LOCUS       NM_001106404            3049 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus solute carrier family 30 member 5 (Slc30a5),
            mRNA.
ACCESSION   NM_001106404 XM_001062806 XM_226722
VERSION     NM_001106404.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3049)
  AUTHORS   Petkovic V, Miletta MC, Eble A, Fluck CE and Mullis PE.
  TITLE     Alteration of ZnT5-mediated zinc import into the early secretory
            pathway affects the secretion of growth hormone from rat pituitary
            cells
  JOURNAL   Horm Res Paediatr 82 (4), 245-251 (2014)
   PUBMED   25196974
  REMARK    GeneRIF: these results suggest that ZnT5 might play an important
            role in regulated growth hormone secretion that is much greater
            than previously anticipated
REFERENCE   2  (bases 1 to 3049)
  AUTHORS   Falcon-Perez JM and Dell'Angelica EC.
  TITLE     Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect
            of adaptor protein 3-depleted fibroblasts by promoting zinc
            accumulation in lysosomes
  JOURNAL   Exp Cell Res 313 (7), 1473-1483 (2007)
   PUBMED   17349999
REFERENCE   3  (bases 1 to 3049)
  AUTHORS   Inoue K, Matsuda K, Itoh M, Kawaguchi H, Tomoike H, Aoyagi T, Nagai
            R, Hori M, Nakamura Y and Tanaka T.
  TITLE     Osteopenia and male-specific sudden cardiac death in mice lacking a
            zinc transporter gene, Znt5
  JOURNAL   Hum Mol Genet 11 (15), 1775-1784 (2002)
   PUBMED   12095919
REFERENCE   4  (bases 1 to 3049)
  AUTHORS   Cragg RA, Christie GR, Phillips SR, Russi RM, Kury S, Mathers JC,
            Taylor PM and Ford D.
  TITLE     A novel zinc-regulated human zinc transporter, hZTL1, is localized
            to the enterocyte apical membrane
  JOURNAL   J Biol Chem 277 (25), 22789-22797 (2002)
   PUBMED   11937503
REFERENCE   5  (bases 1 to 3049)
  AUTHORS   Kambe T, Narita H, Yamaguchi-Iwai Y, Hirose J, Amano T, Sugiura N,
            Sasaki R, Mori K, Iwanaga T and Nagao M.
  TITLE     Cloning and characterization of a novel mammalian zinc transporter,
            zinc transporter 5, abundantly expressed in pancreatic beta cells
  JOURNAL   J Biol Chem 277 (21), 19049-19055 (2002)
   PUBMED   11904301
REFERENCE   6  (bases 1 to 3049)
  AUTHORS   Lacourse KA, Swanberg LJ, Gillespie PJ, Rehfeld JF, Saunders TL and
            Samuelson LC.
  TITLE     Pancreatic function in CCK-deficient mice: adaptation to dietary
            protein does not require CCK
  JOURNAL   Am J Physiol 276 (5), G1302-G1309 (1999)
   PUBMED   10330022
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473955.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001062806.1, XM_226722.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC107651.1, SRR8487226.47775.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3049
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..3049
                     /gene="Slc30a5"
                     /note="solute carrier family 30 member 5"
                     /db_xref="GeneID:294698"
                     /db_xref="RGD:1306931"
     exon            1..226
                     /gene="Slc30a5"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..2432
                     /gene="Slc30a5"
                     /note="zinc transporter 5; solute carrier family 30 (zinc
                     transporter), member 5"
