LOCUS       NM_017216               2305 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 3 member 1 (Slc3a1), mRNA.
ACCESSION   NM_017216
VERSION     NM_017216.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2305)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   2  (bases 1 to 2305)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   3  (bases 1 to 2305)
  AUTHORS   Fernandez,E., Carrascal,M., Rousaud,F., Abian,J., Zorzano,A.,
            Palacin,M. and Chillaron,J.
  TITLE     rBAT-b(0,+)AT heterodimer is the main apical reabsorption system
            for cystine in the kidney
  JOURNAL   Am J Physiol Renal Physiol 283 (3), F540-F548 (2002)
   PUBMED   12167606
REFERENCE   4  (bases 1 to 2305)
  AUTHORS   Chairoungdua,A., Segawa,H., Kim,J.Y., Miyamoto,K., Haga,H.,
            Fukui,Y., Mizoguchi,K., Ito,H., Takeda,E., Endou,H. and Kanai,Y.
  TITLE     Identification of an amino acid transporter associated with the
            cystinuria-related type II membrane glycoprotein
  JOURNAL   J Biol Chem 274 (41), 28845-28848 (1999)
   PUBMED   10506124
REFERENCE   5  (bases 1 to 2305)
  AUTHORS   Pickel,V.M., Pohorille,A., Chan,J., Tate,S.S. and Nirenberg,M.J.
  TITLE     Regional and subcellular distribution of a neutral and basic amino
            acid transporter in forebrain neurons containing nitric oxide
            synthase
  JOURNAL   J Comp Neurol 404 (4), 459-472 (1999)
   PUBMED   9987991
REFERENCE   6  (bases 1 to 2305)
  AUTHORS   Wang,Y. and Tate,S.S.
  TITLE     Oligomeric structure of a renal cystine transporter: implications
            in cystinuria
  JOURNAL   FEBS Lett 368 (2), 389-392 (1995)
   PUBMED   7628645
REFERENCE   7  (bases 1 to 2305)
  AUTHORS   Mosckovitz,R., Udenfriend,S., Felix,A., Heimer,E. and Tate,S.S.
  TITLE     Membrane topology of the rat kidney neutral and basic amino acid
            transporter
  JOURNAL   FASEB J 8 (13), 1069-1074 (1994)
   PUBMED   7926373
REFERENCE   8  (bases 1 to 2305)
  AUTHORS   Yan,N., Mosckovitz,R., Gerber,L.D., Mathew,S., Murty,V.V.,
            Tate,S.S. and Udenfriend,S.
  TITLE     Characterization of the promoter region of the gene for the rat
            neutral and basic amino acid transporter and chromosomal
            localization of the human gene
  JOURNAL   Proc Natl Acad Sci U S A 91 (16), 7548-7552 (1994)
   PUBMED   8052618
REFERENCE   9  (bases 1 to 2305)
  AUTHORS   Wells,R.G. and Hediger,M.A.
  TITLE     Cloning of a rat kidney cDNA that stimulates dibasic and neutral
            amino acid transport and has sequence similarity to glucosidases
  JOURNAL   Proc Natl Acad Sci U S A 89 (12), 5596-5600 (1992)
   PUBMED   1376924
REFERENCE   10 (bases 1 to 2305)
  AUTHORS   Tate,S.S., Yan,N. and Udenfriend,S.
