LOCUS       NM_130415               1808 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 36 member 1 (Slc36a1),
            mRNA.
ACCESSION   NM_130415
VERSION     NM_130415.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1808)
  AUTHORS   Jensen,A., Figueiredo-Larsen,M., Holm,R., Broberg,M.L., Brodin,B.
            and Nielsen,C.U.
  TITLE     PAT1 (SLC36A1) shows nuclear localization and affects growth of
            smooth muscle cells from rats
  JOURNAL   Am J Physiol Endocrinol Metab 306 (1), E65-E74 (2014)
   PUBMED   24222668
  REMARK    GeneRIF: knockdown of (PAT1) led to induced cellular growth,
            suggesting a role for PAT1 in regulating cellular proliferation of
            smooth muscle cells
REFERENCE   2  (bases 1 to 1808)
  AUTHORS   Nielsen,C.U., Frolund,S., Abdulhadi,S., Sari,H., Langthaler,L.,
            Nohr,M.K., Kall,M.A., Brodin,B. and Holm,R.
  TITLE     Sertraline inhibits the transport of PAT1 substrates in vivo and in
            vitro
  JOURNAL   Br J Pharmacol 170 (5), 1041-1052 (2013)
   PUBMED   23962042
  REMARK    GeneRIF: Sertraline is an apparent non-competitive inhibitor of
            PAT1-mediated transport.
REFERENCE   3  (bases 1 to 1808)
  AUTHORS   Murakami,T. and Yoshinaga,M.
  TITLE     Induction of amino acid transporters expression by endurance
            exercise in rat skeletal muscle
  JOURNAL   Biochem Biophys Res Commun 439 (4), 449-452 (2013)
   PUBMED   24016666
  REMARK    GeneRIF: Expression of proton-assisted amino acid transporter 1
            (PAT1) mRNA was slightly but not significantly induced by a single
            bout of exercise in soleus and extensor digitorum longus muscles.
REFERENCE   4  (bases 1 to 1808)
  AUTHORS   Holm,R., Kall,M.A., Frolund,S., Nielsen,A.L., Jensen,A.,
            Broberg,M.L. and Nielsen,C.U.
  TITLE     Rectal absorption of vigabatrin, a substrate of the proton coupled
            amino acid transporter (PAT1, Slc36a1), in rats
  JOURNAL   Pharm Res 29 (4), 1134-1142 (2012)
   PUBMED   22234618
  REMARK    GeneRIF: PAT1(Slc36a1) protein was present in rat rectal
            epithelium.
REFERENCE   5  (bases 1 to 1808)
  AUTHORS   Singh,A.K., Amlal,H., Haas,P.J., Dringenberg,U., Fussell,S.,
            Barone,S.L., Engelhardt,R., Zuo,J., Seidler,U. and Soleimani,M.
  TITLE     Fructose-induced hypertension: essential role of chloride and
            fructose absorbing transporters PAT1 and Glut5
  JOURNAL   Kidney Int 74 (4), 438-447 (2008)
   PUBMED   18496516
  REMARK    GeneRIF: The essential role of chloride and fructose absorbing
            Slc36a1 is reported.
REFERENCE   6  (bases 1 to 1808)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   7  (bases 1 to 1808)
  AUTHORS   Wreden,C.C., Johnson,J., Tran,C., Seal,R.P., Copenhagen,D.R.,
            Reimer,R.J. and Edwards,R.H.
  TITLE     The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1
            localizes to the axon and plasma membrane of hippocampal neurons
  JOURNAL   J Neurosci 23 (4), 1265-1275 (2003)
   PUBMED   12598615
  REMARK    GeneRIF: The H+-coupled electrogenic lysosomal amino acid
            transporter LYAAT1 localizes to the axon and plasma membrane of
            hippocampal neurons.
REFERENCE   8  (bases 1 to 1808)
  AUTHORS   Boll,M., Foltz,M., Rubio-Aliaga,I., Kottra,G. and Daniel,H.
