LOCUS       NM_053380               3515 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 34 member 2 (Slc34a2),
            mRNA.
ACCESSION   NM_053380 XM_346462
VERSION     NM_053380.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3515)
  AUTHORS   Pastor-Arroyo,E.M., Rodriguez,J.M.M., Pellegrini,G., Bettoni,C.,
            Levi,M., Hernando,N. and Wagner,C.A.
  TITLE     Constitutive depletion of Slc34a2/NaPi-IIb in rats causes perinatal
            mortality
  JOURNAL   Sci Rep 11 (1), 7943 (2021)
   PUBMED   33846411
  REMARK    GeneRIF: Constitutive depletion of Slc34a2/NaPi-IIb in rats causes
            perinatal mortality.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3515)
  AUTHORS   Ratcliffe,S., Jugdaohsingh,R., Vivancos,J., Marron,A., Deshmukh,R.,
            Ma,J.F., Mitani-Ueno,N., Robertson,J., Wills,J., Boekschoten,M.V.,
            Muller,M., Mawhinney,R.C., Kinrade,S.D., Isenring,P., Belanger,R.R.
            and Powell,J.J.
  TITLE     Identification of a mammalian silicon transporter
  JOURNAL   Am J Physiol Cell Physiol 312 (5), C550-C561 (2017)
   PUBMED   28179233
  REMARK    GeneRIF: This is the first evidence of an active Si transport
            protein in mammals and points towards an important role for Si in
            vertebrates and explains interactions between dietary phosphate and
            silicon.
REFERENCE   3  (bases 1 to 3515)
  AUTHORS   Giral,H., Cranston,D., Lanzano,L., Caldas,Y., Sutherland,E.,
            Rachelson,J., Dobrinskikh,E., Weinman,E.J., Doctor,R.B., Gratton,E.
            and Levi,M.
  TITLE     NHE3 regulatory factor 1 (NHERF1) modulates intestinal
            sodium-dependent phosphate transporter (NaPi-2b) expression in
            apical microvilli
  JOURNAL   J Biol Chem 287 (42), 35047-35056 (2012)
   PUBMED   22904329
  REMARK    GeneRIF: that NHERF1 associates with NaPi-2b in enterocytes and
            regulates NaPi-2b adaptation.
REFERENCE   4  (bases 1 to 3515)
  AUTHORS   Suyama,T., Okada,S., Ishijima,T., Iida,K., Abe,K. and Nakai,Y.
  TITLE     High phosphorus diet-induced changes in NaPi-IIb phosphate
            transporter expression in the rat kidney: DNA microarray analysis
  JOURNAL   PLoS One 7 (1), e29483 (2012)
   PUBMED   22235299
  REMARK    GeneRIF: NaPi-IIb is upregulated in the kidney in response to the
            active excretion of phosphate in HP diet-fed rats
REFERENCE   5  (bases 1 to 3515)
  AUTHORS   Prie,D., Torres,P.U. and Friedlander,G.
  TITLE     Phosphate handling: new genes, new molecules
  JOURNAL   Horm Res Paediatr 76 Suppl 1, 71-75 (2011)
   PUBMED   21778753
  REMARK    Review article
REFERENCE   6  (bases 1 to 3515)
  AUTHORS   Miyoshi,K., Shillingford,J.M., Smith,G.H., Grimm,S.L., Wagner,K.U.,
            Oka,T., Rosen,J.M., Robinson,G.W. and Hennighausen,L.
  TITLE     Signal transducer and activator of transcription (Stat) 5 controls
            the proliferation and differentiation of mammary alveolar
            epithelium
  JOURNAL   J Cell Biol 155 (4), 531-542 (2001)
   PUBMED   11706048
REFERENCE   7  (bases 1 to 3515)
  AUTHORS   Hashimoto,M., Wang,D.Y., Kamo,T., Zhu,Y., Tsujiuchi,T., Konishi,Y.,
            Tanaka,M. and Sugimura,H.
