LOCUS       NM_138854               1853 bp    mRNA    linear   ROD 19-JUL-2024
DEFINITION  Rattus norvegicus solute carrier family 38, member 5 (Slc38a5),
            transcript variant 2, mRNA.
ACCESSION   NM_138854
VERSION     NM_138854.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1853)
  AUTHORS   Rodriguez,A., Ortega,A., Berumen,L.C., Garcia-Alcocer,M.G.,
            Gimenez,C. and Zafra,F.
  TITLE     Expression of the System N transporter (SNAT5/SN2) during
            development indicates its plausible role in glutamatergic
            neurotransmission
  JOURNAL   Neurochem Int 73, 166-171 (2014)
   PUBMED   24333324
  REMARK    GeneRIF: SNAT5/SN2 expression is coordinated with that of other
            proteins necessary for the operation of glutamatergic synapses
REFERENCE   2  (bases 1 to 1853)
  AUTHORS   Hamdani el,H., Gudbrandsen,M., Bjorkmo,M. and Chaudhry,F.A.
  TITLE     The system N transporter SN2 doubles as a transmitter precursor
            furnisher and a potential regulator of NMDA receptors
  JOURNAL   Glia 60 (11), 1671-1683 (2012)
   PUBMED   22821889
  REMARK    GeneRIF: SN2 doubles as a transmitter precursor furnisher and a
            potential regulator of NMDA receptors.
REFERENCE   3  (bases 1 to 1853)
  AUTHORS   Wang,W., Li,Y., Zhang,W., Zhang,F. and Li,J.
  TITLE     Changes of plasma glutamine concentration and hepatocyte membrane
            system N transporters expression in early endotoxemia
  JOURNAL   J Surg Res 166 (2), 290-297 (2011)
   PUBMED   20036385
  REMARK    GeneRIF: The effect of lipopolysaccharides on system N expression
            occurs not only at the protein level, but also at the mRNA level
REFERENCE   4  (bases 1 to 1853)
  AUTHORS   Baird,F.E., Pinilla-Tenas,J.J., Ogilvie,W.L., Ganapathy,V.,
            Hundal,H.S. and Taylor,P.M.
  TITLE     Evidence for allosteric regulation of pH-sensitive System A (SNAT2)
            and System N (SNAT5) amino acid transporter activity involving a
            conserved histidine residue
  JOURNAL   Biochem J 397 (2), 369-375 (2006)
   PUBMED   16629640
  REMARK    GeneRIF: pH-sensitive System A (SNAT2) and System N (SNAT5) amino
            acid transporter activity allosteric regulation involves a
            conserved histidine residue
REFERENCE   5  (bases 1 to 1853)
  AUTHORS   Umapathy,N.S., Li,W., Mysona,B.A., Smith,S.B. and Ganapathy,V.
  TITLE     Expression and function of glutamine transporters SN1 (SNAT3) and
            SN2 (SNAT5) in retinal Muller cells
  JOURNAL   Invest Ophthalmol Vis Sci 46 (11), 3980-3987 (2005)
   PUBMED   16249471
REFERENCE   6  (bases 1 to 1853)
  AUTHORS   Cubelos,B., Gonzalez-Gonzalez,I.M., Gimenez,C. and Zafra,F.
  TITLE     Amino acid transporter SNAT5 localizes to glial cells in the rat
            brain
  JOURNAL   Glia 49 (2), 230-244 (2005)
   PUBMED   15390093
  REMARK    GeneRIF: this transporter is likely to be involved in glutamatergic
            pathways in the brain.
REFERENCE   7  (bases 1 to 1853)
  AUTHORS   Baird,F.E., Beattie,K.J., Hyde,A.R., Ganapathy,V., Rennie,M.J. and
            Taylor,P.M.
  TITLE     Bidirectional substrate fluxes through the system N (SNAT5)
            glutamine transporter may determine net glutamine flux in rat liver
  JOURNAL   J Physiol 559 (Pt 2), 367-381 (2004)
   PUBMED   15218073
REFERENCE   8  (bases 1 to 1853)
  AUTHORS   Nakanishi,T., Kekuda,R., Fei,Y.J., Hatanaka,T., Sugawara,M.,
            Martindale,R.G., Leibach,F.H., Prasad,P.D. and Ganapathy,V.
