LOCUS       NM_001013243            1690 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Rattus norvegicus solute carrier family 30 member 3 (Slc30a3),
            mRNA.
ACCESSION   NM_001013243 XM_345642
VERSION     NM_001013243.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1690)
  AUTHORS   Nishida,K., Bansho,S., Ikukawa,A., Kubota,T., Ohishi,A. and
            Nagasawa,K.
  TITLE     Expression profile of the zinc transporter ZnT3 in taste cells of
            rat circumvallate papillae and its role in zinc release, a
            potential mechanism for taste stimulation
  JOURNAL   Eur J Histochem 66 (4), 3534 (2022)
   PUBMED   36373349
  REMARK    GeneRIF: Expression profile of the zinc transporter ZnT3 in taste
            cells of rat circumvallate papillae and its role in zinc release, a
            potential mechanism for taste stimulation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1690)
  AUTHORS   Qin,W., Li,L., Wang,T., Huang,H. and Gao,Y.
  TITLE     Urine Proteome Changes in a TNBS-Induced Colitis Rat Model
  JOURNAL   Proteomics Clin Appl 13 (5), e1800100 (2019)
   PUBMED   31095872
REFERENCE   3  (bases 1 to 1690)
  AUTHORS   Ni,H., Chen,S.H., Li,L.L. and Jin,M.F.
  TITLE     Alterations in the Neurobehavioral Phenotype and ZnT3/CB-D28k
            Expression in the Cerebral Cortex Following
            Lithium-Pilocarpine-Induced Status Epilepticus: the Ameliorative
            Effect of Leptin
  JOURNAL   Biol Trace Elem Res 187 (1), 100-106 (2019)
   PUBMED   29687372
  REMARK    GeneRIF: The ZnT3/CB-D28k-associated Zn (2+)/Ca(2+) signaling might
            be involved in neonatal SE-induced long-term brain damage in the
            aspects of neurobehavioral impairment.
REFERENCE   4  (bases 1 to 1690)
  AUTHORS   Hildebrand,M.S., Phillips,A.M., Mullen,S.A., Adlard,P.A.,
            Hardies,K., Damiano,J.A., Wimmer,V., Bellows,S.T., McMahon,J.M.,
            Burgess,R., Hendrickx,R., Weckhuysen,S., Suls,A., De Jonghe,P.,
            Scheffer,I.E., Petrou,S., Berkovic,S.F. and Reid,C.A.
  TITLE     Loss of synaptic Zn2+ transporter function increases risk of
            febrile seizures
  JOURNAL   Sci Rep 5, 17816 (2015)
   PUBMED   26647834
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1690)
  AUTHORS   Tian,T., Ni,H. and Sun,B.L.
  TITLE     Neurobehavioral Deficits in a Rat Model of Recurrent Neonatal
            Seizures Are Prevented by a Ketogenic Diet and Correlate with
            Hippocampal Zinc/Lipid Transporter Signals
  JOURNAL   Biol Trace Elem Res 167 (2), 251-258 (2015)
   PUBMED   25778834
  REMARK    GeneRIF: rats treated with KD (EXP2) showed a significant
            down-regulated expression of ZnT-3, MT-3, ApoE, clusterin, and
            ACAT-1 in hippocampus
REFERENCE   6  (bases 1 to 1690)
  AUTHORS   Salazar,G., Falcon-Perez,J.M., Harrison,R. and Faundez,V.
  TITLE     SLC30A3 (ZnT3) oligomerization by dityrosine bonds regulates its
            subcellular localization and metal transport capacity
  JOURNAL   PLoS One 4 (6), e5896 (2009)
   PUBMED   19521526
  REMARK    GeneRIF: SLC30A3 (ZnT3) oligomerization by dityrosine bonds
            regulates its subcellular localization and metal transport capacity
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1690)
  AUTHORS   Ni,H., Jiang,Y.W., Tao,L.Y., Jin,M.F. and Wu,X.R.
