LOCUS       NM_212541               2254 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus solute carrier family 44, member 4 (Slc44a4),
            mRNA.
ACCESSION   NM_212541 XM_215344
VERSION     NM_212541.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2254)
  AUTHORS   Ma,Z., Xia,W., Liu,F., Ma,J., Sun,S., Zhang,J., Jiang,N., Wang,X.,
            Hu,J. and Ma,D.
  TITLE     SLC44A4 mutation causes autosomal dominant hereditary postlingual
            non-syndromic mid-frequency hearing loss
  JOURNAL   Hum Mol Genet 26 (2), 383-394 (2017)
   PUBMED   28013291
  REMARK    Erratum:[Hum Mol Genet. 2017 Aug 15;26(16):3234. doi:
            10.1093/hmg/ddx232.. PMID: 28859437]
REFERENCE   2  (bases 1 to 2254)
  AUTHORS   Nabokina,S.M., Inoue,K., Subramanian,V.S., Valle,J.E., Yuasa,H. and
            Said,H.M.
  TITLE     Molecular identification and functional characterization of the
            human colonic thiamine pyrophosphate transporter
  JOURNAL   J Biol Chem 289 (7), 4405-4416 (2014)
   PUBMED   24379411
  REMARK    Erratum:[J Biol Chem. 2017 Oct 6;292(40):16526. doi:
            10.1074/jbc.A113.528257.. PMID: 28986434]
REFERENCE   3  (bases 1 to 2254)
  AUTHORS   Song,P., Rekow,S.S., Singleton,C.A., Sekhon,H.S., Dissen,G.A.,
            Zhou,M., Campling,B., Lindstrom,J. and Spindel,E.R.
  TITLE     Choline transporter-like protein 4 (CTL4) links to non-neuronal
            acetylcholine synthesis
  JOURNAL   J Neurochem 126 (4), 451-461 (2013)
   PUBMED   23651124
REFERENCE   4  (bases 1 to 2254)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 2254)
  AUTHORS   Traiffort,E., Ruat,M., O'Regan,S. and Meunier,F.M.
  TITLE     Molecular characterization of the family of choline
            transporter-like proteins and their splice variants
  JOURNAL   J Neurochem 92 (5), 1116-1125 (2005)
   PUBMED   15715662
REFERENCE   6  (bases 1 to 2254)
  AUTHORS   Hurt,P., Walter,L., Sudbrak,R., Klages,S., Muller,I., Shiina,T.,
            Inoko,H., Lehrach,H., Gunther,E., Reinhardt,R. and Himmelbauer,H.
  TITLE     The genomic sequence and comparative analysis of the rat major
            histocompatibility complex
  JOURNAL   Genome Res 14 (4), 631-639 (2004)
   PUBMED   15060004
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX883045.1.
