LOCUS       NM_001077669            2226 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 39 member 4 (Slc39a4),
            mRNA.
ACCESSION   NM_001077669 XM_001075258 XM_216970
VERSION     NM_001077669.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2226)
  AUTHORS   Hashimoto,A., Nakagawa,M., Tsujimura,N., Miyazaki,S., Kizu,K.,
            Goto,T., Komatsu,Y., Matsunaga,A., Shirakawa,H., Narita,H.,
            Kambe,T. and Komai,M.
  TITLE     Properties of Zip4 accumulation during zinc deficiency and its
            usefulness to evaluate zinc status: a study of the effects of zinc
            deficiency during lactation
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 310 (5), R459-R468 (2016)
   PUBMED   26702153
  REMARK    GeneRIF: The rapid upregulation of Zip4 expression in the small
            intestine during zinc deficient conditions corroborates the
            important role of Zip4 in the systemic control of zinc homeostasis.
REFERENCE   2  (bases 1 to 2226)
  AUTHORS   Curry-McCoy,T.V., Guidot,D.M. and Joshi,P.C.
  TITLE     Chronic alcohol ingestion in rats decreases Kruppel-like factor 4
            expression and intracellular zinc in the lung
  JOURNAL   Alcohol Clin Exp Res 37 (3), 361-371 (2013)
   PUBMED   23013362
  REMARK    GeneRIF: Chronic alcohol exposure decreases Kruppel-like factor
            (KLF)4 and ZIP4 expression and consequently decreases zinc
            transport into cells which, in turn, impairs their function.
REFERENCE   3  (bases 1 to 2226)
  AUTHORS   Antala,S. and Dempski,R.E.
  TITLE     The human ZIP4 transporter has two distinct binding affinities and
            mediates transport of multiple transition metals
  JOURNAL   Biochemistry 51 (5), 963-973 (2012)
   PUBMED   22242765
REFERENCE   4  (bases 1 to 2226)
  AUTHORS   Belloni-Olivi,L., Marshall,C., Laal,B., Andrews,G.K. and
            Bressler,J.
  TITLE     Localization of zip1 and zip4 mRNA in the adult rat brain
  JOURNAL   J Neurosci Res 87 (14), 3221-3230 (2009)
   PUBMED   19530166
  REMARK    GeneRIF: The localization of zip1 and zip4 was examined in the
            brains of adult rats
REFERENCE   5  (bases 1 to 2226)
  AUTHORS   Dufner-Beattie,J., Kuo,Y.M., Gitschier,J. and Andrews,G.K.
  TITLE     The adaptive response to dietary zinc in mice involves the
            differential cellular localization and zinc regulation of the zinc
            transporters ZIP4 and ZIP5
  JOURNAL   J Biol Chem 279 (47), 49082-49090 (2004)
   PUBMED   15358787
REFERENCE   6  (bases 1 to 2226)
  AUTHORS   Kim,B.E., Wang,F., Dufner-Beattie,J., Andrews,G.K., Eide,D.J. and
            Petris,M.J.
  TITLE     Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates
            its location at the plasma membrane
  JOURNAL   J Biol Chem 279 (6), 4523-4530 (2004)
   PUBMED   14612438
REFERENCE   7  (bases 1 to 2226)
  AUTHORS   Dufner-Beattie,J., Wang,F., Kuo,Y.M., Gitschier,J., Eide,D. and
            Andrews,G.K.
  TITLE     The acrodermatitis enteropathica gene ZIP4 encodes a
            tissue-specific, zinc-regulated zinc transporter in mice
  JOURNAL   J Biol Chem 278 (35), 33474-33481 (2003)
   PUBMED   12801924
REFERENCE   8  (bases 1 to 2226)
  AUTHORS   Kury,S., Dreno,B., Bezieau,S., Giraudet,S., Kharfi,M., Kamoun,R.
            and Moisan,J.P.
