LOCUS       NM_001191551            3384 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus solute carrier family 2 member 9 (Slc2a9), mRNA.
ACCESSION   NM_001191551 XM_002728120
VERSION     NM_001191551.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3384)
  AUTHORS   Arakawa,H., Amezawa,N., Kawakatsu,Y. and Tamai,I.
  TITLE     Renal Reabsorptive Transport of Uric Acid Precursor Xanthine by
            URAT1 and GLUT9
  JOURNAL   Biol Pharm Bull 43 (11), 1792-1798 (2020)
   PUBMED   33132325
  REMARK    GeneRIF: Renal Reabsorptive Transport of Uric Acid Precursor
            Xanthine by URAT1 and GLUT9.
REFERENCE   2  (bases 1 to 3384)
  AUTHORS   Ebert,K., Ludwig,M., Geillinger,K.E., Schoberth,G.C.,
            Essenwanger,J., Stolz,J., Daniel,H. and Witt,H.
  TITLE     Reassessment of GLUT7 and GLUT9 as Putative Fructose and Glucose
            Transporters
  JOURNAL   J Membr Biol 250 (2), 171-182 (2017)
   PUBMED   28083649
REFERENCE   3  (bases 1 to 3384)
  AUTHORS   DeBosch,B.J., Kluth,O., Fujiwara,H., Schurmann,A. and Moley,K.
  TITLE     Early-onset metabolic syndrome in mice lacking the intestinal uric
            acid transporter SLC2A9
  JOURNAL   Nat Commun 5, 4642 (2014)
   PUBMED   25100214
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3384)
  AUTHORS   Brandstatter,A., Lamina,C., Kiechl,S., Hunt,S.C., Coassin,S.,
            Paulweber,B., Kramer,F., Summerer,M., Willeit,J., Kedenko,L.,
            Adams,T.D. and Kronenberg,F.
  TITLE     Sex and age interaction with genetic association of atherogenic
            uric acid concentrations
  JOURNAL   Atherosclerosis 210 (2), 474-478 (2010)
   PUBMED   20053405
REFERENCE   5  (bases 1 to 3384)
  AUTHORS   Bibert,S., Hess,S.K., Firsov,D., Thorens,B., Geering,K.,
            Horisberger,J.D. and Bonny,O.
  TITLE     Mouse GLUT9: evidences for a urate uniporter
  JOURNAL   Am J Physiol Renal Physiol 297 (3), F612-F619 (2009)
   PUBMED   19587147
REFERENCE   6  (bases 1 to 3384)
  AUTHORS   Kolz,M., Johnson,T., Sanna,S., Teumer,A., Vitart,V., Perola,M.,
            Mangino,M., Albrecht,E., Wallace,C., Farrall,M., Johansson,A.,
            Nyholt,D.R., Aulchenko,Y., Beckmann,J.S., Bergmann,S., Bochud,M.,
            Brown,M., Campbell,H., Connell,J., Dominiczak,A., Homuth,G.,
            Lamina,C., McCarthy,M.I., Meitinger,T., Mooser,V., Munroe,P.,
            Nauck,M., Peden,J., Prokisch,H., Salo,P., Salomaa,V., Samani,N.J.,
            Schlessinger,D., Uda,M., Volker,U., Waeber,G., Waterworth,D.,
            Wang-Sattler,R., Wright,A.F., Adamski,J., Whitfield,J.B.,
            Gyllensten,U., Wilson,J.F., Rudan,I., Pramstaller,P., Watkins,H.,
            Doering,A., Wichmann,H.E., Spector,T.D., Peltonen,L., Volzke,H.,
            Nagaraja,R., Vollenweider,P., Caulfield,M., Illig,T. and Gieger,C.
  CONSRTM   EUROSPAN Consortium; ENGAGE Consortium; PROCARDIS Consortium; KORA
            Study; WTCCC
  TITLE     Meta-analysis of 28,141 individuals identifies common variants
            within five new loci that influence uric acid concentrations
  JOURNAL   PLoS Genet 5 (6), e1000504 (2009)
   PUBMED   19503597
REFERENCE   7  (bases 1 to 3384)
  AUTHORS   Dehghan,A., Kottgen,A., Yang,Q., Hwang,S.J., Kao,W.L.,
            Rivadeneira,F., Boerwinkle,E., Levy,D., Hofman,A., Astor,B.C.,
            Benjamin,E.J., van Duijn,C.M., Witteman,J.C., Coresh,J. and
            Fox,C.S.