  TITLE     Cloning and functional characterization of a new subtype of the
            amino acid transport system N
  JOURNAL   Am J Physiol Cell Physiol 281 (6), C1757-C1768 (2001)
   PUBMED   11698233
REFERENCE   9  (bases 1 to 1853)
  AUTHORS   Nakanishi,T., Sugawara,M., Huang,W., Martindale,R.G., Leibach,F.H.,
            Ganapathy,M.E., Prasad,P.D. and Ganapathy,V.
  TITLE     Structure, function, and tissue expression pattern of human SN2, a
            subtype of the amino acid transport system N
  JOURNAL   Biochem Biophys Res Commun 281 (5), 1343-1348 (2001)
   PUBMED   11243884
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Nov 27, 2020 this sequence version replaced NM_138854.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF276870.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               JAXUCZ010000021.1  16894361-16894470   c
            111-167             JAXUCZ010000021.1  16893728-16893784   c
            168-246             JAXUCZ010000021.1  16893562-16893640   c
            247-362             JAXUCZ010000021.1  16892906-16893021   c
            363-436             JAXUCZ010000021.1  16892730-16892803   c
            437-529             JAXUCZ010000021.1  16891983-16892075   c
            530-608             JAXUCZ010000021.1  16891786-16891864   c
            609-691             JAXUCZ010000021.1  16889685-16889767   c
            692-750             JAXUCZ010000021.1  16889254-16889312   c
            751-879             JAXUCZ010000021.1  16889018-16889146   c
            880-959             JAXUCZ010000021.1  16888761-16888840   c
            960-1060            JAXUCZ010000021.1  16888089-16888189   c
            1061-1176           JAXUCZ010000021.1  16887740-16887855   c
            1177-1321           JAXUCZ010000021.1  16886915-16887059   c
            1322-1425           JAXUCZ010000021.1  16886721-16886824   c
            1426-1853           JAXUCZ010000021.1  16885701-16886128   c
FEATURES             Location/Qualifiers
     source          1..1853
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..1853
                     /gene="Slc38a5"
                     /gene_synonym="SN2"
                     /note="solute carrier family 38, member 5"
                     /db_xref="GeneID:192208"
                     /db_xref="RGD:620702"
     exon            1..110
                     /gene="Slc38a5"
                     /gene_synonym="SN2"
                     /inference="alignment:Splign:2.1.0"
     exon            111..167
                     /gene="Slc38a5"
                     /gene_synonym="SN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1527
                     /gene="Slc38a5"
                     /gene_synonym="SN2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     sodium-coupled neutral amino acid transporter 5; system N
                     transporter 2; amino acid transporter system N2"
                     /codon_start=1
                     /product="sodium-coupled neutral amino acid transporter 5
                     isoform 2"
                     /protein_id="NP_620209.2"
                     /db_xref="GeneID:192208"
                     /db_xref="RGD:620702"
                     /translation="MEMQEPKMNGTLSTGAAAGYRQEREGFLPTTHGPAPGRKPVQFL
                     DFEGKTSFGMSVFNLSNAIMGSGILGLAYAMAHTGVIFFLALLLCIALLSSYSIHLLL
                     TCASVVGIRAYEQLGQRAFGPAGKVVVAIIICLHNVGAMSSYLFIIKSELPLVIGTFL
                     HMDPEGDWFLKGNLLIILVSLLIILPLALMKHLGYLGYTSSLSLTCMLFFLISVIYKK
                     FQLGCVVSHNDTVVESEPAPLQAFNSSCEAKLFTVDSQMSYTVPIMAFAFVCHPEVLP
                     IYTELCCPTQRRMQAVANMSIGAMFIMYGLTATFGYLTFYSTVKAEMLEMYTQEDLLI
                     LCVRLAVLLAVTLTVPVVLFPIRRALQQLLFPSKAFSWPRHVAIALILLILVNILVIC
                     VPTIRDIFGFIGSTSAPSLIFILPSVFYLRIVPADMEPLFSWPKIQALCFGVLGVLFM
                     AISLGFMFANWATGQSRMSGH"
     exon            168..246
                     /gene="Slc38a5"
                     /gene_synonym="SN2"
                     /inference="alignment:Splign:2.1.0"
     exon            247..362
                     /gene="Slc38a5"
                     /gene_synonym="SN2"
