LOCUS       NM_001191715            2032 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus solute carrier family 30 member 7 (Slc30a7),
            mRNA.
ACCESSION   NM_001191715 XM_227612
VERSION     NM_001191715.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2032)
  AUTHORS   Tuncay,E., Aktay,I. and Turan,B.
  TITLE     Overexpression of Slc30a7/ZnT7 increases the mitochondrial matrix
            levels of labile Zn2+ and modifies histone modification in
            hyperinsulinemic cardiomyoblasts
  JOURNAL   J Trace Elem Med Biol 78, 127198 (2023)
   PUBMED   37196548
  REMARK    GeneRIF: Overexpression of Slc30a7/ZnT7 increases the mitochondrial
            matrix levels of labile Zn[2+] and modifies histone modification in
            hyperinsulinemic cardiomyoblasts.
REFERENCE   2  (bases 1 to 2032)
  AUTHORS   Tuncay,E., Bitirim,C.V., Olgar,Y., Durak,A., Rutter,G.A. and
            Turan,B.
  TITLE     Zn2+-transporters ZIP7 and ZnT7 play important role in progression
            of cardiac dysfunction via affecting sarco(endo)plasmic
            reticulum-mitochondria coupling in hyperglycemic cardiomyocytes
  JOURNAL   Mitochondrion 44, 41-52 (2019)
   PUBMED   29307859
  REMARK    GeneRIF: Overall, this study provides an important description
            about the role of ZIP7 and ZnT7, localized to both mitochondria and
            sarco(endo)plasmic reticulum and contribute to cellular
            Zn(2+)-muffling between cellular-compartments in hyperglycemia or
            hypertrophic cardiomyocytes via affecting sarco(endo)plasmic
            reticulum-mitochondria coupling.
REFERENCE   3  (bases 1 to 2032)
  AUTHORS   Zhang,X., Lian,X., Liang,D., Zhang,L., Liu,S., Yang,L., Chi,Z.H.
            and Gu,H.F.
  TITLE     Protective Effect of Znt7 on High Glucose-Induced
            Epithelial-to-Mesenchymal Transition in Renal Tubular Epithelial
            Cells
  JOURNAL   Kidney Blood Press Res 43 (2), 500-512 (2018)
   PUBMED   29627824
  REMARK    GeneRIF: evidence that ZnT7 has a protective effect over
            epithelial-to-mesenchymal transition (EMT) of renal tubular
            epithelial cells in diabetic nephropathy and suggests that the
            inhibition of HG-induced EMT may be achieved through the MAPK/ERK
            and TGF-beta/Smad pathways.
REFERENCE   4  (bases 1 to 2032)
  AUTHORS   Tuncay,E., Bitirim,V.C., Durak,A., Carrat,G.R.J., Taylor,K.M.,
            Rutter,G.A. and Turan,B.
  TITLE     Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause
            Zn2+ Release From the Sarco(endo)plasmic Reticulum and Mediate ER
            Stress in the Heart
  JOURNAL   Diabetes 66 (5), 1346-1358 (2017)
   PUBMED   28232492
  REMARK    GeneRIF: Markedly increased mRNA and protein levels of ZIP7 were
            observed in ventricular cardiomyocytes from diabetic rats or
            high-glucose-treated H9c2 cells while ZnT7 expression was low.
REFERENCE   5  (bases 1 to 2032)
  AUTHORS   Tian,T., Li,L.L., Zhang,S.Q. and Ni,H.
  TITLE     Long-Term Effects of Ketogenic Diet on Subsequent Seizure-Induced
            Brain Injury During Early Adulthood: Relationship of Seizure
            Thresholds to Zinc Transporter-Related Gene Expressions
  JOURNAL   Biol Trace Elem Res 174 (2), 369-376 (2016)
   PUBMED   27147436
  REMARK    GeneRIF: The recurrent seizures plus normal diet group showed worse
            performances in neurological reflex tests and reduced latencies to
            myoclonic seizures induced by penicillin compared with the control,
            which was concomitant with altered expressions of ZnT-7, MT-1,
            MT-2, and ZIP7.
REFERENCE   6  (bases 1 to 2032)
  AUTHORS   Zhang,X., Liang,D., Guo,B., Sun,L., Chi,Z.H., Cai,Y., Wang,L. and
            Ma,J.
