LOCUS       NM_001013969            1900 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Rattus norvegicus solute carrier family 46 member 1 (Slc46a1),
            mRNA.
ACCESSION   NM_001013969 XM_220725
VERSION     NM_001013969.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1900)
  AUTHORS   Wang,D., Wu,H., Yang,J., Li,M., Ling,C., Gao,Z., Lu,H., Shen,H. and
            Tang,Y.
  TITLE     Loss of SLC46A1 decreases tumor iron content in hepatocellular
            carcinoma
  JOURNAL   Hepatol Commun 6 (10), 2914-2924 (2022)
   PUBMED   35811443
  REMARK    GeneRIF: Loss of SLC46A1 decreases tumor iron content in
            hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 1900)
  AUTHORS   Li,H., Zhang,C., Shen,H., Shen,Z., Wu,L., Mo,F. and Li,M.
  TITLE     Physiological stress-induced corticosterone increases heme uptake
            via KLF4-HCP1 signaling pathway in hippocampus neurons
  JOURNAL   Sci Rep 7 (1), 5745 (2017)
   PUBMED   28720846
  REMARK    GeneRIF: Physiological stress could increase heme uptake via heme
            carrier protein 1 (HCP1) in brains through a transcription factor,
            Kruppel-like factor 4 (KLF4).
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1900)
  AUTHORS   Wani,N.A., Thakur,S. and Kaur,J.
  TITLE     Mechanism of intestinal folate transport during folate deficiency
            in rodent model
  JOURNAL   Indian J Med Res 136 (5), 758-765 (2012)
   PUBMED   23287122
REFERENCE   4  (bases 1 to 1900)
  AUTHORS   Watkins,D. and Rosenblatt,D.S.
  TITLE     Update and new concepts in vitamin responsive disorders of folate
            transport and metabolism
  JOURNAL   J Inherit Metab Dis 35 (4), 665-670 (2012)
   PUBMED   22108709
  REMARK    Review article
REFERENCE   5  (bases 1 to 1900)
  AUTHORS   Wani,N.A., Nada,R. and Kaur,J.
  TITLE     Biochemical and molecular mechanisms of folate transport in rat
            pancreas; interference with ethanol ingestion
  JOURNAL   PLoS One 6 (12), e28599 (2011)
   PUBMED   22163044
  REMARK    GeneRIF: decreased levels of PCFT and RFC expression in rat PPM are
            due to decreased association of these proteins with lipid rafts
            (LR) at the PPM
REFERENCE   6  (bases 1 to 1900)
  AUTHORS   Inoue,K., Nakai,Y., Ueda,S., Kamigaso,S., Ohta,K.Y., Hatakeyama,M.,
            Hayashi,Y., Otagiri,M. and Yuasa,H.
  TITLE     Functional characterization of PCFT/HCP1 as the molecular entity of
            the carrier-mediated intestinal folate transport system in the rat
            model
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 294 (3), G660-G668 (2008)
   PUBMED   18174275
  REMARK    GeneRIF: we provide several lines of evidence that indicate
            PCFT/HCP1 has a role as the molecular entity of the intestinal
            folate transport system.
REFERENCE   7  (bases 1 to 1900)
  AUTHORS   Qiu,A., Min,S.H., Jansen,M., Malhotra,U., Tsai,E., Cabelof,D.C.,
            Matherly,L.H., Zhao,R., Akabas,M.H. and Goldman,I.D.
  TITLE     Rodent intestinal folate transporters (SLC46A1): secondary
            structure, functional properties, and response to dietary folate
            restriction
  JOURNAL   Am J Physiol Cell Physiol 293 (5), C1669-C1678 (2007)
   PUBMED   17898134
  REMARK    GeneRIF: Slc46a1/PCFT plays critical role in intestinal folate
            absorption.
REFERENCE   8  (bases 1 to 1900)
  AUTHORS   Nakai,Y., Inoue,K., Abe,N., Hatakeyama,M., Ohta,K.Y., Otagiri,M.,
            Hayashi,Y. and Yuasa,H.
  TITLE     Functional characterization of human proton-coupled folate
            transporter/heme carrier protein 1 heterologously expressed in
            mammalian cells as a folate transporter
  JOURNAL   J Pharmacol Exp Ther 322 (2), 469-476 (2007)
   PUBMED   17475902
REFERENCE   9  (bases 1 to 1900)
  AUTHORS   Qiu,A., Jansen,M., Sakaris,A., Min,S.H., Chattopadhyay,S., Tsai,E.,
            Sandoval,C., Zhao,R., Akabas,M.H. and Goldman,I.D.
  TITLE     Identification of an intestinal folate transporter and the
            molecular basis for hereditary folate malabsorption
  JOURNAL   Cell 127 (5), 917-928 (2006)
   PUBMED   17129779
REFERENCE   10 (bases 1 to 1900)
  AUTHORS   Shayeghi,M., Latunde-Dada,G.O., Oakhill,J.S., Laftah,A.H.,
            Takeuchi,K., Halliday,N., Khan,Y., Warley,A., McCann,F.E.,
            Hider,R.C., Frazer,D.M., Anderson,G.J., Vulpe,C.D., Simpson,R.J.
            and McKie,A.T.
  TITLE     Identification of an intestinal heme transporter
  JOURNAL   Cell 122 (5), 789-801 (2005)
   PUBMED   16143108
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089868.1.
