LOCUS       NM_001033852            4507 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus solute carrier family 44 member 1 (Slc44a1),
            transcript variant 1, mRNA.
ACCESSION   NM_001033852
VERSION     NM_001033852.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4507)
  AUTHORS   Hedtke,V. and Bakovic,M.
  TITLE     Choline transport for phospholipid synthesis: An emerging role of
            choline transporter-like protein 1
  JOURNAL   Exp Biol Med (Maywood) 244 (8), 655-662 (2019)
   PUBMED   30776907
  REMARK    GeneRIF: SLC44A1 acts as a choline transporter both in the plasma
            membrane and in the mitochondria. Novel aspects of choline
            transport regulation in the muscle, nervous system, and cancer are
            reviewed. Review.
            Review article
REFERENCE   2  (bases 1 to 4507)
  AUTHORS   Heffernan,C., Jain,M.R., Liu,T., Kim,H., Barretto,K., Li,H. and
            Maurel,P.
  TITLE     Nectin-like 4 Complexes with Choline Transporter-like Protein-1 and
            Regulates Schwann Cell Choline Homeostasis and Lipid Biogenesis in
            Vitro
  JOURNAL   J Biol Chem 292 (11), 4484-4498 (2017)
   PUBMED   28119456
  REMARK    GeneRIF: CTL1-deficient Schwann cells are significantly impaired in
            their ability to myelinate neurites in vitro.
REFERENCE   3  (bases 1 to 4507)
  AUTHORS   Iwao,B., Yara,M., Hara,N., Kawai,Y., Yamanaka,T., Nishihara,H.,
            Inoue,T. and Inazu,M.
  TITLE     Functional expression of choline transporter like-protein 1 (CTL1)
            and CTL2 in human brain microvascular endothelial cells
  JOURNAL   Neurochem Int 93, 40-50 (2016)
   PUBMED   26746385
REFERENCE   4  (bases 1 to 4507)
  AUTHORS   Pages,M., Lacroix,L., Tauziede-Espariat,A., Castel,D.,
            Daudigeos-Dubus,E., Ridola,V., Gilles,S., Fina,F., Andreiuolo,F.,
            Polivka,M., Lechapt-Zalcman,E., Puget,S., Boddaert,N., Liu,X.Q.,
            Bridge,J.A., Grill,J., Chretien,F. and Varlet,P.
  TITLE     Papillary glioneuronal tumors: histological and molecular
            characteristics and diagnostic value of SLC44A1-PRKCA fusion
  JOURNAL   Acta Neuropathol Commun 3, 85 (2015)
   PUBMED   26671581
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4507)
  AUTHORS   Yamada,T., Inazu,M., Tajima,H. and Matsumiya,T.
  TITLE     Functional expression of choline transporter-like protein 1 (CTL1)
            in human neuroblastoma cells and its link to acetylcholine
            synthesis
  JOURNAL   Neurochem Int 58 (3), 354-365 (2011)
   PUBMED   21185344
REFERENCE   6  (bases 1 to 4507)
  AUTHORS   Traiffort,E., Ruat,M., O'Regan,S. and Meunier,F.M.
  TITLE     Molecular characterization of the family of choline
            transporter-like proteins and their splice variants
  JOURNAL   J Neurochem 92 (5), 1116-1125 (2005)
   PUBMED   15715662
REFERENCE   7  (bases 1 to 4507)
  AUTHORS   Lecomte,M.J., De Gois,S., Guerci,A., Ravassard,P., Faucon
            Biguet,N., Mallet,J. and Berrard,S.
  TITLE     Differential expression and regulation of the high-affinity choline
            transporter CHT1 and choline acetyltransferase in neurons of
            superior cervical ganglia
  JOURNAL   Mol Cell Neurosci 28 (2), 303-313 (2005)
   PUBMED   15691711
REFERENCE   8  (bases 1 to 4507)
  AUTHORS   Yuan,Z., Wagner,L., Poloumienko,A. and Bakovic,M.
  TITLE     Identification and expression of a mouse muscle-specific CTL1 gene
  JOURNAL   Gene 341, 305-312 (2004)
   PUBMED   15474312
REFERENCE   9  (bases 1 to 4507)
  AUTHORS   Che,Y.H., Yamashita,T., Higuchi,H. and Tohyama,M.
  TITLE     Changes in mRNA for choline transporter-like protein following
            facial nerve transection
  JOURNAL   Brain Res Mol Brain Res 101 (1-2), 122-125 (2002)
   PUBMED   12007839
REFERENCE   10 (bases 1 to 4507)
  AUTHORS   O'Regan,S., Traiffort,E., Ruat,M., Cha,N., Compaore,D. and
            Meunier,F.M.
