LOCUS       NM_181090               4612 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 38, member 2 (Slc38a2),
            mRNA.
ACCESSION   NM_181090
VERSION     NM_181090.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4612)
  AUTHORS   Ge,Y., Gu,Y., Wang,J. and Zhang,Z.
  TITLE     Membrane topology of rat sodium-coupled neutral amino acid
            transporter 2 (SNAT2)
  JOURNAL   Biochim Biophys Acta Biomembr 1860 (7), 1460-1469 (2018)
   PUBMED   29678469
  REMARK    GeneRIF: results show that SNAT2 contains 11 transmembrane domains
            (TMDs) with an intracellular N terminus and an extracellular C
            terminus
REFERENCE   2  (bases 1 to 4612)
  AUTHORS   Medras,Z.J.H., El-Sayed,N.M., Zaitone,S.A., Toraih,E.A., Sami,M.M.
            and Moustafa,Y.M.
  TITLE     Glutamine up-regulates pancreatic sodium-dependent neutral
            aminoacid transporter-2 and mitigates islets apoptosis in diabetic
            rats
  JOURNAL   Pharmacol Rep 70 (2), 233-242 (2018)
   PUBMED   29475006
  REMARK    GeneRIF: Treatment with glutamine and its combination with
            liraglutide significantly increased pancreatic expression of SNAT2
            by approximately 30-35 folds.
REFERENCE   3  (bases 1 to 4612)
  AUTHORS   Moen,M.N., Fjaer,R., Hamdani,E.H., Laerdahl,J.K., Menchini,R.J.,
            Vigeland,M.D., Sheng,Y., Undlien,D.E., Hassel,B., Salih,M.A., El
            Khashab,H.Y., Selmer,K.K. and Chaudhry,F.A.
  TITLE     Pathogenic variants in KCTD7 perturb neuronal K+ fluxes and
            glutamine transport
  JOURNAL   Brain 139 (Pt 12), 3109-3120 (2016)
   PUBMED   27742667
REFERENCE   4  (bases 1 to 4612)
  AUTHORS   Chen,C., Wang,J., Cai,R., Yuan,Y., Guo,Z., Grewer,C. and Zhang,Z.
  TITLE     Identification of a Disulfide Bridge in Sodium-Coupled Neutral
            Amino Acid Transporter 2(SNAT2) by Chemical Modification
  JOURNAL   PLoS One 11 (6), e0158319 (2016)
   PUBMED   27355203
  REMARK    GeneRIF: there is a disulfide bond between Cys245 and Cys279 in
            SNAT2 which has no effect on cell surface trafficking, as well as
            transporter function
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4612)
  AUTHORS   Lu,L., Huang,Y.F., Chen,D.X., Wang,M., Zou,Y.C., Wan,H. and
            Wei,L.B.
  TITLE     Astragalus polysaccharides decrease muscle wasting through
            Akt/mTOR, ubiquitin proteasome and autophagy signalling in 5/6
            nephrectomised rats
  JOURNAL   J Ethnopharmacol 186, 125-135 (2016)
   PUBMED   27049295
  REMARK    GeneRIF: These results suggested that Astragalus polysacchrides
            could improve muscle wasting through Akt/mTOR, ubiquitin proteasome
            and autophagy signalling, and SLC38A2 may be one of potential
            targets.
REFERENCE   6  (bases 1 to 4612)
  AUTHORS   Hyde,R., Christie,G.R., Litherland,G.J., Hajduch,E., Taylor,P.M.
            and Hundal,H.S.
  TITLE     Subcellular localization and adaptive up-regulation of the System A
            (SAT2) amino acid transporter in skeletal-muscle cells and
            adipocytes
  JOURNAL   Biochem J 355 (Pt 3), 563-568 (2001)
   PUBMED   11311116
REFERENCE   7  (bases 1 to 4612)
  AUTHORS   Hatanaka,T., Huang,W., Wang,H., Sugawara,M., Prasad,P.D.,
            Leibach,F.H. and Ganapathy,V.