            
            On Apr 20, 2005 this sequence version replaced XM_220725.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089868.1, FQ231269.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1900
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q25"
     gene            1..1900
                     /gene="Slc46a1"
                     /gene_synonym="RGD1309472; rPCFT"
                     /note="solute carrier family 46 member 1"
                     /db_xref="GeneID:303333"
                     /db_xref="RGD:1309472"
     exon            1..266
                     /gene="Slc46a1"
                     /gene_synonym="RGD1309472; rPCFT"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1418
                     /gene="Slc46a1"
                     /gene_synonym="RGD1309472; rPCFT"
                     /note="PCFT/HCP1; heme carrier protein 1; solute carrier
                     family 46 (folate transporter), member 1"
                     /codon_start=1
                     /product="proton-coupled folate transporter"
                     /protein_id="NP_001013991.1"
                     /db_xref="GeneID:303333"
                     /db_xref="RGD:1309472"
                     /translation="MEGRVSPVGSSHRLLTAAVLFRGPVEPLVFLANFALVLQGPLTT
                     QYIWHRISTELGYNGTRHRENCGNQSADPVLKEVETLTSHWTLYMNVGGFLVGLFWST
                     LLGAWSDRVGRRPLLVLASLGLLLQAVVSIFVVQLQLHIGFFVLGRALCALLGDFNGL
                     LAASFASVADVSSNHSRTFRMALLEACIGVAGTLASLLGGHWLRAQGYANPFWLALAV
                     LIVMTLYAAFCFGETVKEPKSTRLFTLRHHRSIVQLYVVPAPEKSRMHLALYSLAIFV
                     VVTVHFGAQDILTLYELSTPLCWDSKLIGYGSAAQHLPYLTSLLGLRLLQFCLADTWV
                     AEIGLAFNILGMVVFAFATITPLMFTGYGLLFLSLVTTPVIRAKLSKLVSESEQGALF
                     SAVACVNSLAMLMASGIFNSLYPATLNFMKGFPFLLGAGLLFIPAILIGVLEKVNPHP
                     EFQQFPQNS"
     exon            267..1119
                     /gene="Slc46a1"
                     /gene_synonym="RGD1309472; rPCFT"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1203
                     /gene="Slc46a1"
                     /gene_synonym="RGD1309472; rPCFT"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1360
                     /gene="Slc46a1"
                     /gene_synonym="RGD1309472; rPCFT"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1878
                     /gene="Slc46a1"
                     /gene_synonym="RGD1309472; rPCFT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagctggttc cgaggtgtca gcccctcggt gttcgcgcat ggaggggcgc gtgagccccg
       61 tgggctcgtc ccaccgtctc ctcaccgccg ccgtgctgtt ccgcggcccc gtggagcccc
      121 tcgttttcct agccaacttt gcgctggttc tacagggacc gctcaccaca cagtacattt
      181 ggcaccgcat cagcaccgag ctcggataca atggcacccg ccaccgggag aactgtggca
      241 accagagcgc ggatcccgtc ctgaaggaag tggagaccct gacatcccac tggaccctct
      301 acatgaacgt gggaggcttc ctggtgggac tcttctggtc caccctcctg ggagcctgga
      361 gtgaccgcgt gggtcgccgc ccattgctgg tgctggcctc tcttggtctg ctgctccagg
      421 ccgtggtgtc catctttgtg gtgcaactac aactgcacat cgggttcttc gtgctcggcc
      481 gagccctttg tgcccttctg ggagatttca acggccttct tgctgctagc tttgcctctg
      541 tggctgatgt tagctctaat cacagtcgca ccttccggat ggctctgctg gaagcatgca
      601 ttggtgtggc cgggaccctg gcaagccttc ttgggggtca ctggctccgg gcccagggtt
      661 atgccaaccc tttctggctg gctttggctg tgctgatcgt tatgactcta tatgcagcat
      721 tctgttttgg tgagacagtg aaggagccaa agtccacgag gcttttcacg ctccgccatc
      781 accgatccat tgtccagctg tatgtggtcc cagccccaga gaagtccagg atgcatctag
      841 ccctgtactc attggccata ttcgtggtgg tcactgtgca ctttggggct caagacatcc
      901 tgacgctcta tgagctaagc acacccctct gctgggactc caagctgatt ggctatggct
      961 cagcagccca gcacttaccc tacctcacca gcctgctggg cctgagactt ctgcagttct
     1021 gcctggccga cacctgggtg gctgagattg gcctggcctt caacatcctg ggaatggtgg
     1081 tctttgcgtt cgcaaccatc acacccctca tgttcacagg gtacggatta ctcttcctgt
     1141 cattggtcac tacgcctgtg atccgggcca agctctccaa gctagtgagc gagtcggagc
     1201 agggtgctct cttttcggct gtggcctgtg tgaatagctt ggccatgttg atggcctccg
     1261 gcatcttcaa ctcactctac ccggccactc tgaacttcat gaagggcttc cccttcctcc
     1321 tgggagctgg cctcctcttt atcccggcca ttctgattgg ggtactggag aaggttaatc
     1381 cacacccaga gttccagcag tttcctcaga actcctgagc tgccagaagc catgagaagc
     1441 agtggctcca caccgactac atacctaaag cccagtgcac cagcgtctct aaggacagta
     1501 ctcactttgg aaacggtgtt caagccagtt atgggcaaca cctattctct gactgagcca
     1561 gtctctgcta gatacagaat ctagtcagga gaggtccact cagggcaggc tgcagggagc
     1621 catcatgcag aaccttccag agtaaaggag atggcattta ggggactaag catgagaatc
     1681 tttctagccc atggtactag gtccctgctg tgttccgtgg cctctaggca ccccttaatg
     1741 ctaactgtgg tacctgggag agcggttttg acacagaagc ctgtctatgg ttggggatca
     1801 gtccttgacc acagcctatc cacctttgac ctcagccgtg ccaattgtca cagtaaattg
     1861 tttgaatcag tctgaaaaaa aaaaaaaaaa aaaaaaaaaa
//
