaaac tcgcctgtca acaggctcaa gtacatgcca atttgaaggt aaatgtggcc
     1441 ctgaattctg ctgtctctca ggagcctgct cacccagtgg gtcctgagag ccatggagaa
     1501 atcatgatga cagatcttga aaaaaaagat gagattcaat tggaccagca gatgaaccag
     1561 caacaagctt tgcctgtcca tccaaaggac agcaataaac tgtctgggaa acagttggcc
     1621 ctacgtcgag ggctcctatt cctcggggta gtcttagtct tggtgggtgg gattttagtg
     1681 agagtctata tcagaactga ataatgtagg aatgaataat ccagcaatgc aggtgctcct
     1741 cagtctgtg
//
