LOCUS       NM_133315               3254 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus solute carrier family 40 member 1 (Slc40a1),
            mRNA.
ACCESSION   NM_133315
VERSION     NM_133315.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3254)
  AUTHORS   Fang,J., Kong,B., Shuai,W., Xiao,Z., Dai,C., Qin,T., Gong,Y.,
            Zhu,J., Liu,Q. and Huang,H.
  TITLE     Ferroportin-mediated ferroptosis involved in new-onset atrial
            fibrillation with LPS-induced endotoxemia
  JOURNAL   Eur J Pharmacol 913, 174622 (2021)
   PUBMED   34748769
  REMARK    GeneRIF: Ferroportin-mediated ferroptosis involved in new-onset
            atrial fibrillation with LPS-induced endotoxemia.
REFERENCE   2  (bases 1 to 3254)
  AUTHORS   Liu,J., Wan,M., Zhang,Y., Zhang,S., Zhang,H. and Wu,S.
  TITLE     Dysfunction of Iron Metabolism and Iron-Regulatory Proteins in the
            Rat Hippocampus After Heat Stroke
  JOURNAL   Shock 51 (6), 780-786 (2019)
   PUBMED   29757912
  REMARK    GeneRIF: ata thereby indicate that heat stroke can decrease
            learning ability and memory in rats. The mechanism may be related
            to changes of iron levels, as well as Fpn1 and hepcidin expression,
            in the hippocampus.
REFERENCE   3  (bases 1 to 3254)
  AUTHORS   Helgudottir,S.S., Lichota,J., Burkhart,A. and Moos,T.
  TITLE     Hepcidin Mediates Transcriptional Changes in Ferroportin mRNA in
            Differentiated Neuronal-Like PC12 Cells Subjected to Iron Challenge
  JOURNAL   Mol Neurobiol 56 (4), 2362-2374 (2019)
   PUBMED   30027341
  REMARK    GeneRIF: These data point towards a transcriptional induction of
            Fpn in response to changes in cellular iron levels.
            Erratum:[Mol Neurobiol. 2019 Apr;56(4):2375-2378. doi:
            10.1007/s12035-018-1282-7.. PMID: 30128649]
REFERENCE   4  (bases 1 to 3254)
  AUTHORS   Carvalho,L., Brait,D., Vaz,M., Lollo,P., Morato,P., Oesterreich,S.,
            Raposo,J. and Freitas,K.
  TITLE     Partially Hydrolyzed Guar Gum Increases Ferroportin Expression in
            the Colon of Anemic Growing Rats
  JOURNAL   Nutrients 9 (3), 228 (2017)
   PUBMED   28273797
  REMARK    GeneRIF: Data suggest that expression of ferroportin in intestinal
            mucosa can be regulated by dietary factors; here, partially
            hydrolyzed guar gum up-regulates expression of ferroportin in cecum
            mucosa in growing rats being treated for iron deficiency anemia
            with this probiotic; intestinal absorption of dietary iron appears
            to be up-regulated, as well.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3254)
  AUTHORS   Gao,G., Liu,S.Y., Wang,H.J., Zhang,T.W., Yu,P., Duan,X.L.,
            Zhao,S.E. and Chang,Y.Z.
  TITLE     Effects of Pregnancy and Lactation on Iron Metabolism in Rats
  JOURNAL   Biomed Res Int 2015, 105325 (2015)
   PUBMED   26788496
  REMARK    GeneRIF: The significantly increased FPN1 level in small intestine
            facilitates digestive iron absorption, which maintains the serum
            iron concentration at a near-normal level to meet the increase of
            iron requirements
REFERENCE   6  (bases 1 to 3254)
  AUTHORS   Devalia,V., Carter,K., Walker,A.P., Perkins,S.J., Worwood,M.,
            May,A. and Dooley,J.S.
