LOCUS       NM_013030               2438 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus solute carrier family 34 member 1 (Slc34a1),
            mRNA.
ACCESSION   NM_013030
VERSION     NM_013030.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2438)
  AUTHORS   Clerin,V., Saito,H., Filipski,K.J., Nguyen,A.H., Garren,J.,
            Kisucka,J., Reyes,M. and Juppner,H.
  TITLE     Selective pharmacological inhibition of the sodium-dependent
            phosphate cotransporter NPT2a promotes phosphate excretion
  JOURNAL   J Clin Invest 130 (12), 6510-6522 (2020)
   PUBMED   32853180
  REMARK    GeneRIF: Selective pharmacological inhibition of the
            sodium-dependent phosphate cotransporter NPT2a promotes phosphate
            excretion.
REFERENCE   2  (bases 1 to 2438)
  AUTHORS   Zhang,Q., Xiao,K., Paredes,J.M., Mamonova,T., Sneddon,W.B., Liu,H.,
            Wang,D., Li,S., McGarvey,J.C., Uehling,D., Al-Awar,R., Joseph,B.,
            Jean-Alphonse,F., Orte,A. and Friedman,P.A.
  TITLE     Parathyroid hormone initiates dynamic NHERF1 phosphorylation
            cycling and conformational changes that regulate NPT2A-dependent
            phosphate transport
  JOURNAL   J Biol Chem 294 (12), 4546-4571 (2019)
   PUBMED   30696771
  REMARK    GeneRIF: multiprotein kinase cascade involving G protein-coupled
            receptor kinase 6A controls the Ser(290) phosphorylation status of
            NHERF1 and regulates PTH-sensitive, NPT2A-mediated phosphate uptake
REFERENCE   3  (bases 1 to 2438)
  AUTHORS   Schlingmann,K.P., Ruminska,J., Kaufmann,M., Dursun,I., Patti,M.,
            Kranz,B., Pronicka,E., Ciara,E., Akcay,T., Bulus,D.,
            Cornelissen,E.A., Gawlik,A., Sikora,P., Patzer,L., Galiano,M.,
            Boyadzhiev,V., Dumic,M., Vivante,A., Kleta,R., Dekel,B.,
            Levtchenko,E., Bindels,R.J., Rust,S., Forster,I.C., Hernando,N.,
            Jones,G., Wagner,C.A. and Konrad,M.
  TITLE     Autosomal-Recessive Mutations in SLC34A1 Encoding Sodium-Phosphate
            Cotransporter 2A Cause Idiopathic Infantile Hypercalcemia
  JOURNAL   J Am Soc Nephrol 27 (2), 604-614 (2016)
   PUBMED   26047794
REFERENCE   4  (bases 1 to 2438)
  AUTHORS   Zhang,C., Shi,L.M., Li,Y., Zhu,Q.G., Jin,C.L., Wang,H.P., Zhou,L.,
            Hu,X.P., Zhang,L., Wang,H., Yuan,G.J., Xu,L., Zhao,Y.K. and Chou,Y.
  TITLE     Effect of hyperphosphatemia on gene expression of the Na-Pi
            cotransporter in rats
  JOURNAL   Genet Mol Res 14 (4), 19404-19410 (2016)
   PUBMED   26782594
  REMARK    GeneRIF: NaPi-IIa mRNA expression is affected by hyperphosphatemia.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2438)
  AUTHORS   Shiga,T., Kimira,Y., Mano,H., Kawata,T., Tadokoro,T., Suzuki,T. and
            Yamamoto,Y.
  TITLE     Vitamin B deficiency-induced increase of osteoclastic bone
            resorption caused by abnormal renal resorption of inorganic
            phosphorus via Napi2a
  JOURNAL   Biosci Biotechnol Biochem 80 (3), 510-513 (2016)
   PUBMED   26460967
  REMARK    GeneRIF: Napi2a, a renal cotransporter for Pi reabsorption,
            accumulated on plasma membranes in a vitamin B12 deficiency
            suggests that vitamin B12 plays an important role in Pi homeostasis
REFERENCE   6  (bases 1 to 2438)
  AUTHORS   Xiao,Y., Boyer,C.J., Vincent,E., Dugre,A., Vachon,V., Potier,M. and
            Beliveau,R.