                     /codon_start=1
                     /product="proton-coupled zinc antiporter SLC30A5"
                     /protein_id="NP_001099874.1"
                     /db_xref="GeneID:294698"
                     /db_xref="RGD:1306931"
                     /translation="MEEKYGGDPRPGPGGGLGPVDVPSARLTKYIVLLCLTKCLKAVG
                     LFESYDLLKAVHIVQFIFILKLGTAFFMVLFQKPFSSGKTVTKHQWIKIFKHAVAGCI
                     ISLLWFFGLTLCGPLRTLLLFEHSDIVVISLLSVLFTSSGGGPAKTRGAAFFIIAVIC
                     LLLFDNDDLMAKMAEHPEGHHDSALTHMLYTAIAFLGVADHKGGVLLLVLALCCKVGF
                     HTASRKLSIDVGGAKRLQALSQLVSVFLLCPWVIVLSVTTESKIESWFPLIMPFTTVI
                     FFVMILDFYMDSVCSVKMEASKCARYGSFPIFISALLFGNFWTHPITDQLRAMNRAAH
                     QESTEHVLSGGVVVSAVFFILSANILSSPSKRGQKGTLIGYSPEGTPLYHFMGDAFQH
                     SSQSVPRFIKDSLKQILEESDSRQIFYFLCLNLLFTFVELFYGVLTNSLGLISDGFHM
                     LFDCSALVMGLFAALVSRWKATRIFSYGYGRIEILSGFINGLFLIVIAFFVFLESVAR
                     LIDPPELDTNMLTPVSIGGLIVNLIGVCAFSHAHSHGHGPSQGHCHSDHGHSHHAHGH
                     SDHGHSHGFTGGGMNANMRGVFLHVLADTLGSIGVIVSTVLIEQFGWFIADPLCSLFI
                     AVLIFLSVIPLIKDACQVLLLRLPPDYEKELHIALEKVQKLEGLISYRDPHFWRHSAS
                     IVAGTIHIQVTSDVLEQRVVQQVTGILKDAGVNNLTIQVEKEAYFQHMSGLSTGFHDV
                     LAMTQQMESMKYCKDGTYIM"
     exon            227..349
                     /gene="Slc30a5"
                     /inference="alignment:Splign:2.1.0"
     exon            350..416
                     /gene="Slc30a5"
                     /inference="alignment:Splign:2.1.0"
     exon            417..502
                     /gene="Slc30a5"
                     /inference="alignment:Splign:2.1.0"
     exon            503..590
                     /gene="Slc30a5"
                     /inference="alignment:Splign:2.1.0"
     exon            591..678
                     /gene="Slc30a5"
                     /inference="alignment:Splign:2.1.0"
     exon            679..755
                     /gene="Slc30a5"
                     /inference="alignment:Splign:2.1.0"
     exon            756..926
                     /gene="Slc30a5"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1215
                     /gene="Slc30a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1424
                     /gene="Slc30a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1582
                     /gene="Slc30a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1712
                     /gene="Slc30a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1905
                     /gene="Slc30a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2132
                     /gene="Slc30a5"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2261
                     /gene="Slc30a5"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..3049
                     /gene="Slc30a5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tacctgccga gcccgggcta gcggtgggga ctgctgagcc tgagaggacg cgactgaaat
       61 gggggagtga cgcgcctgcg cccgcgcttc cgcagcggca gcaagacatg aggagagccc
      121 gcggcgtggg cagcggctcc tgagccggca tggaggagaa gtacggcggg gacccgcggc
      181 ccgggcccgg cggcggcctc gggccggtgg acgtgcccag cgcccgatta acaaaataca
      241 ttgtattact gtgtttaacc aaatgtttga aggctgtggg actttttgaa tcgtatgatc
      301 tcctaaaagc tgttcacatt gttcaattta tttttatatt aaagctcggg actgcgtttt