  TITLE     An electric lobe suppressor for a yeast choline transport mutation
            belongs to a new family of transporter-like proteins
  JOURNAL   Proc Natl Acad Sci U S A 97 (4), 1835-1840 (2000)
   PUBMED   10677542
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AJ420809.1, BM391692.1 and JAXUCZ010000005.1.
            
            Sequence Note: This RefSeq record was created using sequences from
            three different strains, W, Sprague-Dawley and BN/SsNHsdMCW,
            because no single transcript from the same strain was available for
            the full length of the gene.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ420809.1, SRR26643429.19533.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1945              AJ420809.1         1-1945
            1946-2315           BM391692.1         12-381              c
            2316-4507           JAXUCZ010000005.1  72985378-72987569
FEATURES             Location/Qualifiers
     source          1..4507
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..4507
                     /gene="Slc44a1"
                     /gene_synonym="Cdw92; Ctl1"
                     /note="solute carrier family 44 member 1"
                     /db_xref="GeneID:85254"
                     /db_xref="RGD:621426"
     exon            1..46
                     /gene="Slc44a1"
                     /gene_synonym="Cdw92; Ctl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1984
                     /gene="Slc44a1"
                     /gene_synonym="Cdw92; Ctl1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     choline transporter-like protein 1; CDW92 antigen; solute
                     carrier family 44 (choline transporter), member 1"
                     /codon_start=1
                     /product="choline transporter-like protein 1 isoform 1"
                     /protein_id="NP_001029024.1"
                     /db_xref="GeneID:85254"
                     /db_xref="RGD:621426"
                     /translation="MGCCSSASAAQSSKREWKPLEDRSCTDIPWLLLFVLFCIGMGFI
                     CGFSVATGAAARLVSGYDSYGNICGQRNAKLEAIANSGLDHTHRKYVFFLDPCNLDLI
                     NRKIKSMALCVAACPRQELKTLSDVQKFAEINGSALCSYNIKPSEYTLTAKSSAFCPK
                     LPVPASAPIPFFHRCAPVNISCYAKFAEALITFVSDNSVLHRLISGVMTSKEIILGLC
                     LLSLVLSMILMVIIRYISRVLVWILTILVILGSLGGTGVLWWLYAKQRRSPKETVIPE
                     QLQIAEDNLRALLIYAISATVFTVILFLIMLVMRKRVALTIALFHVAGKVFIHLPLLV
                     FQPFWTFFALVLFWAYWIMTLLFLGTTGSAVQNEQGFVEYKISGPLQYMWWYHVVGLI
                     WISEFILACQQMTVAGAVVTYYFTRDKRNLPFTPILASVNRLIRYHLGTVAKGSFIIT
                     LVKIPRMILMYIHSQLKGKENACARCMLKSCICCLWCLEKCLSYLNQNAYTATAINST
                     NFCTSAKDAFVILVENALRVAAINTVGDFMLFLGKVLIVCSTGLAGIMLLNYQQDYTV
                     WVLPLIIVCLFAFLVAHCFLSIYEMVVDVLFLCFAIDTKYNDGSPGREFYMDKVLMEF
                     VENSRKAMKEAGKGGAADARELKPMASGASSA"
     exon            47..136
                     /gene="Slc44a1"
                     /gene_synonym="Cdw92; Ctl1"
                     /inference="alignment:Splign:2.1.0"
     exon            137..279
                     /gene="Slc44a1"
                     /gene_synonym="Cdw92; Ctl1"
                     /inference="alignment:Splign:2.1.0"
     exon            280..416
                     /gene="Slc44a1"
                     /gene_synonym="Cdw92; Ctl1"
                     /inference="alignment:Splign:2.1.0"
     exon            417..510
                     /gene="Slc44a1"
                     /gene_synonym="Cdw92; Ctl1"
                     /inference="alignment:Splign:2.1.0"
     exon            511..680