                     /inference="alignment:Splign:2.1.0"
     exon            363..436
                     /gene="Slc38a5"
                     /gene_synonym="SN2"
                     /inference="alignment:Splign:2.1.0"
     exon            437..529
                     /gene="Slc38a5"
                     /gene_synonym="SN2"
                     /inference="alignment:Splign:2.1.0"
     exon            530..608
                     /gene="Slc38a5"
                     /gene_synonym="SN2"
                     /inference="alignment:Splign:2.1.0"
     exon            609..691
                     /gene="Slc38a5"
                     /gene_synonym="SN2"
                     /inference="alignment:Splign:2.1.0"
     exon            692..750
                     /gene="Slc38a5"
                     /gene_synonym="SN2"
                     /inference="alignment:Splign:2.1.0"
     exon            751..879
                     /gene="Slc38a5"
                     /gene_synonym="SN2"
                     /inference="alignment:Splign:2.1.0"
     exon            880..959
                     /gene="Slc38a5"
                     /gene_synonym="SN2"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1060
                     /gene="Slc38a5"
                     /gene_synonym="SN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1176
                     /gene="Slc38a5"
                     /gene_synonym="SN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1321
                     /gene="Slc38a5"
                     /gene_synonym="SN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1425
                     /gene="Slc38a5"
                     /gene_synonym="SN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1853
                     /gene="Slc38a5"
                     /gene_synonym="SN2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcttcacca cctagttgca ctcgcatact ggtcagttct gtcccaggaa gagggacgct
       61 tcaatttgct tcggtctctg ctgaagaaag tcagaaccgg aataaaagcg gatggaaatg
      121 caggaaccaa agatgaacgg aaccctctct acgggtgctg ctgcgggcta cagacaggaa
      181 cgcgaaggct tcctgcccac cacccatggc cctgctccag ggaggaaacc tgtccaattc
      241 ttggatttcg aggggaagac atcattcgga atgtcagtgt tcaaccttag caatgccatc
      301 atggggagtg gcatcctggg gctcgcctac gccatggccc acactggagt catcttcttc
      361 ttggccctct tgctgtgcat tgccctcctg tcttcttact ctatccacct cctgctgacc
      421 tgcgccagtg ttgtaggaat ccgcgcctat gagcagctgg gacagagggc atttggacct
      481 gccgggaaag tagtggtggc cattatcatc tgtctgcaca atgttggcgc tatgtccagt
      541 tacctgttca tcatcaaatc tgaactgccc ctggttattg gcaccttcct gcacatggac
      601 cctgaggggg actggttctt gaagggaaac ctcctcatca tcctggttag cttgttaatc
      661 atcttgcctc tggctctcat gaaacatctg ggctacttgg ggtatacaag cagcctctct
      721 ctgacctgca tgctgttttt ccttatttca gtcatctata agaagttcca gcttggctgt
      781 gttgtgagcc acaatgacac agtagtggag agtgaaccag ctcccttgca ggcgtttaat
      841 agcagctgtg aggccaagct cttcacagtt gactcacaga tgtcttacac agtgcctatt
      901 atggcttttg cctttgtctg ccaccctgag gtgctgccca tttacacgga actttgctgc
      961 cctactcagc gcaggatgca agctgtggcc aacatgtcca tcggggctat gttcatcatg
     1021 tacggactca cagctacctt tggatacctt accttctaca gcactgtgaa ggcagagatg
     1081 ctggagatgt acacccagga ggacctgctt attctttgtg tgcgcctggc cgtactgctt
     1141 gcagtaaccc tcactgtgcc tgttgtcctt ttccctatcc gccgagccct ccagcagctg
     1201 ctcttcccaa gtaaggcctt cagctggcca cgacatgtgg ccattgccct gatcctgctt
     1261 attttggtca atatccttgt catttgtgtg ccaaccatcc gggatatctt tgggtttatt
     1321 ggctccactt cagcccctag cctcatcttc atccttccca gtgtcttcta cctccgcatt
     1381 gtacctgctg acatggaacc cttgttttcc tggcccaaga tccaggccct gtgttttggc
     1441 gtcctgggag tcctcttcat ggccatcagt ctgggcttta tgtttgctaa ttgggctaca
     1501 ggccagagcc gtatgtctgg ccattgagct ggcctgtcct gcctcactca gtccctgtgc
     1561 tcacatgtgt gtatattagg gaatccaagt cactttcctg agtcccttct gcctgggaca
     1621 tggaggtggc tggtctctag taacactgct gtgggaaatg gggacagtcg aggaggcata
     1681 gtaagtagtc catttccttt tccccagagc tgcctcactg ccgaccccat gagaggagga
     1741 agggaggcca gctccttaga agggttctta cccaacatag ttctcacttc ctagatgaag
     1801 ctgttaggct taccctggcg ctaaaaggga agaataaaga tgctgaatgg caa
//
