LOCUS       NM_001106124            2681 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus solute carrier family 39 member 12 (Slc39a12),
            mRNA.
ACCESSION   NM_001106124 XM_001072845 XM_006254285 XM_225586
VERSION     NM_001106124.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2681)
  AUTHORS   Ye C, Lian G, Wang T, Chen A, Chen W, Gong J, Luo L, Wang H and Xie
            L.
  TITLE     The zinc transporter ZIP12 regulates monocrotaline-induced
            proliferation and migration of pulmonary arterial smooth muscle
            cells via the AKT/ERK signaling pathways
  JOURNAL   BMC Pulm Med 22 (1), 111 (2022)
   PUBMED   35346134
  REMARK    GeneRIF: The zinc transporter ZIP12 regulates monocrotaline-induced
            proliferation and migration of pulmonary arterial smooth muscle
            cells via the AKT/ERK signaling pathways.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2681)
  AUTHORS   Tran HB, Maiolo S, Harper R, Zalewski PD, Reynolds PN and Hodge S.
  TITLE     Dysregulated zinc and sphingosine-1-phosphate signaling in
            pulmonary hypertension: Potential effects by targeting of bone
            morphogenetic protein receptor type 2 in pulmonary microvessels
  JOURNAL   Cell Biol Int 45 (11), 2368-2379 (2021)
   PUBMED   34347342
  REMARK    GeneRIF: Dysregulated zinc and sphingosine-1-phosphate signaling in
            pulmonary hypertension: Potential effects by targeting of bone
            morphogenetic protein receptor type 2 in pulmonary microvessels.
REFERENCE   3  (bases 1 to 2681)
  AUTHORS   Xiao G, Lian G, Wang T, Chen W, Zhuang W, Luo L, Wang H and Xie L.
  TITLE     Zinc-mediated activation of CREB pathway in proliferation of
            pulmonary artery smooth muscle cells in pulmonary hypertension
  JOURNAL   Cell Commun Signal 19 (1), 103 (2021)
   PUBMED   34635097
  REMARK    GeneRIF: Zinc-mediated activation of CREB pathway in proliferation
            of pulmonary artery smooth muscle cells in pulmonary hypertension.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2681)
  AUTHORS   Zhao L, Oliver E, Maratou K, Atanur SS, Dubois OD, Cotroneo E, Chen
            CN, Wang L, Arce C, Chabosseau PL, Ponsa-Cobas J, Frid MG, Moyon B,
            Webster Z, Aldashev A, Ferrer J, Rutter GA, Stenmark KR, Aitman TJ
            and Wilkins MR.
  TITLE     The zinc transporter ZIP12 regulates the pulmonary vascular
            response to chronic hypoxia
  JOURNAL   Nature 524 (7565), 356-360 (2015)
   PUBMED   26258299
  REMARK    GeneRIF: genetic disruption of ZIP12 expression attenuates the
            development of pulmonary hypertension in rats housed in a hypoxic
            atmosphere
REFERENCE   5  (bases 1 to 2681)
  AUTHORS   Chiasserini D, van Weering JR, Piersma SR, Pham TV, Malekzadeh A,
            Teunissen CE, de Wit H and Jimenez CR.
  TITLE     Proteomic analysis of cerebrospinal fluid extracellular vesicles: a
            comprehensive dataset
  JOURNAL   J Proteomics 106, 191-204 (2014)
   PUBMED   24769233
REFERENCE   6  (bases 1 to 2681)
  AUTHORS   Chowanadisai W, Graham DM, Keen CL, Rucker RB and Messerli MA.
  TITLE     Neurulation and neurite extension require the zinc transporter
            ZIP12 (slc39a12)
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 9903-9908 (2013)
   PUBMED   23716681
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000294.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001106124.3.
