LOCUS       NM_001024968            2564 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 46, member 3 (Slc46a3),
            mRNA.
ACCESSION   NM_001024968 XM_237862
VERSION     NM_001024968.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2564)
  AUTHORS   Kim,J.H., Matsubara,T., Lee,J., Fenollar-Ferrer,C., Han,K., Kim,D.,
            Jia,S., Chang,C.J., Yang,H., Nagano,T., Krausz,K.W., Yim,S.H. and
            Gonzalez,F.J.
  TITLE     Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis
  JOURNAL   Nat Commun 12 (1), 290 (2021)
   PUBMED   33436590
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2564)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091179.1.
            
            On Jun 25, 2005 this sequence version replaced XM_237862.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091179.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132294, SAMD00132297
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2564
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..2564
                     /gene="Slc46a3"
                     /gene_synonym="RGD1307594"
                     /note="solute carrier family 46, member 3"
                     /db_xref="GeneID:288454"
                     /db_xref="RGD:1307594"
     exon            1..321
                     /gene="Slc46a3"
                     /gene_synonym="RGD1307594"
                     /inference="alignment:Splign:2.1.0"
     exon            322..535
                     /gene="Slc46a3"
                     /gene_synonym="RGD1307594"
                     /inference="alignment:Splign:2.1.0"
     CDS             347..1732
                     /gene="Slc46a3"
                     /gene_synonym="RGD1307594"
                     /note="lysosomal proton-coupled steroid conjugate and bile
                     acid symporter SLC46A3"
                     /codon_start=1
                     /product="lysosomal proton-coupled steroid conjugate and
                     bile acid symporter SLC46A3 precursor"
                     /protein_id="NP_001020139.1"
                     /db_xref="GeneID:288454"
                     /db_xref="RGD:1307594"
                     /translation="MKISFIEPAILLYAFAMTLTIPLTAQYVYRRIWEETGNYTFTSS
                     SNVSECEQNKSSSTFAFQEEVQKKASLFSLQVEISGLIPGLVSTFMLLSSSDNHGRKL
                     PMVLSSLGSLGTNLWLCAMSYFDLPLQLLVASTFIGALFGNYTTFWGACFAYIVDQEK
                     EYKHRIIRIAVLDFMLGVVTGLTGLSSGYFIRELGFAWSYFIIAVVVLVNLAYILFFL
                     SDPIKESSSQIVTMSCSESLKDLFYRTYMLFKNGSCKRRSLLCLLIFTLVVYFFVVFG
                     ITPVFTLYELGPPLCWNEVYIGYGSALGSLSFLSSFLGIWLFSYCLKDIHIAYVGIFT
                     TMVGMMLTAFTRTTLMMFLVRISFFFTIMPLSILRSMLSKVVHSTEQGVLFACIAFLE
                     TLGGVTSTSAYNGIYSATVAWYPGFVFLLSAGLLVLPAVSLCMVKCIGWEEGSYTLLI
                     HDEPSEHTSDS"
     exon            536..1406
                     /gene="Slc46a3"
                     /gene_synonym="RGD1307594"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1490
                     /gene="Slc46a3"
                     /gene_synonym="RGD1307594"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1647
                     /gene="Slc46a3"
                     /gene_synonym="RGD1307594"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..2385
                     /gene="Slc46a3"