  TITLE     Expression cloning of a Na(+)-independent neutral amino acid
            transporter from rat kidney
  JOURNAL   Proc Natl Acad Sci U S A 89 (1), 1-5 (1992)
   PUBMED   1729674
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M77345.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M77345.1, M80804.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132277 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2305
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..2305
                     /gene="Slc3a1"
                     /gene_synonym="NBAT; rBAT"
                     /note="solute carrier family 3 member 1"
                     /db_xref="GeneID:29484"
                     /db_xref="RGD:3709"
     exon            1..459
                     /gene="Slc3a1"
                     /gene_synonym="NBAT; rBAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..2090
                     /gene="Slc3a1"
                     /gene_synonym="NBAT; rBAT"
                     /note="neutral and basic amino acid transport protein
                     rBAT; D2; NAA-TR; b(0,+)-type amino acid transport
                     protein; solute carrier family 3 (amino acid transporter
                     heavy chain), member 1; neutral and basic amino acid
                     transporter protein; b(0,+)-type amino acid
                     transporter-related heavy chain"
                     /codon_start=1
                     /product="amino acid transporter heavy chain SLC3A1"
                     /protein_id="NP_058912.1"
                     /db_xref="GeneID:29484"
                     /db_xref="RGD:3709"
                     /translation="MNEDKDKRDSIQMSMKGCRTNNGFVQNEDIQEQDPDSRDTPQSN
                     AVSIPAPEEPQLKVVRPYAGMPKEVLFQFSGQARYRVPREILFWLTVVSVFLLIGATI
                     AIIIISPKCLDWWQAGPMYQIYPRSFKDSDKDGNGDLKGIQEKLDYITALNIKTIWIT
                     SFYKSPLKDFRYAVEDFKEIDPIFGTMKDFENLVAAVHDKGLKLIIDFIPNHTSDKHP
                     WFQSSRTRSGKYTDYYIWHNCTHANGVTTPPNNWLSVYGNSSWQFDEERKQCYFHQFL
                     KEQPDLNFRNPAVQEEIKEIIKFWLSKGVDGFSFDAVKFLLEAKDLRNEIQVNTSQIP
                     DTVTRYSELYHDFTTTQVGMHDLVRDFRQTMNQFSREPGRYRFMGTEVSAESTERTMV
                     YYGLSFIQEADFPFNKYLATLDTLSGHTVYEAITSWMENMPEGKWPNWMIGGPETSRL
                     TSRVGSEYVNAMNMLLFTLPGTPITYYGEEIGMGDISITNLNERYDTNALLSKSPMQW
                     DNSSNAGFTEANHTWLPTNSDYHTVNVDVQKTQPSSALRLYQDLSLLHARELLLSRGW
                     FCLLRDDNHSVVYTRELDGIDKVFLVVLNFGESSTVLNLQETISDVPTKLRIRLSTNP
                     ASKGSDVDTHAVSLEKGEGLILEHSMKTLLHHQKAFRDKCFISNRACYSSVLDLLYSS
                     C"
     exon            460..639
                     /gene="Slc3a1"
                     /gene_synonym="NBAT; rBAT"
                     /inference="alignment:Splign:2.1.0"
     exon            640..794
                     /gene="Slc3a1"
                     /gene_synonym="NBAT; rBAT"
                     /inference="alignment:Splign:2.1.0"
     exon            795..920
                     /gene="Slc3a1"
                     /gene_synonym="NBAT; rBAT"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1040
                     /gene="Slc3a1"
                     /gene_synonym="NBAT; rBAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1165
                     /gene="Slc3a1"
                     /gene_synonym="NBAT; rBAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1361
                     /gene="Slc3a1"
