LOCUS       NM_001105985            2243 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus solute carrier family 30, member 10 (Slc30a10),
            mRNA.
ACCESSION   NM_001105985 XM_001065717 XM_223046
VERSION     NM_001105985.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2243)
  AUTHORS   Hutchens,S., Melkote,A., Jursa,T., Shawlot,W., Trasande,L.,
            Smith,D.R. and Mukhopadhyay,S.
  TITLE     Elevated thyroid manganese reduces thyroid iodine to induce
            hypothyroidism in mice, but not rats, lacking SLC30A10 transporter
  JOURNAL   Metallomics 16 (7) (2024)
   PUBMED   38866719
  REMARK    GeneRIF: Elevated thyroid manganese reduces thyroid iodine to
            induce hypothyroidism in mice, but not rats, lacking SLC30A10
            transporter.
REFERENCE   2  (bases 1 to 2243)
  AUTHORS   Zhao,Y., Feresin,R.G., Falcon-Perez,J.M. and Salazar,G.
  TITLE     Differential Targeting of SLC30A10/ZnT10 Heterodimers to
            Endolysosomal Compartments Modulates EGF-Induced MEK/ERK1/2
            Activity
  JOURNAL   Traffic 17 (3), 267-288 (2016)
   PUBMED   26728129
REFERENCE   3  (bases 1 to 2243)
  AUTHORS   Leyva-Illades,D., Chen,P., Zogzas,C.E., Hutchens,S., Mercado,J.M.,
            Swaim,C.D., Morrisett,R.A., Bowman,A.B., Aschner,M. and
            Mukhopadhyay,S.
  TITLE     SLC30A10 is a cell surface-localized manganese efflux transporter,
            and parkinsonism-causing mutations block its intracellular
            trafficking and efflux activity
  JOURNAL   J Neurosci 34 (42), 14079-14095 (2014)
   PUBMED   25319704
REFERENCE   4  (bases 1 to 2243)
  AUTHORS   Tuschl,K., Clayton,P.T., Gospe,S.M. Jr., Gulab,S., Ibrahim,S.,
            Singhi,P., Aulakh,R., Ribeiro,R.T., Barsottini,O.G., Zaki,M.S., Del
            Rosario,M.L., Dyack,S., Price,V., Rideout,A., Gordon,K.,
            Wevers,R.A., Chong,W.K. and Mills,P.B.
  TITLE     Syndrome of hepatic cirrhosis, dystonia, polycythemia, and
            hypermanganesemia caused by mutations in SLC30A10, a manganese
            transporter in man
  JOURNAL   Am J Hum Genet 90 (3), 457-466 (2012)
   PUBMED   22341972
  REMARK    Erratum:[Am J Hum Genet. 2016 Aug 4;99(2):521. doi:
            10.1016/j.ajhg.2016.07.015. PMID: 27486784]
REFERENCE   5  (bases 1 to 2243)
  AUTHORS   Patrushev,N., Seidel-Rogol,B. and Salazar,G.
  TITLE     Angiotensin II requires zinc and downregulation of the zinc
            transporters ZnT3 and ZnT10 to induce senescence of vascular smooth
            muscle cells
  JOURNAL   PLoS One 7 (3), e33211 (2012)
   PUBMED   22427991
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473985.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_001065717.1, XM_223046.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5756307,
                              SAMEA5760393 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2243
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     gene            1..2243
                     /gene="Slc30a10"
                     /gene_synonym="RGD1305098"
                     /note="solute carrier family 30, member 10"
                     /db_xref="GeneID:289353"
                     /db_xref="RGD:1305098"
     exon            1..816
                     /gene="Slc30a10"
                     /gene_synonym="RGD1305098"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..1619
                     /gene="Slc30a10"
                     /gene_synonym="RGD1305098"
                     /note="zinc transporter 10"
                     /codon_start=1
                     /product="calcium/manganese antiporter SLC30A10"
                     /protein_id="NP_001099455.1"
                     /db_xref="GeneID:289353"
                     /db_xref="RGD:1305098"
                     /translation="MGRYSGKTCRLLFMLVLTAAFFVAELVSGYLGNSIALLSDSFNM