  TITLE     Primary structure, functional characteristics and tissue expression
            pattern of human ATA2, a subtype of amino acid transport system A
  JOURNAL   Biochim Biophys Acta 1467 (1), 1-6 (2000)
   PUBMED   10930503
REFERENCE   8  (bases 1 to 4612)
  AUTHORS   Yao,D., Mackenzie,B., Ming,H., Varoqui,H., Zhu,H., Hediger,M.A. and
            Erickson,J.D.
  TITLE     A novel system A isoform mediating Na+/neutral amino acid
            cotransport
  JOURNAL   J Biol Chem 275 (30), 22790-22797 (2000)
   PUBMED   10811809
REFERENCE   9  (bases 1 to 4612)
  AUTHORS   Reimer,R.J., Chaudhry,F.A., Gray,A.T. and Edwards,R.H.
  TITLE     Amino acid transport system A resembles system N in sequence but
            differs in mechanism
  JOURNAL   Proc Natl Acad Sci U S A 97 (14), 7715-7720 (2000)
   PUBMED   10859363
REFERENCE   10 (bases 1 to 4612)
  AUTHORS   Sugawara,M., Nakanishi,T., Fei,Y.J., Huang,W., Ganapathy,M.E.,
            Leibach,F.H. and Ganapathy,V.
  TITLE     Cloning of an amino acid transporter with functional
            characteristics and tissue expression pattern identical to that of
            system A
  JOURNAL   J Biol Chem 275 (22), 16473-16477 (2000)
   PUBMED   10747860
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_181090.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF249673.1, AF173682.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-309               JAXUCZ010000007.1  129742311-129742619 c
            310-504             JAXUCZ010000007.1  129741535-129741729 c
            505-586             JAXUCZ010000007.1  129741061-129741142 c
            587-702             JAXUCZ010000007.1  129740800-129740915 c
            703-776             JAXUCZ010000007.1  129738333-129738406 c
            777-869             JAXUCZ010000007.1  129738119-129738211 c
            870-951             JAXUCZ010000007.1  129737917-129737998 c
            952-1034            JAXUCZ010000007.1  129736594-129736676 c
            1035-1093           JAXUCZ010000007.1  129736325-129736383 c
            1094-1255           JAXUCZ010000007.1  129736070-129736231 c
            1256-1335           JAXUCZ010000007.1  129735588-129735667 c
            1336-1436           JAXUCZ010000007.1  129735386-129735486 c
            1437-1561           JAXUCZ010000007.1  129734754-129734878 c
            1562-1706           JAXUCZ010000007.1  129734368-129734512 c
            1707-1804           JAXUCZ010000007.1  129734164-129734261 c
            1805-4612           JAXUCZ010000007.1  129730450-129733257 c
FEATURES             Location/Qualifiers
     source          1..4612
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q35"
     gene            1..4612
                     /gene="Slc38a2"
                     /gene_synonym="Ata2; Atrc2; Sat2; Snat2"
                     /note="solute carrier family 38, member 2"
                     /db_xref="GeneID:29642"
                     /db_xref="RGD:69420"
     exon            1..309
                     /gene="Slc38a2"
                     /gene_synonym="Ata2; Atrc2; Sat2; Snat2"
                     /inference="alignment:Splign:2.1.0"
     exon            310..504
                     /gene="Slc38a2"
