LOCUS       NM_001008885            2312 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 39 member 7 (Slc39a7),
            transcript variant 2, mRNA.
ACCESSION   NM_001008885 XM_215320
VERSION     NM_001008885.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2312)
  AUTHORS   Tuncay,E., Bitirim,C.V., Olgar,Y., Durak,A., Rutter,G.A. and
            Turan,B.
  TITLE     Zn2+-transporters ZIP7 and ZnT7 play important role in progression
            of cardiac dysfunction via affecting sarco(endo)plasmic
            reticulum-mitochondria coupling in hyperglycemic cardiomyocytes
  JOURNAL   Mitochondrion 44, 41-52 (2019)
   PUBMED   29307859
  REMARK    GeneRIF: Overall, this study provides an important description
            about the role of ZIP7 and ZnT7, localized to both mitochondria and
            sarco(endo)plasmic reticulum and contribute to cellular
            Zn(2+)-muffling between cellular-compartments in hyperglycemia or
            hypertrophic cardiomyocytes via affecting sarco(endo)plasmic
            reticulum-mitochondria coupling.
REFERENCE   2  (bases 1 to 2312)
  AUTHORS   Tuncay,E., Bitirim,V.C., Durak,A., Carrat,G.R.J., Taylor,K.M.,
            Rutter,G.A. and Turan,B.
  TITLE     Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause
            Zn2+ Release From the Sarco(endo)plasmic Reticulum and Mediate ER
            Stress in the Heart
  JOURNAL   Diabetes 66 (5), 1346-1358 (2017)
   PUBMED   28232492
  REMARK    GeneRIF: Markedly increased mRNA and protein levels of ZIP7 were
            observed in ventricular cardiomyocytes from diabetic rats or
            high-glucose-treated H9c2 cells while ZnT7 expression was low. ZIP7
            phosphorylation was increased in response to high glucose in vivo
            and in vitro.
REFERENCE   3  (bases 1 to 2312)
  AUTHORS   Walter,L. and Gunther,E.
  TITLE     Physical mapping and evolution of the centromeric class I
            gene-containing region of the rat MHC
  JOURNAL   Immunogenetics 51 (10), 829-837 (2000)
   PUBMED   10970097
REFERENCE   4  (bases 1 to 2312)
  AUTHORS   Reichel,H., Recker,A., Deppisch,R., Stier,E. and Ritz,E.
  TITLE     25-Hydroxyvitamin D3 metabolism in vitro by mononuclear cells from
            hemodialysis patients
  JOURNAL   Nephron 62 (4), 404-412 (1992)
   PUBMED   1300435
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC079141.1.
            
            On Sep 17, 2009 this sequence version replaced NM_001008885.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079141.1, EX490269.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2312
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2312
                     /gene="Slc39a7"
                     /gene_synonym="Ke4; RT1-Ke4; Rt1Ke4; ZIP7"
                     /note="solute carrier family 39 member 7"
                     /db_xref="GeneID:294281"
                     /db_xref="RGD:1593280"
     exon            1..720
                     /gene="Slc39a7"
                     /gene_synonym="Ke4; RT1-Ke4; Rt1Ke4; ZIP7"
                     /inference="alignment:Splign:2.1.0"
     CDS             328..1734
                     /gene="Slc39a7"
                     /gene_synonym="Ke4; RT1-Ke4; Rt1Ke4; ZIP7"
                     /note="RT1 region expressed gene KE4; Histidine-rich
                     membrane protein; RT1 class I, locus Ke4; zinc transporter
                     SLC39A7; solute carrier family 39 (zinc transporter),
                     member 7; zrt-, Irt-like protein 7"
                     /codon_start=1
                     /product="zinc transporter SLC39A7 precursor"
                     /protein_id="NP_001008885.1"
                     /db_xref="GeneID:294281"
                     /db_xref="RGD:1593280"
                     /translation="MARVLRDPHWVAVGLLTWAALGLLVAGHEGHGDLHRDVEEDFHG
                     HSHGHSHEDFHHGHSHGHGHTHESIWHGHAHSHDHGHSREDVHHGHSHGHSHDSLHHR
                     GHGHSHGASREAGAPGIKHHLDTVTLWAYALGATVLISAAPFFVLFLIPVESNSPRHR
                     SLLQILLSFASGGLLGDAFLHLIPHALEPHSHDTPAQPGHGHSHSGQGPILSVGLWVL
                     SGIVAFLVVEKFVRHVKGGHGHAHAHGHGHSHGDSHAHGHSHAHGDRHECPSKGKPSS