                     /gene="Slc44a1"
                     /gene_synonym="Cdw92; Ctl1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..770
                     /gene="Slc44a1"
                     /gene_synonym="Cdw92; Ctl1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..910
                     /gene="Slc44a1"
                     /gene_synonym="Cdw92; Ctl1"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1097
                     /gene="Slc44a1"
                     /gene_synonym="Cdw92; Ctl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1263
                     /gene="Slc44a1"
                     /gene_synonym="Cdw92; Ctl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1420
                     /gene="Slc44a1"
                     /gene_synonym="Cdw92; Ctl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1504
                     /gene="Slc44a1"
                     /gene_synonym="Cdw92; Ctl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1642
                     /gene="Slc44a1"
                     /gene_synonym="Cdw92; Ctl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1879
                     /gene="Slc44a1"
                     /gene_synonym="Cdw92; Ctl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1960
                     /gene="Slc44a1"
                     /gene_synonym="Cdw92; Ctl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..4507
                     /gene="Slc44a1"
                     /gene_synonym="Cdw92; Ctl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccggcccc gccatgggct gctgcagctc cgcctccgcc gcgcagagct ccaaacgaga
       61 atggaagccg ttggaggacc gtagctgcac agacatacca tggctgctgc tcttcgttct
      121 gttctgcatt gggatgggat ttatttgtgg cttttcagta gcaacaggtg cagcagcaag
      181 actagtgtca ggatacgaca gctatggaaa tatctgtggg cagagaaatg caaaactgga
      241 agcaatagcg aacagtggcc tggaccacac ccaccggaag tatgtgttct ttttggaccc
      301 atgcaatctg gacttgataa acaggaagat caagtctatg gcactgtgtg tagcggcatg
      361 tccacgacag gagttgaaaa ccctgagtga cgtccagaag tttgccgaga tcaatggttc
      421 agcactgtgt agctacaaca taaagccttc cgagtacact ctgactgcaa aatcctctgc
      481 cttttgcccc aaactaccag taccagccag tgcacctatt ccattcttcc atcgctgtgc
      541 tcctgtgaac atttcctgct atgccaagtt tgcagaggcc ctgatcacct ttgtcagtga
      601 caatagtgtc ttacacaggc tgattagtgg agtaatgacc agcaaagaaa ttatattggg
      661 actttgcttg ttatcactag ttctgtccat gattttgatg gtgattatcc ggtatatctc
      721 aagagtgcta gtgtggatcc taacgattct ggtcatcctg ggttcactag gtggcaccgg
      781 tgtactatgg tggctatatg caaagcagag aaggtccccc aaagaaacag ttattcctga
      841 acagcttcag atcgcggaag acaatctgcg ggcgctcctc atctatgcca tttctgctac
      901 ggtgttcact gtcattctct tcctgatcat gctggttatg cgtaaacgcg tcgctctcac
      961 catcgccttg ttccacgtgg ctggcaaggt cttcatacac ctgcctctgc tagtcttcca
     1021 gcccttctgg actttttttg ctctcgtctt attttgggca tactggataa tgacacttct
     1081 cttccttggc actactggca gtgctgttca gaatgaacaa ggtttcgtgg agtacaaaat
     1141 ctctgggcct ttgcagtaca tgtggtggta ccacgtggtc ggcctgattt ggatcagtga
     1201 gttcattctc gcctgtcagc agatgactgt ggcaggagct gtggtaacat actactttac
     1261 aagggataaa cggaatttgc ctttcacacc tattctggca tcagtgaacc gccttattcg
     1321 ttaccacctc ggtactgtgg ccaaaggatc cttcattatc accctcgtca agatccccag
     1381 gatgatcctt atgtatatcc acagtcagct caaagggaag gaaaacgctt gtgcacgatg
     1441 catgctgaaa tcctgcattt gctgcctttg gtgtcttgaa aagtgcctga gctacttaaa
     1501 ccagaatgca tacacagcca cagccatcaa tagcaccaac ttctgcacct cagcaaagga
     1561 tgccttcgtc attctagtgg agaatgctct gcgagtggct gccatcaaca cagtggggga
