LOCUS       NM_001130538            1278 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus solute carrier family 30 member 8 (Slc30a8),
            mRNA.
ACCESSION   NM_001130538 XM_001065623 XM_235269
VERSION     NM_001130538.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1278)
  AUTHORS   Xu,G., Kang,D., Zhang,C., Lou,H., Sun,C., Yang,Q., Lu,L., Xu,G.T.,
            Zhang,J. and Wang,F.
  TITLE     Erythropoietin Protects Retinal Cells in Diabetic Rats Through
            Upregulating ZnT8 via Activating ERK Pathway and Inhibiting
            HIF-1alpha Expression
  JOURNAL   Invest Ophthalmol Vis Sci 56 (13), 8166-8178 (2015)
   PUBMED   26720469
  REMARK    GeneRIF: In diabetic retinas, EPO maintains zinc homeostasis
            through activating the ERK pathway and downregulating HIF-1alpha,
            and thus upregulating ZnT8 expression.
REFERENCE   2  (bases 1 to 1278)
  AUTHORS   Somboonwong,J., Traisaeng,S. and Saguanrungsirikul,S.
  TITLE     Moderate-intensity exercise training elevates serum and pancreatic
            zinc levels and pancreatic ZnT8 expression in
            streptozotocin-induced diabetic rats
  JOURNAL   Life Sci 139, 46-51 (2015)
   PUBMED   26281917
  REMARK    GeneRIF: Diabetes caused reductions in the serum and pancreatic
            zinc levels and pancreatic ZnT8 expression. Following moderate
            exercise training, there was a significant increase in all of these
            parameters.
REFERENCE   3  (bases 1 to 1278)
  AUTHORS   Deniro,M. and Al-Mohanna,F.A.
  TITLE     Zinc transporter 8 (ZnT8) expression is reduced by ischemic
            insults: a potential therapeutic target to prevent ischemic
            retinopathy
  JOURNAL   PLoS One 7 (11), e50360 (2012)
   PUBMED   23209723
  REMARK    GeneRIF: ischemic retinopathy maybe mediated by aberrant Zn(++)
            homeostasis caused by ZnT8 downregulation, whereas YC-1 plays a
            neuroprotective role against ischemic insult
REFERENCE   4  (bases 1 to 1278)
  AUTHORS   Petersen,A.B., Smidt,K., Magnusson,N.E., Moore,F., Egefjord,L. and
            Rungby,J.
  TITLE     siRNA-mediated knock-down of ZnT3 and ZnT8 affects production and
            secretion of insulin and apoptosis in INS-1E cells
  JOURNAL   APMIS 119 (2), 93-102 (2011)
   PUBMED   21208276
  REMARK    GeneRIF: Both ZnT3 and ZnT8 seem to play a role in beta-cell
            survival and the ability of these cells to react appropriately to
            surrounding glucose concentrations.
REFERENCE   5  (bases 1 to 1278)
  AUTHORS   Lemaire,K., Ravier,M.A., Schraenen,A., Creemers,J.W., Van de
            Plas,R., Granvik,M., Van Lommel,L., Waelkens,E., Chimienti,F.,
            Rutter,G.A., Gilon,P., in't Veld,P.A. and Schuit,F.C.
  TITLE     Insulin crystallization depends on zinc transporter ZnT8
            expression, but is not required for normal glucose homeostasis in
            mice
  JOURNAL   Proc Natl Acad Sci U S A 106 (35), 14872-14877 (2009)
   PUBMED   19706465
REFERENCE   6  (bases 1 to 1278)
  AUTHORS   Pound,L.D., Sarkar,S.A., Benninger,R.K., Wang,Y., Suwanichkul,A.,
            Shadoan,M.K., Printz,R.L., Oeser,J.K., Lee,C.E., Piston,D.W.,
            McGuinness,O.P., Hutton,J.C., Powell,D.R. and O'Brien,R.M.
  TITLE     Deletion of the mouse Slc30a8 gene encoding zinc transporter-8
            results in impaired insulin secretion
  JOURNAL   Biochem J 421 (3), 371-376 (2009)
   PUBMED   19450229
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1278)
  AUTHORS   Murgia,C., Devirgiliis,C., Mancini,E., Donadel,G., Zalewski,P. and
            Perozzi,G.
  TITLE     Diabetes-linked zinc transporter ZnT8 is a homodimeric protein
            expressed by distinct rodent endocrine cell types in the pancreas
            and other glands
  JOURNAL   Nutr Metab Cardiovasc Dis 19 (6), 431-439 (2009)
   PUBMED   19095428
  REMARK    GeneRIF: Diabetes-linked zinc transporter ZnT8 is a homodimeric
            protein expressed by distinct rodent endocrine cell types in the
            pancreas and other glands.
REFERENCE   8  (bases 1 to 1278)
  AUTHORS   Egefjord,L., Jensen,J.L., Bang-Berthelsen,C.H., Petersen,A.B.,
            Smidt,K., Schmitz,O., Karlsen,A.E., Pociot,F., Chimienti,F.,
            Rungby,J. and Magnusson,N.E.
  TITLE     Zinc transporter gene expression is regulated by pro-inflammatory
            cytokines: a potential role for zinc transporters in beta-cell
            apoptosis?
  JOURNAL   BMC Endocr Disord 9, 7 (2009)
   PUBMED   19243577
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1278)
  AUTHORS   Chimienti,F., Devergnas,S., Pattou,F., Schuit,F., Garcia-Cuenca,R.,
            Vandewalle,B., Kerr-Conte,J., Van Lommel,L., Grunwald,D., Favier,A.
            and Seve,M.
