LOCUS       NM_139338               2045 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Rattus norvegicus solute carrier family 34 member 3 (Slc34a3),
            mRNA.
ACCESSION   NM_139338
VERSION     NM_139338.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2045)
  AUTHORS   Matsuzaki,H., Katsumata,S., Kajita,Y. and Miwa,M.
  TITLE     Magnesium deficiency regulates vitamin D metabolizing enzymes and
            type II sodium-phosphate cotransporter mRNA expression in rats
  JOURNAL   Magnes Res 26 (2), 83-86 (2013)
   PUBMED   23816829
  REMARK    GeneRIF: Magnesium deficiency induces downregulation of
            1alpha(OH)ase and type IIa and IIc Na/Pi cotransporters, and
            upregulation of 24(OH)ase in the kidney.
REFERENCE   2  (bases 1 to 2045)
  AUTHORS   Prie,D., Torres,P.U. and Friedlander,G.
  TITLE     Phosphate handling: new genes, new molecules
  JOURNAL   Horm Res Paediatr 76 Suppl 1, 71-75 (2011)
   PUBMED   21778753
  REMARK    Review article
REFERENCE   3  (bases 1 to 2045)
  AUTHORS   Picard,N., Capuano,P., Stange,G., Mihailova,M., Kaissling,B.,
            Murer,H., Biber,J. and Wagner,C.A.
  TITLE     Acute parathyroid hormone differentially regulates renal brush
            border membrane phosphate cotransporters
  JOURNAL   Pflugers Arch 460 (3), 677-687 (2010)
   PUBMED   20526720
  REMARK    GeneRIF: expression in renal brush border not reduced by
            parathyroid hormones
REFERENCE   4  (bases 1 to 2045)
  AUTHORS   Villa-Bellosta,R. and Sorribas,V.
  TITLE     Compensatory regulation of the sodium/phosphate cotransporters
            NaPi-IIc (SCL34A3) and Pit-2 (SLC20A2) during Pi deprivation and
            acidosis
  JOURNAL   Pflugers Arch 459 (3), 499-508 (2010)
   PUBMED   19841935
  REMARK    GeneRIF: Results describe the regulation of the sodium/phosphate
            cotransporters SCL34A3 and SLC20A2 during phosphate deprivation and
            acidosis in rat kidney.
REFERENCE   5  (bases 1 to 2045)
  AUTHORS   Breusegem,S.Y., Takahashi,H., Giral-Arnal,H., Wang,X., Jiang,T.,
            Verlander,J.W., Wilson,P., Miyazaki-Anzai,S., Sutherland,E.,
            Caldas,Y., Blaine,J.T., Segawa,H., Miyamoto,K., Barry,N.P. and
            Levi,M.
  TITLE     Differential regulation of the renal sodium-phosphate
            cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium
            deficiency
  JOURNAL   Am J Physiol Renal Physiol 297 (2), F350-F361 (2009)
   PUBMED   19493963
  REMARK    GeneRIF: Differential regulation of the renal sodium-phosphate
            cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium
            deficiency.
REFERENCE   6  (bases 1 to 2045)
  AUTHORS   Segawa,H., Yamanaka,S., Onitsuka,A., Tomoe,Y., Kuwahata,M., Ito,M.,
            Taketani,Y. and Miyamoto,K.
  TITLE     Parathyroid hormone-dependent endocytosis of renal type IIc Na-Pi
            cotransporter
  JOURNAL   Am J Physiol Renal Physiol 292 (1), F395-F403 (2007)
   PUBMED   16985216
  REMARK    Erratum:[Am J Physiol Renal Physiol. 2017 May 1;312(5):F849-F851.
            doi: 10.1152/ajprenal.zh2-8174-corr.2017.. PMID: 28428336]
REFERENCE   7  (bases 1 to 2045)
  AUTHORS   Bergwitz,C., Roslin,N.M., Tieder,M., Loredo-Osti,J.C., Bastepe,M.,
            Abu-Zahra,H., Frappier,D., Burkett,K., Carpenter,T.O., Anderson,D.,
            Garabedian,M., Sermet,I., Fujiwara,T.M., Morgan,K., Tenenhouse,H.S.
            and Juppner,H.
  TITLE     SLC34A3 mutations in patients with hereditary hypophosphatemic
            rickets with hypercalciuria predict a key role for the
            sodium-phosphate cotransporter NaPi-IIc in maintaining phosphate
            homeostasis
  JOURNAL   Am J Hum Genet 78 (2), 179-192 (2006)
   PUBMED   16358214
REFERENCE   8  (bases 1 to 2045)
  AUTHORS   Segawa,H., Kawakami,E., Kaneko,I., Kuwahata,M., Ito,M., Kusano,K.,
            Saito,H., Fukushima,N. and Miyamoto,K.
