LOCUS       NM_172066               5411 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus solute carrier family 30 member 4 (Slc30a4),
            mRNA.
ACCESSION   NM_172066 NM_001025030 XM_346659
VERSION     NM_172066.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5411)
  AUTHORS   Murgia,C., Grosser,D., Truong-Tran,A.Q., Roscioli,E.,
            Michalczyk,A., Ackland,M.L., Stoltenberg,M., Danscher,G., Lang,C.,
            Knight,D., Perozzi,G., Ruffin,R.E. and Zalewski,P.
  TITLE     Apical localization of zinc transporter ZnT4 in human airway
            epithelial cells and its loss in a murine model of allergic airway
            inflammation
  JOURNAL   Nutrients 3 (11), 910-928 (2011)
   PUBMED   22254085
  REMARK    GeneRIF: The loss of ZnT4 in airway inflammation contributes to
            airway epithelium vulnerability in diseases such as asthma.
REFERENCE   2  (bases 1 to 5411)
  AUTHORS   Aguilar-Alonso,P., Martinez-Fong,D., Pazos-Salazar,N.G.,
            Brambila,E., Gonzalez-Barrios,J.A., Mejorada,A., Flores,G.,
            Millan-Perezpena,L., Rubio,H. and Leon-Chavez,B.A.
  TITLE     The increase in zinc levels and upregulation of zinc transporters
            are mediated by nitric oxide in the cerebral cortex after transient
            ischemia in the rat
  JOURNAL   Brain Res 1200, 89-98 (2008)
   PUBMED   18289514
  REMARK    GeneRIF: The upregulation of ZnT1, ZnT2, and ZnT4 was to decrease
            the cytosolic zinc levels caused by NO after transient occlusion of
            the CCA.
REFERENCE   3  (bases 1 to 5411)
  AUTHORS   Flach,C.F., Qadri,F., Bhuiyan,T.R., Alam,N.H., Jennische,E.,
            Holmgren,J. and Lonnroth,I.
  TITLE     Differential expression of intestinal membrane transporters in
            cholera patients
  JOURNAL   FEBS Lett 581 (17), 3183-3188 (2007)
   PUBMED   17575980
REFERENCE   4  (bases 1 to 5411)
  AUTHORS   Falcon-Perez,J.M. and Dell'Angelica,E.C.
  TITLE     Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect
            of adaptor protein 3-depleted fibroblasts by promoting zinc
            accumulation in lysosomes
  JOURNAL   Exp Cell Res 313 (7), 1473-1483 (2007)
   PUBMED   17349999
REFERENCE   5  (bases 1 to 5411)
  AUTHORS   Kelleher,S.L. and Lonnerdal,B.
  TITLE     Zn transporter levels and localization change throughout lactation
            in rat mammary gland and are regulated by Zn in mammary cells
  JOURNAL   J Nutr 133 (11), 3378-3385 (2003)
   PUBMED   14608047
REFERENCE   6  (bases 1 to 5411)
  AUTHORS   Ranaldi,G., Perozzi,G., Truong-Tran,A., Zalewski,P. and Murgia,C.
  TITLE     Intracellular distribution of labile Zn(II) and zinc transporter
            expression in kidney and MDCK cells
  JOURNAL   Am J Physiol Renal Physiol 283 (6), F1365-F1375 (2002)
   PUBMED   12388418
REFERENCE   7  (bases 1 to 5411)
  AUTHORS   Kelleher,S.L. and Lonnerdal,B.
  TITLE     Zinc transporters in the rat mammary gland respond to marginal zinc
            and vitamin A intakes during lactation
  JOURNAL   J Nutr 132 (11), 3280-3285 (2002)
   PUBMED   12421840
REFERENCE   8  (bases 1 to 5411)
  AUTHORS   Murgia,C., Vespignani,I., Cerase,J., Nobili,F. and Perozzi,G.
  TITLE     Cloning, expression, and vesicular localization of zinc transporter
            Dri 27/ZnT4 in intestinal tissue and cells
  JOURNAL   Am J Physiol 277 (6), G1231-G1239 (1999)
   PUBMED   10600821
REFERENCE   9  (bases 1 to 5411)
  AUTHORS   Huang,L. and Gitschier,J.
  TITLE     A novel gene involved in zinc transport is deficient in the lethal
            milk mouse
  JOURNAL   Nat Genet 17 (3), 292-297 (1997)
   PUBMED   9354792
REFERENCE   10 (bases 1 to 5411)
  AUTHORS   Ackland,M.L. and Mercer,J.F.