                     LSDLISLCVGLGSGYIARRGPRGSSATYGYVRAEVVGALSNAVFLTALCFTIFVEAVL
                     RLARPERIDDPELVLIVGALGLAVNVVGLLIFQDCGACFSRCTRGHRTRPSQPPRQGD
                     TGGALGCPREAATATDPGSDSAVTLRGASAGRKQQEGATVFSNVAGDSLNTQNEPEET
                     TKKEKKSEALNIRGVLLHVMGDALGSVIVVVTAIIFYVRPLRHEDPCNWQCYIDPSLT
                     VVMVIIILSSAFPLIKETAVILLQMVPKGVNMEELMSQLSMVPGVSSVHEVHIWELIS
                     GKVIATLHIKHQEGTEYQDASRKVREIFHHAGIHNVTIQFETLDLKEALEQKDFLPTC
                     SAPCISQSCAKKLCCPPGTLPLALVNGCAEHNGGPNLESYRSIEAPEVVIDVALDGCP
                     RKQGQVHSKTQERQHCENSTHF"
     exon            817..894
                     /gene="Slc30a10"
                     /gene_synonym="RGD1305098"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1134
                     /gene="Slc30a10"
                     /gene_synonym="RGD1305098"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..2243
                     /gene="Slc30a10"
                     /gene_synonym="RGD1305098"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaatcaggct tgggcggcga gggaggaggg gcaggggccc cgggaggtgc cctttgcgac
       61 tctggggcca ctcctgcaga ctctggtccc gcgagcgcga gctagtggca taaaaggccc
      121 gggagggtaa gggcgggcct gccgccggag gtgggctcca gacccccgca acctgttgcg
      181 gggctcagcg ggctgtaaag atgggccgtt attcgggcaa gacctgtcgg ctgctgttca
      241 tgctggtgct caccgcggcc ttcttcgtgg ccgaactggt gtcgggttac ctgggcaact
      301 ccatcgcgct gctctcggac tcgttcaaca tgctgtctga tctgatctcg ctgtgcgtgg
      361 gcctgggctc cggctacatc gcgcgacgcg gtccccgcgg ctccagcgcc acctacggct
      421 atgtgcgggc ggaggtggtg ggcgcgctca gcaacgcagt cttcctcacc gcgctctgct
      481 ttaccatctt cgtggaggcc gtgttgcggc tcgcgcggcc cgagcgcatc gacgacccgg
      541 agctggtact catcgtgggc gccctggggc tggcagtcaa cgtggtgggg ctgctcatct
      601 tccaggactg cggcgcctgc ttctcccgct gcacgcgggg tcaccggacc cgcccttcgc
      661 agccgccgcg ccagggggac actggtggcg ctttggggtg tccccgggag gctgcgacag
      721 ccacagaccc cggctcagac tcagcagtga ctctccgggg ggcctcggcc ggaagaaagc
      781 agcaggaggg cgcgacggtg ttctcgaatg tagcaggtga ttccctgaac acccagaatg
      841 aaccagaaga gacaacaaaa aaggagaaga agtctgaagc actgaatatc agaggtgttc
      901 ttttgcatgt gatgggagat gccctggggt ccgtgattgt ggttgtcaca gccatcatat
      961 tctatgttcg tcccctgaga catgaagacc cgtgtaactg gcaatgctac attgacccca
     1021 gtttgactgt tgtcatggtc atcattatct tatcatcagc ctttccactc atcaaggaga
     1081 ctgctgtcat cctgctgcag atggttccca agggagtcaa catggaggag ctgatgagcc
     1141 agctgtctat ggtgcctggg gttagcagtg tgcatgaagt gcacatctgg gaactgataa
     1201 gtgggaaggt tattgccacc ttgcacatca agcaccagga gggcacggaa taccaggatg
     1261 ccagcagaaa agtccgcgag atcttccacc atgcaggaat ccacaacgtg accatccagt
     1321 ttgaaacatt ggacttgaag gaagccctgg agcagaagga cttcttgcca acctgcagtg
     1381 caccctgcat ctcccagagt tgcgctaaga agctctgctg tcccccgggg acactgcctc
     1441 tggctctcgt caatggttgt gcagagcaca atggtgggcc caatctagag tcttaccgaa
     1501 gcatagaagc tccagaagtg gtcatagatg tggctttgga tggctgtcca aggaagcaag
     1561 gacaggttca cagcaagact caagagagac agcattgtga aaacagcact catttttagt
     1621 gggttcccac acaaatcaaa cagtctaaac agacactttg gtgtcactgg ctctgcttgt
     1681 gggaagagct ctgtggatgt gtatcctgtc agtaggggtc agccatttga gatgttagtg
     1741 gaacaagcct gctgattttc atgtggtgga taaccccttt ccagtactct gggcatctca
     1801 tggttctctg tgacagtttc agtacggata tgaatttcct aaagcagact gccctagtgt
     1861 atatatcagg agtgttgaag ggctcagcaa ctatgacagg ggacatgaag taggtcttgt
     1921 ctgtcttgtg gtgctgggga attgcataca gggctcgtgc gtgctaagga actgctctgt
     1981 taccgagatg aactctgtat gtagcctttg ttttcaaaca catcagaact tctagttgac
     2041 tctcaggtga gctcaaagct tacgtgggta gaaaagcagt taagcacctt aactatgttt
     2101 tcctctcttc ccctcaaaga tcataaaaga tgaacatcag gttttcgtgg ccctgcagaa
     2161 acatatattc ttaagtccat tcttggacca cgagaaacag acacctaata aataaattca
     2221 agatgcatag ttattaagat gga
//
