LOCUS       NM_001011952            3097 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus solute carrier family 39 member 8 (Slc39a8),
            mRNA.
ACCESSION   NM_001011952 XM_227699
VERSION     NM_001011952.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3097)
  AUTHORS   Ding,W., Ge,Y., Sun,H., Xu,J., Gu,H., Bian,C., Chen,H., Jiang,L.
            and Yin,X.
  TITLE     ZIP8 mediates the extracellular matrix degradation of nucleus
            pulposus cells via NF-kappaB signaling pathway
  JOURNAL   Biochem Biophys Res Commun 550, 30-36 (2021)
   PUBMED   33677133
  REMARK    GeneRIF: ZIP8 mediates the extracellular matrix degradation of
            nucleus pulposus cells via NF-kappaB signaling pathway.
REFERENCE   2  (bases 1 to 3097)
  AUTHORS   Steimle,B.L., Smith,F.M. and Kosman,D.J.
  TITLE     The solute carriers ZIP8 and ZIP14 regulate manganese accumulation
            in brain microvascular endothelial cells and control brain
            manganese levels
  JOURNAL   J Biol Chem 294 (50), 19197-19208 (2019)
   PUBMED   31699897
REFERENCE   3  (bases 1 to 3097)
  AUTHORS   Cheng,G., Chang,F.J., You,P.H., Lin,J., Huang,X.Y., Wu,H.Y.,
            Yan,L., Deng,J.Z., You,H.J. and Sun,C.F.
  TITLE     ZIP8 induces monocyte adhesion to the aortas ex-vivo by regulating
            zinc influx
  JOURNAL   Int Immunopharmacol 62, 203-211 (2018)
   PUBMED   30015240
REFERENCE   4  (bases 1 to 3097)
  AUTHORS   Choi,E.K., Nguyen,T.T., Gupta,N., Iwase,S. and Seo,Y.A.
  TITLE     Functional analysis of SLC39A8 mutations and their implications for
            manganese deficiency and mitochondrial disorders
  JOURNAL   Sci Rep 8 (1), 3163 (2018)
   PUBMED   29453449
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3097)
  AUTHORS   Lin,W., Li,D., Cheng,L., Li,L., Liu,F., Hand,N.J., Epstein,J.A. and
            Rader,D.J.
  TITLE     Zinc transporter Slc39a8 is essential for cardiac ventricular
            compaction
  JOURNAL   J Clin Invest 128 (2), 826-833 (2018)
   PUBMED   29337306
REFERENCE   6  (bases 1 to 3097)
  AUTHORS   Liu,Z., Li,H., Soleimani,M., Girijashanker,K., Reed,J.M., He,L.,
            Dalton,T.P. and Nebert,D.W.
  TITLE     Cd2+ versus Zn2+ uptake by the ZIP8 HCO3--dependent symporter:
            kinetics, electrogenicity and trafficking
  JOURNAL   Biochem Biophys Res Commun 365 (4), 814-820 (2008)
   PUBMED   18037372
REFERENCE   7  (bases 1 to 3097)
  AUTHORS   Wang,B., Schneider,S.N., Dragin,N., Girijashanker,K., Dalton,T.P.,
            He,L., Miller,M.L., Stringer,K.F., Soleimani,M., Richardson,D.D.
            and Nebert,D.W.
  TITLE     Enhanced cadmium-induced testicular necrosis and renal proximal
            tubule damage caused by gene-dose increase in a Slc39a8-transgenic
            mouse line
  JOURNAL   Am J Physiol Cell Physiol 292 (4), C1523-C1535 (2007)
   PUBMED   17108009
REFERENCE   8  (bases 1 to 3097)
  AUTHORS   He,L., Girijashanker,K., Dalton,T.P., Reed,J., Li,H., Soleimani,M.
            and Nebert,D.W.
  TITLE     ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter
            family: characterization of transporter properties
  JOURNAL   Mol Pharmacol 70 (1), 171-180 (2006)
   PUBMED   16638970
REFERENCE   9  (bases 1 to 3097)
  AUTHORS   Dalton,T.P., He,L., Wang,B., Miller,M.L., Jin,L., Stringer,K.F.,
            Chang,X., Baxter,C.S. and Nebert,D.W.
  TITLE     Identification of mouse SLC39A8 as the transporter responsible for
            cadmium-induced toxicity in the testis
  JOURNAL   Proc Natl Acad Sci U S A 102 (9), 3401-3406 (2005)
   PUBMED   15722412
REFERENCE   10 (bases 1 to 3097)
  AUTHORS   Begum,N.A., Kobayashi,M., Moriwaki,Y., Matsumoto,M., Toyoshima,K.
            and Seya,T.
