LOCUS       NM_145776               2334 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus solute carrier family 38, member 3 (Slc38a3),
            mRNA.
ACCESSION   NM_145776
VERSION     NM_145776.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2334)
  AUTHORS   Dong,W., Todd,A.C., Broer,A., Hulme,S.R., Broer,S. and Billups,B.
  TITLE     PKC-Mediated Modulation of Astrocyte SNAT3 Glutamine Transporter
            Function at Synapses in Situ
  JOURNAL   Int J Mol Sci 19 (4), 924 (2018)
   PUBMED   29561757
  REMARK    GeneRIF: This indicates a role for PKC in dynamically controlling
            the trafficking of SNAT3 transporters in astrocytes in situ.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2334)
  AUTHORS   Todd,A.C., Marx,M.C., Hulme,S.R., Broer,S. and Billups,B.
  TITLE     SNAT3-mediated glutamine transport in perisynaptic astrocytes in
            situ is regulated by intracellular sodium
  JOURNAL   Glia 65 (6), 900-916 (2017)
   PUBMED   28272791
  REMARK    GeneRIF: Results demonstrate that SNAT3 is functionally active in
            perisynaptic astrocytes in situ. As a result, astrocytic Nai+
            signaling, as would be stimulated by neighboring synaptic activity,
            has the capacity to stimulate astrocytic glutamine release to
            support glutamate recycling
REFERENCE   3  (bases 1 to 2334)
  AUTHORS   Nissen-Meyer,L.S., Popescu,M.C., Hamdani el,H. and Chaudhry,F.A.
  TITLE     Protein kinase C-mediated phosphorylation of a single serine
            residue on the rat glial glutamine transporter SN1 governs its
            membrane trafficking
  JOURNAL   J Neurosci 31 (17), 6565-6575 (2011)
   PUBMED   21525297
REFERENCE   4  (bases 1 to 2334)
  AUTHORS   Doi,T., Ueda,Y., Takaki,M. and Willmore,L.J.
  TITLE     Differential molecular regulation of glutamate in kindling
            resistant rats
  JOURNAL   Brain Res 1375, 1-6 (2011)
   PUBMED   21138736
REFERENCE   5  (bases 1 to 2334)
  AUTHORS   Balkrishna,S., Broer,A., Kingsland,A. and Broer,S.
  TITLE     Rapid downregulation of the rat glutamine transporter SNAT3 by a
            caveolin-dependent trafficking mechanism in Xenopus laevis oocytes
  JOURNAL   Am J Physiol Cell Physiol 299 (5), C1047-C1057 (2010)
   PUBMED   20739622
  REMARK    GeneRIF: Data report that the transport activity of the glutamine
            transporter SNAT3 is rapidly reduced on PKC activation by phorbol
            esters via a specific trafficking mechanism in oocytes.
REFERENCE   6  (bases 1 to 2334)
  AUTHORS   Broer,A., Albers,A., Setiawan,I., Edwards,R.H., Chaudhry,F.A.,
            Lang,F., Wagner,C.A. and Broer,S.
  TITLE     Regulation of the glutamine transporter SN1 by extracellular pH and
            intracellular sodium ions
  JOURNAL   J Physiol 539 (Pt 1), 3-14 (2002)
   PUBMED   11850497
REFERENCE   7  (bases 1 to 2334)
  AUTHORS   Chaudhry,F.A., Krizaj,D., Larsson,P., Reimer,R.J., Wreden,C.,
            Storm-Mathisen,J., Copenhagen,D., Kavanaugh,M. and Edwards,R.H.
  TITLE     Coupled and uncoupled proton movement by amino acid transport
            system N
  JOURNAL   EMBO J 20 (24), 7041-7051 (2001)
   PUBMED   11742981
REFERENCE   8  (bases 1 to 2334)
  AUTHORS   Fei,Y.J., Sugawara,M., Nakanishi,T., Huang,W., Wang,H.,
            Prasad,P.D., Leibach,F.H. and Ganapathy,V.
  TITLE     Primary structure, genomic organization, and functional and
            electrogenic characteristics of human system N 1, a Na+- and
            H+-coupled glutamine transporter
  JOURNAL   J Biol Chem 275 (31), 23707-23717 (2000)
   PUBMED   10823827
REFERENCE   9  (bases 1 to 2334)
  AUTHORS   Gu,S., Roderick,H.L., Camacho,P. and Jiang,J.X.
  TITLE     Identification and characterization of an amino acid transporter
            expressed differentially in liver
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3230-3235 (2000)
   PUBMED   10716701
REFERENCE   10 (bases 1 to 2334)
  AUTHORS   Chaudhry,F.A., Reimer,R.J., Krizaj,D., Barber,D.,
            Storm-Mathisen,J., Copenhagen,D.R. and Edwards,R.H.
