LOCUS       NM_138832               2121 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Rattus norvegicus solute carrier family 38, member 1 (Slc38a1),
            mRNA.
ACCESSION   NM_138832
VERSION     NM_138832.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2121)
  AUTHORS   Nusken,E., Gellhaus,A., Kuhnel,E., Swoboda,I., Wohlfarth,M.,
            Vohlen,C., Schneider,H., Dotsch,J. and Nusken,K.D.
  TITLE     Increased Rat Placental Fatty Acid, but Decreased Amino Acid and
            Glucose Transporters Potentially Modify Intrauterine Programming
  JOURNAL   J Cell Biochem 117 (7), 1594-1603 (2016)
   PUBMED   26590355
  REMARK    GeneRIF: Increased Rat Placental Fatty Acid, but Decreased Amino
            Acid and Glucose Transporters Potentially Modify Intrauterine
            Programming
REFERENCE   2  (bases 1 to 2121)
  AUTHORS   Takarada,T., Ogura,M., Nakamichi,N., Kakuda,T., Nakazato,R.,
            Kokubo,H., Ikeno,S., Nakamura,S., Kutsukake,T., Hinoi,E. and
            Yoneda,Y.
  TITLE     Upregulation of Slc38a1 Gene Along with Promotion of Neurosphere
            Growth and Subsequent Neuronal Specification in Undifferentiated
            Neural Progenitor Cells Exposed to Theanine
  JOURNAL   Neurochem Res 41 (1-2), 5-15 (2016)
   PUBMED   25957749
  REMARK    GeneRIF: Overexpression of X-box binding protein-1 led to a marked
            increase in luciferase activity in P19 cells transfected with the
            Slc38a1 reporter plasmid. These results suggest that theanine
            accelerates cellular proliferation and subsequent neuronal
            specification through a mechanism relevant to upregulation of
            Slc38a1 gene in undifferentiated neural progenitor cells
REFERENCE   3  (bases 1 to 2121)
  AUTHORS   Park,Y.Y., Sohn,B.H., Johnson,R.L., Kang,M.H., Kim,S.B., Shim,J.J.,
            Mangala,L.S., Kim,J.H., Yoo,J.E., Rodriguez-Aguayo,C., Pradeep,S.,
            Hwang,J.E., Jang,H.J., Lee,H.S., Rupaimoole,R., Lopez-Berestein,G.,
            Jeong,W., Park,I.S., Park,Y.N., Sood,A.K., Mills,G.B. and Lee,J.S.
  TITLE     Yes-associated protein 1 and transcriptional coactivator with
            PDZ-binding motif activate the mammalian target of rapamycin
            complex 1 pathway by regulating amino acid transporters in
            hepatocellular carcinoma
  JOURNAL   Hepatology 63 (1), 159-172 (2016)
   PUBMED   26389641
REFERENCE   4  (bases 1 to 2121)
  AUTHORS   Doi,T., Ueda,Y., Takaki,M. and Willmore,L.J.
  TITLE     Differential molecular regulation of glutamate in kindling
            resistant rats
  JOURNAL   Brain Res 1375, 1-6 (2011)
   PUBMED   21138736
REFERENCE   5  (bases 1 to 2121)
  AUTHORS   King,N., Lin,H. and Suleiman,M.S.
  TITLE     Oxidative stress increases SNAT1 expression and stimulates cysteine
            uptake in freshly isolated rat cardiomyocytes
  JOURNAL   Amino Acids 40 (2), 517-526 (2011)
   PUBMED   20602128
  REMARK    GeneRIF: Oxidative stress increases SNAT1 expression and stimulates
            cysteine uptake in rat cardiomyocytes.
REFERENCE   6  (bases 1 to 2121)
  AUTHORS   Mackenzie,B., Schafer,M.K., Erickson,J.D., Hediger,M.A., Weihe,E.
            and Varoqui,H.
  TITLE     Functional properties and cellular distribution of the system A
            glutamine transporter SNAT1 support specialized roles in central
            neurons
  JOURNAL   J Biol Chem 278 (26), 23720-23730 (2003)
   PUBMED   12684517
  REMARK    GeneRIF: distribution of SNAT1 in central nervous system neurons
            and characterization of its transport properties
REFERENCE   7  (bases 1 to 2121)
  AUTHORS   Chaudhry,F.A., Schmitz,D., Reimer,R.J., Larsson,P., Gray,A.T.,
            Nicoll,R., Kavanaugh,M. and Edwards,R.H.
  TITLE     Glutamine uptake by neurons: interaction of protons with system a
            transporters
  JOURNAL   J Neurosci 22 (1), 62-72 (2002)
   PUBMED   11756489
REFERENCE   8  (bases 1 to 2121)
  AUTHORS   Albers,A., Broer,A., Wagner,C.A., Setiawan,I., Lang,P.A.,
            Kranz,E.U., Lang,F. and Broer,S.