  TITLE     Association of three genetic loci with uric acid concentration and
            risk of gout: a genome-wide association study
  JOURNAL   Lancet 372 (9654), 1953-1961 (2008)
   PUBMED   18834626
REFERENCE   8  (bases 1 to 3384)
  AUTHORS   Vitart,V., Rudan,I., Hayward,C., Gray,N.K., Floyd,J., Palmer,C.N.,
            Knott,S.A., Kolcic,I., Polasek,O., Graessler,J., Wilson,J.F.,
            Marinaki,A., Riches,P.L., Shu,X., Janicijevic,B.,
            Smolej-Narancic,N., Gorgoni,B., Morgan,J., Campbell,S.,
            Biloglav,Z., Barac-Lauc,L., Pericic,M., Klaric,I.M., Zgaga,L.,
            Skaric-Juric,T., Wild,S.H., Richardson,W.A., Hohenstein,P.,
            Kimber,C.H., Tenesa,A., Donnelly,L.A., Fairbanks,L.D., Aringer,M.,
            McKeigue,P.M., Ralston,S.H., Morris,A.D., Rudan,P., Hastie,N.D.,
            Campbell,H. and Wright,A.F.
  TITLE     SLC2A9 is a newly identified urate transporter influencing serum
            urate concentration, urate excretion and gout
  JOURNAL   Nat Genet 40 (4), 437-442 (2008)
   PUBMED   18327257
REFERENCE   9  (bases 1 to 3384)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   10 (bases 1 to 3384)
  AUTHORS   Carayannopoulos,M.O., Schlein,A., Wyman,A., Chi,M.,
            Keembiyehetty,C. and Moley,K.H.
  TITLE     GLUT9 is differentially expressed and targeted in the
            preimplantation embryo
  JOURNAL   Endocrinology 145 (3), 1435-1443 (2004)
   PUBMED   14657010
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Jul 17, 2010 this sequence version replaced XM_002728120.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR23984936.169646.1,
                                           SRR22582416.1191526.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               JAXUCZ010000014.1  76560955-76561068
            115-213             JAXUCZ010000014.1  76563462-76563560
            214-374             JAXUCZ010000014.1  76576894-76577054
            375-499             JAXUCZ010000014.1  76587960-76588084
            500-645             JAXUCZ010000014.1  76592191-76592336
            646-778             JAXUCZ010000014.1  76614128-76614260
            779-966             JAXUCZ010000014.1  76625279-76625466
            967-1077            JAXUCZ010000014.1  76633398-76633508
            1078-1179           JAXUCZ010000014.1  76642157-76642258
            1180-1255           JAXUCZ010000014.1  76644183-76644258
            1256-1383           JAXUCZ010000014.1  76660519-76660646
            1384-3384           JAXUCZ010000014.1  76672277-76674277
FEATURES             Location/Qualifiers
     source          1..3384
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..3384
                     /gene="Slc2a9"
                     /note="solute carrier family 2 member 9"
                     /db_xref="GeneID:501925"
                     /db_xref="RGD:1597012"
     CDS             1..1638
                     /gene="Slc2a9"
                     /note="solute carrier family 2 (facilitated glucose
                     transporter), member 9"
                     /codon_start=1
                     /product="solute carrier family 2, facilitated glucose
                     transporter member 9"