                     /gene_synonym="Ata2; Atrc2; Sat2; Snat2"
                     /inference="alignment:Splign:2.1.0"
     CDS             389..1903
                     /gene="Slc38a2"
                     /gene_synonym="Ata2; Atrc2; Sat2; Snat2"
                     /note="amino acid transporter, cationic 2 (low affinity);
                     sodium-coupled neutral amino acid transporter 2; system A
                     transporter 1; amino acid transporter A2; system A amino
                     acid transporter 2; system N amino acid transporter 2;
                     amino acid transporter system A2; amino acid transporter
                     cationic 2"
                     /codon_start=1
                     /product="sodium-coupled neutral amino acid symporter 2"
                     /protein_id="NP_851604.2"
                     /db_xref="GeneID:29642"
                     /db_xref="RGD:69420"
                     /translation="MKKTEMGRFNISPDEDSSSYSSNGDFNYSYPTKQAALKSHYVDV
                     DPENQNFLLESNLGKKKYETDFHPGTTSFGMSVFNLSNAIVGSGILGLSYAMANTGIA
                     LFIILLTFVSIFSLYSVHLLLKTANEGGSLLYEQLGHKAYGLAGKLAASGSITMQNIG
                     AMSSYLFIVKYELPLVIKALMNIEDTNGLWYLNGDYLVLLVSFVLILPLSLLRNLGYL
                     GYTSGLSLLCMIFFLIVVICKKFQIPCPVEVALMANETVNGTFTQVALAALASNSTAA
                     DTCRPRYFIFNSQTVYAVPILTFSFVCHPAVLPIYEELKSRSRRRMMNVSKISFFAMF
                     LMYLLAALFGYLTFYEHVESELLHTYSAIVGTDILLLVVRLAVLVAVTLTVPVVIFPI
                     RSSVTHLLCPTKEFSWFRHSVITVTILAFTNLLVIFVPTIRDIFGFIGASAAAMLIFI
                     LPSAFYIKLVKKEPMRSVQKIGALCFLLSGVVVMIGSMGLIVLDWVHDASAGGH"
     exon            505..586
                     /gene="Slc38a2"
                     /gene_synonym="Ata2; Atrc2; Sat2; Snat2"
                     /inference="alignment:Splign:2.1.0"
     exon            587..702
                     /gene="Slc38a2"
                     /gene_synonym="Ata2; Atrc2; Sat2; Snat2"
                     /inference="alignment:Splign:2.1.0"
     exon            703..776
                     /gene="Slc38a2"
                     /gene_synonym="Ata2; Atrc2; Sat2; Snat2"
                     /inference="alignment:Splign:2.1.0"
     exon            777..869
                     /gene="Slc38a2"
                     /gene_synonym="Ata2; Atrc2; Sat2; Snat2"
                     /inference="alignment:Splign:2.1.0"
     exon            870..951
                     /gene="Slc38a2"
                     /gene_synonym="Ata2; Atrc2; Sat2; Snat2"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1034
                     /gene="Slc38a2"
                     /gene_synonym="Ata2; Atrc2; Sat2; Snat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1093
                     /gene="Slc38a2"
                     /gene_synonym="Ata2; Atrc2; Sat2; Snat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1255
                     /gene="Slc38a2"
                     /gene_synonym="Ata2; Atrc2; Sat2; Snat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1335
                     /gene="Slc38a2"
                     /gene_synonym="Ata2; Atrc2; Sat2; Snat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1436
                     /gene="Slc38a2"
                     /gene_synonym="Ata2; Atrc2; Sat2; Snat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1561