  TITLE     Molecular analysis of system N suggests novel physiological roles
            in nitrogen metabolism and synaptic transmission
  JOURNAL   Cell 99 (7), 769-780 (1999)
   PUBMED   10619430
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000200.1.
            
            [WARNING] On Mar 20, 2024 this sequence was replaced by
            NM_145776.3.
            
            On Nov 27, 2020 this sequence version replaced NM_145776.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF273025.1, BC081717.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                JACYVU010000200.1  11298705-11298742   c
            39-190              JACYVU010000200.1  11290912-11291063   c
            191-269             JACYVU010000200.1  11290732-11290810   c
            270-385             JACYVU010000200.1  11290446-11290561   c
            386-459             JACYVU010000200.1  11289831-11289904   c
            460-552             JACYVU010000200.1  11289652-11289744   c
            553-634             JACYVU010000200.1  11289473-11289554   c
            635-717             JACYVU010000200.1  11287389-11287471   c
            718-776             JACYVU010000200.1  11287249-11287307   c
            777-944             JACYVU010000200.1  11286894-11287061   c
            945-1024            JACYVU010000200.1  11286730-11286809   c
            1025-1125           JACYVU010000200.1  11286264-11286364   c
            1126-1250           JACYVU010000200.1  11285937-11286061   c
            1251-1395           JACYVU010000200.1  11285707-11285851   c
            1396-1499           JACYVU010000200.1  11283628-11283731   c
            1500-2334           JACYVU010000200.1  11282703-11283537   c
FEATURES             Location/Qualifiers
     source          1..2334
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2334
                     /gene="Slc38a3"
                     /gene_synonym="Nat1; Sn1; Snat3"
                     /note="solute carrier family 38, member 3"
                     /db_xref="GeneID:252919"
                     /db_xref="RGD:628620"
     exon            1..38
                     /gene="Slc38a3"
                     /gene_synonym="Nat1; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     exon            39..190
                     /gene="Slc38a3"
                     /gene_synonym="Nat1; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1604
                     /gene="Slc38a3"
                     /gene_synonym="Nat1; Sn1; Snat3"
                     /note="N-system amino acid transporter 1; system N amino
                     acid transporter 1; Na(+)-coupled neutral amino acid
                     transporter 3; system N1 amino acid transporter"
                     /codon_start=1
                     /product="sodium-coupled neutral amino acid transporter 3"
                     /protein_id="NP_665719.1"
                     /db_xref="GeneID:252919"
                     /db_xref="RGD:628620"
                     /translation="MEIPRQTEMVELVPNGKHLEGLLPVGMPTADTQRAEDAQHCGEG
                     KGFLQQSSSKEPHFTDFEGKTSFGMSVFNLSNAIMGSGILGLAYAMANTGIILFLFLL
                     TAVALLSSYSIHLLLKSSGIVGIRAYEQLGYRAFGTPGKLAAALAITLQNIGAMSSYL
                     YIIKSELPLVIQTFLNLEKPTPVWYMDGNYLVILVSVIIILPLALMRQLGYLGYSSGF
                     SLSCMVFFLIAVIYKKFQVPCPLAHNLVNATGNFSHMVVVEEKSQLQSEPDTAEAFCT
                     PSYFTLNSQTAYTIPIMAFAFVCHPEVLPIYTELKDPSKRKMQHISNLSIAVMYVMYF
                     LAALFGYLTFYDGVESELLHTYSKVDPFDVLILCVRVAVLIAVTLTVPIVLFPVRRAI
                     QQMLFQNQEFSWLRHVLIATGLLTCINLLVIFAPNILGIFGIIGATSAPCLIFIFPAI
                     FYFRIMPTEKEPVRSTPKILALCFAAVGFLLMTMSLSFIITDWVSGTSQHGGNH"
     exon            191..269
                     /gene="Slc38a3"
                     /gene_synonym="Nat1; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     exon            270..385
                     /gene="Slc38a3"
                     /gene_synonym="Nat1; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     exon            386..459
                     /gene="Slc38a3"
                     /gene_synonym="Nat1; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     exon            460..552
                     /gene="Slc38a3"
                     /gene_synonym="Nat1; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     exon            553..634