                     /protein_id="NP_001178480.1"
                     /db_xref="GeneID:501925"
                     /db_xref="RGD:1597012"
                     /translation="MDARELALASLIHDTSGPGEPPVGPPVGRRGWRPRRTKNWSCSL
                     IVAALVGAFGSSFLYGYNLSVVNAPTPYIKAFYNETWYRRHGQPIDPDTLTLLWSVTV
                     SIFAIGGLVGTLMVKMIGKFLGRKYTLLVNNGFAISAALLMACSLQAGTFEMLIVGRF
                     IMGVDGGIALSALPMYLNEISPKEIRGSLGQVTAIFICIGVFSGQLLGLPELLGKERT
                     WPYLFGVIIVPALAQLASLPFLPESPRYLLFEKHDEAGATKAFQTFLGKADVSQELEE
                     ALAESRVQRNLRLVSVFELLRAPFVRWQVITVVITMASYQLCGLNAIWFYTNSIFGKA
                     GVPQDKIPYITLSTGGIETLAAIFSGLVIERLGRRPLLIGGFGLMALFFGMLTVTLTL
                     QDQAPWIPYLSIVCILAIIASFCSGPGGIPFILTGEFFQQSERPAAFIIAGTVNWLSN
                     FVVGLLFPFIQKSLESYCFLVFATICIAGAIYFYFVLPETKNRTHAEISQAFAKRNKA
                     HPPEVKADSAMAEEKANSQPETDPSSTLDSYGQNRIV"
     exon            1..114
                     /gene="Slc2a9"
                     /inference="alignment:Splign:2.1.0"
     exon            115..213
                     /gene="Slc2a9"
                     /inference="alignment:Splign:2.1.0"
     exon            214..374
                     /gene="Slc2a9"
                     /inference="alignment:Splign:2.1.0"
     exon            375..499
                     /gene="Slc2a9"
                     /inference="alignment:Splign:2.1.0"
     exon            500..645
                     /gene="Slc2a9"
                     /inference="alignment:Splign:2.1.0"
     exon            646..778
                     /gene="Slc2a9"
                     /inference="alignment:Splign:2.1.0"
     exon            779..966
                     /gene="Slc2a9"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1077
                     /gene="Slc2a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1179
                     /gene="Slc2a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1255
                     /gene="Slc2a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1383
                     /gene="Slc2a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..3384
                     /gene="Slc2a9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggatgcca gggagcttgc cctagcttcc ctgatacatg acaccagtgg ccctggggag
       61 ccgcctgtgg ggccacctgt ggggcgccgg ggctggcggc cgaggaggac aaagaactgg
      121 tcctgctcgc tcatcgtggc cgcgcttgtg ggagccttcg ggtcctcctt cctctatggg
      181 tacaacctct ccgtggtgaa cgcgcccacg ccgtatatca aggcctttta caatgaaacc
      241 tggtacagaa ggcatggaca gcccatagat ccggataccc tgaccctgct ctggtctgta
      301 actgtgtcca tattcgcgat tggtggcctg gtgggaacac tgatggtgaa gatgattgga
      361 aagtttcttg gaaggaagta cacactgctg gtcaacaacg gatttgccat ttctgcagca
      421 ttgctgatgg cgtgctcact ccaggcagga acctttgaga tgctcattgt gggacgcttc
      481 atcatgggcg tggatggagg catcgcgctc agtgcgctcc ccatgtacct caatgagatc
      541 tcacccaagg agatccgagg ctccctgggc caggtgactg ccatcttcat ctgcattggc
      601 gtgttttctg gacagttgct gggcctgcct gagcttctgg gaaaggagag aacctggcca
      661 tacctgttcg gagtgatcat tgtccctgcc ttggcccagc tggcaagcct gccatttctc
      721 cctgagagtc cacgatacct cctctttgaa aagcacgacg aggcaggagc cacgaaagcc
      781 ttccaaacat tcctggggaa agcagatgtc tcccaagagc tggaggaggc cctggctgag