                     /gene_synonym="RGD1307594"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcgaccga gccaccacta gggcccaaag aaccagagtg cagcgaagcg gggagcggag
       61 gagactgagt ccagggccac taaagccccg gaggtgtgct tatctatctt tggcttctaa
      121 cagacctcca gtgtcccgtt ccaagggacg tccccctctc gcggtccagt ccacctctct
      181 gccctgtcct ttggctgtcc ccagctggaa aaccgtgctg aaaagacggg ggccgctgcg
      241 ccccgcactg ggtaaccgag aacacagtgc tgagctcggt ccaacctgtg ccgtgcctag
      301 caggaagacc ttaaccgtgg gactccacca gcccgcttga gcagatatga agatctcatt
      361 catcgagccc gccattctcc tttacgcctt tgctatgacg ctgaccatcc cgctgacagc
      421 gcagtatgtg taccggagga tatgggaaga aaccggtaac tacaccttta cctccagtag
      481 caatgtctct gaatgcgagc aaaacaaaag cagttccacc tttgcattcc aggaggaagt
      541 tcagaaaaag gcatctctct tcagcctgca ggtggaaata agtgggttaa ttcctggtct
      601 agtgtctacc ttcatgcttt tatcgagtag cgacaaccac ggacggaaac ttcccatggt
      661 cctgtcatct cttggctctc tgggaaccaa cctttggctg tgtgcgatgt cctactttga
      721 ccttcccctc cagcttctgg tagcatccac ctttattggc gccctctttg ggaattacac
      781 cacgttctgg ggagcttgct tcgcctacat tgtggatcag gagaaagaat acaagcacag
      841 aatcatccgc atagccgtcc tggattttat gctgggagtc gttactgggc taacaggcct
      901 gtcgtctggc tatttcatcc gagagctggg ttttgcgtgg tcctatttca ttattgccgt
      961 agttgttcta gtcaacctgg cctacattct atttttcctc agtgatccca taaaggagtc
     1021 ttcatctcag atagtcacta tgtcctgtag tgaaagcctc aaggacctat tttaccggac
     1081 ttacatgctg tttaaaaatg gttcctgtaa gcggcgttct ttgctctgtc tgctgatttt
     1141 tacccttgtc gtctattttt ttgtggtctt cggcatcacc ccggttttca cactctatga
     1201 gctgggtcct ccgctctgct ggaatgaggt ctacataggc tatggctcag ctttgggcag
     1261 cctctccttc ctgagtagtt tcctgggcat ctggctgttc tcttactgtt tgaaggatat
     1321 tcacatcgcc tatgtcggca tttttaccac gatggtggga atgatgctca ccgccttcac
     1381 caggaccact ctgatgatgt ttttagtccg aatatcgttc tttttcacca tcatgccact
     1441 ttccattctg aggtccatgc tgtcaaaggt ggtccactca acggaacaag gtgtgctgtt
     1501 tgcttgcata gctttcttag aaacgcttgg cggcgtcact tcgacctcgg cgtataatgg
     1561 gatttattca gccactgttg cctggtaccc tgggttcgtc ttcctgctgt ccgctggcct
     1621 cctggtcctc ccagccgtca gtctctgcat ggtcaaatgc attggctggg aagagggaag
     1681 ctatacactg ctcatccatg acgagcccag tgagcacaca tcagactcgt gacagcagca
     1741 atgcacacgc cctgtgtgcg actcctgaag aactgcgact cctgaagaac tgctccgcag
     1801 tcagtatttc actagcgatc cacgtgacaa aaccctgtct ccaaccaagt gagttgggag
     1861 gacacaccga gctctgctgc ttctggggcc acccagcagc acactgggtt cttcaaagag
     1921 cagaccccag taccgtcctc acttctccat ggaccagaga aacacagtgg agagcagagg
     1981 aatgcttgcg aaaccttgct aaaactttaa agcaataact tcactgacat gctccagtct
     2041 cccatgagga gactaaggag ttctgacctc agtctctccg tctgcacaat gggcttgctg
     2101 gcctctcagg gatttttttg aagacacaat gaggaatttt tatttgcaat aatcactgaa
     2161 atggaaatgt ctcaggcatt tctagttctt cctggacttg actgacgttt caagagcctg
     2221 tcaaggcttt actaatggaa tgaaaaatga agcacctttt aaaatgtgtt tttcattttt
     2281 cctagtgttt tattctgtga caagcctgat gatgttttta tatgtaatga agggggtggg
     2341 tagaaaatca gattataaat aaaatcgtcc taatgtgaaa actcaaaaaa aaaaaaaaaa
     2401 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2461 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2521 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