  TITLE     Autosomal dominant reticuloendothelial iron overload associated
            with a 3-base pair deletion in the ferroportin 1 gene (SLC11A3)
  JOURNAL   Blood 100 (2), 695-697 (2002)
   PUBMED   12091367
REFERENCE   7  (bases 1 to 3254)
  AUTHORS   Wallace,D.F., Pedersen,P., Dixon,J.L., Stephenson,P., Searle,J.W.,
            Powell,L.W. and Subramaniam,V.N.
  TITLE     Novel mutation in ferroportin1 is associated with autosomal
            dominant hemochromatosis
  JOURNAL   Blood 100 (2), 692-694 (2002)
   PUBMED   12091366
  REMARK    GeneRIF: the finding of a novel mutation (V162del) in ferroportin1
            in an Australian family with autosomal dominant hemochromatosis;
            the mutation disrupts the function of the ferroportin1 protein,
            leading to impaired iron homeostasis and iron overload
REFERENCE   8  (bases 1 to 3254)
  AUTHORS   Haile,D.J.
  TITLE     Assignment of Slc11a3 to mouse chromosome 1 band 1B and SLC11A3 to
            human chromosome 2q32 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 88 (3-4), 328-329 (2000)
   PUBMED   10828623
REFERENCE   9  (bases 1 to 3254)
  AUTHORS   Gong,J., Xu,J., Bezanilla,M., van Huizen,R., Derin,R. and Li,M.
  TITLE     Differential stimulation of PKC phosphorylation of potassium
            channels by ZIP1 and ZIP2
  JOURNAL   Science 285 (5433), 1565-1569 (1999)
   PUBMED   10477520
REFERENCE   10 (bases 1 to 3254)
  AUTHORS   Itoh,A., Miyabayashi,T., Ohno,M. and Sakano,S.
  TITLE     Cloning and expressions of three mammalian homologues of Drosophila
            slit suggest possible roles for Slit in the formation and
            maintenance of the nervous system
  JOURNAL   Brain Res Mol Brain Res 62 (2), 175-186 (1998)
   PUBMED   9813312
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB808602.1, AF394785.3, CK364414.1, CV104407.1, DY313693.1,
            CV796629.1 and BI288312.1.
            
            On Oct 25, 2007 this sequence version replaced NM_133315.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U76714.1, AF394785.3 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132273,
                                           SAMD00132291 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                CB808602.1         12-66
            56-459              AF394785.3         1-404
            460-1078            CK364414.1         92-710
            1079-1531           CV104407.1         151-603
            1532-2004           AF394785.3         1477-1949
            2005-2460           DY313693.1         233-688
            2461-3027           CV796629.1         16-582              c
            3028-3254           BI288312.1         1-227               c
FEATURES             Location/Qualifiers
     source          1..3254
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q22"
     gene            1..3254
                     /gene="Slc40a1"
                     /gene_synonym="Fpn1; Slc11a3; Slc39a1"
                     /note="solute carrier family 40 member 1"
                     /db_xref="GeneID:170840"
                     /db_xref="RGD:620180"
     exon            1..334
                     /gene="Slc40a1"
                     /gene_synonym="Fpn1; Slc11a3; Slc39a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..2004
                     /gene="Slc40a1"