                     /gene="Slc38a2"
                     /gene_synonym="Ata2; Atrc2; Sat2; Snat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1706
                     /gene="Slc38a2"
                     /gene_synonym="Ata2; Atrc2; Sat2; Snat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1804
                     /gene="Slc38a2"
                     /gene_synonym="Ata2; Atrc2; Sat2; Snat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..4612
                     /gene="Slc38a2"
                     /gene_synonym="Ata2; Atrc2; Sat2; Snat2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgccacgc cgtcgcccgc gccaccaccc cttagtctct gctggaggat cgtgaccgcc
       61 attccccgct ttttttttct ttttataatc tcttgaataa ttaaatctaa gaaagaaaaa
      121 aatccatctc ttgtgcctgt tggattgcgg ggattttctt ttttttttaa tttaaaaaag
      181 aaaggaaaaa aagggggggg ggactccgac cacacttatt tttgcctcgt tttacaattc
      241 tggtgtgacc gagacagccc gcgggagacg ctgccgtgag gtgggccagc tcgcaggaag
      301 agcaccgagg cagcctcgag ggccagtgcg ccgccaagga caaaaggaag ctcgcgccgc
      361 gcgctgaaca ccgttcctcc ggatcagcat gaagaagacc gaaatgggaa ggttcaacat
      421 ctccccggat gaggacagca gcagttacag ctccaacggt gacttcaact actcataccc
      481 cacgaagcag gctgctctaa aaagccatta tgtggacgtg gaccccgaaa accagaactt
      541 tttacttgaa tcgaatctgg ggaagaagaa gtacgaaaca gactttcatc caggtactac
      601 ttcctttgga atgtcagtat ttaatctgag caatgcgatt gtgggcagtg gaatccttgg
      661 gctttcttat gccatggcta atactggaat tgctcttttt ataattctct tgacgttcgt
      721 gtcgattttt tctctgtact ccgttcacct cctcctcaag actgccaacg aaggagggtc
      781 tttattatac gaacagttgg gacataaggc atacggtctg gctgggaagc tggcagcctc
      841 cggatcgatt acaatgcaga acatcggagc tatgtcaagc tacctcttca tagtgaaata
      901 tgagttacct ttggtgatca aggcgttaat gaacattgaa gatacgaatg ggctgtggta
      961 tctgaacggc gactatctgg tccttctggt gtccttcgtg ctcattctcc cattgtcact
     1021 gctgagaaat ctaggatact tggggtatac cagcggcctt tctctgctct gtatgatatt
     1081 ctttctgatt gtggtgattt gcaagaagtt tcagattcct tgccctgtgg aagtggcttt
     1141 gatggctaac gaaacggtga atggcacctt tacccaggtg gctttggcag cgctggcgtc
     1201 caacagcacc gcagccgata cctgcaggcc ccgttacttt atcttcaact cacagactgt
     1261 gtatgctgtg cccatcctga cgttttcctt tgtctgccat cccgctgtcc ttcccatcta
     1321 tgaagagctg aagagccgca gccggagaag gatgatgaac gtgtccaaga tttctttctt
     1381 cgccatgttt ctgatgtatt tgcttgccgc cctcttcgga tacctgacat tttacgagca
     1441 cgtggagtca gaactgctac atacctactc tgcgatcgtg ggaactgaca ttctcctcct
     1501 cgttgtccgc ctggctgtgc tggtggctgt caccctcact gtccccgtcg tcattttccc
     1561 aatccggagt tcggtcactc acttactgtg ccctacaaaa gagttcagtt ggttccggca
     1621 cagtgtcatt actgtgacga tcctggcctt caccaatttg ctcgtcatct ttgtccccac
     1681 tatcagggac atcttcgggt tcattggtgc atcggccgct gcaatgctga tcttcatcct
     1741 tccgtctgct ttctacatca agttagtgaa gaaagaaccc atgagatccg tgcaaaagat
     1801 tggggctctg tgttttctcc tgagtggcgt agtcgtgatg attggaagca tgggcttgat
     1861 tgtcctggac tgggtccacg atgcctctgc aggcggacat taaccgcccc actcaaactg
     1921 aacggtccat ctgcctgccg cgttgggtcc actcaactcg ctcagacttc acccgatgct
     1981 ttcgggtcac ttccttctga agtgcagcct cctcgctggt tcttctggat gcagaataag
