LOCUS       NM_001083122            3100 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus solute carrier family 30 member 2 (Slc30a2),
            transcript variant 1, mRNA.
ACCESSION   NM_001083122
VERSION     NM_001083122.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3100)
  AUTHORS   Golan,Y., Berman,B. and Assaraf,Y.G.
  TITLE     Heterodimerization, altered subcellular localization, and function
            of multiple zinc transporters in viable cells using bimolecular
            fluorescence complementation
  JOURNAL   J Biol Chem 290 (14), 9050-9063 (2015)
   PUBMED   25657003
REFERENCE   2  (bases 1 to 3100)
  AUTHORS   Iguchi,K., Morihara,N., Usui,S., Hayama,M., Sugimura,Y. and
            Hirano,K.
  TITLE     Castration- and aging-induced changes in the expression of zinc
            transporter and metallothionein in rat prostate
  JOURNAL   J Androl 32 (2), 144-150 (2011)
   PUBMED   20798384
  REMARK    GeneRIF: expression of the zinc transporter in ventral prostate
            (VP) of aged rats (21 months) was approximately 21-fold higher than
            that in VP of young rats (4 months), and zinc levels in VP of young
            rats increased significantly compared with that in aged rats.
REFERENCE   3  (bases 1 to 3100)
  AUTHORS   Guo,L., Lichten,L.A., Ryu,M.S., Liuzzi,J.P., Wang,F. and
            Cousins,R.J.
  TITLE     STAT5-glucocorticoid receptor interaction and MTF-1 regulate the
            expression of ZnT2 (Slc30a2) in pancreatic acinar cells
  JOURNAL   Proc Natl Acad Sci U S A 107 (7), 2818-2823 (2010)
   PUBMED   20133611
REFERENCE   4  (bases 1 to 3100)
  AUTHORS   Song,Y., Elias,V., Wong,C.P., Scrimgeour,A.G. and Ho,E.
  TITLE     Zinc transporter expression profiles in the rat prostate following
            alterations in dietary zinc
  JOURNAL   Biometals 23 (1), 51-58 (2010)
   PUBMED   19760107
  REMARK    GeneRIF: The results indicate that ZnT2 may play a significant role
            in the maintenance of zinc homeostasis in the prostate.
REFERENCE   5  (bases 1 to 3100)
  AUTHORS   Aguilar-Alonso,P., Martinez-Fong,D., Pazos-Salazar,N.G.,
            Brambila,E., Gonzalez-Barrios,J.A., Mejorada,A., Flores,G.,
            Millan-Perezpena,L., Rubio,H. and Leon-Chavez,B.A.
  TITLE     The increase in zinc levels and upregulation of zinc transporters
            are mediated by nitric oxide in the cerebral cortex after transient
            ischemia in the rat
  JOURNAL   Brain Res 1200, 89-98 (2008)
   PUBMED   18289514
  REMARK    GeneRIF: The upregulation of ZnT1, ZnT2, and ZnT4 was to decrease
            the cytosolic zinc levels caused by NO after transient occlusion of
            the CCA.
REFERENCE   6  (bases 1 to 3100)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   7  (bases 1 to 3100)
  AUTHORS   Falcon-Perez,J.M. and Dell'Angelica,E.C.
  TITLE     Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect
            of adaptor protein 3-depleted fibroblasts by promoting zinc
            accumulation in lysosomes
  JOURNAL   Exp Cell Res 313 (7), 1473-1483 (2007)
   PUBMED   17349999
REFERENCE   8  (bases 1 to 3100)
  AUTHORS   Asano,N., Kondoh,M., Ebihara,C., Fujii,M., Nakanishi,T.,
            Soares,M.J., Nakashima,E., Tanaka,K., Sato,M. and Watanabe,Y.
  TITLE     Expression profiles of zinc transporters in rodent placental models
  JOURNAL   Toxicol Lett 154 (1-2), 45-53 (2004)
   PUBMED   15475177
  REMARK    GeneRIF: There were no differences between the mRNA expression
            levels of ZnT family members in undifferentiated Rcho-1 cells and
            differentiated Rcho-1 cells.
REFERENCE   9  (bases 1 to 3100)
  AUTHORS   Iguchi,K., Usui,S., Inoue,T., Sugimura,Y., Tatematsu,M. and
            Hirano,K.
  TITLE     High-level expression of zinc transporter-2 in the rat lateral and
            dorsal prostate
  JOURNAL   J Androl 23 (6), 819-824 (2002)
   PUBMED   12399528
  REMARK    GeneRIF: Expression of zinc transporter-2 in lateral and dorsal
            prostate was unaffected by castration. Factors regulating zinc
            homeostasis other than zinc transporters are involved in lowering
            zinc content after castration in rat prostate.
REFERENCE   10 (bases 1 to 3100)
  AUTHORS   Palmiter,R.D., Cole,T.B. and Findley,S.D.