                     /gene_synonym="Fpn1; Slc11a3; Slc39a1"
                     /note="CAR1; ferroportin-1; cell adhesion regulator;
                     solute carrier family 39 (iron-regulated transporter),
                     member 1; solute carrier family 40 (iron-regulated
                     transporter), member 1"
                     /codon_start=1
                     /product="ferroportin"
                     /protein_id="NP_579849.2"
                     /db_xref="GeneID:170840"
                     /db_xref="RGD:620180"
                     /translation="MTKSRDQTHQEGCCGSLANYLTSAKFLLYLGHSLSTWGDRMWHF
                     AVSVFLVELYGNSLLLTAVYGLVVAGSVLVLGAIIGDWVDKNARLKVAQTSLVVQNVS
                     VILCGIILMMVFLHKNELLNMYHGWVLTVCYILIITIANIANLASTATAITIQRDWIV
                     VVAGENRSRLADMNATIRRIDQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLVSMCV
                     EYFLLWKVYQKTPALAVKAALKVEESELKQLTSPKDTEPKPLEGTHLMGEKDSNIREL
                     ECEQEPTCASQIAEPFRTFRDGWVSYYNQPVFLAGMGLAFLYMTVLGFDCITTGYAYT
                     QGLSGSILSVLMGASAITGIMGTVAFTWLRRKCGLVRTGLFSGLAQLSCLILCVISVF
                     MPGSPLDLSVSPFEDIRSRFIHEEAVSSTTKIPETEMLMSNVSNVVNTVHEMSTKSVP
                     IISVSLLFAGVIAARIGLWSFDLTVTQLLQENVIESERGIINGVQNSMNYLLDLLHFI
                     MVILAPNPEAFGLLVLISVSFVAMGHLMYFRFAQKTLGNQIFVCAPDEKEVTDESQPN
                     TSVV"
     exon            335..402
                     /gene="Slc40a1"
                     /gene_synonym="Fpn1; Slc11a3; Slc39a1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..562
                     /gene="Slc40a1"
                     /gene_synonym="Fpn1; Slc11a3; Slc39a1"
                     /inference="alignment:Splign:2.1.0"
     exon            563..678
                     /gene="Slc40a1"
                     /gene_synonym="Fpn1; Slc11a3; Slc39a1"
                     /inference="alignment:Splign:2.1.0"
     exon            679..805
                     /gene="Slc40a1"
                     /gene_synonym="Fpn1; Slc11a3; Slc39a1"
                     /inference="alignment:Splign:2.1.0"
     exon            806..1051
                     /gene="Slc40a1"
                     /gene_synonym="Fpn1; Slc11a3; Slc39a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1690
                     /gene="Slc40a1"
                     /gene_synonym="Fpn1; Slc11a3; Slc39a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..3236
                     /gene="Slc40a1"
                     /gene_synonym="Fpn1; Slc11a3; Slc39a1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggcttagg gtctactgcg gccggtggac cctccaaccc gcttccataa ggctttagct
       61 ttccaacttc agctacagtg ttagctaagt ttggaaagaa gacataaaga agaccccggt
      121 ggcagctttg ctgttctttg ccttagttgt cctttggggt ctttcggcac aaggctgctg
      181 tgcttatagc cgtgctatct ccggttcctc acactcctgt gaagaagccc ctgggcaaga
      241 gcagctaaag ctactagcat ccgaacaaac aaggggagag cgtctggtgc catgaccaag
      301 tcaagagatc agacccatca ggaaggatgc tgtggatctt tagcaaacta cctgacctca
      361 gcaaaattcc tcctctacct tggccactct ctctccactt ggggggatcg gatgtggcac
      421 tttgcagtgt ctgtgtttct ggtggaactc tacggaaaca gcctcctctt gacagctgtc
      481 tacgggttgg tggtggcagg ctctgttctg gtcctgggag ccatcattgg tgactgggtg
      541 gataagaatg ccagacttaa agtggcccag acgtccctgg tggttcagaa tgtatcagtc
