LOCUS       NM_001271089            1854 bp    mRNA    linear   ROD 11-AUG-2024
DEFINITION  Rattus norvegicus solute carrier family 3 member 2 (Slc3a2),
            transcript variant 2, mRNA.
ACCESSION   NM_001271089
VERSION     NM_001271089.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1854)
  AUTHORS   Yan,R., Zhao,X., Lei,J. and Zhou,Q.
  TITLE     Structure of the human LAT1-4F2hc heteromeric amino acid
            transporter complex
  JOURNAL   Nature 568 (7750), 127-130 (2019)
   PUBMED   30867591
REFERENCE   2  (bases 1 to 1854)
  AUTHORS   Kaira,K., Kawashima,O., Endoh,H., Imaizumi,K., Goto,Y.,
            Kamiyoshihara,M., Sugano,M., Yamamoto,R., Osaki,T., Tanaka,S.,
            Fujita,A., Imai,H., Kogure,Y., Seki,Y., Shimizu,K., Mogi,A.,
            Shitara,Y., Oyama,T., Kanai,Y. and Asao,T.
  TITLE     Expression of amino acid transporter (LAT1 and 4F2hc) in pulmonary
            pleomorphic carcinoma
  JOURNAL   Hum Pathol 84, 142-149 (2019)
   PUBMED   30300664
REFERENCE   3  (bases 1 to 1854)
  AUTHORS   Wang,S., Han,H., Hu,Y., Yang,W., Lv,Y., Wang,L., Zhang,L. and Ji,J.
  TITLE     SLC3A2, antigen of mAb 3G9, promotes migration and invasion by
            upregulating of mucins in gastric cancer
  JOURNAL   Oncotarget 8 (51), 88586-88598 (2017)
   PUBMED   29179459
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1854)
  AUTHORS   Domercq,M., Szczupak,B., Gejo,J., Gomez-Vallejo,V., Padro,D.,
            Gona,K.B., Dolle,F., Higuchi,M., Matute,C., Llop,J. and Martin,A.
  TITLE     PET Imaging with [(18)F]FSPG Evidences the Role of System xc(-) on
            Brain Inflammation Following Cerebral Ischemia in Rats
  JOURNAL   Theranostics 6 (11), 1753-1767 (2016)
   PUBMED   27570548
  REMARK    GeneRIF: Taken together, these results suggest that system xc(-)
            plays a key role in the inflammatory reaction underlying
            experimental stroke.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1854)
  AUTHORS   Milkereit,R., Persaud,A., Vanoaica,L., Guetg,A., Verrey,F. and
            Rotin,D.
  TITLE     LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and
            promotes mTORC1 activation
  JOURNAL   Nat Commun 6, 7250 (2015)
   PUBMED   25998567
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1854)
  AUTHORS   Ohkame,H., Masuda,H., Ishii,Y. and Kanai,Y.
  TITLE     Expression of L-type amino acid transporter 1 (LAT1) and 4F2 heavy
            chain (4F2hc) in liver tumor lesions of rat models
  JOURNAL   J Surg Oncol 78 (4), 265-71 (2001)
   PUBMED   11745822
REFERENCE   7  (bases 1 to 1854)
  AUTHORS   Matsuo,H., Tsukada,S., Nakata,T., Chairoungdua,A., Kim,D.K.,
            Cha,S.H., Inatomi,J., Yorifuji,H., Fukuda,J., Endou,H. and Kanai,Y.
  TITLE     Expression of a system L neutral amino acid transporter at the
            blood-brain barrier
  JOURNAL   Neuroreport 11 (16), 3507-3511 (2000)
   PUBMED   11095508
REFERENCE   8  (bases 1 to 1854)
  AUTHORS   Prasad,P.D., Wang,H., Huang,W., Kekuda,R., Rajan,D.P., Leibach,F.H.
            and Ganapathy,V.
  TITLE     Human LAT1, a subunit of system L amino acid transporter: molecular
            cloning and transport function
  JOURNAL   Biochem Biophys Res Commun 255 (2), 283-288 (1999)
   PUBMED   10049700
REFERENCE   9  (bases 1 to 1854)
  AUTHORS   Kanai,Y., Segawa,H., Miyamoto,Ki., Uchino,H., Takeda,E. and
            Endou,H.