  TITLE     ZnT-2, a mammalian protein that confers resistance to zinc by
            facilitating vesicular sequestration
  JOURNAL   EMBO J 15 (8), 1784-1791 (1996)
   PUBMED   8617223
  REMARK    GeneRIF: Transfection and mutation studies show that translation
            initiates at a non-AUG (CUG) start codon.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB778290.1 and BC061997.1.
            
            Summary: The protein encoded by this gene is a zinc transporter. It
            is localized in the vesicles and suggested to protect the cells
            from zinc toxicity by facilitating vesicular sequestration.
            Alternatively spliced transcript variants have been found for this
            gene, one of which initiates translation from a non-AUG (CUG) start
            codon. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168237.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               CB778290.1         1-154
            155-3100            BC061997.1         97-3042
FEATURES             Location/Qualifiers
     source          1..3100
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3100
                     /gene="Slc30a2"
                     /gene_synonym="ZnT-2; Znt2"
                     /note="solute carrier family 30 member 2"
                     /db_xref="GeneID:25362"
                     /db_xref="RGD:3707"
     exon            1..123
                     /gene="Slc30a2"
                     /gene_synonym="ZnT-2; Znt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1192
                     /gene="Slc30a2"
                     /gene_synonym="ZnT-2; Znt2"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     transporter 2; solute carrier family 30 (zinc
                     transporter), member 2; proton-coupled zinc antiporter
                     SLC30A2"
                     /codon_start=1
                     /product="proton-coupled zinc antiporter SLC30A2 isoform
                     1"
                     /protein_id="NP_001076591.1"
                     /db_xref="GeneID:25362"
                     /db_xref="RGD:3707"
                     /translation="MQTMDKQNLLESTRGARSFFGALWKSEASRIPPVNLPSVELAVQ
                     SNHYCHAQKDSGSHPNSEKQRARRKLYVASAICLVFMIGEIIGGYLAQSLAIMTDAAH
                     LLTDFASMLISLFSLWVSSRPATKTMNFGWQRAEILGALLSVLSIWVVTGVLVYLAVQ
                     RLISGDYEIKGDTMLITSGCAVAVNIIMGLALHQSGHGHSHGHSHEDSSQQQQNPSVR
                     AAFIHVVGDLLQSVGVLVAAYIIYFKPEYKYVDPICTFLFSILVLGTTLTILRDVILV
                     LMEGTPKGVDFTTVKNLLLSVDGVEALHSLHIWALTVAQPVLSVHIAIAQNVDAQAVL
                     KVARDRLQGKFNFHTMTIQIESYSEDMKSCQECQGPSE"
     exon            124..332
                     /gene="Slc30a2"
                     /gene_synonym="ZnT-2; Znt2"
                     /inference="alignment:Splign:2.1.0"
     exon            333..479
                     /gene="Slc30a2"
                     /gene_synonym="ZnT-2; Znt2"
                     /inference="alignment:Splign:2.1.0"
     exon            480..633
                     /gene="Slc30a2"
                     /gene_synonym="ZnT-2; Znt2"
                     /inference="alignment:Splign:2.1.0"
     exon            634..805
                     /gene="Slc30a2"
                     /gene_synonym="ZnT-2; Znt2"
                     /inference="alignment:Splign:2.1.0"
     exon            806..911
                     /gene="Slc30a2"
                     /gene_synonym="ZnT-2; Znt2"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1046
                     /gene="Slc30a2"
                     /gene_synonym="ZnT-2; Znt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..3089
                     /gene="Slc30a2"
                     /gene_synonym="ZnT-2; Znt2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3066..3071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc30a2"
                     /gene_synonym="ZnT-2; Znt2"
     polyA_site      3089
                     /gene="Slc30a2"