  TITLE     Mycobacterium bovis BCG cell wall and lipopolysaccharide induce a
            novel gene, BIGM103, encoding a 7-TM protein: identification of a
            new protein family having Zn-transporter and Zn-metalloprotease
            signatures
  JOURNAL   Genomics 80 (6), 630-645 (2002)
   PUBMED   12504855
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089844.1.
            
            On Feb 11, 2005 this sequence version replaced XM_227699.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089844.1, CB605620.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3097
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..3097
                     /gene="Slc39a8"
                     /note="solute carrier family 39 member 8"
                     /db_xref="GeneID:295455"
                     /db_xref="RGD:1308236"
     exon            1..474
                     /gene="Slc39a8"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..1644
                     /gene="Slc39a8"
                     /note="zinc transporter ZIP8; ZIP-8; zrt- and Irt-like
                     protein 8; solute carrier family 39 (metal ion
                     transporter), member 8; solute carrier family 39 (zinc
                     transporter), member 8; metal cation symporter ZIP8"
                     /codon_start=1
                     /product="metal cation symporter ZIP8 precursor"
                     /protein_id="NP_001011952.1"
                     /db_xref="GeneID:295455"
                     /db_xref="RGD:1308236"
                     /translation="MAPGRAVAGLLLLAATGLGRPSEGPELAFTEDVLRVFGANQSLS
                     AAQLGRLLERLGAAPQQGALELGQLHFNQCLSAEDIFSLHGFSNVTQITSSNFTAICP
                     AILQQLNFHPCEDPQKHSVKPSFSEVWGYGFLSVTIINLASLLGLILTPLIKKSYFPK
                     ILTYFVGLAIGTLFSNAIFQLIPEAFGFNPKIDNYVEKAVAVFGGFYMLFFVERTLKM
                     LLKTYGQNDHTHFRNDDFGSKEKAHQPKTLPLPPVNGVTCYANPAVTEPNGHIHFDTV
                     SVVSLQDGKAESSSCTCLKGPKLSEIGTIAWMITLCDALHNFIDGLAIGASYTLSLLQ
                     GLSTSIAILCEEFPHELGDFVILLNAGMSTRQALLFNFLSACSCYVGLAFGILVGNNF
                     APNIIFALAGGMFLYISLADMFPEMNDMLREKVTGRQTDFTFFMIQNAGMLTGFTAIL
                     LITLYAGDIELQ"
     exon            475..637
                     /gene="Slc39a8"
                     /inference="alignment:Splign:2.1.0"
     exon            638..807
                     /gene="Slc39a8"
                     /inference="alignment:Splign:2.1.0"
     exon            808..930
                     /gene="Slc39a8"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1101
                     /gene="Slc39a8"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1309
                     /gene="Slc39a8"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1494
                     /gene="Slc39a8"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..3075
                     /gene="Slc39a8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctttgttcc ttttatctca ggctccgcag gaggcccgga gaggccacac tgcctaccgt
       61 cctcctggct gtggtacctc ttcaatgccc cgaaggtctg aggctgcaga ggagcggggg
      121 caccgagctt ctcgctaact ggggcaggca gtgacgtgag accggcggac ctcccacccc
      181 caccctaagg gcaccgacac ccgggcactc gctcggatcc ctgcatccgc tagctccgga
      241 gctgcgcgct ccacgatggc tccgggccgg gcagtggccg ggctgctgct actggcggcc
      301 accggcctgg gacgcccctc ggaggggccg gagctcgcct tcactgagga tgtgctgaga