     2041 tgaacttttc tttctctttg gttttttttt taaaagaagc ttatctgtgt gttagggaat
     2101 ggatattaac accaaaaacc acgagccttg ggttaaggga agtgacagtt tattccattc
     2161 cagagaatgg acggactttt atcaaagcca catgtctggc tgtctcattg tttaacttgg
     2221 atattttatg attttacttg aatgtgccta acggaaccat tcgatgtgag aaacacttct
     2281 taatttacag caaagtattg aaataagcat tgagaaaaac acttattttt tgtaccaaaa
     2341 aaaatacttt aaaagacctc agaagcacta ttttactttg aagaaattgc attttttgaa
     2401 ctttatccag aaccagttgt caataaactc cgtaaaacaa tttcattgat atttaaaaat
     2461 gaatattagt attatgaaat tatttgcctt ttttataggc attataagcc aaatactttt
     2521 ttaccccaaa atcattttcg ggaaaatgtt acgcaaagtt gcaccatgag ttagcatggt
     2581 tttgttttgc tcatttcaga ttcatttgaa ggataattgg taattgctgc accaaatccg
     2641 gtgagcctcc ctccgttcat cgctgtcttt gccttcagat aattggttca ttaaaactaa
     2701 aatgtttgtg tcttcaatta ggctgggaaa cactgtagga aatgaaataa ctgattttga
     2761 ggtaccaaat agtgcaattg ggtaaaacag ggtttattca gttgcgtctg tccccagagt
     2821 tctactgtca actctgggtc gtgcttttgg gcccatcctt taaaacatcg cttccaaaag
     2881 tgaaaatggg cgtttgatgg cccgcaggcc aaagctgtcc aatagaaagc agtagaactt
     2941 tcaaacgctc gcctactgga agcgtgattt acttgacaac acgcggctca gttgtgttcc
     3001 tgctgtgtct acagtagagg tctagacggc aggctgcacc gtgctgtaca ctgcaagctc
     3061 tcttcagaaa ggtcactggg tttctcatgc agtaagcttt ctaagaactc gcactggatc
     3121 gtcatctcat tgtacgatgc agaattgctt gtttacatgg aacgagtgat cagttaggga
     3181 agcagtacga gcgattgtac ccagttctgg tccagctgca tgcttagctt tccacttcag
     3241 ctccagttac aagtggaagc atttctttga ggcttggctt taagagcaca tttactgtat
     3301 gttaacggtg tatggtgaat atattattaa ataatgtggt acttgcccat caggcataat
     3361 gtctaagatc taatatacat aattccatta agcggtggag ggaagcaagt ggaatcgtca
     3421 tctggctcct gaggtttttc tcttgaacta aacttttttt tttggttcga ggcaagggcc
     3481 agaacaaatg tgacacacat ggtttttgtt acagtcttgt attgtatatg tgactaaatt
     3541 cataggcaag atgtgtctgc tactaaagac ccttgcagac gggaagacgt ctggtagtgc
     3601 tacgttgggt acaaccaatg gtcagttctg tcccgaagat gaaattgctg gggatcatgt
     3661 agacgcaaag gcagtgagaa gaagacactc caccctgctg cttttcagtc cttcaagtcc
     3721 agaacctcac ctttagtcaa aagacttggc acttctgctc gaagtcctaa aaagagtcgc
     3781 cgctaaggtc tgccagggga gctgaggaac aggcatccaa gaaaaggtgc catggcaacc
     3841 aggatcctcc tcacagccga tcagtgtgga gagagcacaa ctgaaggttc acaatgaatt
     3901 tcaggccaaa ttccaacgct tggggctctg tcagccttga ggttcctaaa ccgagttctc
     3961 agtcttgagc agtcttcagt attaaaacca ctgtcccgtc acctcggttt gcattactgt
     4021 cttccacgga acgtttcaat aactgtactg ttatttatag agcagcatta atccattaaa
     4081 gctaacctat ttttcaatat ttatggtaaa ctgtacatac attgtccata tgtatttgta
     4141 aataagctgt atatactgtt ggaattgggt cttgggttca agtgtatata ttccccctaa
     4201 attttcttaa ctgcattttg atgaattcac attatatata ggtccccgga ttacttgtac
     4261 agaggattca atattgacat tgtgtataat actaaaattg aaaataactt gtttaaattg
     4321 tatttgcaat aaactggttg gtcatcaaca caagttcaga tatcaaacta aaagctttaa
     4381 atgaggtgtc taaattttca aaatgcagta ggtacaacac ggctatctgg taacttgtca
     4441 tgtgatttca atggaagtca cgtggactcc ttgtatgtat atagtgtaaa tgcccccgct
     4501 gtactgtaga ggctgacagg ccactgtggc ttgttggcag ggagtgctat gccagtttca
     4561 atgaaacaat gtatgtttgt tttaactgaa ctaaaataaa cacttaatcc tg
//