  TITLE     Na+ transport by the neural glutamine transporter ATA1
  JOURNAL   Pflugers Arch 443 (1), 92-101 (2001)
   PUBMED   11692272
REFERENCE   9  (bases 1 to 2121)
  AUTHORS   Gu,S., Roderick,H.L., Camacho,P. and Jiang,J.X.
  TITLE     Characterization of an N-system amino acid transporter expressed in
            retina and its involvement in glutamine transport
  JOURNAL   J Biol Chem 276 (26), 24137-24144 (2001)
   PUBMED   11325958
REFERENCE   10 (bases 1 to 2121)
  AUTHORS   Varoqui,H., Zhu,H., Yao,D., Ming,H. and Erickson,J.D.
  TITLE     Cloning and functional identification of a neuronal glutamine
            transporter
  JOURNAL   J Biol Chem 275 (6), 4049-4054 (2000)
   PUBMED   10660562
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF075704.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF075704.1, BC097283.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2121
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q35"
     gene            1..2121
                     /gene="Slc38a1"
                     /gene_synonym="Ata1; GlnT; Sat1; Snat1"
                     /note="solute carrier family 38, member 1"
                     /db_xref="GeneID:170567"
                     /db_xref="RGD:69645"
     exon            1..139
                     /gene="Slc38a1"
                     /gene_synonym="Ata1; GlnT; Sat1; Snat1"
                     /inference="alignment:Splign:2.1.0"
     exon            140..355
                     /gene="Slc38a1"
                     /gene_synonym="Ata1; GlnT; Sat1; Snat1"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..1691
                     /gene="Slc38a1"
                     /gene_synonym="Ata1; GlnT; Sat1; Snat1"
                     /note="contains 11 putative transmembrane domains;
                     sodium-coupled neutral amino acid transporter 1; rATA1;
                     glutamine transporter; system A transporter 2; amino acid
                     transporter A1; N-system amino acid transporter 2; system
                     A amino acid transporter 1; system N amino acid
                     transporter 1; amino acid transporter system A1"
                     /codon_start=1
                     /product="sodium-coupled neutral amino acid symporter 1"
                     /protein_id="NP_620187.1"
                     /db_xref="GeneID:170567"
                     /db_xref="RGD:69645"
                     /translation="MMHFKSGLELTELQNMTVPEDDNVSNDSNDFTEVENGQINSKFI
                     SDRESRRSLTNSHLEKRKCDEYIPGTTSLGMSVFNLSNAIMGSGILGLAFALANTGIL
                     LFLILLTSVTLLSIYSINLLLICSKETGCMVYEKLGEQVFGTTGKLVIFGATSLQNTG
                     AMLSYLFIVKNELPSAIKSLMGEEETFSAWYVDGRVLVVMVTFGIILPLCLLKNLGYL
                     GYTSGFSLSCMVFFLIVVIYKKFQIPCMNGEQNSTVSANVTDACTPKYVTFNSKTVYA
                     LPTIAFAFVCHPSVLPIYSELKDRSQKKMQMVSNISFFAMFVMYFLTAIFGYLTFYEK
                     VQSDLLHKYQSTGDILILTVRLAVIVAVILTVPVLFFTVRSSLFELAKKTKFHLCRHV
                     LVTIILLVIINLLVIFIPSMKDIFGVVGVTSANMLIFILPSSLYLKITNQDGDKNTQR
                     IWAALFLALGVLFSLISIPLVIYDWACSSSNGEGH"
     exon            356..431
                     /gene="Slc38a1"
                     /gene_synonym="Ata1; GlnT; Sat1; Snat1"
                     /inference="alignment:Splign:2.1.0"
     exon            432..547
                     /gene="Slc38a1"
                     /gene_synonym="Ata1; GlnT; Sat1; Snat1"
                     /inference="alignment:Splign:2.1.0"
     exon            548..621
                     /gene="Slc38a1"
                     /gene_synonym="Ata1; GlnT; Sat1; Snat1"
                     /inference="alignment:Splign:2.1.0"
     exon            622..714
                     /gene="Slc38a1"
                     /gene_synonym="Ata1; GlnT; Sat1; Snat1"
                     /inference="alignment:Splign:2.1.0"
     exon            715..796
                     /gene="Slc38a1"
                     /gene_synonym="Ata1; GlnT; Sat1; Snat1"
                     /inference="alignment:Splign:2.1.0"
     exon            797..879