  TITLE     In vivo expression and functional characterization of the zinc
            transporter ZnT8 in glucose-induced insulin secretion
  JOURNAL   J Cell Sci 119 (Pt 20), 4199-4206 (2006)
   PUBMED   16984975
REFERENCE   10 (bases 1 to 1278)
  AUTHORS   Chimienti,F., Devergnas,S., Favier,A. and Seve,M.
  TITLE     Identification and cloning of a beta-cell-specific zinc
            transporter, ZnT-8, localized into insulin secretory granules
  JOURNAL   Diabetes 53 (9), 2330-2337 (2004)
   PUBMED   15331542
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473950.2.
            
            On or before Jul 28, 2008 this sequence version replaced
            XM_235269.4, XM_001065623.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..1278
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q31"
     gene            1..1278
                     /gene="Slc30a8"
                     /gene_synonym="ZnT-8"
                     /note="solute carrier family 30 member 8"
                     /db_xref="GeneID:299903"
                     /db_xref="RGD:1308282"
     exon            1..380
                     /gene="Slc30a8"
                     /gene_synonym="ZnT-8"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..1278
                     /gene="Slc30a8"
                     /gene_synonym="ZnT-8"
                     /note="zinc transporter 8; solute carrier family 30 (zinc
                     transporter), member 8"
                     /codon_start=1
                     /product="proton-coupled zinc antiporter SLC30A8"
                     /protein_id="NP_001124010.1"
                     /db_xref="GeneID:299903"
                     /db_xref="RGD:1308282"
                     /translation="MEFLERTYLVNDQATKMYAFTSDRERGQKPVNKDQCPGDGPERP
                     EAGAIYHCHNSFKATGNRSSKQVHAKWRLCAASAICFFFMVAEVVGGHVAGSLAVLTD
                     AAHLLIDLTSFLLSLFSLWLSSRPPSKRLTFGWYRAEILGALLSVLCIWVVTGVLVYL
                     ACERLLYPDYQIQAGIMITVSGCAVAANIVLTLILHQRHLGHNHKDAQANASVRAAFV
                     HALGDVFQSTSVLISALIIYFKPDYKMADPVCTFISSVLALASTVMILKDFSILLMEG
                     VPKGLSYNSVKELLLTVDGVISVHNLHIWSLTVNQVILSVHVATGQ"
     exon            381..577
                     /gene="Slc30a8"
                     /gene_synonym="ZnT-8"
                     /inference="alignment:Splign:2.1.0"
     exon            578..724
                     /gene="Slc30a8"
                     /gene_synonym="ZnT-8"
                     /inference="alignment:Splign:2.1.0"
     exon            725..878
                     /gene="Slc30a8"
                     /gene_synonym="ZnT-8"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1029
                     /gene="Slc30a8"
                     /gene_synonym="ZnT-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1135
                     /gene="Slc30a8"
                     /gene_synonym="ZnT-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1278
                     /gene="Slc30a8"
                     /gene_synonym="ZnT-8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtgtacac acacacacac acacacacac acacacacac tttttaggat tccattttcc
       61 agtctcccag aaaagcagtt tctgtgggtg atagaatgag tccaagtgat catccaagaa
      121 gaccgttaat tttcacagac ctaccaacag cactgatgta ggacgcacta ttaactcaag
      181 tactggaagg atttttctat tttcttagga agttgtgtga atataataat ctcagtgctt
      241 ctttacttcc aaaactggac agcaggtcat atatcaaaaa caacagtgtc agctcctgtc
      301 cctgctacca tggagtttct tgagaggact taccttgtga atgatcaagc caccaagatg
      361 tatgccttca cttcagacag agaacgtgga cagaagcctg tgaataaaga tcagtgtcct
      421 ggagacgggc cagagcgtcc ggaggcagga gccatctatc actgccacaa cagcttcaag
      481 gccacaggga acaggtcgag caagcaagtg catgccaagt ggagactctg tgctgcttca
      541 gcaatatgct tcttctttat ggtggcagag gtggtgggtg gacatgttgc tgggagtctg
      601 gcggtcctca ctgatgctgc tcatctctta attgacctga ctagtttcct gctcagtctc
      661 ttttctttgt ggttatcttc aaggccccct tccaagcggc tgacatttgg gtggtatcga
      721 gcagagatcc tcggtgccct gctgtctgtc ctttgcatct gggtggtgac tggtgtgctg
      781 gtgtaccttg cctgtgagcg cctcttgtat cctgattacc agatccaagc aggcatcatg
      841 atcactgttt caggctgtgc agtggcagcc aacattgtac taactctgat tttgcaccaa
      901 cggcatcttg gccacaacca caaggatgca caagctaatg ccagcgttcg agcggccttt
      961 gtgcatgccc tgggggatgt gtttcagagc accagtgtgc taattagtgc tctcattatc
     1021 tactttaagc ccgactacaa aatggctgat ccagtgtgca catttatctc ttccgtcttg
     1081 gctttggcca gcaccgtcat gatcttaaaa gacttctcca tcttactcat ggaaggtgtt
     1141 ccaaagggcc tgagttacaa cagtgtgaaa gaactcctcc tcacagtcga tggcgtgatc
     1201 tccgtgcaca atctacacat ctggtcgctg acagtgaacc aagtgattct ctctgttcat
     1261 gttgctacag gtcagtga
//
