LOCUS       NM_133600               1417 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus solute carrier family 31 member 1 (Slc31a1),
            mRNA.
ACCESSION   NM_133600
VERSION     NM_133600.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1417)
  AUTHORS   Zheng,G., Zhang,J., Xu,Y., Shen,X., Song,H., Jing,J., Luo,W.,
            Zheng,W. and Chen,J.
  TITLE     Involvement of CTR1 and ATP7A in lead (Pb)-induced copper (Cu)
            accumulation in choroidal epithelial cells
  JOURNAL   Toxicol Lett 225 (1), 110-118 (2014)
   PUBMED   24316150
  REMARK    GeneRIF: CTR1 and ATP7A play important roles in Cu transport in
            choroidal epithelial cells, and the Pb-induced intracellular Cu
            accumulation appears to be mediated, at least in part, via the
            alteration of CTR1 and ATP7A expression levels following Pb
            exposure.
REFERENCE   2  (bases 1 to 1417)
  AUTHORS   Ohrvik,H., Nose,Y., Wood,L.K., Kim,B.E., Gleber,S.C., Ralle,M. and
            Thiele,D.J.
  TITLE     Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal
            transporter lacking the copper- and cisplatin-binding ecto-domain
  JOURNAL   Proc Natl Acad Sci U S A 110 (46), E4279-E4288 (2013)
   PUBMED   24167251
REFERENCE   3  (bases 1 to 1417)
  AUTHORS   Liu,J.J., Kim,Y., Yan,F., Ding,Q., Ip,V., Jong,N.N., Mercer,J.F.
            and McKeage,M.J.
  TITLE     Contributions of rat Ctr1 to the uptake and toxicity of copper and
            platinum anticancer drugs in dorsal root ganglion neurons
  JOURNAL   Biochem Pharmacol 85 (2), 207-215 (2013)
   PUBMED   23123662
  REMARK    GeneRIF: Data suggest that Ctr1 is responsible for transport (and
            accumulation) of copper salts (CuCl2; CuSO4) and organoplatinum
            compounds in dorsal root ganglion neurons; Ctr1 is thus involved in
            neurotoxicity of such antineoplastic drugs.
REFERENCE   4  (bases 1 to 1417)
  AUTHORS   Sancho-Martinez,S.M., Prieto-Garcia,L., Prieto,M., Lopez-Novoa,J.M.
            and Lopez-Hernandez,F.J.
  TITLE     Subcellular targets of cisplatin cytotoxicity: an integrated view
  JOURNAL   Pharmacol Ther 136 (1), 35-55 (2012)
   PUBMED   22796517
  REMARK    Review article
REFERENCE   5  (bases 1 to 1417)
  AUTHORS   Ciarimboli,G.
  TITLE     Membrane transporters as mediators of Cisplatin effects and side
            effects
  JOURNAL   Scientifica (Cairo) 2012, 473829 (2012)
   PUBMED   24278698
  REMARK    Review article
REFERENCE   6  (bases 1 to 1417)
  AUTHORS   Aller,S.G. and Unger,V.M.
  TITLE     Projection structure of the human copper transporter CTR1 at 6-A
            resolution reveals a compact trimer with a novel channel-like
            architecture
  JOURNAL   Proc Natl Acad Sci U S A 103 (10), 3627-3632 (2006)
   PUBMED   16501047
REFERENCE   7  (bases 1 to 1417)
  AUTHORS   Samsonov,S.A., Platonova,N.A., Skvortsov,A.N., Tsymbalenko,N.V.,
            Vasin,A.V. and Puchkova,L.V.
  TITLE     [Relations between CTR1 gene activity and copper status in
            different rat organs]
  JOURNAL   Mol Biol (Mosk) 40 (2), 239-251 (2006)
   PUBMED   16637264
  REMARK    GeneRIF: It has been shown that SLC31A1 gene activity correlates
            with the rate of both intracellular and extracellular
            copper-containing enzymes formation.
REFERENCE   8  (bases 1 to 1417)
  AUTHORS   Gambling,L., Dunford,S. and McArdle,H.J.
  TITLE     Iron deficiency in the pregnant rat has differential effects on
            maternal and fetal copper levels
  JOURNAL   J Nutr Biochem 15 (6), 366-372 (2004)
   PUBMED   15157943
REFERENCE   9  (bases 1 to 1417)
  AUTHORS   Klomp,A.E., Juijn,J.A., van der Gun,L.T., van den Berg,I.E.,
            Berger,R. and Klomp,L.W.
  TITLE     The N-terminus of the human copper transporter 1 (hCTR1) is
            localized extracellularly, and interacts with itself
  JOURNAL   Biochem J 370 (Pt 3), 881-889 (2003)
   PUBMED   12466020
REFERENCE   10 (bases 1 to 1417)
  AUTHORS   Lee,J., Petris,M.J. and Thiele,D.J.
  TITLE     Characterization of mouse embryonic cells deficient in the ctr1
            high affinity copper transporter. Identification of a
            Ctr1-independent copper transport system
  JOURNAL   J Biol Chem 277 (43), 40253-40259 (2002)
   PUBMED   12177073
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000161.1.