  TITLE     Zinc transporter 7 induced by high glucose attenuates
            epithelial-to-mesenchymal transition of peritoneal mesothelial
            cells
  JOURNAL   Biol Trace Elem Res 151 (1), 138-147 (2013)
   PUBMED   23104082
  REMARK    GeneRIF: Data suggest that the ZnT7 (Slc30A7) may account for the
            inhibition of high glucose (HG)-induced epithelial-to-mesenchymal
            transition (EMT) in peritoneal mesothelial cells (PMCs).
REFERENCE   7  (bases 1 to 2032)
  AUTHORS   Zhang,L., Chi,Z.H., Ren,H., Rong,M., Dahlstrom,A., Huang,L. and
            Wang,Z.Y.
  TITLE     Imunoreactivity of zinc transporter 7 (ZNT7) in mouse dorsal root
            ganglia
  JOURNAL   Brain Res Bull 74 (4), 278-283 (2007)
   PUBMED   17720550
REFERENCE   8  (bases 1 to 2032)
  AUTHORS   Falcon-Perez,J.M. and Dell'Angelica,E.C.
  TITLE     Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect
            of adaptor protein 3-depleted fibroblasts by promoting zinc
            accumulation in lysosomes
  JOURNAL   Exp Cell Res 313 (7), 1473-1483 (2007)
   PUBMED   17349999
REFERENCE   9  (bases 1 to 2032)
  AUTHORS   Kirschke,C.P. and Huang,L.
  TITLE     ZnT7, a novel mammalian zinc transporter, accumulates zinc in the
            Golgi apparatus
  JOURNAL   J Biol Chem 278 (6), 4096-4102 (2003)
   PUBMED   12446736
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jul 17, 2010 this sequence version replaced XM_227612.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.1505140.1,
                                           SRR26360176.508062.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-230               JAXUCZ010000002.1  206606814-206607043 c
            231-332             JAXUCZ010000002.1  206606496-206606597 c
            333-446             JAXUCZ010000002.1  206593704-206593817 c
            447-534             JAXUCZ010000002.1  206590881-206590968 c
            535-661             JAXUCZ010000002.1  206590142-206590268 c
            662-811             JAXUCZ010000002.1  206585513-206585662 c
            812-862             JAXUCZ010000002.1  206578926-206578976 c
            863-998             JAXUCZ010000002.1  206575492-206575627 c
            999-1089            JAXUCZ010000002.1  206555440-206555530 c
            1090-1239           JAXUCZ010000002.1  206552716-206552865 c
            1240-2032           JAXUCZ010000002.1  206544800-206545592 c
FEATURES             Location/Qualifiers
     source          1..2032
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..2032
                     /gene="Slc30a7"
                     /note="solute carrier family 30 member 7"
                     /db_xref="GeneID:310801"
                     /db_xref="RGD:1307873"
     exon            1..230
                     /gene="Slc30a7"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..1287
                     /gene="Slc30a7"
                     /note="znT-7; solute carrier family 30 (zinc transporter),
                     member 7"
                     /codon_start=1
                     /product="zinc transporter 7"
                     /protein_id="NP_001178644.1"
                     /db_xref="GeneID:310801"
                     /db_xref="RGD:1307873"
                     /translation="MLPLSIKDDEYKPPKFNLFGKISGWFRSILSDKTSRNLFFFLCL
                     NLSFAFVELLYGIWSNCLGLISDSFHMFFDSTAILAGLAASVISKWRDNDAFSYGYVR
                     AEVLAGFVNGLFLIFTAFFIFSEGVERALAPPDVHHERLLLVSILGFVVNLVGIFVFN
                     HGGHGHSHGSGHGHSHSLFNGALDHSHGHEDHCHSHGAKHGGAHSHDHDHAHGHGHLH
                     SHDGPSFKETAGPSRQILQGVFLHILADTLGSIGVIASAIMMQNFGLMIADPICSILI
                     AILIVVSVIPLLRESIGILMQRTPPSLENVLPQCYQRVQQLQGVYNLQEQHFWTLCSD