  TITLE     Expression cloning and characterization of a transporter for large
            neutral amino acids activated by the heavy chain of 4F2 antigen
            (CD98)
  JOURNAL   J Biol Chem 273 (37), 23629-23632 (1998)
   PUBMED   9726963
REFERENCE   10 (bases 1 to 1854)
  AUTHORS   Yao,S.Y., Muzyka,W.R., Elliott,J.F., Cheeseman,C.I. and Young,J.D.
  TITLE     Cloning and functional expression of a cDNA from rat jejunal
            epithelium encoding a protein (4F2hc) with system y+L amino acid
            transport activity
  JOURNAL   Biochem J 330 (Pt 2) (Pt 2), 745-752 (1998)
   PUBMED   9480885
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Sep 4, 2012 this sequence version replaced NM_001271089.1.
            
            Transcript Variant: This variant (2) contains an alternate segment
            in the 5' UTR, lacks a portion of the 5' coding region, and
            initiates translation at a downstream start codon, compared to
            variant 1. The encoded isoform (2) has a shorter N-terminus
            compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061989.1, U59324.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-511               JAXUCZ010000001.1  215039160-215039670 c
            512-685             JAXUCZ010000001.1  215038537-215038710 c
            686-780             JAXUCZ010000001.1  215037614-215037708 c
            781-849             JAXUCZ010000001.1  215035691-215035759 c
            850-908             JAXUCZ010000001.1  215035526-215035584 c
            909-1089            JAXUCZ010000001.1  215035232-215035412 c
            1090-1233           JAXUCZ010000001.1  215035004-215035147 c
            1234-1317           JAXUCZ010000001.1  215034235-215034318 c
            1318-1854           JAXUCZ010000001.1  215033601-215034137 c
FEATURES             Location/Qualifiers
     source          1..1854
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1854
                     /gene="Slc3a2"
                     /gene_synonym="Mdu1"
                     /note="solute carrier family 3 member 2"
                     /db_xref="GeneID:50567"
                     /db_xref="RGD:3073"
     exon            1..511
                     /gene="Slc3a2"
                     /gene_synonym="Mdu1"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1689
                     /gene="Slc3a2"
                     /gene_synonym="Mdu1"
                     /note="isoform 2 is encoded by transcript variant 2; 4F2
                     cell-surface antigen heavy chain; 4F2hc; antigen
                     identified by monoclonal antibodies 4F2; solute carrier
                     family 3 (amino acid transporter heavy chain), member 2;
                     solute carrier family 3 (activators of dibasic and neutral
                     amino acid transport), member 2; amino acid transporter
                     heavy chain SLC3A2"
                     /codon_start=1
                     /product="amino acid transporter heavy chain SLC3A2
                     isoform 2"
                     /protein_id="NP_001258018.1"
                     /db_xref="GeneID:50567"
                     /db_xref="RGD:3073"
                     /translation="MSQDTEVDMKDVELNELEPEKQPMNAADGAAAGEKNGLVKIKVA
                     EDEAEAGVKFTGLSKEELLKVAGSPGWVRTRWALLLLFWLGWLGMLAGAVVIIVRAPR
                     CRELPVQRWWHKGALYRIGDLQAFVGPEARGIAGLKNHLEYLSTLKVKGLVLGPIHKN
                     QKDEVNETDLKQIDPDLGSQEDFKDLLQSAKKKSIHIILDLTPNYKGQNAWFLPPQAD
                     IVATKMKEALSSWLQDGVDGFQVRDVGKLANASLYLAEWQNITKNFSEDRLLIAGTAS
                     SDLQQIVNILESTSDLLLTSSYLSQPVFTGEHAELLVIKYLNATGSRWCSWSVSQAGL
                     LTSFIPAQFLRLYQLLLFTLPGTPVFSYGDELGLQAVALPGQPMEAPFMLWNESSNSQ