            
            On Aug 30, 2004 this sequence version replaced XM_215344.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079178.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2254
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2254
                     /gene="Slc44a4"
                     /gene_synonym="Ng22"
                     /note="solute carrier family 44, member 4"
                     /db_xref="GeneID:294255"
                     /db_xref="RGD:1303167"
     exon            1..41
                     /gene="Slc44a4"
                     /gene_synonym="Ng22"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..2131
                     /gene="Slc44a4"
                     /gene_synonym="Ng22"
                     /note="thiamine pyrophosphate transporter 1"
                     /codon_start=1
                     /product="choline transporter-like protein 4"
                     /protein_id="NP_997706.1"
                     /db_xref="GeneID:294255"
                     /db_xref="RGD:1303167"
                     /translation="MGKKQKENEAYGNSAKYDPSFRGPIKNRGCTDIICCVLFLVFIL
                     GYIVVGLVAWVYGDPRQVLYPRNSTGAYCGVGDNKDKPYVLYFNILSCAAAINVISIA
                     ENGLQCPTPQVCVSSCPQTPWVVEGFQLSNTVGDVYKEYRNFCVPAVSPDMVVMDSLQ
                     KGLCPSFLLPSTPALGRCFPLPNINFTLPEQLQINNTTVSKGISGLLDSINARDVSVK
                     IFEDFAQSWYWILVALGVALVLSLLFILLLRLVAAPLVLLLIVGVLAVLAYGIYHCWQ
                     QYRELRDQGVSITQLGFTANLSAYQNVKETWLAALIILAVLEGVLLLMLIFLRQRIRI
                     AIALLKEASRAVGQMMSTMFYPLVTFVLLVICIGYWAVTALYLATSGQPQYVYWVHNT
                     STPGCEKVLVNVSCDPMAPLNSSCPELKCTFTGYSSSGLAQRSLFNLQIYGILGLFWT
                     VNWVLALGQCVLAGAFASFYWAFHKPRDIPTFPLSSAFIRTLRYHTGSLAFGALILTL
                     VQIARVILEYIDHKLRGSQNPVARCIICCFKCCLWCLEKFIKFLNRNAYIMIAIYGKN
                     FCVSAKNAFMLLMRNVVRVVVLDKVTDLLLFFGKLLVVGGVGVLSFFFFSGRIKGLGK
                     DFKNPDLNYYWLPIMTSIMGAYVIASGFFSVFGMCVDTLFLCFLEDLERNDGSQERPY
                     YMPKALLKILGKKNEVPTGGKNRKK"
     exon            42..90
                     /gene="Slc44a4"
                     /gene_synonym="Ng22"
                     /inference="alignment:Splign:2.1.0"
     exon            91..164
                     /gene="Slc44a4"
                     /gene_synonym="Ng22"
                     /inference="alignment:Splign:2.1.0"
     exon            165..243
                     /gene="Slc44a4"
                     /gene_synonym="Ng22"
                     /inference="alignment:Splign:2.1.0"
     exon            244..343
                     /gene="Slc44a4"
                     /gene_synonym="Ng22"
                     /inference="alignment:Splign:2.1.0"
     exon            344..466
                     /gene="Slc44a4"
                     /gene_synonym="Ng22"
                     /inference="alignment:Splign:2.1.0"
     exon            467..527
                     /gene="Slc44a4"
                     /gene_synonym="Ng22"
                     /inference="alignment:Splign:2.1.0"
     exon            528..618
                     /gene="Slc44a4"
                     /gene_synonym="Ng22"
                     /inference="alignment:Splign:2.1.0"
     exon            619..702
                     /gene="Slc44a4"
                     /gene_synonym="Ng22"
                     /inference="alignment:Splign:2.1.0"
     exon            703..938
                     /gene="Slc44a4"
                     /gene_synonym="Ng22"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1038
                     /gene="Slc44a4"
                     /gene_synonym="Ng22"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1131
                     /gene="Slc44a4"
                     /gene_synonym="Ng22"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1234
                     /gene="Slc44a4"
                     /gene_synonym="Ng22"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1485
