LOCUS       NM_022853               2610 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Rattus norvegicus solute carrier family 30 member 1 (Slc30a1),
            mRNA.
ACCESSION   NM_022853
VERSION     NM_022853.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2610)
  AUTHORS   Pan,R. and Liu,K.J.
  TITLE     ZNT-1 Expression Reduction Enhances Free Zinc Accumulation in
            Astrocytes After Ischemic Stroke
  JOURNAL   Acta Neurochir Suppl 121, 257-261 (2016)
   PUBMED   26463958
  REMARK    GeneRIF: Hypoxia/reoxygenation dramatically decreased ZnT-1
            expression in rat astrocytes.
REFERENCE   2  (bases 1 to 2610)
  AUTHORS   Mellone,M., Pelucchi,S., Alberti,L., Genazzani,A.A., Di Luca,M. and
            Gardoni,F.
  TITLE     Zinc transporter-1: a novel NMDA receptor-binding protein at the
            postsynaptic density
  JOURNAL   J Neurochem 132 (2), 159-168 (2015)
   PUBMED   25319628
  REMARK    GeneRIF: ZNT-1 interacts with GluN2A-containing NMDA receptors at
            the glutamatergic synapse. This complex is regulated by synaptic
            plasticity induction. ZNT-1 expression modulation in hippocampal
            neurons shrank dendritic spines and reduced GluN2A surface levels.
REFERENCE   3  (bases 1 to 2610)
  AUTHORS   Liu,C., He,X., Hong,X., Kang,F., Chen,S., Wang,Q., Chen,X., Hu,D.
            and Sun,Q.
  TITLE     Suppression of placental metallothionein 1 and zinc transporter 1
            mRNA expressions contributes to fetal heart malformations caused by
            maternal zinc deficiency
  JOURNAL   Cardiovasc Toxicol 14 (4), 329-338 (2014)
   PUBMED   24807795
  REMARK    GeneRIF: These data indicate that maternal zinc deficiency resulted
            in an elevated incidence of fetal heart malformations, which was
            associated with significant decreases in placental MT-1 and ZnT-1
            mRNA expressions
REFERENCE   4  (bases 1 to 2610)
  AUTHORS   Shusterman,E., Beharier,O., Shiri,L., Zarivach,R., Etzion,Y.,
            Campbell,C.R., Lee,I.H., Okabayashi,K., Dinudom,A., Cook,D.I.,
            Katz,A. and Moran,A.
  TITLE     ZnT-1 extrudes zinc from mammalian cells functioning as a
            Zn(2+)/H(+) exchanger
  JOURNAL   Metallomics 6 (9), 1656-1663 (2014)
   PUBMED   24951051
REFERENCE   5  (bases 1 to 2610)
  AUTHORS   Sindreu,C., Bayes,A., Altafaj,X. and Perez-Clausell,J.
  TITLE     Zinc transporter-1 concentrates at the postsynaptic density of
            hippocampal synapses
  JOURNAL   Mol Brain 7, 16 (2014)
   PUBMED   24602382
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2610)
  AUTHORS   Nolte,C., Gore,A., Sekler,I., Kresse,W., Hershfinkel,M.,
            Hoffmann,A., Kettenmann,H. and Moran,A.
  TITLE     ZnT-1 expression in astroglial cells protects against zinc toxicity
            and slows the accumulation of intracellular zinc
  JOURNAL   Glia 48 (2), 145-155 (2004)
   PUBMED   15378655
  REMARK    GeneRIF: The elevated ZnT-1 expression following zinc priming or
            after heterologous expression of ZnT-1 may explain the reduced zinc
            accumulation and the subsequent reduction in sensitivity toward
            toxic zinc levels. [ZnT-1]
            Erratum:[Glia. 2004 Dec;48(4):346]
REFERENCE   7  (bases 1 to 2610)
  AUTHORS   Segal,D., Ohana,E., Besser,L., Hershfinkel,M., Moran,A. and
            Sekler,I.
  TITLE     A role for ZnT-1 in regulating cellular cation influx
  JOURNAL   Biochem Biophys Res Commun 323 (4), 1145-1150 (2004)
   PUBMED   15451416
  REMARK    GeneRIF: Our findings therefore indicate that ZnT-1 modulates the
            permeation of cations through LTCC, thereby, regulating cation
            homeostasis through this pathway.
