LOCUS       NM_053494               2105 bp    mRNA    linear   ROD 06-FEB-2024
DEFINITION  Rattus norvegicus solute carrier family 2 member 8 (Slc2a8), mRNA.
ACCESSION   NM_053494
VERSION     NM_053494.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2105)
  AUTHORS   Kelly,S.D., Harrell,C.S. and Neigh,G.N.
  TITLE     Chronic stress modulates regional cerebral glucose transporter
            expression in an age-specific and sexually-dimorphic manner
  JOURNAL   Physiol Behav 126, 39-49 (2014)
   PUBMED   24382486
  REMARK    GeneRIF: Hippocampal mRNA abundance of GLUT8 decreases with age in
            males and females
REFERENCE   2  (bases 1 to 2105)
  AUTHORS   Corpe,C.P., Eck,P., Wang,J., Al-Hasani,H. and Levine,M.
  TITLE     Intestinal dehydroascorbic acid (DHA) transport mediated by the
            facilitative sugar transporters, GLUT2 and GLUT8
  JOURNAL   J Biol Chem 288 (13), 9092-9101 (2013)
   PUBMED   23396969
REFERENCE   3  (bases 1 to 2105)
  AUTHORS   Gomez,O., Ballester,B., Romero,A., Arnal,E., Almansa,I.,
            Miranda,M., Mesonero,J.E. and Terrado,J.
  TITLE     Expression and regulation of insulin and the glucose transporter
            GLUT8 in the testes of diabetic rats
  JOURNAL   Horm Metab Res 41 (5), 343-349 (2009)
   PUBMED   19194835
  REMARK    GeneRIF: Insulin depletion and hyperglycemia do not regulate the
            expression of GLUT8 in testes.
REFERENCE   4  (bases 1 to 2105)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   5  (bases 1 to 2105)
  AUTHORS   Widmer,M., Uldry,M. and Thorens,B.
  TITLE     GLUT8 subcellular localization and absence of translocation to the
            plasma membrane in PC12 cells and hippocampal neurons
  JOURNAL   Endocrinology 146 (11), 4727-4736 (2005)
   PUBMED   16109784
  REMARK    GeneRIF: In cells normally expressing it, GLUT8 was associated with
            a specific intracellular compartment in which it may play an
            as-yet-uncharacterized role.
REFERENCE   6  (bases 1 to 2105)
  AUTHORS   Ibberson,M., Riederer,B.M., Uldry,M., Guhl,B., Roth,J. and
            Thorens,B.
  TITLE     Immunolocalization of GLUTX1 in the testis and to specific brain
            areas and vasopressin-containing neurons
  JOURNAL   Endocrinology 143 (1), 276-284 (2002)
   PUBMED   11751619
REFERENCE   7  (bases 1 to 2105)
  AUTHORS   Scheepers,A., Doege,H., Joost,H.G. and Schurmann,A.
  TITLE     Mouse GLUT8: genomic organization and regulation of expression in
            3T3-L1 adipocytes by glucose
  JOURNAL   Biochem Biophys Res Commun 288 (4), 969-974 (2001)
   PUBMED   11689004
REFERENCE   8  (bases 1 to 2105)
  AUTHORS   Carayannopoulos,M.O., Chi,M.M., Cui,Y., Pingsterhaus,J.M.,
            McKnight,R.A., Mueckler,M., Devaskar,S.U. and Moley,K.H.
  TITLE     GLUT8 is a glucose transporter responsible for insulin-stimulated
            glucose uptake in the blastocyst
  JOURNAL   Proc Natl Acad Sci U S A 97 (13), 7313-7318 (2000)
   PUBMED   10860996
REFERENCE   9  (bases 1 to 2105)
  AUTHORS   Doege,H., Schurmann,A., Bahrenberg,G., Brauers,A. and Joost,H.G.
  TITLE     GLUT8, a novel member of the sugar transport facilitator family
            with glucose transport activity
  JOURNAL   J Biol Chem 275 (21), 16275-16280 (2000)
   PUBMED   10821868
REFERENCE   10 (bases 1 to 2105)
  AUTHORS   Ibberson,M., Uldry,M. and Thorens,B.
  TITLE     GLUTX1, a novel mammalian glucose transporter expressed in the
            central nervous system and insulin-sensitive tissues
  JOURNAL   J Biol Chem 275 (7), 4607-4612 (2000)
   PUBMED   10671487
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AJ245935.1 and BU759499.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_053494.3.