  TITLE     Isolation and localization of type IIb Na/Pi cotransporter in the
            developing rat lung
  JOURNAL   Am J Pathol 157 (1), 21-27 (2000)
   PUBMED   10880371
REFERENCE   8  (bases 1 to 3515)
  AUTHORS   Xu,H., Bai,L., Collins,J.F. and Ghishan,F.K.
  TITLE     Molecular cloning, functional characterization, tissue
            distribution, and chromosomal localization of a human, small
            intestinal sodium-phosphate (Na+-Pi) transporter (SLC34A2)
  JOURNAL   Genomics 62 (2), 281-284 (1999)
   PUBMED   10610722
REFERENCE   9  (bases 1 to 3515)
  AUTHORS   Feild,J.A., Zhang,L., Brun,K.A., Brooks,D.P. and Edwards,R.M.
  TITLE     Cloning and functional characterization of a sodium-dependent
            phosphate transporter expressed in human lung and small intestine
  JOURNAL   Biochem Biophys Res Commun 258 (3), 578-582 (1999)
   PUBMED   10329428
REFERENCE   10 (bases 1 to 3515)
  AUTHORS   Hilfiker,H., Hattenhauer,O., Traebert,M., Forster,I., Murer,H. and
            Biber,J.
  TITLE     Characterization of a murine type II sodium-phosphate cotransporter
            expressed in mammalian small intestine
  JOURNAL   Proc Natl Acad Sci U S A 95 (24), 14564-14569 (1998)
   PUBMED   9826740
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC070898.1.
            
            On Jun 10, 2007 this sequence version replaced NM_053380.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070898.1, AF157026.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676785, SAMN16676786
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3515
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q11"
     gene            1..3515
                     /gene="Slc34a2"
                     /note="solute carrier family 34 member 2"
                     /db_xref="GeneID:84395"
                     /db_xref="RGD:620889"
     exon            1..28
                     /gene="Slc34a2"
                     /inference="alignment:Splign:2.1.0"
     exon            29..143
                     /gene="Slc34a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..2119
                     /gene="Slc34a2"
                     /note="naPi-2b; sodium/phosphate cotransporter 2B;
                     sodium-phosphate transport protein 2B; Na(+)/Pi
                     cotransporter 2B; Na(+)-dependent phosphate cotransporter
                     2B; rNaPi IIb; type IIb sodium-phosphate transporter;
                     solute carrier family 34 (sodium phosphate), member 2;
                     solute carrier family 34 (type II sodium/phosphate
                     contransporter), member 2; solute carrier family 34 (type
                     II sodium/phosphate cotransporter), member 2"
                     /codon_start=1
                     /product="sodium-dependent phosphate transport protein 2B"
                     /protein_id="NP_445832.1"
                     /db_xref="GeneID:84395"
                     /db_xref="RGD:620889"
                     /translation="MAPWPELENAHPNPNKFIEGASGPQSSIPDKDKGTSKTNDSGTP
                     VAKIELLPSYSALVLIEEPPEGNDPWDLPELQDNGIKWSERDSKGKILCIFQGIGKFI
                     LLLGFLYLFVCSLDVLSSAFQLVGGKMAGQFFSNNSIMSNPVAGLVIGVLVTVMVQSS