  TITLE     Involvement of disulphide bonds in the renal sodium/phosphate
            co-transporter NaPi-2
  JOURNAL   Biochem J 323 (Pt 2) (Pt 2), 401-408 (1997)
   PUBMED   9163330
REFERENCE   7  (bases 1 to 2438)
  AUTHORS   Katai,K., Segawa,H., Haga,H., Morita,K., Arai,H., Tatsumi,S.,
            Taketani,Y., Miyamoto,K., Hisano,S., Fukui,Y. and Takeda,E.
  TITLE     Acute regulation by dietary phosphate of the sodium-dependent
            phosphate transporter (NaP(i)-2) in rat kidney
  JOURNAL   J Biochem 121 (1), 50-55 (1997)
   PUBMED   9058191
REFERENCE   8  (bases 1 to 2438)
  AUTHORS   Wagner,C.A., Waldegger,S., Osswald,H., Biber,J., Murer,H.,
            Busch,A.E. and Lang,F.
  TITLE     Heavy metals inhibit Pi-induced currents through human brush-border
            NaPi-3 cotransporter in Xenopus oocytes
  JOURNAL   Am J Physiol 271 (4 Pt 2), F926-F930 (1996)
   PUBMED   8898024
REFERENCE   9  (bases 1 to 2438)
  AUTHORS   Lotscher,M., Kaissling,B., Biber,J., Murer,H., Kempson,S.A. and
            Levi,M.
  TITLE     Regulation of rat renal Na/Pi-cotransporter by parathyroid hormone:
            immunohistochemistry
  JOURNAL   Kidney Int 49 (4), 1010-1011 (1996)
   PUBMED   8691716
REFERENCE   10 (bases 1 to 2438)
  AUTHORS   Magagnin,S., Werner,A., Markovich,D., Sorribas,V., Stange,G.,
            Biber,J. and Murer,H.
  TITLE     Expression cloning of human and rat renal cortex Na/Pi cotransport
  JOURNAL   Proc Natl Acad Sci U S A 90 (13), 5979-5983 (1993)
   PUBMED   8327470
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Nov 26, 2020 this sequence version replaced NM_013030.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L13257.1, BC078876.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN06680416,
                                           SAMN06680417 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                JAXUCZ010000017.1  9238952-9238983     c
            33-162              JAXUCZ010000017.1  9238184-9238313     c
            163-312             JAXUCZ010000017.1  9237916-9238065     c
            313-441             JAXUCZ010000017.1  9237699-9237827     c
            442-585             JAXUCZ010000017.1  9237482-9237625     c
            586-697             JAXUCZ010000017.1  9235732-9235843     c
            698-893             JAXUCZ010000017.1  9235412-9235607     c
            894-989             JAXUCZ010000017.1  9235210-9235305     c
            990-1053            JAXUCZ010000017.1  9229619-9229682     c
            1054-1221           JAXUCZ010000017.1  9229219-9229386     c
            1222-1338           JAXUCZ010000017.1  9226077-9226193     c
            1339-1463           JAXUCZ010000017.1  9225828-9225952     c
            1464-2438           JAXUCZ010000017.1  9224010-9224984     c
FEATURES             Location/Qualifiers
     source          1..2438
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..2438
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-2; NaPi2A; Npt2; Slc17a2"
                     /note="solute carrier family 34 member 1"
                     /db_xref="GeneID:25548"
                     /db_xref="RGD:3708"
     exon            1..32
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-2; NaPi2A; Npt2; Slc17a2"
                     /inference="alignment:Splign:2.1.0"
     exon            33..162