  TITLE     Functional characterization of two novel mammalian electrogenic
            proton-dependent amino acid cotransporters
  JOURNAL   J Biol Chem 277 (25), 22966-22973 (2002)
   PUBMED   11959859
REFERENCE   9  (bases 1 to 1808)
  AUTHORS   Sagne,C., Agulhon,C., Ravassard,P., Darmon,M., Hamon,M., El
            Mestikawy,S., Gasnier,B. and Giros,B.
  TITLE     Identification and characterization of a lysosomal transporter for
            small neutral amino acids
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7206-7211 (2001)
   PUBMED   11390972
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 26, 2020 this sequence version replaced NM_130415.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF361239.1, SRR26643298.60580.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               JAXUCZ010000010.1  39825035-39825172
            139-283             JAXUCZ010000010.1  39834920-39835064
            284-374             JAXUCZ010000010.1  39840532-39840622
            375-463             JAXUCZ010000010.1  39841077-39841165
            464-559             JAXUCZ010000010.1  39841912-39842007
            560-644             JAXUCZ010000010.1  39843592-39843676
            645-863             JAXUCZ010000010.1  39845463-39845681
            864-962             JAXUCZ010000010.1  39846870-39846968
            963-1129            JAXUCZ010000010.1  39848166-39848332
            1130-1299           JAXUCZ010000010.1  39850229-39850398
            1300-1808           JAXUCZ010000010.1  39854403-39854911
FEATURES             Location/Qualifiers
     source          1..1808
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..1808
                     /gene="Slc36a1"
                     /gene_synonym="Lyaat1"
                     /note="solute carrier family 36 member 1"
                     /db_xref="GeneID:155205"
                     /db_xref="RGD:619801"
     exon            1..138
                     /gene="Slc36a1"
                     /gene_synonym="Lyaat1"
                     /inference="alignment:Splign:2.1.0"
     exon            139..283
                     /gene="Slc36a1"
                     /gene_synonym="Lyaat1"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1571
                     /gene="Slc36a1"
                     /gene_synonym="Lyaat1"
                     /note="LYAAT-1; proton/amino acid transporter 1; neutral
                     amino acid/proton symporter; ysosomal amino acid
                     transporter 1; lysosomal amino acid transporter 1; solute
                     carrier family 36 (proton/amino acid symporter), member 1"
                     /codon_start=1
                     /product="proton-coupled amino acid transporter 1"
                     /protein_id="NP_569099.1"
                     /db_xref="GeneID:155205"
                     /db_xref="RGD:619801"
                     /translation="MSTQRLRNEDYHDYSSTDVSPEESPSEGLGSFSPGSYQRLGENS
                     SMTWFQTLIHLLKGNIGTGLLGLPLAVKNAGLLLGPLSLLVIGIVAVHCMGILVKCAH
                     HLCRRLNKPFLDYGDTVMYGLECSPSTWIRNHSHWGRRIVDFFLVVTQLGFCCVYFVF
                     LADNFKQVIEAANGTTTNCNNNETVILTPTMDSRLYMLTFLPFLVLLSFIRNLRILSI
                     FSLLANISMFVSLIMIYQFIVQRIPDPSHLPLVAPWKTYPLFFGTAIFAFEGIGVVLP
                     LENKMKDSQKFPLILYLGMAIITVLYISLGSLGYLQFGADIKGSITLNLPNCWLYQSV
                     KLLYSIGIFFTYALQFYVAAEIIIPAIVSRVPERFELVVDLSARTAMVCVTCVLAVLI
                     PRLDLVISLVGSVSSSALALIIPPLLEVTTYYGEGISPLTITKDALISILGFVGFVVG
                     TYESLWELIQPSHSDSSTNSTSAFI"
     exon            284..374
                     /gene="Slc36a1"