REFERENCE   8  (bases 1 to 2610)
  AUTHORS   Andrews,G.K., Wang,H., Dey,S.K. and Palmiter,R.D.
  TITLE     Mouse zinc transporter 1 gene provides an essential function during
            early embryonic development
  JOURNAL   Genesis 40 (2), 74-81 (2004)
   PUBMED   15452870
REFERENCE   9  (bases 1 to 2610)
  AUTHORS   McMahon,R.J. and Cousins,R.J.
  TITLE     Regulation of the zinc transporter ZnT-1 by dietary zinc
  JOURNAL   Proc Natl Acad Sci U S A 95 (9), 4841-4846 (1998)
   PUBMED   9560190
REFERENCE   10 (bases 1 to 2610)
  AUTHORS   Palmiter,R.D. and Findley,S.D.
  TITLE     Cloning and functional characterization of a mammalian zinc
            transporter that confers resistance to zinc
  JOURNAL   EMBO J 14 (4), 639-649 (1995)
   PUBMED   7882967
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U17133.1.
            
            On Aug 31, 2012 this sequence version replaced NM_022853.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U17133.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2610              U17133.1           2-2611
FEATURES             Location/Qualifiers
     source          1..2610
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q27"
     gene            1..2610
                     /gene="Slc30a1"
                     /note="solute carrier family 30 member 1"
                     /db_xref="GeneID:58976"
                     /db_xref="RGD:61918"
     exon            1..791
                     /gene="Slc30a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1696
                     /gene="Slc30a1"
                     /function="zinc transporter"
                     /note="zinc transporter 1; znT-1; solute carrier family 30
                     (zinc transporter), member 1"
                     /codon_start=1
                     /product="proton-coupled zinc antiporter SLC30A1"
                     /protein_id="NP_074044.1"
                     /db_xref="GeneID:58976"
                     /db_xref="RGD:61918"
                     /translation="MGCWGRNRGRLLCMLLLTFMFMVLEVVVSRVTASLAMLSDSFHM
                     LSDVLALVVALVAERFARRTHATQKNTFGWIRAEVMGALVNAIFLTGLCFAILLEAVE
                     RFIEPHEMQQPLVVLSVGVAGLLVNVLGLCLFHHHSGEGQGAGHGHSHGHGHGHLAKG
                     ARKAGRAGGEAGAPPGRAPDQEPDQEETNTLVANTSNSNGLKADQAEPEKLRSDDPVD
                     VQVNGNLIQESDSLESEDNRAGQLNMRGVFLHVLGDALGSVIVVVNALVFYFSWKGCT
                     EDDFCVNPCFPDPCKSSVELMNSTQAPMHEAGPCWVLYLDPTLCIIMVCILLYTTYPL
                     LKESALILLQTVPKQIDIKHLVKELRDVEGVEEVHELHVWQLAGSRIIATAHIKCEDP
                     ASYMQVAKTIKDVFHNHGIHATTIQPEFASVGSKSSVVPCELACRTQCALKQCCGTRP
                     QVHSGKEAEKAPTVSISCLELSENLEKKPRRTKAEGSVPAVVIEIKNVPNKQPESSL"
     exon            792..2610
                     /gene="Slc30a1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcggtctcc cgagcgcctc ggtccgatgc tcggcagccc ctcggtacgc agtggcccgc
       61 cgcgccctcc gcctcgccag tacagccgag cgccggcgct tgagtagctg cgcggccggc
      121 ggtttctcca cagcgccgct cccgcgtcag cgccgagctt caggccgccg ccatgggctg