                     STSSSIIVSMVASSLLSVRAAIPIIMGANIGTSITNTIVALMQAGDRNEFRRAFAGAT
                     VHDFFNWLSVLVLLPLEAATHYLEKLTNLVLETFSFQNGEDAPDILKVITDPFTKLII
                     QLDKKVIQQIAMGDSEAQNKSLIKIWCKTISNVIEENVTVPSPDNCTSPSYCWTDGIQ
                     TWTIQNVTEKENIAKCQHIFVNFSLPDLAVGIILLTVSLLILCGCLIMIVKLLGSVLR
                     GQVATVIKKTLNTDFPFPFAWLTGYLAILVGAGMTFIVQSSSVFTSAMTPLIGIGVIS
                     IERAYPLTLGSNIGTTTTAILAALASPGNTLRSSLQIALCHFFFNISGILLWYPIPFT
                     RLPIRLAKGLGNISAKYRWFAVFYLIFFFLLTPLTVFGLSLAGWPVLVGVGVPIILLI
                     LLVLCLRMLQARCPRILPLKLRDWNFLPLWMHSLKPWDNIISLATSCFQRRCCCCCRV
                     CCRVCCMVCGCKCCRCSKCCKNLEEEEKEQDVPVKASGGFDNTAMSKECQDEGKGQVE
                     VLGMKALSNTTVF"
     exon            144..281
                     /gene="Slc34a2"
                     /inference="alignment:Splign:2.1.0"
     exon            282..410
                     /gene="Slc34a2"
                     /inference="alignment:Splign:2.1.0"
     exon            411..554
                     /gene="Slc34a2"
                     /inference="alignment:Splign:2.1.0"
     exon            555..666
                     /gene="Slc34a2"
                     /inference="alignment:Splign:2.1.0"
     exon            667..862
                     /gene="Slc34a2"
                     /inference="alignment:Splign:2.1.0"
     exon            863..958
                     /gene="Slc34a2"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1079
                     /gene="Slc34a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1247
                     /gene="Slc34a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1364
                     /gene="Slc34a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1489
                     /gene="Slc34a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..3492
                     /gene="Slc34a2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgtccctta cctgcgaagg gagcgctgac catggctcct tggcccgagt tggaaaatgc
       61 ccaccccaac cccaataaat tcatcgaagg ggcctcaggt ccacagtcta gcataccaga
      121 caaagacaag gggaccagca aaacaaatga cagcgggact cctgtagcca agattgaact
      181 tctaccctca tattccgccc tggttctcat agaggagccc cctgagggga acgacccctg
      241 ggacctgcct gaactccaag acaatgggat caaatggtca gagagagact ccaaagggaa
      301 gattctctgc attttccagg ggattgggaa attcatcctt ctcctggggt ttctctactt
      361 gtttgtgtgc tccctggatg tactcagtag tgccttccag cttgttggag gaaaaatggc
      421 cggccagttc ttcagcaaca actccattat gtctaatcct gtggctggac ttgtgatagg
      481 ggtgctggtg acagtcatgg tgcaaagctc cagcacgtcc tcgtcaatca tcgtcagcat
      541 ggttgcctcc tccttgctgt cagtccgcgc tgccatcccc atcatcatgg gtgctaacat
      601 cgggacctcc atcaccaaca cgattgtggc acttatgcag gcaggagaca gaaatgagtt
      661 cagaagggca tttgcaggag ctactgtcca tgacttcttc aactggctct ctgtgttggt
      721 gctcttacct ctggaggctg ccacccatta cctggagaaa ctgaccaacc ttgtgttgga
      781 aaccttcagc ttccagaatg gagaagatgc cccagacatt ctgaaagtca taacagaccc
      841 cttcacaaag ctcatcatcc agctggataa aaaagtcatc caacaaattg caatgggtga
      901 ctcagaagcc cagaacaaga gcctgatcaa gatctggtgt aaaactataa gcaatgtgat