  TITLE     The murine mutation, lethal milk, results in production of
            zinc-deficient milk
  JOURNAL   J Nutr 122 (6), 1214-1218 (1992)
   PUBMED   1588438
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_172066.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y16774.1, SRR26360176.349449.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-657               JAXUCZ010000003.1  130228232-130228888 c
            658-804             JAXUCZ010000003.1  130220639-130220785 c
            805-958             JAXUCZ010000003.1  130214813-130214966 c
            959-1163            JAXUCZ010000003.1  130213153-130213357 c
            1164-1269           JAXUCZ010000003.1  130212432-130212537 c
            1270-1404           JAXUCZ010000003.1  130211487-130211621 c
            1405-5411           JAXUCZ010000003.1  130206852-130210858 c
FEATURES             Location/Qualifiers
     source          1..5411
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..5411
                     /gene="Slc30a4"
                     /note="solute carrier family 30 member 4"
                     /db_xref="GeneID:64469"
                     /db_xref="RGD:619750"
     exon            1..657
                     /gene="Slc30a4"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..1559
                     /gene="Slc30a4"
                     /note="zinc transporter 4; znT-4; dri 27 protein; Dri
                     27/ZnT4 protein; solute carrier family 30 (zinc
                     transporter), member 4"
                     /codon_start=1
                     /product="probable proton-coupled zinc antiporter SLC30A4"
                     /protein_id="NP_742063.2"
                     /db_xref="GeneID:64469"
                     /db_xref="RGD:619750"
                     /translation="MAGPGAWKRLKSLLRKDDTPLFLNDTSAFDFSDEVSDEGLSRFN
                     KLRVVVADDDSEAPERPVNGAHPALQADDDSLLDQDLPLTNSQLSLKMDPCDNCSKRR
                     ELLKQRKVKTRLTIAAVLYLLFMIGELVGGYMANSLAIMTDALHMLTDLSAIILTLLA
                     LWLSSKSPTRRFTFGFHRLEVLSAMISVMLVYVLMGFLLYEAVQRTIHMNYEINGDVM
                     LITAAVGVAVNVIMGFLLNQSGHHHSHAHSHSLPSNSPSMVSSGHSHGQDSLAVRAAF
                     VHALGDLVQSVGVLIAAYIIRFKPEYKIADPICTYIFSLLVAFTTLRIIWDTVVIILE
                     GVPSHLNVDYIKESLMKIEDVYSVEDLNIWSLTSGKATAIVHMQLIPGSSSKWEEVQS
                     KAKHLLLNTFGMYKCTVQLQSYRQEATRTCANCQSSST"
     exon            658..804
                     /gene="Slc30a4"
                     /inference="alignment:Splign:2.1.0"
     exon            805..958
                     /gene="Slc30a4"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1163
                     /gene="Slc30a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1269
                     /gene="Slc30a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1404
                     /gene="Slc30a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..5411
                     /gene="Slc30a4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcggggcgg gcgggtgcag cggcttgggc tcggcctccg tccctggccc gggtcgcagc
       61 agcgcgagcc tcccgagcgg ggatgcgcgg cggcggcggc ggcggccagc aggtagccga
      121 gcgccgccgg gtccagagct ggcgcgcggc cgggcgcggc gacagtagcg ggtctcgttc
      181 tcctcacgat gggcagggac gcgccgcgct gccctgagga gcccgagcgc ccgtgaaggc