  TITLE     ZnT-1, ZnT-3, CaMK II, PRG-1 expressions in hippocampus following
            neonatal seizure-induced cognitive deficit in rats
  JOURNAL   Toxicol Lett 184 (3), 145-150 (2009)
   PUBMED   19059322
  REMARK    GeneRIF: ZnT-1, ZnT-3, CaMK II, PRG-1 expressions in hippocampus
            following neonatal seizure-induced cognitive deficit in rats.
REFERENCE   8  (bases 1 to 1690)
  AUTHORS   Falcon-Perez,J.M. and Dell'Angelica,E.C.
  TITLE     Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect
            of adaptor protein 3-depleted fibroblasts by promoting zinc
            accumulation in lysosomes
  JOURNAL   Exp Cell Res 313 (7), 1473-1483 (2007)
   PUBMED   17349999
REFERENCE   9  (bases 1 to 1690)
  AUTHORS   Salazar,G., Craige,B., Love,R., Kalman,D. and Faundez,V.
  TITLE     Vglut1 and ZnT3 co-targeting mechanisms regulate vesicular zinc
            stores in PC12 cells
  JOURNAL   J Cell Sci 118 (Pt 9), 1911-1921 (2005)
   PUBMED   15860731
  REMARK    GeneRIF: the coupling of zinc transporter 3 and Vglut1 transport
            mechanisms regulates neurotransmitter content in secretory vesicles
REFERENCE   10 (bases 1 to 1690)
  AUTHORS   Cole,T.B., Wenzel,H.J., Kafer,K.E., Schwartzkroin,P.A. and
            Palmiter,R.D.
  TITLE     Elimination of zinc from synaptic vesicles in the intact mouse
            brain by disruption of the ZnT3 gene
  JOURNAL   Proc Natl Acad Sci U S A 96 (4), 1716-1721 (1999)
   PUBMED   9990090
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY538655.1.
            
            On Apr 20, 2005 this sequence version replaced XM_345642.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY538655.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1690
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..1690
                     /gene="Slc30a3"
                     /gene_synonym="ZnT3"
                     /note="solute carrier family 30 member 3"
                     /db_xref="GeneID:366568"
                     /db_xref="RGD:1359689"
     exon            1..175
                     /gene="Slc30a3"
                     /gene_synonym="ZnT3"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1247
                     /gene="Slc30a3"
                     /gene_synonym="ZnT3"
                     /note="solute carrier family 30 protein; zinc transporter
                     3; znT-3; zinc transporter ZnT-3; solute carrier family 30
                     (zinc transporter), member 3"
                     /codon_start=1
                     /product="probable proton-coupled zinc antiporter SLC30A3"
                     /protein_id="NP_001013261.1"
                     /db_xref="GeneID:366568"
                     /db_xref="RGD:1359689"
                     /translation="MEPSPASGGSETTRLVSPRDRSSAGGGLRLKSLFTEPSEPLPEG
                     PKLEGMAFHHCHKNRVSQSGLSPERAQARRQLYAACVVCFIFMAGEVVGGYLAHSLAI
                     MTDAAHLLADIGSMMASLFSLWLSTRPATRTMTFGWHRSETLGALASVVSLWIVTGIL
                     LYLAFLRLLHSDYHIEAGAMLLTASIAVCANMIMAFVLHQTGAPHSHGPRGAEYAPLE
                     EGHGHPLSLGNTSVRAAFVHVLGDLLQSLGVLAASILIYFKPQYKVADPISTFLFSIC
                     ALGSTAPTLRDVLLVLMEGAPRSVEFEPVRDTLLSVPGVRATHDLHLWALTLTYHVAS
                     AHLAIDSTADPEAILAEASSRLYSRFGFSSCTLQVEKYRSEMAHCLRCREPPKA"