                     TSSPVSLNMTVKGQNEDPGSLLTQFRRLSDLRGKERSLLHGDFDALSSSSGLFSYVRH
                     WDQNERYLVVLNFQDVGLSARVGASNLPAGISLPASANLLLSTDSTRLSREEGTSLSL
                     ENLSLNPYEGLLLQFPFVA"
     exon            512..685
                     /gene="Slc3a2"
                     /gene_synonym="Mdu1"
                     /inference="alignment:Splign:2.1.0"
     exon            686..780
                     /gene="Slc3a2"
                     /gene_synonym="Mdu1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..849
                     /gene="Slc3a2"
                     /gene_synonym="Mdu1"
                     /inference="alignment:Splign:2.1.0"
     exon            850..908
                     /gene="Slc3a2"
                     /gene_synonym="Mdu1"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1089
                     /gene="Slc3a2"
                     /gene_synonym="Mdu1"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1233
                     /gene="Slc3a2"
                     /gene_synonym="Mdu1"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1317
                     /gene="Slc3a2"
                     /gene_synonym="Mdu1"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1854
                     /gene="Slc3a2"
                     /gene_synonym="Mdu1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaagcagtt agggaagcta agctaactag cctcacggga cacctctcca aactaggcga
       61 cccactgact acaggccgtg tcctgtcacc gtttctgcag gtaccatgag ccaggacacc
      121 gaagtggaca tgaaagatgt ggagctgaac gagctggaac cggagaagca gcctatgaat
      181 gcagcggacg gggcggcagc cggggagaag aacggtctgg tgaagattaa ggtggccgaa
      241 gacgaggcgg aagccggggt caagttcaca ggcttatcca aggaggagct attgaaggta
      301 gctggcagcc cgggctgggt gcgcacccgc tgggcgctgc tgctgctctt ctggctcggt
      361 tggctgggta tgctggcggg cgccgtggtt atcatcgttc gggcgccacg ctgccgtgag
      421 ctgccggtac agagatggtg gcacaagggc gccctctacc gcatcggcga ccttcaggcc
      481 ttcgtaggcc cggaagcgag aggcatagct ggtctgaaga accatctgga gtacttgagc
      541 accctgaagg tgaagggcct agttttgggc ccaattcaca agaaccagaa ggatgaagtc
      601 aatgaaaccg acttgaaaca gattgatccc gatttaggct cccaggaaga ttttaaagac
      661 cttctacaaa gtgccaagaa aaagagcatt cacatcattt tggacctcac tcccaactat
      721 aagggccaga atgcatggtt cctccctcct caggctgaca ttgtagccac caaaatgaag
      781 gaggctctga gttcttggtt gcaggacggt gtggatggtt tccaagttcg ggatgtggga
      841 aagctggcga atgcatcctt gtacttggct gagtggcaga atatcaccaa gaacttcagt
      901 gaggacaggc ttttgattgc agggaccgcg tcctctgacc tgcaacaaat tgtcaacata
      961 cttgaatcca ccagcgatct gctgctgacc agctcatacc tgtcacagcc cgttttcact
     1021 ggggagcatg cagaactcct agtgattaag tatttgaatg ccactggcag ccgctggtgc
     1081 agctggagtg tgtcgcaggc aggactcctg acatccttta taccggctca gtttctccga
     1141 ctctaccagc tgctgctctt cactctgcca ggaactcctg ttttcagcta tggggatgag
     1201 cttggccttc aggcagttgc ccttcctgga cagcctatgg aggctccatt catgctgtgg
     1261 aatgagtcta gcaactccca aacctcaagt cctgtaagcc tcaacatgac agtgaagggc
     1321 caaaatgaag accccggctc cctcctcacc cagttccggc gactgagtga cctccgtggt
     1381 aaggagcgct ctctgttaca cggtgacttt gatgcactgt cttcctcatc tggcctcttc
     1441 tcctacgtcc gccactggga ccagaatgag cgttacctgg tggtgctcaa cttccaggat
     1501 gtgggcctgt cagccagggt aggagcctcc aacctccctg ctggcataag cctgccagcc
     1561 agtgctaacc ttttgcttag tactgacagc acccggctaa gccgtgagga gggcacctcc
     1621 ctgagcctgg aaaacctgag cctgaatcct tatgagggct tgttgttaca gttccctttt
     1681 gtggcctgat ccctctacac agaacctgcc acccttcttt cctctctcag gcctttggaa
     1741 ttctggtctt tctctcctta ttttgttttt gtttttaaac ttttgcagat tacatatgaa
     1801 ttcttacact gggtgttttt gtcttcaaaa taaaaaaaat cacccctgcc tcat
//