  TITLE     Identification of SLC39A4, a gene involved in acrodermatitis
            enteropathica
  JOURNAL   Nat Genet 31 (3), 239-240 (2002)
   PUBMED   12068297
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Mar 15, 2021 this sequence version replaced NM_001077669.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127514.1, SRR26643293.41810.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760434,
                                           SAMN12840124 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               JAXUCZ010000007.1  110217919-110218202 c
            285-569             JAXUCZ010000007.1  110217222-110217506 c
            570-765             JAXUCZ010000007.1  110216594-110216789 c
            766-920             JAXUCZ010000007.1  110216339-110216493 c
            921-1092            JAXUCZ010000007.1  110216079-110216250 c
            1093-1265           JAXUCZ010000007.1  110215653-110215825 c
            1266-1421           JAXUCZ010000007.1  110215388-110215543 c
            1422-1541           JAXUCZ010000007.1  110215199-110215318 c
            1542-1596           JAXUCZ010000007.1  110215070-110215124 c
            1597-1749           JAXUCZ010000007.1  110214817-110214969 c
            1750-1937           JAXUCZ010000007.1  110214397-110214584 c
            1938-2226           JAXUCZ010000007.1  110214017-110214305 c
FEATURES             Location/Qualifiers
     source          1..2226
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2226
                     /gene="Slc39a4"
                     /note="solute carrier family 39 member 4"
                     /db_xref="GeneID:300051"
                     /db_xref="RGD:1306701"
     exon            1..284
                     /gene="Slc39a4"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..2066
                     /gene="Slc39a4"
                     /note="zinc transporter ZIP4; ZIP-4; zrt- and Irt-like
                     protein 4; solute carrier family 39 (zinc transporter),
                     member 4"
                     /codon_start=1
                     /product="zinc transporter ZIP4 precursor"
                     /protein_id="NP_001071137.2"
                     /db_xref="GeneID:300051"
                     /db_xref="RGD:1306701"
                     /translation="MMLPKSLTQGLLLAMLVGTAAMVQPYHLLSLLTSGQGALDRTAL
                     DGLLNTLVARVHCTDGPCEKCLSVETALALGKPDKPQLAPESVLESRYITYLSAAAAL
                     YLNDPEKTCKDIRAGLLASHVDDYLAKLESPEAMTLGLSQLLQKIEAHDASQPTREET
                     CVDVPQLLEEAEEAGVSRSPGLVLTALLDHVLNGSCFQGLPSPQYFVDFVFRQLSSKP
                     RNITLPELEDLMHHLGVGGEDHSDHGDHVDHSHLDREANHQDSELHATHNSSSSVWDT
                     LCLSAKDVMAVYGLSEEAGVSPQAWAQLTPALVQQQLSEACSSSPIIHVQDQLSQAER
                     YLYGSLATLLICLCAVFGLLLLTCAKCSTATHYIMQTFLSLAVGALTGDALLHLIPKV
                     LGLHTHSGEVHSHEEESIGGQSTWRLLAVLGGFYIFFLFESFFNLLLPRDQDHEKDGP
                     CSHGGHSHGISLQLSPSNLRQSKQPHESSRSDLVTEETPELLNPDTRRLRAELRMLPY
                     LITLGDAVHNFADGLAVGAAFSSTWKTGLATSLAVFCHELPHELGDFAALLHAGLTVK
                     RALLLNLASALTAFAGLYVALAVGVGEEGETWILAVATGLFLYVALCDMLPAMMNVRD
                     QRPWLLFLLHNVGLLGGWTILLLLSLYEDSITF"
     exon            285..569
                     /gene="Slc39a4"
                     /inference="alignment:Splign:2.1.0"
     exon            570..765
                     /gene="Slc39a4"
                     /inference="alignment:Splign:2.1.0"
     exon            766..920
                     /gene="Slc39a4"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1092