  TITLE     Effect of hydrolysis-resistant FGF23-R179Q on dietary phosphate
            regulation of the renal type-II Na/Pi transporter
  JOURNAL   Pflugers Arch 446 (5), 585-592 (2003)
   PUBMED   12851820
REFERENCE   9  (bases 1 to 2045)
  AUTHORS   Ohkido,I., Segawa,H., Yanagida,R., Nakamura,M. and Miyamoto,K.
  TITLE     Cloning, gene structure and dietary regulation of the type-IIc
            Na/Pi cotransporter in the mouse kidney
  JOURNAL   Pflugers Arch 446 (1), 106-115 (2003)
   PUBMED   12690469
REFERENCE   10 (bases 1 to 2045)
  AUTHORS   Segawa,H., Kaneko,I., Takahashi,A., Kuwahata,M., Ito,M., Ohkido,I.,
            Tatsumi,S. and Miyamoto,K.
  TITLE     Growth-related renal type II Na/Pi cotransporter
  JOURNAL   J Biol Chem 277 (22), 19665-19672 (2002)
   PUBMED   11880379
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Mar 21, 2021 this sequence version replaced NM_139338.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB077042.1, SRR26643287.7294.1
                                           [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN12840124,
                                           SAMN16418986 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                JAXUCZ010000003.1  28447954-28447997   c
            45-168              JAXUCZ010000003.1  28447093-28447216   c
            169-255             JAXUCZ010000003.1  28446749-28446835   c
            256-384             JAXUCZ010000003.1  28446020-28446148   c
            385-528             JAXUCZ010000003.1  28445795-28445938   c
            529-640             JAXUCZ010000003.1  28445609-28445720   c
            641-836             JAXUCZ010000003.1  28445326-28445521   c
            837-926             JAXUCZ010000003.1  28445085-28445174   c
            927-1014            JAXUCZ010000003.1  28444884-28444971   c
            1015-1182           JAXUCZ010000003.1  28444637-28444804   c
            1183-1299           JAXUCZ010000003.1  28444308-28444424   c
            1300-1424           JAXUCZ010000003.1  28444108-28444232   c
            1425-2045           JAXUCZ010000003.1  28442457-28443077   c
FEATURES             Location/Qualifiers
     source          1..2045
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..2045
                     /gene="Slc34a3"
                     /note="solute carrier family 34 member 3"
                     /db_xref="GeneID:246234"
                     /db_xref="RGD:708551"
     exon            1..44
                     /gene="Slc34a3"
                     /inference="alignment:Splign:2.1.0"
     exon            45..168
                     /gene="Slc34a3"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1889
                     /gene="Slc34a3"
                     /note="naPi-2c; sodium/phosphate cotransporter 2C;
                     sodium-phosphate transport protein 2C; solute carrier
                     family 34 (type II sodium/phosphate cotransporter), member
                     3; Na(+)/Pi cotransporter 2C; Na(+)-dependent phosphate
                     cotransporter 2C; Na+/Pi-cotransporter type IIc; solute
                     carrier family 34 (sodium phosphate), member 3; solute
                     carrier family 34 (type II sodium/phosphate
                     contransporter), member 3"
                     /codon_start=1
                     /product="sodium-dependent phosphate transport protein 2C"
                     /protein_id="NP_647554.2"
                     /db_xref="GeneID:246234"
                     /db_xref="RGD:708551"
                     /translation="MPNSLAGDQVPNPTLDAIGLVDWSLRNAGTSGSTPGLEEGGTDP
                     WTFSQLKNTDQLKEVGTASKLHQVVSGFLKACGLLGSLYFFICSLDILSSAFQLLGSK
                     MAGDIFKDNVVLSNPVAGLVIGVVVTVLVQSSSTSSSIVVSMVASKLLTVQASVPIIM
                     GVNVGTSITSTLVSMAQSGDRDEFQRAFGGSAVHGIFNWLTVLVLLPLENATAALERL
                     SELALGAASLQPGGQAPDILKALTRPFTHLIIQLDSSVVTSSITSNTTNSSLIKHWCG
                     FRGETPQGSSEECDLSGSCTERNSSASPGEDRLLCHHLFAGSELTDLAVGFILLAGSL
                     LVLCVCLVLIVKLLNSVLRGRIAQAVKTVINADFPFPFGWLSGYLAILVGAGLTFLLQ