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-2; NaPi2A; Npt2; Slc17a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1967
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-2; NaPi2A; Npt2; Slc17a2"
                     /note="naPi-2a; sodium/phosphate cotransporter 2A; solute
                     carrier family 34 (sodium phosphate), member 1;
                     sodium-phosphate transport protein 2A; Na(+)/Pi
                     cotransporter 2A; Na(+)-dependent phosphate cotransporter
                     2A; sodium-phosphate co-transporter type II; solute
                     carrier family 17 (sodium/hydrogen exchanger) member 2;
                     solute carrier family 34 (type II sodium/phosphate
                     cotransporter), member 1"
                     /codon_start=1
                     /product="sodium-dependent phosphate transport protein 2A"
                     /protein_id="NP_037162.1"
                     /db_xref="GeneID:25548"
                     /db_xref="RGD:3708"
                     /translation="MMSYSERLGGPAVSPLPVRGRHMVHGAAFAYVPSPQVLHRIPGT
                     TTYAISSLSPVALTEHSCPYGEVLECHDPLPAKLAQEEEQKPEPRLSQKLAQVGTKLL
                     KVPLMLGFLYLFVCSLDVLSSAFQLAGGKVAGDIFKDNAILSNPVAGLVVGILVTVLV
                     QSSSTSTSIIVSMVSSGLLEVSSAIPIIMGSNIGTSVTNTIVALMQAGDRTDFRRAFA
                     GATVHDCFNWLSVLVLLPLEAATGYLHHVTGLVVASFNIRGGRDAPDLLKVITEPFTK
                     LIIQLDKSVITSIAVGDESLRNHSLIRIWCQPETKEASTSMSRVEAIGSLANTTMEKC
                     NHIFVDTGLPDLAVGLILLAGSLVVLCTCLILLVKMLNSLLKGQVANVIQKVINTDFP
                     APFTWVTGYFAMVVGASMTFVVQSSSVFTSAITPLIGLGVISIERAYPLTLGSNIGTT
                     TTAILAALASPREKLSSSFQIALCHFFFNISGILLWYPLPCTRLPIRMAKALGKRTAK
                     YRWFAVLYLLVCFLLLPSLVFGISMAGWQAMVGVGTPFGALLAFVVLVNVLQSRSPGH
                     LPKWLQTWDFLPRWMHSLQPLDGLITRATLCYARPEPRSPQLPPRVFLEELPPATPSP
                     RLALPAHHNATRL"
     exon            163..312
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-2; NaPi2A; Npt2; Slc17a2"
                     /inference="alignment:Splign:2.1.0"
     exon            313..441
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-2; NaPi2A; Npt2; Slc17a2"
                     /inference="alignment:Splign:2.1.0"
     exon            442..585
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-2; NaPi2A; Npt2; Slc17a2"
                     /inference="alignment:Splign:2.1.0"
     exon            586..697
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-2; NaPi2A; Npt2; Slc17a2"
                     /inference="alignment:Splign:2.1.0"
     exon            698..893
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-2; NaPi2A; Npt2; Slc17a2"
                     /inference="alignment:Splign:2.1.0"
     exon            894..989
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-2; NaPi2A; Npt2; Slc17a2"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1053
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-2; NaPi2A; Npt2; Slc17a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1221
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-2; NaPi2A; Npt2; Slc17a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1338
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-2; NaPi2A; Npt2; Slc17a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1463