            
            On or before Nov 23, 2022 this sequence version replaced
            XM_006254285.4, NM_001106124.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760396 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               JACYVU010000294.1  15929777-15929879
            104-438             JACYVU010000294.1  15930648-15930982
            439-720             JACYVU010000294.1  15939206-15939487
            721-928             JACYVU010000294.1  15943207-15943414
            929-1098            JACYVU010000294.1  15949181-15949350
            1099-1273           JACYVU010000294.1  15951728-15951902
            1274-1446           JACYVU010000294.1  15957506-15957678
            1447-1596           JACYVU010000294.1  15976001-15976150
            1597-1704           JACYVU010000294.1  15977457-15977564
            1705-1771           JACYVU010000294.1  15980118-15980184
            1772-1930           JACYVU010000294.1  15985906-15986064
            1931-2118           JACYVU010000294.1  15988065-15988252
            2119-2681           JACYVU010000294.1  16015784-16016346
FEATURES             Location/Qualifiers
     source          1..2681
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..2681
                     /gene="Slc39a12"
                     /note="solute carrier family 39 member 12"
                     /db_xref="GeneID:291328"
                     /db_xref="RGD:1309305"
     exon            1..103
                     /gene="Slc39a12"
                     /inference="alignment:Splign:2.1.0"
     exon            104..438
                     /gene="Slc39a12"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..2247
                     /gene="Slc39a12"
                     /note="zinc transporter ZIP12; solute carrier family 39
                     (zinc transporter), member 12"
                     /codon_start=1
                     /product="zinc transporter ZIP12 precursor"
                     /protein_id="NP_001099594.2"
                     /db_xref="GeneID:291328"
                     /db_xref="RGD:1309305"
                     /translation="MCFWTELSVWVVLVSHSFSLASSTETSKALTQDNSRVGSHSLLE
                     VLRVLSAGDDRSLNHPQSLIKILLERTGCPQRTDGTQEDCKLCLEPDALSLTAGGDLE
                     DELREEVVQRVSLLLLYYIIHQEEICSSKLNMSNREYEFYLHSLLSLRQDEDSYFLSE
                     KETDDILASTRKYFGTSTSPCMETKILQRESGIQSSNGADEKMLPQLAATIIALSLQG
                     VCLGRKDSPSPDDFTEYIFSFLNRTNALHLSELEELLNMLSTRRACTKINTLHEHQRK
                     QNTAVHGLRDPKSAAAMDKVSGDHSVSWDQACFSAQQLVEIFLQNHSSLSISKEDFKQ
                     LSPGIIQQLLSCSCQVPRDQKAKPPPTTLEKYGYSTVAVTLLTLGSMLGTALVLFHSC
                     EENYSLILQLFVGLAVGTLSGDALLHLIPQVLGLHKQEAELGHFHESQSPIWKLLGLL
                     GGIHGFFLIEKCFILLVSPNTKGLPLVNGHAGHTHHLGLSPELNDQSGGGKSISTIQL
                     KGPEDSQTAELPKGNVPASNRNRKTISLLAVMVLVGDGLHNFADGLVIGTAFSSSLES
                     GVTTTIAILCHEIPHEMGDFAVLLSSGLSIRTAILMNFLSALTAFIGLYIGLSVSADP
                     RVQDWILTVTAGMFLYLSLVGMLPEMTHVQTQRPWMTFLLQNVGLVLGWFSLLLLAVY
                     EQNIKI"
     exon            439..720
                     /gene="Slc39a12"
                     /inference="alignment:Splign:2.1.0"
     exon            721..928
                     /gene="Slc39a12"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1098
                     /gene="Slc39a12"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1273
                     /gene="Slc39a12"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1446
                     /gene="Slc39a12"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1596
                     /gene="Slc39a12"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1704
                     /gene="Slc39a12"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1771