      601 attctctgcg ggatcatcct gatgatggtt ttcttacaca agaatgagct tctgaacatg
      661 tatcatggat gggtccttac tgtctgctac atcctgatca tcaccattgc aaacattgcg
      721 aatttggcca gtactgccac tgcaattaca atccaaaggg actggattgt tgtcgtagca
      781 ggagaaaaca ggagcagatt agcagacatg aatgctacca ttagaaggat tgaccagcta
      841 accaacatcc tggcccccat ggctgttggc cagattatga cattcggttc cccagtcatt
      901 ggctgtggtt tcatttctgg ttggaatttg gtgtccatgt gtgtggagta cttcttgctc
      961 tggaaggttt accagaagac ccctgctctg gctgtaaaag ctgctctcaa ggtagaggag
     1021 tcagaactga agcagctgac ctcacctaaa gatactgagc caaaaccttt ggagggaact
     1081 cacctaatgg gtgagaaaga ctctaacatc cgtgaacttg aatgtgaaca agaacccacc
     1141 tgtgcctccc agatcgcaga acccttccgc acttttcgag atggatgggt ctcctactat
     1201 aaccagcccg tatttttggc tggcatgggc ctggctttcc tctatatgac agtcctgggc
     1261 ttcgactgta tcaccacagg atatgcttac actcagggac tgagtggttc catcctcagt
     1321 gttttgatgg gagcatcagc aataactgga ataatgggaa ctgtggcctt cacttggcta
     1381 cgtcgaaaat gtggccttgt tcggactggt ctgttctcag gactggctca gctttcttgt
     1441 ttgatcttgt gtgtgatctc cgtgttcatg cctggaagcc ccttggacct gtctgtttct
     1501 ccatttgaag atatccgttc taggtttata catgaggagg cagtgtcctc aactaccaaa
     1561 atacctgaaa cagaaatgct tatgtctaat gtgtctaatg ttgtcaatac cgtccatgag
     1621 atgagtacta aatccgtccc cataatctcc gtcagcctgc tgtttgcagg agtcattgct
     1681 gctagaatcg gtctttggtc ctttgatttg actgtgacac agttgctgca agaaaatgta
     1741 attgaatcag aaagaggcat tatcaatggt gtgcagaact ccatgaacta ccttctcgac
     1801 cttctgcatt tcatcatggt catcttggcc ccaaatcctg aagcttttgg cttgctagta
     1861 ttgatttcag tctcctttgt ggcaatggga catcttatgt atttccgttt tgcccagaag
     1921 actctgggca accagatttt tgtttgtgct cctgatgaaa aggaagttac agatgaaagt
     1981 cagcctaata catctgttgt gtaaaatagt ttagctgtgg cccctgttac tagatttgtg
     2041 gagagcatgt gtgcttattt tgtactacag aattccaata aatgcctgca cttttctctg
     2101 tttttactac agctgtgcct taagggttag gggcactaac gaaccttcac cagcgaagat
     2161 ggttatttct ccttacatgt aaacatgggg aaataagagg gagaggaaaa gtcagcatgt
     2221 gggtaggatg ggtttaatgg taaaatgagt ttcccatact cttatgagta tattaaattt
     2281 taaagagtgg ctgtcaggtg agttaaatta ctccatagta gatattgtcc actagaatgc
     2341 agataaatca attcacccca aaactcactc ttgtaaaagt ctggctcact tccctttttt
     2401 ttttaaagat gagtagtatt tttctcagtt acgttacaga aacaagtttt tctccttgta
     2461 ggaagattat agtctgataa tgagcattat tcttattaat cccattgaac ttagggaatt
     2521 tattatatgt gaaggatgaa atacataact aaacttcttc aaaaggctca tggtataacc
     2581 tttgcatttt gactatcagc tagggcaaaa tattacagta atgtgtgtat gtggctcttc
     2641 ctaaaatgac tgcagagaga agaaaagctg tagatttcta gtgcagtaca gaaggactta
     2701 aagcacgtta ttggtgtggt tgtagaaact ggaagctaat ggggaggacc tcacgtaacc
     2761 agagtcactg ttgtcagtga tcactaacta tcctggtata tgaaagagct ggccctaggc
     2821 ctagcacctg acaggcagaa aagcagccca cgcttggaaa ggactgcaca tcaatgatga
     2881 gcttgtacag agcattttac cttcactgac ttgggccgac gtgtttatta tctctgtctt
     2941 tttctagagc aagaatagtc acaaaggttc ccctttcaat atctctgaaa agaataaaga
     3001 aaaaactgtt tgtaaatatt ttttaaactg ttctacaagt ctttttgtaa tatgcagtac
     3061 caacatggga cattgcttta acttttgatg cactttcatg gagaccgcca tgcgttgcta
     3121 ggagcacttt ctttccattt aatatttttc ttcacccttc tgcagtatga cataatgatt
     3181 gactatgtta taaaatcttc ataaaatatt tctatataaa atgtttgtaa aatcttaaaa
     3241 aaaaaaaaaa aaaa
//