      841 agccgtgtgc aaaggaacct tcgcctggtg tccgtgtttg agcttctgag ggcacccttt
      901 gtccgatggc aggtcatcac tgtcgttatc accatggcca gctaccaact atgtggactc
      961 aatgcgatct ggttctacac caacagcatc ttcgggaaag ctggggttcc tcaggacaag
     1021 atcccataca tcaccctgag caccggagga attgagacgc tagctgctat cttctctggc
     1081 ttagtcattg agcgcttagg aaggagacct ctcctcattg gtggctttgg gctgatggcc
     1141 ctcttctttg ggatgctcac cgtgacactg accctgcagg accaagctcc ctggatccct
     1201 tacctaagca ttgtgtgcat cttggccatc attgcctcgt tctgcagcgg tccaggtggg
     1261 atcccgttca tcctgaccgg agagttcttc caacagtcag agcggccagc agccttcatt
     1321 atcgcaggca cagtcaactg gctctccaac ttcgttgtag ggctcctttt ccccttcatc
     1381 cagaaaagcc tggagtccta ctgcttcctc gtctttgcca caatatgtat agcgggcgct
     1441 atctacttct attttgtcct cccagagacc aagaacagaa cccatgcaga aatcagccag
     1501 gcattcgcca agaggaacaa ggctcacccc ccagaggtga aggctgactc agccatggca
     1561 gaggagaagg ccaacagcca gcctgagaca gatccatcgt ctacgctgga cagctatggc
     1621 caaaacagaa ttgtttaaat gtgtgttctc actacagtaa ccaaagactt tcccaaacct
     1681 tataaggttt caggtgacca aagccatctg agactcttgg gagttaggaa gaaacctgtg
     1741 agaatcaaac ctctcagctg cacgtccaaa ctcccgtgga agcattccca tggtttgcta
     1801 cactcagtgc actatacaga ccaagggctg ccttcctcgt gattgaaccc gtagctctga
     1861 aatttaaagt tggaagaaag gttgccttga ccaggttgcc ttctcatagg aaagccatct
     1921 ggtctgatgg acactcattg tactggaaat ggcagcctgg gtcatctcag ctgtgctgtt
     1981 gctaagcaac cttgacccat cctcagcctc cagcctccag gtctccagat cttggaaggt
     2041 tttctgactt ccatgggaag attctttgtc ccactaacag atgcctgttg ctaatctttg
     2101 gttgtacccc atggacctga agcttgggaa cacttcttac caatccacca ggctgctgat
     2161 cctaccaagg caggctctgt ccccagcgct caaggctgcc aggtctgagg ctgtctttag
     2221 ttcagactgt tacagagagc acacagggga ccaacaagta atatggaaaa gaactttgtg
     2281 gtacctaggg gacagagact acacggtggg ctctgaacac taagaatgac tctgagacta
     2341 aacctagatt tgatgggaaa gaacactggg attgattgac gatgtctgtc ctggatgtag
     2401 gaatgacagc ttcagttcct gagccttgtg tttacaatgg gaaggagatt catcttcaga
     2461 ggtagtgaac tgccagaaag acactcaaca tcactcctat tgctctggtg aaggctgggg
     2521 cactggggaa tcactgtctc agtggttatt caggaagtca aagaggcagt tctaggtgtt
     2581 agagtgggtg tctggttggg caacttgcat cttgccatca tgtttggctg aatcccttct
     2641 tctgccttca acaaagtaca tatgataaat gccataagca aatggcaggt gtgtcaactg
     2701 gcttggtgtg tttaagtctc cagaccaggc aacactgctg ttttcctgac cattctggat
     2761 gaggttggcc ttaaccaaaa cccgtgttct gacttttccc tcctggttaa acactcttca
     2821 tctggggcct cttccttggt gcaatcccag ttcagggaac cataccatcc agcactggtt
     2881 tgaccagtgt gtgtcagtat agattgcaac gtatagattt gacaaggtcc tgtcccaaaa
     2941 tgactgatgt gaattgtaaa acaaaaatca taacatggca ttcacttgaa gatttaagta
     3001 ttctgtcaat aaatatttat tagccaatca ttactctgcc ttggctgagt attgaagata
     3061 gatccatggg caagggaaca cactatcctg acctacacac tctggtgtct gacacagagg
     3121 tggaccatca gagcactcat ggttcagtag aggagtgggg acaatgatgt gggggacaca
     3181 tagcaggaat agatggtgtc ttagcagaga aagagaaatg ccttcccaga caaggggtag
     3241 agcagagcca gggccacagt gaccatgagg ccagaggcca gcaatgagta ttgctatgtt
     3301 cttatatttg aaattacagt gaagccacac taaaggcatt ttgggaaaaa gtgaatctca
     3361 taataaaact gatcatctcc aaca
//