      361 ttatggtttt gtttcaaaaa ccgttttctt ctgggaaaac cgttacaaag catcagtgga
      421 tcaaaatatt taaacatgca gttgctggat gtatcatatc acttttatgg ttttttggcc
      481 ttactctctg tggaccacta aggactttgc tgctgtttga acacagtgac attgtcgtca
      541 tctctctgct cagtgtttta ttcactagct ctggaggagg accagcaaag acaagaggag
      601 ctgctttttt cattattgct gtgatctgtt tattgctttt cgacaatgat gatctcatgg
      661 ctaagatggc cgaacacccg gaaggccatc atgacagtgc tctcactcac atgctttata
      721 cagctatcgc cttcctgggt gtggcagatc acaagggtgg cgtactcttg ctggtgctgg
      781 ctttatgttg taaagttggt tttcacacgg cctccagaaa gctctctata gatgttggtg
      841 gagctaagcg ccttcaggcc ttatcccagc ttgtttctgt gtttctccta tgcccatggg
      901 tgattgttct ttctgtgaca actgagagta agatcgagtc ttggttccca ctcatcatgc
      961 ctttcaccac agtcatcttc tttgtcatga tcctggattt ctacatggat tccgtttgtt
     1021 ctgtcaaaat ggaagcttcc aaatgtgccc gctatggatc cttccccatc tttattagtg
     1081 ctctgctctt tggaaacttc tggacacatc caataacaga ccaactgcgg gctatgaaca
     1141 gagcagcaca ccaggagagc acagagcatg tcctgtctgg aggagtggta gtgagtgctg
     1201 tgttcttcat tctgtcggcc aacatcctct catctccctc taagagagga cagaaaggta
     1261 cccttattgg atattctcca gaaggaacac cgctctatca cttcatgggt gatgcttttc
     1321 agcacagctc tcagtcggtc cctaggttta ttaaggactc actgaaacag attcttgagg
     1381 agagtgactc taggcagatc ttttacttct tgtgcttgaa tctgctcttc acctttgtgg
     1441 agttgttcta tggagtgctc accaacagtc tgggcctgat ctcagacgga ttccacatgc
     1501 tctttgactg ctccgccttg gtcatgggac tgtttgctgc cctggtgagc agatggaaag
     1561 ccacccggat tttctcctac gggtatggcc gaatagaaat tctctctgga tttattaatg
     1621 gacttttcct gatagtgata gctttttttg tgtttctgga gtcagtggct agactgattg
     1681 atcctccgga acttgacaca aacatgctga caccagtgtc cattggaggg ctgatagtaa
     1741 accttattgg agtctgtgcc tttagtcacg cccacagtca tggccatggg ccttctcaag
     1801 gacactgcca ctcggatcac ggccattccc accatgctca tggacacagc gaccatggtc
     1861 acagccacgg attcacaggt ggaggcatga atgcgaacat gaggggtgta tttctccatg
     1921 ttttggcaga tacactgggc agcattggcg tgattgtgtc cacagttctt atagagcagt
     1981 tcggatggtt tattgctgat cccctgtgtt ctctttttat tgccgtgtta atatttctca
     2041 gtgttatccc actgattaaa gacgcctgtc aagttttact tctgagacta ccacctgact
     2101 atgaaaaaga actacatatt gctttagaaa aggtacagaa actcgaagga ttaatatcct
     2161 accgagaccc tcatttttgg cgccattctg ccagtattgt agcagggaca attcacattc
     2221 aggtgacatc tgatgtgctg gaacagagag ttgtgcagca ggttacagga atacttaaag
     2281 atgcgggagt aaacaaccta acaatacagg tggaaaagga ggcgtacttc cagcacatgt
     2341 ctggcctaag cactggcttc cacgatgtcc tggctatgac tcagcagatg gaatccatga
     2401 agtactgcaa agacggcact tacatcatgt gagatgagcc ccagcggcgt gaacagtgga
     2461 ggtggataat gtcagttcag agtgaaagtt gcacacaact gtacagaaac cttgaaagct
     2521 ccctattgtt ggattaggca gtctttttta aaagaaaatt gaggtgcgga atgaagcatt
     2581 cattgtataa gagagctatc tgctactctg tttgaattat gtacttgaaa ggaatcttac
     2641 gttggaatga acatgatgta accttcagag acggacacat gatgatggat tctggagaag
     2701 accacgtttc ttctgtgcat ttactttctg tcagaaagca tctctactgt aaatatgtat
     2761 ttacatgttt attacaaaga cccagatgaa gtttttagtc gatttttgca tatctgaagg
     2821 acaaaatggg aataaaattc tatatttatg aattttctgt atataaaact gatttctaat
     2881 tctaacttaa gtccattaag tgagagctgt ctttctgctt ggactgtaaa ctatccagga
     2941 gaaatttcaa cccctgatct gagagaacaa tgagaataga gaactgtgat atagttcttg
     3001 gtgtatacga gatttaacca ctccagtaaa taaatttttt atttttggt
//