      241 ggagtcgccg gccgccctcc gctgccatgg ccggccccgg cgcgtggaag cgcctcaaat
      301 ccctgctgag gaaagacgac acgccgctgt tcttaaatga caccagcgcc ttcgacttct
      361 cggacgaggt gagcgacgag gggctttcgc gctttaataa acttcgagtc gtggtggccg
      421 acgatgactc ggaagccccg gaaaggcctg tgaacggggc gcacccggcc ctccaggccg
      481 acgatgactc cttattggac caggacttac ctttgaccaa cagtcagctg agtttgaaga
      541 tggacccctg tgacaactgc agcaaacggc gcgagttgct gaagcagagg aaggtgaaga
      601 ccaggctgac catcgctgcc gtcctctact tgcttttcat gatcggagag cttgtaggtg
      661 gatacatggc aaatagctta gcaataatga cagatgcact tcatatgcta actgacctta
      721 gtgccatcat actcactctt cttgctttgt ggctgtcttc aaagtcacca accagaagat
      781 tcacctttgg atttcatcgc ctagaggttc tgtcggccat gatcagtgtc atgctggtgt
      841 atgtacttat gggattcctc ttatacgagg ctgtgcagag aaccatccat atgaactatg
      901 aaatcaatgg cgatgtcatg ctcatcactg cagctgttgg agttgcagtt aatgtgataa
      961 tggggtttct gttgaaccag tccggtcacc accattctca cgctcattcc cactccctac
     1021 cttcaaattc tccgagcatg gtatctagtg gacacagcca tgggcaggac agcttggccg
     1081 tgagagctgc atttgtacac gccctggggg atttggtaca aagtgttggt gtgcttatag
     1141 ctgcatacat catacgattc aagccagaat acaagattgc tgaccccatc tgtacatata
     1201 tattttcatt acttgtggca ttcacaacgc tccgcattat atgggacaca gtagtgataa
     1261 tactggaagg tgtaccgagc catttgaatg tagactatat caaagagtcg ttgatgaaga
     1321 tagaagatgt atattctgtg gaagatttga atatctggtc tctcacttct ggaaaagcca
     1381 ctgccatagt gcacatgcag ctaattcccg gaagttcatc aaaatgggag gaagtgcagt
     1441 cgaaagctaa gcacctcttg ctgaacacat tcggcatgta caagtgcact gttcagctcc
     1501 agagctacag acaggaagcc accagaactt gtgcaaattg tcaaagttcc agtacctgat
     1561 tctatgtcct tggggtctac agccttattt atcccgcagt cacagacttg agagcaataa
     1621 acgcaaacct aatggagtcc ctgacagctg tgtccatgtc aagccccagt ctccccaaaa
     1681 cagactctgt tctgactgat atttgcatga ttttcaggca aagaagttcc aaagtactgt
     1741 ttacagaatg agctgtaact ctgaagatac ctcatagaag acaatccaag accatacttc
     1801 attaatttga cagagtacgc aacatgtaca ggaagactca gaattcagta tttgcatcta
     1861 aaaactactt ttttcgagcc ttttatatga agtcagtgct agcaaactca gtgttgaact
     1921 atttgagatt tttgtctatg tgtaatcttg gcatccagtt tctggaattg tgttctcttt
     1981 ttataaaaat tagccctcaa cagatttcag aaaatattta tatccagaaa atggaataag
     2041 catgtattcc taagtgtttc agaactgttt tatttcacaa ataacttata agcagatttt
     2101 ccagatagta ctggattttg aatctcaaca cttttgatta tttgtaatct tgtcagaaat
     2161 attcacatta tgccgtcact gtccttcagt tatgtaggaa aactttaata taattacgaa
     2221 tggcagaaat tagatttaac ctcaaattcc cttaccatat gatgatctta aacagagaag
     2281 ccaagtggta ggctgtggag ttttggattc tgtcttcctg aacatcactt ctgtgcttta
     2341 tgtagaattg tcttaggaca gtaagagaca acagagtttc agcagttgtc cagtgtgctc
     2401 cttagaactc cgacgtttgt tagtaagttt gcttagcacc ttgttctcag gtgtactcag
     2461 tatcatttgt ggacatcttc cccagtacct acaaatggcc aagacggagg ttagtaacac
     2521 ctaccactgg agtaccttcg ttactccaga gagaatttat gttatgatat aggctagggg
     2581 ttctccacag attgcagaaa ctcccaaggt acaatcttga agttttacaa taatgccata
     2641 gcagaaagat acaaaggcgt tgggtggaga aagctctttg agaaaacaca aggtaaaagg
     2701 ttctgttttg tcttgtttag ttttgtttga ccatgtatgt gcacagaaga actgaaataa
     2761 ggatggacac taaaactgtc tgggaagcag cgtaaatatt tccaagctca agggaaggca