      181 ctggggccgc aaccgcggcc ggctgctgtg catgctgctg ctgaccttca tgttcatggt
      241 gctggaggtg gtggtgagcc gggtgaccgc gtcgctcgcc atgctgtccg actccttcca
      301 catgctgtcg gacgtgctgg cgctcgtggt ggcgctggtg gccgagcgct tcgcccggag
      361 gactcacgcc acgcagaaga acacattcgg ctggatccgc gctgaggtga tgggcgcgct
      421 ggtgaacgcc atcttcctca cggggctgtg cttcgccatc ctgctggaag ccgtcgagcg
      481 cttcatcgag ccgcatgaga tgcagcagcc gctcgtggtg cttagcgtcg gcgtggcggg
      541 gctgctagtc aacgtgctgg ggctctgcct gttccaccac cacagcggcg agggccaggg
      601 cgcaggccac ggccactcgc acggccacgg ccacggccac ctcgccaagg gcgcgcgcaa
      661 ggcgggccgc gcggggggcg aagcgggcgc gccgccgggc cgggcgccgg accaggagcc
      721 ggaccaggag gagaccaaca cgctagtggc taacaccagc aattccaacg ggctgaaggc
      781 ggaccaggca gagccagaga agttgagaag tgatgatcca gtggatgtac aggtaaatgg
      841 gaatctcatc caggagtcag acagtctgga atcagaagac aacagggctg gacagctgaa
      901 catgcgagga gtgtttctgc acgtccttgg agatgccctg ggctctgtga tcgttgttgt
      961 gaatgccttg gtcttctact tttcctggaa gggttgtact gaagacgact tttgtgtgaa
     1021 cccgtgtttt cctgatccct gcaaatcgtc tgtagagctg atgaacagca cccaggcccc
     1081 catgcacgag gctggtccgt gctgggtcct ctacctagat ccaaccctgt gcattataat
     1141 ggtttgtata cttctttaca cgacgtaccc actgctcaag gagtccgctc tcattcttct
     1201 acagactgtt cctaagcaaa ttgatatcaa acatttggta aaagagctac gagatgttga
     1261 aggagtggag gaagtccatg agttacacgt ctggcagctc gccggaagca ggatcatcgc
     1321 cactgctcat ataaaatgtg aagacccagc ttcatacatg caggtggcca aaaccattaa
     1381 agatgttttt cacaatcatg gaattcacgc caccaccatc cagcctgaat tcgctagcgt
     1441 aggctctaaa tcaagtgtcg tcccgtgtga gctcgcctgc agaactcagt gtgctttgaa
     1501 gcagtgctgt gggacacggc cacaggtcca ttctggaaag gaggcagaga aggctccaac
     1561 agttagcatt tcttgtttag aactcagtga aaacctagag aagaagccca ggaggactaa
     1621 agctgaaggc agtgtccccg ctgtggtgat agagattaaa aatgtgccaa acaaacagcc
     1681 cgaatcatct ttgtgagcct tgagaaagat gtgatatttg actttgcttt taaactgcaa
     1741 gagaaaatag actccattga aatgctaagt ttgccacgta gtgtaattga agtcctcgtc
     1801 tggtcgcaca gtttaattct atttttgtca gaacgtaatg gaactgcaga atagagtgcg
     1861 ctacagcaca gcctcgcgat tactagtgca tagtgcagct gtgctggagc acgctttgaa
     1921 agccagttta acactatgtt acatttttgt ttaaagtaag tatagacctt atatgacata
     1981 atgacatttg attcctggtt ttcccatgat aaaaattagg gggataaata aaattgttac
     2041 tggaatttct ctgcttttct ttcccccatt gttatatctt atctgttagg attgtaattg
     2101 ctaggccttt aaagtcatca agcttgtttc ctctgatgtt gaggggtagt tacgtgccct
     2161 ttgagatcat aagcctagca taattgcagc atgtttccag agcaagtcat gactattagc
     2221 aggaaacgag attagttact actctgttct ccacttctga gtagtcgagt aaaccgtgag
     2281 gtaattcaca agatgagtta gagtttacac attgtagagc atatagggga gaagagcaag
     2341 gaagaaggca atatgtcagt tattacctat taatgtggag attatagctc taaattacct
     2401 tgaaaatctc aaatggcttt attctaccaa agtcagtcta aacacttctg ccagtgttgc
     2461 tttctttcaa agactggtat tagcaacatt gagctaaaag ttctaaatgc atgaatagtt
     2521 ttgaaaatgc agactcctta actgcaaact attaaattgt gtcttaaaaa aacttccata
     2581 gtgacctgtc agatggattg aatacctttc
//