                     /gene="Slc44a4"
                     /gene_synonym="Ng22"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1580
                     /gene="Slc44a4"
                     /gene_synonym="Ng22"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1684
                     /gene="Slc44a4"
                     /gene_synonym="Ng22"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1758
                     /gene="Slc44a4"
                     /gene_synonym="Ng22"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1829
                     /gene="Slc44a4"
                     /gene_synonym="Ng22"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1924
                     /gene="Slc44a4"
                     /gene_synonym="Ng22"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2009
                     /gene="Slc44a4"
                     /gene_synonym="Ng22"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2254
                     /gene="Slc44a4"
                     /gene_synonym="Ng22"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgagccatg gggaaaaagc agaaggagaa cgaggcttac gggaattcag ccaaatacga
       61 cccctccttt cgaggaccca tcaaaaacag gggctgcaca gacatcatct gctgtgttct
      121 cttcctggtc ttcatcttgg gttacatcgt agtggggctt gtggcctggg tgtacggaga
      181 ccctcggcaa gtgctttacc ccagaaactc cacaggagcc tactgcggcg tgggcgacaa
      241 caaggataaa ccctacgtcc tgtacttcaa catcttaagc tgtgcggcgg ccatcaacgt
      301 catctccatt gctgagaatg gcctacagtg ccccacaccc caggtgtgcg tctcttcctg
      361 cccacagacc ccgtgggttg tggaggggtt ccagctctca aacacagtcg gtgacgttta
      421 taaagaatac aggaacttct gtgtaccagc ggtgtcccca gatatggtag tgatggacag
      481 cctgcaaaag ggactctgtc ccagtttcct ccttccttct actccagctc tgggacgttg
      541 ttttccgctc cccaacatca acttcacatt acctgaacag ttacagatca ataacaccac
      601 tgtctctaaa ggaatcagtg gcctcctgga cagcatcaat gcccgggatg tctctgtgaa
      661 gatctttgaa gattttgccc agtcctggta ctggattctc gtggcgctgg gtgtggccct
      721 ggtgctaagt ctgctgttca tcctgctcct gcgcctggtg gcggcccccc tggtgctgct
      781 gctgattgtg ggggtgctgg ccgtgctggc ctatggtatc taccactgct ggcaacagta
      841 ccgagagctg cgggaccagg gtgtctccat cacccagcta ggcttcactg ccaacctcag
      901 tgcctaccag aatgtgaagg agacatggct ggctgctctg attatcctgg ctgtcctgga
      961 gggcgtcttg ttgctcatgc tcattttcct gcgccagcgg atccggattg ccattgctct
     1021 gctgaaagaa gctagcagag ctgtgggaca gatgatgtca actatgttct atcctctggt
     1081 caccttcgtc ctcctggtca tttgcattgg ttactgggcc gtgacagctc tgtacctggc
     1141 tacatccggg caaccccagt acgtctattg ggtgcataac accagtacac cgggctgtga
     1201 gaaagttctt gtgaacgtgt cctgtgaccc catggcccca ttgaactcct cgtgcccaga
     1261 gctcaagtgc accttcacag gctactcgtc ctcaggctta gcccaacgtt ctctcttcaa
     1321 cctgcaaatc tatggaatcc tggggctctt ctggactgtt aactgggtac tggccctggg
     1381 ccagtgtgtc ctcgctgggg cctttgcctc cttctactgg gcctttcaca agcctcgaga
     1441 catccctact ttccccttga gctcagcctt catccgcaca ctccgttatc acactggctc
     1501 actggcgttt ggagccctca tcctgaccct tgtgcaaata gcccgggtta tcctggaata
     1561 cattgaccac aagctaagag gatcccagaa tcctgtggcc cgctgcatca tctgctgctt
     1621 caagtgttgt ctctggtgtc tggagaagtt tattaagttc ctcaaccgta atgcctacat
     1681 catgatcgcc atctatggga agaatttctg tgtctccgcc aaaaacgcct tcatgctgct
     1741 catgaggaac gttgtcaggg tagtcgtcct ggataaagtc actgatttac tgctcttctt
     1801 tgggaagctg ctggtggtcg gaggtgtcgg tgttctgtcc ttcttctttt tctccggtcg
     1861 tatcaaggga ctggggaaag actttaagaa ccccgacctc aactattact ggctgcccat
     1921 catgacctcc atcatgggag cctatgtcat tgccagtggc ttcttcagcg tttttggaat
     1981 gtgtgtagac acgctcttcc tctgcttcct tgaggacctg gagaggaatg acggttccca
     2041 agagcggcca tactacatgc ccaaggcact cctgaagatt ctgggcaaga agaatgaggt
     2101 acctacgggg ggaaaaaaca ggaagaagtg agagactcat cgtgacccac gactgcagcc
     2161 ctcctgtaca gaaaccctgc cattgatgcc ttgagaatca taattttgta gaaaacagat
     2221 tttattaaag attaatattt tatattcttg ataa
//