      361 gtgttcggcg ccaaccagag cctgtcggcc gcgcagctgg ggcgcctgct ggagcgcctg
      421 ggggctgcac cccagcaggg agcgctggag ctgggccagc tccacttcaa ccagtgtctg
      481 tcagcggaag acatcttttc tcttcatggt ttctcaaacg tcacccagat aaccagctcg
      541 aacttcactg ccatctgccc tgcgatctta cagcagctga actttcatcc ctgtgaggat
      601 ccacagaagc acagcgtaaa gcccagtttt tccgaagtct ggggctatgg attcttgtca
      661 gtgacaatca tcaatttggc ctctctcctg ggattgattt taaccccctt gataaagaag
      721 tcgtatttcc ccaagatttt gacttatttt gtggggctgg ctattgggac ccttttctca
      781 aatgccattt tccagcttat tccagaggca tttggattta atcccaaaat tgacaattat
      841 gttgaaaagg cagttgctgt gtttggtgga ttttacatgc ttttctttgt tgaaagaaca
      901 cttaagatgc tactgaaaac gtacggccag aatgaccata ctcacttcag gaatgatgac
      961 ttcggttcta aagaaaaagc ccatcaaccc aaaacgttgc cattacctcc tgtcaatgga
     1021 gtgacatgct atgccaaccc cgctgtcact gagcctaatg gacacatcca cttcgacact
     1081 gtcagtgttg tgtccctgca ggatggaaaa gcagagtcaa gttcatgcac ctgtttgaag
     1141 gggcccaaac tgtcagaaat aggaacgatt gcttggatga tcacgctctg tgatgccctt
     1201 cacaatttca ttgatggctt ggcgatcggg gcatcctata ctctgtctct tcttcaagga
     1261 ctcagtactt ccatagcgat cctgtgtgag gagtttcctc atgagttagg ggactttgtg
     1321 atcttgctca atgcagggat gagcactcgg caagccttgc tgtttaactt cctctctgca
     1381 tgttcctgct acgttgggct tgctttcggc attttggtgg gcaacaactt tgctccaaat
     1441 attatatttg cacttgctgg aggcatgttc ctttacattt ctctggcaga tatgtttcca
     1501 gagatgaacg acatgctgag agaaaaagta actggaagac aaacggactt caccttcttc
     1561 atgatccaga acgcagggat gttaaccgga ttcactgcca tcttgctcat caccttgtac
     1621 gcaggggaca tcgaattgca gtagctggga gtatgacgtc agcgcggcaa ggcatttaat
     1681 aaacaacaac acagaagaaa catctccata gggaattttt ttaaaaaagt gtatcctatt
     1741 tagttaaaag agattttttt tttaaatttt caactagagg ctaagaaatc taatgactgg
     1801 tttcagacac gtagaatagg tgaaatttgt tgttaaaaat ttctttaaaa ggttttcggt
     1861 ttcagtctga aatggctggt gtatggggcc tttggtaaat acctgttttt caatatttta
     1921 tgcctattag aaaattatca tgaagcaaac acatgcattc agtagcagac atacagaccc
     1981 agagaaaaac acaatctgag tcatgcaagg ctttagaact tggttggatt aaacacacac
     2041 acacacacac acacacacac acacacacac acacacacac acacacgtgt tttcagggtg
     2101 gttttcttcc gattaatgtg ttcgtctgct tttaaaggca ggtgcttcaa atgtggaagg
     2161 aaatcaaaac agttccagtg catgcaggaa ggattccagt gccttaatga accccagaga
     2221 gattgtgcac agcgtttgtt cagctttttg tctcagttgg cgacctgtag gattgttttg
     2281 aaagctatcc caaagtaaca tgaattagga aaggatgaga gtcttgctag ccaggtgaag
     2341 cttgggctta gtgcttggtc cctgagtata taagcttgaa cacactctgc agaagaccag
     2401 aatttgctgt gctgtgactt aggttgtggt tccagacaac agaaatggcc gaggagtaag
     2461 actggtcaga acgcagtcgt gccgtgctct gggattgctt tgtaagggtg aagaatgtgt
     2521 tgggtgggag agagaaattg aatataattt tgagcaattt acttttttaa aggtgagcat
     2581 aattatttag cagggaggat ttcaataaat gcaaaataac agctgggctg ggctgtgtca
     2641 gagactgatg gtggaggaag cgtgtgttca ttaggggtga ctgacagtca gaaacatctt
     2701 cttttatgcc cagcatactt tgttcccata tgctatacct ttggatggaa aacactcaac
     2761 atactgtgct tatttttcta cctttggtaa aacacagagc tcgctgagtt tttgagcagg
     2821 ctgtagacaa ttagtctgaa ttgaacatcc caatctcaat tcacactccc aaggaaccca
     2881 aaagagatga tttgacagtg atgaggatga ttaatagaac acaacttatc ccaggattgt
     2941 gtttccctat aagccaaaac acattttcat gtaagaacaa tgcaaactcg ataaacgtta
     3001 acatatatgt ttgtgtgttt cactctatga ctgacaatta aaacttattt gaccagacag
     3061 taaacgattt taaaaaaaaa aaaaaaaaaa aaaaaaa
//