                     /gene_synonym="Lyaat1"
                     /inference="alignment:Splign:2.1.0"
     exon            375..463
                     /gene="Slc36a1"
                     /gene_synonym="Lyaat1"
                     /inference="alignment:Splign:2.1.0"
     exon            464..559
                     /gene="Slc36a1"
                     /gene_synonym="Lyaat1"
                     /inference="alignment:Splign:2.1.0"
     exon            560..644
                     /gene="Slc36a1"
                     /gene_synonym="Lyaat1"
                     /inference="alignment:Splign:2.1.0"
     exon            645..863
                     /gene="Slc36a1"
                     /gene_synonym="Lyaat1"
                     /inference="alignment:Splign:2.1.0"
     exon            864..962
                     /gene="Slc36a1"
                     /gene_synonym="Lyaat1"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1129
                     /gene="Slc36a1"
                     /gene_synonym="Lyaat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1299
                     /gene="Slc36a1"
                     /gene_synonym="Lyaat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1808
                     /gene="Slc36a1"
                     /gene_synonym="Lyaat1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggaagcgg ctgtccagga ggctaaaaac catggctagg ggtcggcgct gaggctgcgc
       61 gaggtgggct gagcgggagc cagagcggga gcccgagccg gagccggagc cagagcccgg
      121 gccgggccgg gccgaccgct accatgtcca cacagaggct tcggaacgaa gactatcatg
      181 actacagttc cactgacgtg agccccgagg agagcccatc tgaaggcctc gggagcttct
      241 cccccggctc ctaccagcgc ttaggagaga acagtagcat gacatggttc cagaccctga
      301 tccacctgct aaaaggcaac atcggcaccg ggctgctggg gctgcctcta gcagtgaaga
      361 atgcaggcct cttgttgggc cctctcagcc tgctggtgat tggcatcgtg gctgtgcact
      421 gcatgggcat cctggtgaag tgcgctcatc acttgtgtcg gagactgaac aaaccctttc
      481 tggactatgg ggacacggtg atgtatggac tagaatgcag ccccagcacc tggatccgga
      541 accactccca ctggggaagg cgcatcgtgg acttcttcct cgtcgtcact cagctgggtt
      601 tctgctgcgt ctactttgtg tttctggcag acaactttaa acaggtgata gaggcagcca
      661 acgggaccac caccaactgc aacaacaatg agaccgtgat cctaacgccc accatggact
      721 ctcgactcta catgctcact ttcctgccct tcctggtgct gctgtctttc atcaggaact
      781 tgcgtatctt gtccatcttc tccctgctgg ccaacatcag catgttcgtc agccttatca
      841 tgatatacca gttcattgtc cagaggatcc cagaccccag ccacctcccc ttggtggctc
      901 catggaagac ctaccctctg ttctttggca cagcgatttt tgctttcgaa ggcattggag
      961 tggtgctacc ccttgagaac aaaatgaagg actcacagaa atttccactg atcctgtatt
     1021 tggggatggc tatcatcact gtgctctaca tcagcctggg gagcctgggg tacctgcagt
     1081 ttggagctga tatcaagggc agcatcacac tcaacctgcc caactgctgg ttgtaccagt
     1141 cggtgaagct gctgtactcc ataggcatct tcttcacgta tgcgctccag ttttatgtcg
     1201 cagctgagat catcatccca gccattgtgt cccgagtgcc tgaacgtttc gagctggtgg
     1261 tggacctcag tgctcgcact gccatggtct gtgtgacatg tgttctggcc gtcctcatcc
     1321 cccgcctgga cctggtcatc tccctggtgg gctctgtgag cagcagcgcc ctggccctca
     1381 tcatcccacc cctgctggag gtgaccacct actatggaga gggcattagt cccctgacca
     1441 tcaccaagga tgccctcatc agcatcctag gcttcgtggg cttcgtggtg gggacctatg
     1501 agtctctgtg ggagctaatc cagccaagcc atagcgactc ctctaccaat tccaccagtg
     1561 ccttcatata aggatctggg tgtgctccct ttacctgccc agccctaccc tgtgtgtctc
     1621 ccagtagtgt cccacatcct taggtgtggc tcagcctctg gaaaaaggca gggttactgc
     1681 ctgggcactc ctctggcatt ggacccttgg gtaacctggg ctacatgaga cagatgaggg
     1741 gagggcaggg agcaccctcc acttgtgatg gtgcagtcac tgctcccctt tatcatgcct
     1801 cctccttc
//