     2821 gctgactgca gttgtgttaa agagacagtc atgaatattc atgcttcatt cccagcagtt
     2881 gctttgatag gagctccttt cagcttagac actgtggatg gctcttgtct cctcagaatc
     2941 agagtggagt aacactgtcc caaacaggtt gtgaagttct agaaatccaa gagacgtgta
     3001 aatgaagagt gagaagttga gacattctct gtgtgtaaaa ctaaaataag aaatagggtc
     3061 aaaaaacagc tggtgttact ccataaaact caatgggtat gtgttgaatt caaagtttac
     3121 tttgaaaaaa acaaaaagtt tactttaatt tttattgtaa gtccatttaa aattataaat
     3181 atttgaactt caaattttct tagaatataa ataaaacaat gattaacctg agtagatggc
     3241 aggcatttaa gtggctacct gggcatttgt ggccttttga tatctagggg aaaaggaaag
     3301 tgtgcatttt atacttaaca ttttcccaca ttgggtgagc tcatttcttg taaacaaccc
     3361 tttaccatag tgtgggtata tccggatatt catgttgact tagtccttaa gaccagttct
     3421 ggaagtctta actgtcatat tcacgtaaag tgggatgcct gaggtctctg cacttcacct
     3481 tgcagcagga cctagactct gtgcctcact gggtccacaa gatggaaagc tggtagacct
     3541 tatgagttaa attgtcaacc catagaggaa agacattaag tcagcagtta catcagggac
     3601 tacacagctg tgaggtttga cctgtctttc ccccattgag acacagtgca ccgtggcaca
     3661 gcctctcagt taactatgaa aactctttgc tctgcaaaaa gcaggatctg aattgatttg
     3721 ggagatatag tgctaatctt gtactgggaa acaccatggc atttctccac ggcagtatgt
     3781 tctaaggagt atttcagata attagttact gtagacatta acctgtattt cacaccttgg
     3841 gcccatgaag tcttttgttt taggaagact gtctgactaa cagtcttgct gtctgaagaa
     3901 gaccaagaat gcagttgagt aagcatactc aataggcaga actggagcta ctgtgcttct
     3961 tactggcagc tatgttaact tccacagcta aaggtcttaa tgtgagcata gattttcaca
     4021 ttcacagctt ccatccgcat tgtttagcag atcactagat gtcttggttt accatttttc
     4081 ttgtcagttt ggggtagagg ttttcatttt cctctatgat atatttcctg attatatgac
     4141 tctcagtgtt ctgtcttaag cccaggtcac ccacttgcca gtatttgtct tcaggagatc
     4201 cttcccacag tggacacagt gaagatcaga gagatacaca agcttctctc catttttcag
     4261 agactttcag ccaatactta gaaatacgtt tccaggtgag aaaggtttta aaacctcaga
     4321 tcatcccctg accaggattt ctgcatggga acatggtaga gaatatgaga cagaaataga
     4381 ctgagcagct actgtgaacc tttgaggttc tcacagtgcc agtccgcaag cacacttaga
     4441 gattttgatc ctgaagccta cttcagctcc atctggtttt ctgtagttat aaccattggt
     4501 tcatcatcat atgatgctct cacagactct gagctcgttt gctgttgact accttgtagg
     4561 tagtaaactg aaaggtctag aatgtgccac tctatatacc tataatacca ttcagttcag
     4621 ttcatctttg gaccctctta gttacaaatg atcagtgaca tctcactagc tactgtcctg
     4681 agggagggag caagtctgat ctctaggtaa ttgacttaac atctctgtag ccagaacacc
     4741 atttgcaaac tcataattcc aactccaggt ctgtcaaatg aatcctatgg accagggctg
     4801 cagatttgat tctataggta gatatattgt ttgtgatgtt agtgggagca tgcaaactag
     4861 agagaaaaat ttgtgggaat tcctcagtat tgtgtgtctc catttaggca acacatcagt
     4921 gagttcttgg ttacagaatg tttgttggag atcaacagtc attttctgat ttttgttaag
     4981 attggtaagt gtttatggag accttgccag ctaaatccat ggcagtgtcc atttaaatag
     5041 tgcaattaag aataccccga aataaatgga acccaaagtt gaaacatgcc aggatgcccc
     5101 ttttctaccc aggagaaacc ttatatttgg aaactgtctg cctctctaaa taaatatgtg
     5161 attaataagc catatcacag tttaaggaat tgtatatact ttcctgtatg cccctccaaa
     5221 aaccaagtat tttgcaaatg attgatttta gaaagatttt gaagctgggg tttatctgtg
     5281 taatgaagac cagattcttt gtatatgtac tgtatttgta attttcaaat gaaatttcct
     5341 atatgattat taaataaagt gttgttttgc cttgtggttt attaaaaact tacaatgtac
     5401 agccacctaa a
//