                     /gene_synonym="ZnT-2; Znt2"
ORIGIN      
        1 gctgaaagta gaaggtgact gcgagctgcc atcgtcccgc gcgcaacttc gagggctcac
       61 cgggagaggt ggcatgcaga ccatggacaa gcagaacctg ctggagagca cgcgcggagc
      121 ccggtctttc tttggagctc tgtggaagag tgaagctagc cgaatcccgc ctgtgaacct
      181 gccctctgtt gaactggctg tccagagcaa ccattactgt catgcgcaga aggattctgg
      241 aagtcacccc aactccgaga agcagagggc ccgacgcaaa ctctatgtgg cctctgccat
      301 ctgcctggtg ttcatgattg gagagattat tggtgggtac ctggcacaga gcttagccat
      361 catgaccgac gcggcccacc tgctcactga tttcgccagc atgctcatta gtctcttctc
      421 cctctgggtg tcctcccggc cagccaccaa gaccatgaac ttcggctggc agcgagctga
      481 gatccttgga gccttgctgt ctgtactgtc tatctgggtg gtgaccgggg tgctcgtgta
      541 cctggctgta cagcggttga tttctggaga ttatgagatc aaaggggaca ccatgttgat
      601 cacttcgggc tgcgctgtgg ctgtgaacat cataatgggg ctggccctcc atcagtctgg
      661 acatggacac agccatgggc acagccatga ggacagcagc cagcagcagc agaaccccag
      721 tgtccgagct gccttcattc atgtggttgg ggaccttcta cagagtgtgg gcgtcctggt
      781 ggcagcctat attatatact tcaagcccga gtacaagtac gtggacccca tctgcacctt
      841 cctcttctcc atcctggtct tggggacaac gttaaccatc ctgagagatg tgatcttggt
      901 tctcatggaa gggactccca aaggtgtgga cttcacaact gtgaaaaatc ttctgctgtc
      961 cgtggatggt gtggaagcct tacacagcct gcatatctgg gcgctgacag tggcccagcc
     1021 cgtgctgtct gtccacatag ccattgccca gaatgttgat gcccaggctg tgctgaaggt
     1081 ggctagggac cgcctccagg ggaagttcaa tttccacacc atgaccatcc aaattgagag
     1141 ctactctgag gacatgaaga gctgccagga gtgccagggt ccctcggaat aactccctgg
     1201 ccagacacca tctcattgga agtatggcca agacctgagg gcagaatagt ccgtgtgcag
     1261 ccgggacccc aggatcaaga catggcctgg tccactacac catgggactc tcctaggatg
     1321 gggacatagc agacgaggcc ccacttctct ttcaggactg tgtttaggct ggatcctgga
     1381 ctaatgttat gctcacacca cagctggaga gacactgagg cgcagaaagg gattttgggg
     1441 tgtccttgta taagccaggg tctctgtctg aaccaaaagt tgaacaagat ccacgtgtca
     1501 cgtgactgga tagttggagc tccctttaaa agaatcggtc acattgataa aagagttttt
     1561 gaaccggagt cagggggaag atctgaggat gttttattag aatttgggag aaggaaaaaa
     1621 aaaaaacaaa cccaatcaca gtccaggcaa gccaagccgg acatctcagc agctgctgaa
     1681 ggagagggag gttggagaga gagccagggc ttctgagtta gggtcagcag tggagttctg
     1741 taaacagctg gatggttata atgggggagc gggttaaagg aacagtgaga gtgtcacaca
     1801 ccggcaagca ggtgtgcgtg cacacacgat ttaaagacaa aaatgaagag aggaaaaggg
     1861 ggaaggagaa accggcttct gagttagttt gggaaagcga gctaacttag cggttaaggt
     1921 ctataagcaa gtgcctgtat gtgggacccc agggaaccat gagtgaccta atcaaagaac
     1981 taattgttcc ttggcatgtc tttgggtgac tgaccggccc aactgaacaa actctgaaag
     2041 actgcgtaga ggtcgggccg taacttggtg gaattgttcc tctctgtctt taggtgaatt
     2101 tctgtgatca gtgtcaggta atcaggtctg agccaccctc gagggagggc tatgggaggt
     2161 tgggacaggt taactccatc ctcaccaggg gtagaaagaa cctagtttcc attcttttgt
     2221 ccaggaggaa tttgctccta ggggatccgt ctctgattag ctttactgaa ctgggagaag
     2281 agcctatgtc ttggctatat aacatggctt gccaaggcct tggggacagc attcatacaa
     2341 ctgcccccaa gacatgaggc caaggggcac ctgaggcttc cctctgcctt gctcactttg
     2401 actgttgggc cccaagtgac ttcctggaag agaaggagga agagaggcct cttcataggg
     2461 aaaaacctgg ctggttcctt cctggtaccc cagcccagga agccatgtca gtggccttaa
     2521 caggtggcag ggacagattc cagttagctc ttgttctcat agccccaggg ccaggccact
     2581 tcccttgacc tgtctcaaga gatagaagat cctgctctgt tgcctaatcg accgtgacct
     2641 tattaggggt gaggacgagt ccaggggctg acaggagggg tgtccttgga gtccatttga
     2701 agaatcctta gagctggctt gaggttacag gcgcaacagt tgagagatgt ccccaatctt
     2761 atacaggtga caggcctgcc ttcgtaggaa gtcctgggcc aatgtgtaca tgttcatgca
     2821 ggccaactgg ttgtcacttc ttagtacccg tgactcacac gaagaccagg gacatcctga
     2881 catctccccc acaggagtgt gcaggcagcc cagcctggtg gttgtgtatt ggtttctttg
     2941 atcagtgtcc tggaaaggct cttgtgaagg gccagacagg cctcccacgt tcctgtattg
     3001 gctgccctag cacataagag gaaaggctag gtgttggcct ccaccaacac cacccaattt
     3061 taaaaaataa atggctagca tttgctttaa aaaaaaaaaa
//