     exon            176..357
                     /gene="Slc30a3"
                     /gene_synonym="ZnT3"
                     /inference="alignment:Splign:2.1.0"
     exon            358..504
                     /gene="Slc30a3"
                     /gene_synonym="ZnT3"
                     /inference="alignment:Splign:2.1.0"
     exon            505..658
                     /gene="Slc30a3"
                     /gene_synonym="ZnT3"
                     /inference="alignment:Splign:2.1.0"
     exon            659..857
                     /gene="Slc30a3"
                     /gene_synonym="ZnT3"
                     /inference="alignment:Splign:2.1.0"
     exon            858..963
                     /gene="Slc30a3"
                     /gene_synonym="ZnT3"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1098
                     /gene="Slc30a3"
                     /gene_synonym="ZnT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1689
                     /gene="Slc30a3"
                     /gene_synonym="ZnT3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttgggccgc tgggatttgg cgcaaggcct gccccgcctc accccctctg tgcggcctag
       61 acggtcgagg cagcggggac atggaacctt ctccggccag cggaggctcg gagaccaccc
      121 gcctagtgag tccccgagac cgcagcagcg ccggcggcgg cctgcgattg aagagtcttt
      181 tcacagagcc ctcagagccc ctgccggagg ggcccaagct tgaggggatg gccttccacc
      241 actgccacaa gaaccgcgtg tctcagtcag gcctctctcc agagagggcg caggcccgga
      301 ggcagctgta tgctgcctgc gtcgtgtgct tcatcttcat ggctggggag gtggttggtg
      361 ggtatttagc acacagcttg gccatcatga ccgacgccgc ccacttgctg gcagacatag
      421 gcagtatgat ggccagcctc ttttccctct ggctctctac tcggccagcc acccgcacca
      481 tgacctttgg ctggcaccgc tcagagactc tgggagcttt ggcctccgtg gtctccctct
      541 ggatagtcac cggcatcctc ctgtacctgg ccttcctccg cctgcttcac agtgactacc
      601 acattgaggc gggcgccatg ctgctgactg ccagcattgc tgtctgtgcc aacatgataa
      661 tggcctttgt gctgcaccag actggagccc cccacagcca cggacctagg ggtgcagagt
      721 atgcaccact ggaggagggg cacgggcacc cactgtccct gggaaacacc agtgtccggg
      781 ctgcctttgt gcatgtgctg ggagatctcc ttcagagcct cggggtcctg gccgcctcta
      841 tcctcatcta cttcaagccc cagtacaagg tggccgaccc catcagcacc ttcctcttct
      901 ctatctgcgc ccttgggtcc acagctccta cacttcgaga tgttctcctc gtcctcatgg
      961 aaggtgcccc tcggagtgtg gaatttgagc ctgtaaggga caccttgttg tcagtgccgg
     1021 gtgtccgagc cacccatgat ctccacctgt gggcgctgac gcttacttac cacgttgcct
     1081 ccgcacacct ggctattgac tccacggctg accctgaagc catcctggct gaagcctcat
     1141 cccggctcta ttcccggttt ggattctcta gctgcaccct gcaggtggag aaataccggt
     1201 ctgagatggc ccactgtctt cgctgccggg agccccccaa agcctgagcc tcagccccac
     1261 cctcgcccca ctgccaggac taggcttgtg cctggaccct cagcacctgc ctcccagatc
     1321 acagaagaga cctttctctc tccatcttcc acctgccaaa tgccctcacc cctgccccgg
     1381 tggtcaagac caaagtgtat atgaaggcag tggggggagg ggaggatcgg attgaatagc
     1441 tgtaagcgat tcaggggtgt ggggcgtgtg gaagccccct gccatccgtg ctccacatgg
     1501 agagagtcat gcttgtcctc tacgattcct gtgtccctgt ggcaggctgg ctggctagct
     1561 ggggacatct gcctgtctgt gtgctgttcg tgtgcctatg cctggggagg tcagcagggg
     1621 ccccctcccc acgtgatcct tgctcttgtc tatgcagggg ccccaaagcc tgcactttgt
     1681 ttgtgtgcca
//