            
            [WARNING] On Mar 30, 2024 this sequence was replaced by
            NM_133600.3.
            
            On Nov 27, 2020 this sequence version replaced NM_133600.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF268030.1, BC078745.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               JACYVU010000161.1  51239387-51239502
            117-288             JACYVU010000161.1  51262288-51262459
            289-361             JACYVU010000161.1  51262857-51262929
            362-530             JACYVU010000161.1  51264427-51264595
            531-1417            JACYVU010000161.1  51265285-51266171
FEATURES             Location/Qualifiers
     source          1..1417
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..1417
                     /gene="Slc31a1"
                     /gene_synonym="Ctr1; LRRGT00200"
                     /note="solute carrier family 31 member 1"
                     /db_xref="GeneID:171135"
                     /db_xref="RGD:620059"
     exon            1..116
                     /gene="Slc31a1"
                     /gene_synonym="Ctr1; LRRGT00200"
                     /inference="alignment:Splign:2.1.0"
     exon            117..288
                     /gene="Slc31a1"
                     /gene_synonym="Ctr1; LRRGT00200"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..732
                     /gene="Slc31a1"
                     /gene_synonym="Ctr1; LRRGT00200"
                     /note="rCTR1; copper transporter 1; solute carrier family
                     31 (copper transporters), member 1; liver
                     regeneration-related protein LRRGT00200; Copper uptake
                     transporter 1; solute carrier family 31 (copper
                     transporter), member 1"
                     /codon_start=1
                     /product="high affinity copper uptake protein 1"
                     /protein_id="NP_598284.1"
                     /db_xref="GeneID:171135"
                     /db_xref="RGD:620059"
                     /translation="MRMNHMEMHHMGMNHTDDNITMPPHQHPTTSASHSHEMMMPMTF
                     YFGFKNVDLLFSSLVINTPGEMAGAFVAVFLLAMFYEGLKIAREGLLRKSQVSIRYNS
                     MPVPGPNGTILMETHKTVGQQMLSFPHLLQTVLHIIQVVISYFLMLIFMTYNGYLCIA
                     VAAGAGTGYFLFSWKKAVVVDITEHCH"
     exon            289..361
                     /gene="Slc31a1"
                     /gene_synonym="Ctr1; LRRGT00200"
                     /inference="alignment:Splign:2.1.0"
     exon            362..530
                     /gene="Slc31a1"
                     /gene_synonym="Ctr1; LRRGT00200"
                     /inference="alignment:Splign:2.1.0"
     exon            531..1417
                     /gene="Slc31a1"
                     /gene_synonym="Ctr1; LRRGT00200"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggtcctggg acacgtcgag ccgggcagta gttgcggggg cttgggagaa gtccagacct
       61 ggttagggat ccagttctga gaggaagact caggcggtgg ggcttgccct gggaagacct
      121 ttgcgctgac tctcatcttt ttctggaaaa ctggatcctt cggaccacat gaggatgaac
      181 cacatggaga tgcatcatat ggggatgaac cacacggacg acaacatcac catgccaccc
      241 caccagcacc ccaccacctc ggcctcacac tcccacgaga tgatgatgcc tatgaccttc
      301 tactttggct ttaagaatgt ggacctattg ttttccagtt tggtaatcaa cacacctgga
      361 gaaatggctg gagcttttgt ggcagtgttt ttactagcaa tgttttatga aggactcaag
      421 atagcccgag agggtctgct tcgaaagtct caagtcagca ttcgctacaa ttccatgcct
      481 gtgccaggac caaatggaac catccttatg gagacacaca aaactgttgg gcagcagatg
      541 ctgagcttcc cccacctcct gcagacagtg ctgcacatca tccaagtagt catcagctac
      601 ttcctcatgc tcatcttcat gacctacaat gggtacctat gcattgcagt agccgcaggg
      661 gctgggacag gatactttct cttcagctgg aagaaggctg tggtggtgga catcacagag
      721 cactgccatt aacgttagac tccacagacg gccttattaa ttgctgtagg aagcatcttg
      781 ggactggaag atatgattcc ctctccaatc atccctcctc tctcctgtct ctttatacac
      841 acacacctac tgaatagagg tctagctgac agtctctgag tagtggtttt tctaataaga
      901 tgaaattgac ttttctcttg aaagtcacct gtgagatgtc ttctccctca tcatcctgag
      961 ccttgtctaa tccaggtagc ttcctagtta atgatttggt tatctgcttc tttctacttt
     1021 tccagggttt tttttttggg gggggggtgc atttttgttt taaacagata ctatgtgtat
     1081 ttggtggctg gggttctggg tcagtgatgg aacaggattg atggcaatta gggacatctc
     1141 atccagtcgg gacttaaatt tcacactaga aaataatctc cagtcttagc acagtgtggg
     1201 aaacacaggt gcctctccag acctagtgca cttacgccga aacccgagta gtgtgtgggg
     1261 cagacaggga ctaaacgcag gccgagttcc cgcccactca tctacttgtg ttcctactta
     1321 acattttgat tagaatgaac ttgccaatcc aaacaaaaac aggacaatca atttaagaca
     1381 acaggaatag attgttaaat aaaaccatta gtatttg
//