      961 tgaggagaat gtcactgtcc cctcgcctga taactgcacc tctccttcat attgctggac
     1021 tgatggcata cagacctgga ccatccagaa tgtgaccgag aaggagaaca ttgctaaatg
     1081 ccagcacatc ttcgtgaatt tcagcctccc agacctcgct gtgggcatca tcctgctcac
     1141 tgtctccctg ctgatccttt gcggctgtct gatcatgatt gtcaaactgt tgggttctgt
     1201 gctcagggga caggttgcca ctgtcatcaa gaagaccctt aatactgatt tcccctttcc
     1261 ctttgcctgg ctgactggct acctggccat ccttgtgggg gcaggcatga ccttcatagt
     1321 gcaaagcagc tctgtgttca cttctgccat gacgccactc atcggtattg gggtgatcag
     1381 catcgagagg gcatatccac tcacgctggg ctccaacatt ggcaccacca cgactgccat
     1441 tctggctgcc ttggccagcc caggcaacac attgaggagt tccctccaga ttgccctgtg
     1501 ccattttttc ttcaacatct ctggaatatt gctgtggtac ccaatcccat tcacccgtct
     1561 gcccatccgt ctggctaaag gcctgggcaa catctctgcc aagtatcgct ggttcgcagt
     1621 cttctatctc atcttcttct tcctcctgac cccgctgaca gtgtttggcc tgtccctggc
     1681 tggctggcca gtgctggtgg gcgtgggtgt gcccatcatt ctgctgatcc tcctggtcct
     1741 gtgcctccgg atgctgcagg cccgctgccc tcgcatcctg cccctgaagc tccgggactg
     1801 gaatttccta cccttgtgga tgcactctct gaaaccctgg gacaacatca tctccctggc
     1861 cacctcctgc ttccagaggc gctgttgctg ctgttgccgt gtgtgctgcc gtgtctgctg
     1921 catggtgtgt ggctgcaagt gctgccgctg cagcaagtgc tgcaagaacc tggaggagga
     1981 ggaaaaggag caggacgtcc cagtcaaggc ttctgggggc tttgacaata cagctatgag
     2041 caaagaatgc caagatgagg gcaagggcca agtggaagtt ctgggcatga aggccctgtc
     2101 caacactaca gtgttctagg agcacctagg agtcaggggt gcctccctcc cataagacag
     2161 aacagagatg tagactgtga acatggccca cagatgacca catccaccca tggcctataa
     2221 tgccttcaaa gtccatcctc acccaaagac attaagaggg aggcattagg gaaggttctg
     2281 gaaagatcca atgtaaagag tatttgtaaa tatatgtaca aagcagttgt ttcttggtat
     2341 aaaacctcag ccacatctct cattttataa gtccactcct acccaataac ttctcctact
     2401 cacccctgcc ccagagcagc caagttcaaa cacactgaat gtttgtagcc cataggtgtg
     2461 agcctttcta gctcacactg cagggcatgt tctattaagg catcgtctgg tatagtcagg
     2521 ccaagcagct gaccacagtg tcctctgaag tccgtggtgc tcagcttcct aggatggagt
     2581 gaatggggtt cacgacgtgt ttggcacatt gttggttttt ctatgcctag ggctggacta
     2641 gaataggaga cattgttgct acatatttct gatggaactt gtaagacctg tgtcccaggc
     2701 cttctctcca ttgctactgc ctgggtcatc tgctggtgaa gggtctgcct atctttctct
     2761 tttgtgcaag gagactttcc gggccagctt ttcatgctct gtttcatcca ccccctcacc
     2821 ctcctgctca tgtattcatt tcaaacccat cgtcttacac agatgagctt cctacccctt
     2881 ccatgcctac aaagttccaa gggattgctt aggagggagg agatgggaaa tggctaaaat
     2941 gcccttagaa tcaagatgaa gccagtaagt agggttggga gtgtgcatgt gggagcctgt
     3001 atggcacagg atgccatagt catacgctgt gctcatgtgc agtccccatg gtggctctgc
     3061 aagcattccc atcccatccc cctccccaca agaacgggcc tcagcttgac ttgggtcagg
     3121 ctgtgtggtt ccacggccat cctcttccat catactgcat gggaagaggc tgagggccag
     3181 cccgagcccc tctgtagata aacgttcccc aagagccatt tatgcggcat aatttatagc
     3241 catgcatctg tacagaatac ttcataactt atagtaaata gtgacttgtt ttatagtgtc
     3301 tcatttggaa atgaggcagg gttcttttat gtactgtgaa cagaaagaac acctttgtat
     3361 attttgtaat actgccttta aacacaactc tcgaggtcat gctacacctc cccctgtaaa
     3421 tatgtaaggt acaccccagg aagtggcttt gccctctgtt gattactttt tttaaaaaaa
     3481 atgggatctt tgaaaaaaaa aaaaaaaaaa aaaaa
//