                     /gene="Slc39a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1265
                     /gene="Slc39a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1421
                     /gene="Slc39a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1541
                     /gene="Slc39a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1596
                     /gene="Slc39a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1749
                     /gene="Slc39a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1937
                     /gene="Slc39a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2226
                     /gene="Slc39a4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccagctcca gtctggcccc aggcagtccc agcagtctcc tgctagccca gaagccagca
       61 ccactgcagg gaacactttg ggagcgtgag gcatgatgct cccaaagtcg ctcacacagg
      121 ggctcttgtt ggcgatgctg gtgggcacag cagcaatggt ccagccctat cacctgctca
      181 gcctactcac ctcgggccag ggtgctctgg atcgaacggc actggacggc ctgttaaata
      241 cgctggtggc ccgtgtgcac tgcaccgacg ggccgtgtga aaagtgtctg tctgtggaga
      301 ctgccttggc tctaggcaaa cctgataagc cacagcttgc cccagaatca gtcctggagt
      361 ccagatacat tacttacctc agtgccgccg ctgccctcta cctcaacgac ccagagaaaa
      421 catgcaagga catccgagct ggcctcttgg cctctcatgt ggacgattac ctggccaaac
      481 tggagagtcc agaggccatg accctgggtc tgagccagct actgcagaag attgaggccc
      541 atgatgccag ccaacccacc agggaggaga cctgtgtaga tgttccccaa ctgctggagg
      601 aggctgagga agcaggggtt tccagaagcc ctggcctggt cttgacagcc ttgctggatc
      661 acgtccttaa tggatcctgc ttccaaggcc tgcctagccc tcagtacttt gtggactttg
      721 tgttcaggca actcagtagt aagcctcgca atatcacgct gcccgaattg gaggatttga
      781 tgcatcacct tggggtgggt ggagaggatc acagtgacca tggtgaccat gttgaccaca
      841 gtcatctgga cagggaagcc aaccaccaag actctgagct ccatgctacc cacaacagca
      901 gctccagtgt atgggacacg ctgtgcctga gtgccaaaga tgtaatggct gtgtatgggc
      961 tatctgaaga ggccggggtg agccctcagg cctgggccca actgacccct gccttggtcc
     1021 agcagcagct aagtgaagcc tgcagctcca gtcccattat ccatgtacag gaccagctca
     1081 gtcaagcaga gaggtatctg tatggctctc tggccaccct gctcatctgc ctctgcgctg
     1141 tgttcggtct tctgctgctg acctgtgcca aatgcagcac agccacccac tacatcatgc
     1201 agaccttcct aagcttggct gtgggtgcac tcacaggcga tgctctcctg cacctgatac
     1261 ccaaggtgct gggattgcac acgcatagtg gagaggttca ctcccacgag gaggagagca
     1321 ttggtggaca gtccacctgg cgcctgctgg ctgtacttgg aggcttctac attttcttcc
     1381 tgtttgagag cttcttcaac ctcttattgc ccagagacca ggatcatgag aaagatgggc
     1441 cttgtagcca cggtgggcac agccatggaa tatcactgca gctatcaccc agcaatctcc
     1501 ggcaatccaa acagccccat gagagctctc gctcagactt ggtgacagag gagaccccgg
     1561 aactactgaa cccagacacc cggcgactga gagcagagct gagaatgttg ccctatctga
     1621 tcacactggg tgacgccgtg cacaactttg ctgatgggct cgctgtgggc gcagccttct
     1681 catccacatg gaagactggg ctggccacct cattggcagt gttctgccat gagctgcctc
     1741 acgaacttgg ggactttgct gctctgctgc atgccgggct gactgtgaaa cgtgcgcttc
     1801 tgctgaatct ggcctcagcg ctcacagcat tcgctggcct ctacgtggct ctagcagtcg
     1861 gagtaggcga ggagggcgag acttggattc tggcggtagc cactggcctc ttcctttacg
     1921 tggcgctctg tgacatgctc ccagccatga tgaatgtgcg ggaccagcgg ccctggcttc
     1981 ttttcctgct ccacaacgtg ggtctgctgg gcggctggac catcctgctg ctgctgtcat
     2041 tgtacgaaga cagcatcacc ttctgatggc tctgtcccat tccagtcctt gtccctgcct
     2101 gctgattctg ctttactgcc ttaatccgtc taacagttgg atccactacg ggtagctgga
     2161 gggttcagcc tcatttcccc tgctctgact tcaataaaga cttgcccatc tgcacttcaa
     2221 acccaa
//