                     SSSVFTAAIVPLMGVGVINLERAYPLFLGSNIGTTTTALLAALASPADTLLFAVQVAL
                     IHFFFNLAGILLWYLVPVLRLPIPLAKRFGDLTAQYRWVAIVYLLLTFLLLPLAAFGL
                     SLAGGSVLAAVGGPLVGLVLLIILVNVLQRHRPSWLPRRLQSWAWLPLWLHSLEPWDR
                     LVTGCCPFKAYSNSHMTSKVAHCYENPQVIASQQL"
     exon            169..255
                     /gene="Slc34a3"
                     /inference="alignment:Splign:2.1.0"
     exon            256..384
                     /gene="Slc34a3"
                     /inference="alignment:Splign:2.1.0"
     exon            385..528
                     /gene="Slc34a3"
                     /inference="alignment:Splign:2.1.0"
     exon            529..640
                     /gene="Slc34a3"
                     /inference="alignment:Splign:2.1.0"
     exon            641..836
                     /gene="Slc34a3"
                     /inference="alignment:Splign:2.1.0"
     exon            837..926
                     /gene="Slc34a3"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1014
                     /gene="Slc34a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1182
                     /gene="Slc34a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1299
                     /gene="Slc34a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1424
                     /gene="Slc34a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..2045
                     /gene="Slc34a3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctgggcct cctccccgct ggtgccccct caccacacat gcagatctag gattgggcct
       61 gggtcttcca cttcttgaaa tccatgccga attcccttgc tggcgaccag gtccccaacc
      121 ctactctgga tgcaattggc ctggtggact ggagtctgag aaatgcaggg acctctggtt
      181 ccaccccagg cttagaggag ggaggcacag acccctggac cttctctcag ctgaagaata
      241 ctgaccaact caaagaggtt ggcacagcca gcaagctgca ccaggtggtc agcggcttcc
      301 tcaaggcatg cggactcctg ggaagcctct actttttcat ctgctccctg gacatcctca
      361 gctctgcgtt ccagctacta ggcagcaaga tggccggaga catttttaag gacaatgtgg
      421 tgctgtccaa ccctgtggct ggcttggtca ttggtgtggt ggtcaccgtc cttgtacaga
      481 gctccagcac atcttcctct atcgtggtca gcatggtggc ctctaagttg ctgactgtcc
      541 aagcgtctgt ccctatcatc atgggcgtca acgtgggcac ttccatcacc agcactctgg
      601 tctcgatggc acagtcaggg gatcgggatg aatttcagag ggccttcggc ggctcggccg
      661 tgcacggcat cttcaactgg ctcacagtgt tggtactgct gccactggag aatgccactg
      721 cggcactaga gagactgagt gagctggccc tgggtgctgc tagcctgcag ccaggggggc
      781 aggcccccga catcctcaag gcactgactc gacctttcac acacctcatc atccagctgg
      841 atagcagtgt ggttaccagc agcattacca gcaacaccac taacagcagc ctgattaagc
      901 actggtgtgg cttcaggggg gagacgcccc agggaagcag tgaggaatgc gacctctcgg
      961 gctcttgcac agagaggaac agctcagcat ctccaggaga ggacagactg ctctgccatc
     1021 acctgtttgc aggctcagag ctcacagacc tggctgtggg cttcatcctg ctggcaggtt
     1081 cgctgctggt gctctgtgtc tgtctggtcc tcatcgttaa actgctcaac tctgtgctgc
     1141 ggggtcgcat tgcacaggct gtgaagaccg ttatcaatgc agattttccc ttcccctttg
     1201 gctggctcag cggctacttg gccatcctcg ttggagcagg cttaaccttc ttgcttcaga
     1261 gcagtagtgt cttcacggca gccattgtgc ctctcatggg ggttggggtg atcaacctgg
     1321 aacgggccta ccccctcttc ctgggctcca acattggcac caccaccaca gccttactgg
     1381 ctgccctggc cagccctgca gacacgttac tcttcgcagt tcaggttgct ctcatccact
     1441 tctttttcaa cctggctggc atactgctgt ggtacctggt gcctgtcttg agactgccaa
     1501 ttccattggc caagcgcttt ggggacctga ctgcacaata ccgctgggta gccattgtct
     1561 acttactact caccttcctt ctgctacccc tagcagcctt tggactttcc ctggctgggg
     1621 gttcagtgct ggctgcagtg gggggtcctc tggtggggct ggtactcctt atcatcctgg
     1681 ttaatgtcct gcaacgacac cgaccatctt ggttgcctcg ccgtcttcaa tcctgggcct
     1741 ggctgccact ttggctccat tctctggagc cctgggaccg cctggtgact ggttgttgcc
     1801 ccttcaaggc ctacagcaac tcccatatga ccagcaaagt ggctcactgc tatgagaacc
     1861 cacaagtcat agcttctcag cagttgtgag aagtgggtgc ccatcaaaac ccagttccac
     1921 tagcttcggg gcattggagg caggagaaac cactggccaa tcttccctgg ggctgagtgg
     1981 cagggctcca catggatgtt ttagtctctg catcctctcc ttttcaaata aacgaggtta
     2041 ctatt
//