     1621 cttcatgtta ttcctaggca aggtgctgat agtctgcagc acgggcctgg ctgggattat
     1681 gctgctcaac taccagcaag attacacagt gtgggtgctg cctctcatca tcgtctgcct
     1741 ctttgctttc ctagtcgctc attgcttcct gtccatttac gaaatggtag tggatgtgtt
     1801 gtttttgtgt tttgccattg atacaaaata caatgatggg agcccaggcc gagaattcta
     1861 tatggacaaa gtcctaatgg agtttgtgga aaacagtagg aaagcaatga aagaagctgg
     1921 taagggaggc gccgcggatg cccgagagct aaagccgatg gcttcgggag caagttctgc
     1981 ttgaacatag ccggcggtta tggaccccat tgacattcca aaacaatata tacacataac
     2041 tatgtatttg tgtgtgtggg tgtgtgtata tatgtatatg tatgtgtgtg tatatatata
     2101 tatgtatatg tatatacaca cacacacata atcagccaaa atcagagaaa aggaacaggg
     2161 atttaatacc ttttttatgc ttatttttgt caaacatgta ctcctttcat acgggtggct
     2221 tttacaaggc aacttccgtc atttaatgtt ttcaattgta attgtcttaa tggaaatgtt
     2281 agattcatat ctgattaaag tttttaataa ctagaggaaa ttttaacttt agttacttaa
     2341 cctagataaa aattattgta ccaaatcctt gtgtaagttt ttgcaggggt gatttccctg
     2401 gtgtatgttt aaaaccagta tctcatttta cggatgcata agtcctagtg tgtcagacta
     2461 ggcatgtgcg ttcagataaa taagagattt ctccagtctg ttttctccaa tccaagaagc
     2521 catgccattt ttctttgaga agcatgtgag tgggcccacc gtgggaaatt tcataatagc
     2581 tcatgcattt gtcagccaac attcaaaagt acccaactgc tcaggtatct gtagtttacc
     2641 ctaatgcttc tgtagaagaa agtaggaaac agagagggaa aggggtagat agtctttatt
     2701 atgcaaactt ttttcttgtg ttttgtttct ttcctctttg atttttagta gcacccgcca
     2761 cacatccatg tgcctgatct gaaaggaggc tggggcaccc agccaagtgt aacctttctg
     2821 tgtattaatt ttcagcctag gtaattctag aaaggataaa agaagaaaga aacaagaagc
     2881 acgacgcact gagcattcca gtgctctgtt tcagaggcag gtcaggagct tagggttaaa
     2941 cggccatctc ttcaaatgct tgctctaaag tctgaacaca ccggcaggtg ctccactcct
     3001 tggttattcc tcgtatccag agttctacag tgtttcactg aagaaccggt tggtgttgat
     3061 cctcaagtgt gaatgtgctt tatgtttggg ggtacgtttg gggtttcttg ttttgccggg
     3121 tttttttttt ttttatttct aaagcttacc agatatgaat ggctaatatt ccattgttct
     3181 gcttattgta atggtgaatg ctttaagaaa aaaaaagtgt aatttgctaa gaataattca
     3241 tgatctgttt atgcgataac tcctttttgt tacaattttt ttaaaaaaag ctatttttgt
     3301 taatgtaaag taaatatttc agagcaaatt ttttaaactt attgcactaa atacaggctc
     3361 tgtaaaaaaa aaaaaaaaaa gaaattaaaa aaaaaaagcc tcagcattta tcattccatg
     3421 gaaggaagat cttttgaaag aaagcattgc ctatagaggt agatgtgaat tagactggtg
     3481 ttgtggggat tgcatacaat gtcccgaggg ctcaagaagc agctgcttgc taatgtgctt
     3541 cctttcaaag ggttggacct ttaaattgct gcaaaaggta aattgtattt tcttttttaa
     3601 gtactggtgt tctttaatct agctaggcta aattttgcta aatgccttgg tttcttttca
     3661 aagctcatga atatttctga accttcagag tatttgcaat aagagtctgg attaaaacaa
     3721 cagtaaacca cacacacaca cacacacaca cacacacaca cacacacaca attaagagtg
     3781 catgtctaag caggatctgg gaagccagca ttgagaaagc atagctattg tgaaataata
     3841 attcgccaga aattacatct aacatctagc gctgccaaat agtgtcactg tactatttta
     3901 tatcattcga aatggaattc aattctgtaa ctaacaactg tcctactagg tgagagagaa
     3961 agattatgtg agaaaatcag aataccatgt gatttgtaga tttgggacgt tcagaaacat
     4021 tgggaactaa atttagaatg ggccaaagcc tggaagatgg gtctcacacc agaagacatt
     4081 ccaggagcta gccattttag gagatgtccc tccaaagtgt cgcgatgatg gccttgcact
     4141 tgggaatcag gtcctgctca cttggacatc cctgcgtcat ggactcttgc tgcccccgtt
     4201 ccatgtgctc gcaattccag ctactggaag ccaccaggaa tgctttctaa ttatcatttg
     4261 caactagaac tgtaatcaga aagaaaattt gtatttttgt ataactcgat tgtgtgccat
     4321 tttatataac aggtcctgtt ttacaaataa attttgtttt actaactttg tgtttagaaa
     4381 ttatgctcta tgtgtaacca tgtcatttga gttcaattaa tttccaggct gttttccctg
     4441 aataagtttg tgtgccacat agtcatatgc aagcatgcat atctattcca tgggtgcaca
     4501 cagagag
//