                     /gene_synonym="NBAT; rBAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1529
                     /gene="Slc3a1"
                     /gene_synonym="NBAT; rBAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1646
                     /gene="Slc3a1"
                     /gene_synonym="NBAT; rBAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..2263
                     /gene="Slc3a1"
                     /gene_synonym="NBAT; rBAT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctactggaaa gcactgggaa gagctgcacc ggatagacat gaatgaggac aaagacaaga
       61 gagactctat ccagatgagt atgaagggat gccggacgaa taacgggttt gtccaaaatg
      121 aagacatcca ggagcaggac ccagactcca gggacactcc acagtccaac gctgttagta
      181 tccctgctcc agaggagcct caactaaagg tggtgcggcc ctatgcaggg atgcccaagg
      241 aggtgctgtt ccagttctct ggccaggctc gctaccgggt gcctcgggag atcctcttct
      301 ggctcaccgt ggtctccgtg ttcctgctca tcggagccac catagccatc atcatcatct
      361 ctccaaaatg ccttgactgg tggcaggcag gtcccatgta ccagatctac ccgaggtctt
      421 ttaaggacag tgacaaggat gggaatggag acctgaaagg tatccaagag aagctggact
      481 acatcactgc tttaaatata aagaccattt ggatcacttc cttttataaa tcacctttga
      541 aagattttag atatgctgtt gaagatttca aagaaattga ccctattttc ggaacaatga
      601 aagattttga gaatttggtt gctgcggtcc atgacaaagg tttaaaatta ataattgact
      661 tcataccaaa ccacaccagt gacaaacatc cttggttcca atcgagtagg acacggagcg
      721 ggaaatacac tgattattac atctggcaca actgtaccca cgccaacggt gtaaccaccc
      781 ctcccaacaa ctggctgagc gtgtatggaa actccagctg gcagtttgat gaagaacgaa
      841 agcaatgtta ttttcaccag tttttgaaag agcagccgga tcttaatttc cgaaatcctg
      901 ctgttcaaga agaaataaag gaaataataa agttctggct ctcaaagggt gttgatgggt
      961 ttagtttcga tgcagttaaa tttcttctgg aagcaaagga cctgagaaat gaaatccaag
     1021 taaatacatc ccaaattccg gacacagtga cccgctactc agaactgtac cacgacttca
     1081 ccactaccca ggtgggaatg catgaccttg tccgggactt ccggcagacc atgaaccagt
     1141 tcagccggga gcctggcaga taccggttca tggggacgga ggtgtcagct gagagcaccg
     1201 agaggaccat ggtgtactat ggcctgtcat ttatccagga agctgacttc cctttcaaca
     1261 agtacttagc cacactagac actctttccg ggcatactgt gtacgaagct atcacatcct
     1321 ggatggaaaa catgccggaa ggaaaatggc ccaactggat gattggcgga ccagagactt
     1381 ctcggctgac ttctcgagta gggagcgagt atgtcaatgc catgaacatg cttctgttca
     1441 cactcccagg aacccccata acttactatg gggaagaaat agggatggga gatatttcca
     1501 ttacaaacct caacgagcgc tatgacacta acgcccttct ctccaagtca ccgatgcagt
     1561 gggacaatag ttcaaatgcg gggtttactg aggccaacca cacctggctc cccacaaact
     1621 ctgactacca cacagtgaat gtggatgtcc aaaaaaccca gccgagctca gcactgaggc
     1681 tatatcagga tctgagtcta ctccatgcca gagagctgct tctcagcaga ggctggtttt
     1741 gccttttgag ggacgacaat cactctgttg tgtacaccag ggagctggat ggcatagata
     1801 aagtcttcct tgtggttctg aattttggag aatcatcaac tgtgctaaat ctacaggaaa
     1861 ctatttcaga tgttcctaca aaactgagaa taagattaag taccaatcca gcctccaaag
     1921 gcagtgatgt tgatacccat gccgtttctc tggagaaggg agaggggctc atcttggaac
     1981 acagcatgaa gactctcctc catcaccaga aagctttcag agacaaatgt tttatttcca
     2041 accgtgcatg ctactccagc gtgctggacc ttctgtatag ctcgtgctag gcagctctgt
     2101 aagaggtggc caccctgcgt ctggtatgct tgccatcaca catgcaaggg cctcaggaat
     2161 ggcatcagtt cttagatatt tctgtagcac gaatgcattg ttttaggtaa gattctcaaa
     2221 tgtttggaag gacaataaaa tgtttaaaag attaccccca aaaaaaaaaa aaaaaaaaaa
     2281 aaaaaaaaaa aaaaaaaaaa aaaaa
//