                     /gene="Slc38a3"
                     /gene_synonym="Nat1; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     exon            635..717
                     /gene="Slc38a3"
                     /gene_synonym="Nat1; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     exon            718..776
                     /gene="Slc38a3"
                     /gene_synonym="Nat1; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     exon            777..944
                     /gene="Slc38a3"
                     /gene_synonym="Nat1; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1024
                     /gene="Slc38a3"
                     /gene_synonym="Nat1; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1125
                     /gene="Slc38a3"
                     /gene_synonym="Nat1; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1250
                     /gene="Slc38a3"
                     /gene_synonym="Nat1; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1395
                     /gene="Slc38a3"
                     /gene_synonym="Nat1; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1499
                     /gene="Slc38a3"
                     /gene_synonym="Nat1; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..2334
                     /gene="Slc38a3"
                     /gene_synonym="Nat1; Sn1; Snat3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggaacgga gtgctgaacg tgcccaccac gaggccagat acctgacggt gtttgtgtga
       61 gagcggtgct ctggggtggt ttcagagcca tggagatacc ccgacagaca gagatggtgg
      121 agctggtgcc caatggcaaa cacctggagg ggcttctacc agtgggcatg cccacggcag
      181 acacccagag ggctgaagac gcccaacact gtggagaggg caagggcttc cttcagcaaa
      241 gctccagcaa ggagccacac ttcaccgatt tcgaggggaa gacatcgttt gggatgtcgg
      301 tgttcaatct cagcaacgcc atcatgggca gtggcatcct ggggctcgcc tatgccatgg
      361 ccaatacggg catcatcctc ttcctgttcc tgcttacggc ggttgccctg ttgtctagct
      421 actccattca cctgctcctc aagtcttctg ggattgtggg catccgtgcc tatgagcagt
      481 tgggctaccg tgcctttggg accccaggaa agctggcagc agccttggcc atcacgcttc
      541 agaacattgg agccatgtcc agctatctgt acatcatcaa gtctgaactg cctcttgtca
      601 tacagacctt cctgaatctg gagaagccaa ccccggtgtg gtacatggat ggcaactacc
      661 ttgtgatcct ggtatccgtc atcatcattc tgcccctggc actaatgcga cagcttggct
      721 acctgggcta ctccagtggc ttctctctca gctgcatggt gttcttcttg atcgcagtca
      781 tctacaagaa gttccaagtg ccttgcccac tggcacacaa cttggtcaat gccacaggta
      841 acttcagcca catggtggtg gtggaggaga agtcgcagct gcagagcgaa cctgacactg
      901 ctgaagcctt ctgcacccca agctacttca cactcaactc acagacggca tacaccatcc
      961 ccatcatggc cttcgccttt gtctgccacc ctgaggtgct gcccatatat acggagctca
     1021 aggacccctc caagaggaag atgcagcaca tctccaacct gtccattgct gtcatgtatg
     1081 tcatgtactt cctggctgcc ctcttcggct acctcacctt ctatgacggg gtggagtcag
     1141 agctgctgca cacctacagc aaggtggacc catttgatgt gctgatcttg tgtgtgcgcg
     1201 tggccgtgct gatagcggtc acacttacgg ttccgatcgt tctgttcccg gtacgacggg
     1261 ccatccagca gatgctgttt cagaaccagg agttcagctg gttgcggcac gtgcttattg
     1321 ccaccggcct ccttacttgc atcaacttgc tggttatctt cgcccccaac atcttgggca
     1381 tatttgggat cattggtgct acatctgctc cgtgcctcat cttcatcttc cctgccatct
     1441 tctacttccg aatcatgccc actgagaagg agcctgtgag atccaccccc aaaatcctgg
     1501 ccctttgctt tgctgcggtt ggcttcttgc tgatgaccat gagtttgagt ttcatcatca
     1561 ctgactgggt ctctgggacc agccaacatg gaggaaacca ttaggatgac ctccatcttg
     1621 ctctgtttat tcctcctagt accccctgcc ctctctctct ccagcccctg ctcccagcca
     1681 ggggctaagg aaggggagaa agacagggga gaaagactct gtaaatacta tggcatttgg
     1741 ctccacccat atcctctccg tcggaaggtt tttgttgaag agccaaggcc cttggaccac
     1801 ccctgctggg ctccagagct gcaggggctt cctgcactag gaacagggtg gggctgtcgc
     1861 cttagatccc accgaaaccc tccatcctcc tccagcagct gtgtacactg aggcctagca
     1921 gccacctcct gaggtcacac aggctgcagg ggcacacaga gccagaaccc aggtctgaag
     1981 acatccccta gtcctgctgg gagcccacag tccctggtct ccagctcctt ttccaacact
     2041 tggggcccca agtcttagat acaggggccc ttcctcttcc atctcgtccg taggagacac
     2101 tgtcccaacc catatctggg gtcagcaggt tctgctgagg atggggctgg tgtgtacccc
     2161 cagagatccc tgctgttgga ccttcaccag tcctggggag gctgggactc ccacacctca
     2221 agcccgggct atgacttaca ttccactgct gggagaagag aggcggggcc cagagtatcc
     2281 tgcccttggg agtcaaagac cctaggagcc aggctggcac agggatgggg aggc
//