                     /gene="Slc39a12"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1930
                     /gene="Slc39a12"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2118
                     /gene="Slc39a12"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2681
                     /gene="Slc39a12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcaaggaa ttttaaaacg gagaactggg ggaccacaaa atgctctcag aaatttaaag
       61 gcccaaggag gctcgagata aataaccatt tctctttctt gaggaacccc tctggttata
      121 agtttatcct acgcaaagcc tcccactcac ccccagggca actccagcca gagagtggat
      181 atgtgcttct ggacagagct ctcagtatgg gtggtcctag tgtcccactc cttcagcctt
      241 gcttcctcta ctgagaccag caaagccctc actcaggata acagcagagt tgggagccac
      301 agcctgttag aagttctgag agtcctctct gctggtgacg acaggtccct caaccatcca
      361 caaagtctca tcaagattct gttggagagg actgggtgtc cacagagaac agacgggaca
      421 caagaagatt gcaagctgtg tttggaacca gatgcactat cactcacagc tgggggagat
      481 ttggaggatg agttgagaga ggaggtggtc cagagagttt ctctcctcct cctctattac
      541 atcattcatc aggaagagat ctgctcttcc aaactcaaca tgagcaacag agaatatgag
      601 ttctacctgc acagccttct cagcctcagg caggatgaag actcctattt cctctcagag
      661 aaggagactg atgacatctt ggcttccacc aggaagtact ttggcacctc cactagtccg
      721 tgtatggaaa ctaagattct acagagggaa tctggcattc agagcagcaa tggtgctgat
      781 gaaaagatgc ttcctcagct ggctgccacc atcattgctc tgtcgctcca aggagtttgt
      841 ttggggagaa aagactcgcc ttccccagat gactttacag aatatatttt cagtttcctg
      901 aatagaacca atgccctcca cctctctgaa ctagaggaac ttctgaacat gctctcgacc
      961 agaagggcct gtaccaaaat aaataccctc catgaacacc aaaggaaaca aaacacagca
     1021 gtacatggtt tgagagaccc caagtcagct gcagcaatgg acaaagtgtc tggtgatcat
     1081 tctgtttcct gggatcaggc ttgcttctct gctcagcagc tggtggagat atttcttcag
     1141 aaccacagca gtctgtccat ttcgaaggag gactttaagc agctaagtcc agggatcatc
     1201 cagcaactcc tcagctgctc ttgtcaggtg cccagggacc agaaagcaaa gcccccaccc
     1261 accactctgg agaaatatgg ttatagcacg gtggcagtga cactactaac cttgggctcc
     1321 atgcttggga ccgcgctggt ccttttccac agctgcgagg agaattacag tctgatttta
     1381 cagttattcg tgggcttggc cgtggggaca ctctccgggg atgccctgct ccatctcatt
     1441 cctcaggttc ttggtttaca taagcaggaa gcagagcttg ggcatttcca cgaaagccaa
     1501 agtcctattt ggaagctgtt gggactactt ggaggcatcc atggattttt cttgatagaa
     1561 aaatgtttta tccttcttgt atcgccaaat accaagggcc tgccattagt taatggacat
     1621 gcaggacata cccaccatct tggactcagt cctgagttaa atgaccagtc aggtggaggc
     1681 aagtctatat caaccattca gctgaaaggc ccagaagatt cacagacagc tgagctaccc
     1741 aaaggcaatg tgccagcctc caacagaaac cgcaaaacca tcagcttgtt ggctgttatg
     1801 gtcctggttg gagatggcct gcacaatttt gccgatggcc tagtaatagg cacagccttc
     1861 tcttcttcat tggagtcagg agtgaccaca acaatcgcta ttttgtgtca tgaaattcca
     1921 catgaaatgg gagactttgc tgtgctctta agctctggac tctccatcag gactgccatc
     1981 ctaatgaatt tcctaagtgc cctgacagcc ttcataggac tgtacattgg tctctcggtg
     2041 tctgctgatc cacgtgtcca agactggatt ttaacagtga ctgctgggat gttcttgtat
     2101 ttatccttgg tggggatgct tcctgaaatg actcatgtgc agacacaacg accctggatg
     2161 acgtttctcc tgcagaatgt tggattggtc cttggctggt tttcactttt gctcttagct
     2221 gtatatgaac agaatattaa aatataagtt aagaatctct gatgccttcc aaattgaatt
     2281 tatatgttca catctcatat cttccatgtt ctctatgctc atcactaaat ttggcattta
     2341 tatttgagac aaaggatgtg tcatttatct taacttatta ttctgtattg taaatgtttt
     2401 agaaatacat acaagtgagt ctgtcttgca ttaaaatctt tatttttgtt tctgacactg
     2461 tgatgagccc taataaactt tagtgttaga aaattctgaa atctagccag ctgcaaaaat
     2521 attatttccc tacaaaagaa tgtttatttc ttgtatttga agcagacatt tttgctagtt
     2581 tttaattgtt aataatacat ttattttcta tgtgatttat aaaccataag caaatagcat
     2641 tatagtattg taataaagcc ttaatgtggt agtttcaatg a
//