                     VYVGTLKLVVAPDADARWILSQTHNIFTQAGVRQLYVQIDFAAM"
     exon            231..332
                     /gene="Slc30a7"
                     /inference="alignment:Splign:2.1.0"
     exon            333..446
                     /gene="Slc30a7"
                     /inference="alignment:Splign:2.1.0"
     exon            447..534
                     /gene="Slc30a7"
                     /inference="alignment:Splign:2.1.0"
     exon            535..661
                     /gene="Slc30a7"
                     /inference="alignment:Splign:2.1.0"
     exon            662..811
                     /gene="Slc30a7"
                     /inference="alignment:Splign:2.1.0"
     exon            812..862
                     /gene="Slc30a7"
                     /inference="alignment:Splign:2.1.0"
     exon            863..998
                     /gene="Slc30a7"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1089
                     /gene="Slc30a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1239
                     /gene="Slc30a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..2032
                     /gene="Slc30a7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtgtgtgt ctgtgtctgt gtctcgcggc ggtgccgcgg ccgtcaagcg ctttgggatc
       61 cgcgtctgaa tcgtctctgc tgtcactgcc gccaccatac cgagtcactt ctagagggac
      121 agagacccgg cctttcgccg ggtggagaag atgttgcccc tgtccatcaa ggatgatgaa
      181 tacaagccac ccaagttcaa tctgttcggc aagatttcag gctggtttag gtccatcctg
      241 tctgacaaga catcccggaa cctgtttttc ttcctgtgcc tgaacctctc tttcgctttt
      301 gtggaactac tctacggcat ctggagcaac tgcctaggct tgatctccga ctcgttccac
      361 atgttttttg atagtactgc catattggct ggattggcag cttctgtcat ttccaagtgg
      421 agagataatg acgctttctc ttatgggtat gttagagcgg aagtcctggc tggctttgtc
      481 aatgggctgt ttttgatctt cactgctttc tttattttct cagaaggcgt tgagagagca
      541 ttggctcctc cagatgtaca ccacgagaga ctgctgcttg tttcgattct tggatttgtg
      601 gtaaacctag taggaatatt tgttttcaat catggaggtc acggacattc tcacggctct
      661 ggccatggac acagtcattc cctctttaat ggtgctctag atcacagcca tggccatgaa
      721 gaccattgcc atagtcacgg agccaaacat ggaggtgcac acagccatga ccatgaccat
      781 gctcatggac atgggcactt gcattcccac gatggcccat ccttcaaaga aacagcagga
      841 cccagcagac agattttaca aggtgtattt ttacacattc tggcagatac acttgggagt
      901 attggtgtaa ttgcctccgc catcatgatg cagaatttcg ggttgatgat agcagatcct
      961 atctgttcga ttcttatagc cattcttata gttgtaagtg ttattccact tttaagagag
     1021 tctattggaa tattaatgca aagaactcct ccctcgttgg aaaatgtgct tccccagtgc
     1081 tatcagaggg tgcaacagtt acaaggagtt tacaacttgc aagaacagca cttctggaca
     1141 ctctgttctg atgtttacgt tggaaccttg aagcttgtag tagcccctga tgcagacgcc
     1201 aggtggatct tgagccaaac acataatatt tttactcagg ctggagtgag acagctttat
     1261 gtacagattg actttgcggc aatgtagtca aagaaaggaa attgatggag gaccaaactt
     1321 tccagtactg tacaatccaa ggcattgtac tacccagtgc tctgcggcag acgtgaccac
     1381 tgcagcccgg aagcaccaag cacgcaggta gagccagtgt gagctcgggg gtcacagcca
     1441 atccgcccag acctgcctgt gtgcttttcc cttcaagcca ttctgactgc tgaggtttct
     1501 gggttcgttc tagggtactg ggttatctct ccccctgggg gttctcgctg atcacttcac
     1561 cccatcctta tctccccacc cagccagtga gaaattcaga ccggaggcct tcacccttct
     1621 gaatgtcttc actacagctg ctggaaacca ctgcttttat ccccataaaa ccagtgttgt
     1681 ttttacaaaa agaagtgttt tctatgtgat gtcacagttg ctgacgttct tcagtgtaat
     1741 catacgtttg taaaaattgt ttgtaccttg caaacttaca aaccaaacca tattgggttt
     1801 tcaaagtgcc tttgtatcag aaatatattt gccagcatag aaatgtacca acaaaggtca
     1861 tatgtatgtt ttttttaaaa aggatattct gtaatttgta caaaataaga cttgctaata
     1921 acatacataa ttgtctttgt gtatttccaa tatagactta aatatattaa atttttgtct
     1981 tgtgaaaaat gacattattt tgctttataa aaaaatccag ttattacatt aa
//