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-2; NaPi2A; Npt2; Slc17a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..2438
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-2; NaPi2A; Npt2; Slc17a2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcagtcgag ctggagctaa gccatagtca aggactcatt gtgggtgccc atcatgatgt
       61 cctacagcga gagattgggg ggaccggctg tctccccact tccagtccgt gggagacaca
      121 tggtgcatgg ggcagccttt gcttatgtcc ccagcccaca agtcctgcac aggattcctg
      181 ggacaaccac ctatgccatc tccagtctga gcccggtagc cctcacagag cacagctgtc
      241 cctatgggga ggtcctggaa tgtcatgacc cgctccctgc caagctggcc caggaagagg
      301 agcaaaagcc agagcccagg ctgtcccaga agcttgccca ggttggcaca aagctcctga
      361 aggtgccgtt gatgctaggc ttcctttacc tctttgtctg ctccctggac gtgctcagct
      421 ctgccttcca actggccgga gggaaagtgg ctggggacat cttcaaggac aatgccatcc
      481 tgtccaaccc agtggcaggg ctggtggtgg gaatcctggt gacagttctg gtgcagagct
      541 ccagcacctc gacatccatc attgtcagca tggtctcctc tggcttgttg gaggtgagct
      601 ccgccattcc gataatcatg ggctccaaca tcgggacctc tgtcaccaac accattgtgg
      661 ccctgatgca ggcgggggac aggactgact tcaggcgggc ttttgcaggg gcaacagtgc
      721 atgactgctt taactggctg tctgttctgg tcctgctgcc cctggaggct gccacgggct
      781 acctgcacca cgtcaccggg cttgtggttg cctccttcaa catccgtggt ggccgtgatg
      841 cccctgacct tctcaaggtt atcacagagc ccttcacaaa gcttatcatc cagctggaca
      901 agtctgtgat taccagcatt gccgtggggg atgagtccct gaggaatcac agtctcattc
      961 ggatttggtg tcaaccagag acaaaagagg cttccacttc tatgtccagg gtagaggcca
     1021 ttggcagcct tgcaaacacc accatggaga aatgcaacca tatcttcgtg gatactgggc
     1081 tgcccgacct ggccgtgggg ctcattctgc tggcgggctc cctggtggtc ctgtgcactt
     1141 gtcttatcct cctcgtcaag atgctcaact ctctgctgaa gggccaagtg gccaatgtca
     1201 tccagaaggt catcaacaca gacttcccag cccccttcac ttgggtcaca ggctactttg
     1261 ccatggtggt gggcgccagc atgacgtttg ttgtccagag cagttccgtg ttcacctcag
     1321 ccatcactcc gctcattggc ctgggtgtga tcagtattga gcgggcctac cctctcaccc
     1381 tgggctccaa cattggtacc accactacag ccatcctggc agcactggcc agccccaggg
     1441 agaagctctc cagctccttt cagattgccc tctgccactt cttcttcaac atctcgggca
     1501 tcctcctgtg gtacccgctg ccctgcacac gtctgcccat ccgcatggcc aaggcactgg
     1561 gcaaacgcac tgccaagtac cgctggtttg ccgtcctcta cctcctcgtg tgcttcctgc
     1621 tcctgccctc actggtgttt ggcatttcta tggcaggctg gcaggctatg gtcggtgtgg
     1681 gcacaccctt tggggccctg ctcgccttcg tggtgcttgt taacgtcctg cagagtcgaa
     1741 gtcccgggca cctccccaag tggctgcaga catgggactt cctaccccgc tggatgcact
     1801 ctctgcagcc cctggatggc cttatcacaa gagccacctt gtgctatgcc aggcccgagc
     1861 cccgttcacc ccaacttccc cccagagtct tcctggagga gcttcctcct gccacgccct
     1921 ctccccgcct ggcactgccc gctcaccaca atgccacccg gctctaggct gcaggtccag
     1981 actattgcct ggagcgaggg acgggatttt tacagagccc acagtagaaa ggcacagcat
     2041 gtttgtgagt gtgtgtgcat gcatgtagat gcatgtcact tgaggtacat gattttgtgc
     2101 cacccttggg tacctgtccc tactcagggc cacagcgggg tgggcttttt ttgcaattaa
     2161 gaagcagtgt gcacaaatac atgctaggtc ctgagccttt gtggccatca ggacaggagt
     2221 atgcgagtgc atggtgtggg tacaggggat gcagatgcat gaggagcccc caaaattttc
     2281 tgggaagagt cggctatgcc ctctcacctt ctcactaccc ttgtcccaac aggagaggca
     2341 gaagagcagc tggccttctg tatacatgag cctttcctct gccaattctg ctaactgtgc
     2401 atagaaaaag ttttaaaagt tgcatctgtc ctgatcat
//