                     /gene="Slc38a1"
                     /gene_synonym="Ata1; GlnT; Sat1; Snat1"
                     /inference="alignment:Splign:2.1.0"
     exon            880..938
                     /gene="Slc38a1"
                     /gene_synonym="Ata1; GlnT; Sat1; Snat1"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1049
                     /gene="Slc38a1"
                     /gene_synonym="Ata1; GlnT; Sat1; Snat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1129
                     /gene="Slc38a1"
                     /gene_synonym="Ata1; GlnT; Sat1; Snat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1230
                     /gene="Slc38a1"
                     /gene_synonym="Ata1; GlnT; Sat1; Snat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1349
                     /gene="Slc38a1"
                     /gene_synonym="Ata1; GlnT; Sat1; Snat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1491
                     /gene="Slc38a1"
                     /gene_synonym="Ata1; GlnT; Sat1; Snat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1589
                     /gene="Slc38a1"
                     /gene_synonym="Ata1; GlnT; Sat1; Snat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..2121
                     /gene="Slc38a1"
                     /gene_synonym="Ata1; GlnT; Sat1; Snat1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggatcctc cccgcccagt cttacagacc aggggccacc tttccctagg cagaccttga
       61 caccaagagg acatctaact gccggggacg gcctggaagg gcggacactt tggcggcgcc
      121 tttcccttta tttctcgagg ggtctcgggc atctctattc actgctgtct gctactcaag
      181 gtcctcagaa cagaagacat tcggattgat ttcttgacta cagacaccca aatatgatgc
      241 atttcaaaag tggcctcgag ttaacggagc tgcagaacat gacggtgccc gaggatgaca
      301 atgtcagcaa cgactctaat gacttcacgg aagtggagaa cggccagata aatagcaagt
      361 tcatctctga tcgggagagt aggaggagtc tcacgaacag ccatctggag aaaaggaaat
      421 gcgacgagta tattccagga acaacctctc tgggaatgtc tgtctttaac ctgagcaacg
      481 ccatcatggg cagtgggatc ttgggcctcg ccttcgcctt ggccaacacg gggatcctcc
      541 tgtttctgat acttctgact tcggtgacgt tactgtctat atactcaata aacctactac
      601 tgatctgctc caaggaaacc ggctgcatgg tctacgaaaa gctgggagag caagtcttcg
      661 gcaccacggg gaagctggtg atcttcggag ccacctctct gcagaacact ggcgcgatgc
      721 tgagctacct cttcatagtg aaaaatgaac ttccttcagc cataaaatcc ctcatgggag
      781 aggaggagac attttcagcc tggtacgtcg atggccgagt gttggtggtg atggtaacct
      841 ttggcataat tctcccgctg tgtctcttga agaacctggg gtatcttggc tacactagtg
      901 gattttcctt gagctgcatg gtttttttcc tgatagtggt catctacaag aaatttcaga
      961 ttccttgcat gaatggggaa cagaactcaa cagtaagtgc taacgtgact gacgcgtgca
     1021 caccaaagta tgtcaccttc aactcaaaga cggtgtacgc tttaccaacc atcgcgtttg
     1081 cgtttgtctg ccacccgtct gtcctgccaa tctacagcga gctcaaagat cggtcacaga
     1141 aaaaaatgca gatggtttcc aacatctcct tctttgctat gtttgtcatg tacttcctga
     1201 ccgccatctt tgggtacctg accttttatg aaaaggtgca gtcagacctc cttcacaagt
     1261 accagagcac aggcgacatt ctcatcctga ctgtgcgact ggccgtcatt gtggccgtca
     1321 tcctcacggt gcccgtactg ttcttcacag tccggtcctc gttgtttgag ctggccaaga
     1381 agacgaagtt ccacctgtgt cgccatgtcc tggtgaccat catactcctt gtgattatca
     1441 acctgttggt gatcttcatc ccatccatga aggatatatt tggagtcgta ggggtgacgt
     1501 ctgctaacat gctcattttc atccttcctt cgtcccttta tttaaaaatc acgaaccagg
     1561 atggagacaa gaatactcaa aggatttggg cggccctttt cttggccctg ggggtgttgt
     1621 tctccttgat cagcatcccc ctagtcatct acgactgggc ttgctcctcc agcaatggtg
     1681 aaggccactg aaaccagcag cgaccaaccc agcacctgct cacacccatc cagtccccat
     1741 cagcagtcct cctactcttc ttttgcaagt ttacagagac agaaacgcac agagctcctc
     1801 ttgggttgcg acacagagac tcactcctag aagactcatg ccctctcggg accgccgctt
     1861 aggaaccttg gattcccacc tctctggatt tcgtgcagcc gtcttgtcca gcccttccca
     1921 cagttctcct tccctctcct cactgatgtg gcttctctct ctcagaactt cggaaacatg
     1981 atcaacagtc gtcttcacct gttagatacc cagctcctga agtcgttttc ctactgacgc
     2041 tccgcccacg ctatctggat ctttttagaa gagaaaataa tcttgaattg tatatattta
     2101 ttttgcttta tggaaaaaaa a
//