                     EDEKEAGGLRKRRGGDTGPRDGPLKPQNPEEEKTGSDLRVSGYLNLAADLAHNFTDGL
                     AIGASFRGGRGLGILTTMTVLLHEVPHEVGDFAILVQSGCSKKQAMRLQLLTAIGALA
                     GTACALLTEGGAVGSEVAGGAGPGWVLPFTAGGFIYVATVSVLPELLREASPLQSLLE
                     VLGLLGGVAMMVLIAHLE"
     exon            721..889
                     /gene="Slc39a7"
                     /gene_synonym="Ke4; RT1-Ke4; Rt1Ke4; ZIP7"
                     /inference="alignment:Splign:2.1.0"
     exon            890..943
                     /gene="Slc39a7"
                     /gene_synonym="Ke4; RT1-Ke4; Rt1Ke4; ZIP7"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1126
                     /gene="Slc39a7"
                     /gene_synonym="Ke4; RT1-Ke4; Rt1Ke4; ZIP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1264
                     /gene="Slc39a7"
                     /gene_synonym="Ke4; RT1-Ke4; Rt1Ke4; ZIP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1461
                     /gene="Slc39a7"
                     /gene_synonym="Ke4; RT1-Ke4; Rt1Ke4; ZIP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..2252
                     /gene="Slc39a7"
                     /gene_synonym="Ke4; RT1-Ke4; Rt1Ke4; ZIP7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgagaacgga gaggatcccg gagccggtga gaactccctg ctgctccctt acggcgcttt
       61 ccatgctttt accctaacta ctgagccata gagacgaggg cccagagaga ccgtaaagtt
      121 gcggatcaaa ggctagagcg gtgttggggg gtgggaggtt tgggggagct gcatccagga
      181 agggtgtcgg ggatgaagag aactggcctt gggaacaatg taagagggga gcaagtggta
      241 tagagtggac ggaagggctt caagggaagc ggatcccgca taggtagaga gtcaagtaga
      301 ctcgtctctg ttcctctggt cagcgtgatg gccagggtcc tgcgggaccc ccactgggtg
      361 gctgtgggac tgctgacctg ggcagctttg gggctgctgg tagccggaca cgagggtcat
      421 ggtgacctgc acagagacgt ggaagaggac ttccatggcc acagccacgg acactcacat
      481 gaagatttcc accatggcca cagccatggc catggccaca ctcatgagag catctggcat
      541 gggcatgccc acagccacga ccatggacat tcacgggagg atgtgcacca tggccatagc
      601 catggccact cccacgatag cctccaccac agaggacatg gacatagcca tggagcctct
      661 agggaggctg gggctccagg catcaagcac cacctggaca ctgtcaccct ctgggcctat
      721 gcactggggg ccacagtgct aatctccgcg gctcccttct tcgtgctctt cctcatccct
      781 gtggagtcaa actctcccag gcatcgttct ctgctccaga tcctgctcag ttttgcttct
      841 ggggggctcc tgggagatgc cttcctccac ctcatccctc acgccttgga acctcattcg
      901 cacgatactc cggcacagcc tggccacgga cactcccaca gcggccaggg ccccattctc
      961 tctgtggggc tgtgggttct cagtgggatt gtcgcctttc ttgtggtgga gaagtttgtg
     1021 agacacgtga aaggagggca cggacacgcg cacgcgcacg gacacggaca ctcgcacgga
     1081 gacagccacg cgcacggaca cagccacgca cacggggata ggcatgagtg tccttcaaag
     1141 ggaaagccca gttcagagga tgaaaaggaa gcagggggct tgcggaaaag gagaggagga
     1201 gacacggggc ccagagatgg ccctctgaaa cctcagaacc ctgaagaaga aaaaacaggc
     1261 tcagacctgc gtgtgtctgg gtacctgaat ctggctgctg acttggcaca caacttcaca
     1321 gacgggctgg ccattggtgc ttccttccgt gggggccgag ggcttgggat cctgaccacg
     1381 atgacagtcc tgctgcatga agtgcctcat gaggttgggg actttgccat cttggtccag
     1441 tctggctgca gcaagaaaca ggcgatgcgt ctgcaactct tgactgcaat tggagcattg
     1501 gcaggcacag cctgtgccct tctcactgag ggaggggcag tgggcagtga ggtggctggt
     1561 ggtgcaggtc ccggctgggt tctgccattc actgcaggtg gattcatcta tgtggcaaca
     1621 gtgtccgtgc tacctgagct actgagagag gcatccccgt tacagtctct cttggaggtg
     1681 ctggggctgc tggggggcgt tgccatgatg gtactgattg cccatcttga gtgaggggtg
     1741 ggtgacctgt cctaccccta actccaaaat aaaggcagtt gggaccctgg ccagtgcatt
     1801 gtcaggaggc tcagcctgga gaatggcatc tttggtattt gaggccttag aggtatgaga
     1861 gtcacacaga gcatgagagg ccagagggac catgctgtgg gagacagccc agcagtgttg
     1921 ttggttttgg agaaataaat gggaccatga agaaggctgg gagacagtag cctacctggt
     1981 ggtccctagt ctacgttttc ccagcaccag catgccacac aagggtcctc caaggtccat
     2041 ctccctctga actggttagt gatggcttca gggaaggcct ggcagaagga ctggggtaga
     2101 catcaatcgt gtgtcctgat ttgagggggt gggtggtgtt ccttggaaaa atgtcatggc
     2161 ctgatttttg tttctactca ttttatacca ctgtttgaat gggtggggag gaacgactac
     2221 cagaaataaa agtacttgga tcttctgccc taaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2281 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