            
            On Dec 8, 2007 this sequence version replaced NM_053494.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ245935.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1667              AJ245935.1         1-1667
            1668-2105           BU759499.1         1-438               c
FEATURES             Location/Qualifiers
     source          1..2105
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p11"
     gene            1..2105
                     /gene="Slc2a8"
                     /gene_synonym="Glut8"
                     /note="solute carrier family 2 member 8"
                     /db_xref="GeneID:85256"
                     /db_xref="RGD:620611"
     exon            1..85
                     /gene="Slc2a8"
                     /gene_synonym="Glut8"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1466
                     /gene="Slc2a8"
                     /gene_synonym="Glut8"
                     /note="GLUT-8; glucose transporter type 8; glucose
                     transporter type X1; solute carrier family 2, (facilitated
                     glucose transporter) member 8"
                     /codon_start=1
                     /product="solute carrier family 2, facilitated glucose
                     transporter member 8"
                     /protein_id="NP_445946.2"
                     /db_xref="GeneID:85256"
                     /db_xref="RGD:620611"
                     /translation="MSPEDPQETQPLLRSPGARAPGGRRVFLATFAAALGPLSFGFAL
                     GYSSPAIPSLRRTAPPALRLGDTAASWFGAVVTLGAAAGGVLGGWLLDRAGRKLSLLL
                     CTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSC
                     VQLMVVTGILLAYVAGWVLEWRWLAVLGCVPPTLMLLLMCYMPETPRFLLTQHQYQEA
                     MAALRFLWGSEEGWEEPPVGAEHQGFQLAMLRRPGVHKPLIIGICLMVFQQLSGVNAI
                     MFYANTIFEEAKFKDSSLASVTVGIIQVLFTAVAALIMDRAGRKLLLALSGVIMVFSM
                     SAFGTYFKLTQSGPSNSSHVGLLVPISAEPADVHLGLAWLAVGSMCLFIAGFAVGWGP
                     IPWLLMSEIFPLHIKGVATGVCVLTNWFMAFLVTKEFNSIMEILRPYGAFWLTAAFCI
                     LSVLFTLTFVPETKGRTLEQITAHFEGR"
     exon            86..248
                     /gene="Slc2a8"
                     /gene_synonym="Glut8"
                     /inference="alignment:Splign:2.1.0"
     exon            249..455
                     /gene="Slc2a8"
                     /gene_synonym="Glut8"
                     /inference="alignment:Splign:2.1.0"
     exon            456..555
                     /gene="Slc2a8"
                     /gene_synonym="Glut8"
                     /inference="alignment:Splign:2.1.0"
     exon            556..755
                     /gene="Slc2a8"
                     /gene_synonym="Glut8"
                     /inference="alignment:Splign:2.1.0"
     exon            756..899
                     /gene="Slc2a8"
                     /gene_synonym="Glut8"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1008
                     /gene="Slc2a8"
                     /gene_synonym="Glut8"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1182
                     /gene="Slc2a8"
                     /gene_synonym="Glut8"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1328
                     /gene="Slc2a8"
                     /gene_synonym="Glut8"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..2089
                     /gene="Slc2a8"
                     /gene_synonym="Glut8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgacagttcg cgggtcagac cctgttgaca tgtcgcccga ggacccccag gaaacacagc
       61 cgctgttgcg gtcgccgggc gccagggctc ccggcggccg ccgggtcttc cttgccacct
      121 tcgccgccgc cctgggcccg ctcagcttcg gcttcgcgct tggctacagc tcccccgcca
      181 tccccagcct gcggcgcacc gcaccccctg ccctacgcct cggagacact gcggcctcct
      241 ggttcggggc cgtcgtgacc ctgggcgctg cggcaggggg cgtgctgggc ggctggctcc
      301 tggaccgtgc agggcgcaag ctgagcctcc tgctctgcac cgtgcccttc gtgaccggtt
      361 ttgctgtcat caccgcggcc cgggatgtgt ggatgctgct cggaggccgc ctcctcaccg
      421 gcctagcctg cggagtcgcc tcattagtgg caccggtcta tatctcggaa atcgcctacc
      481 cagccgttcg aggactgctc ggctcctgtg tgcagctgat ggttgtcact ggcatcctct
      541 tggcctacgt ggcaggctgg gtcctagaat ggcgctggtt ggctgtgctg ggctgtgtgc
      601 cccccaccct catgctgctg ctcatgtgct acatgcccga gaccccacgc ttcctcctga
      661 cgcaacacca gtaccaggag gccatggctg ccctgcgctt cctgtggggc tctgaggagg
      721 gctgggaaga gccccctgtt ggggctgagc accagggctt ccagctggct atgctgaggc
      781 gccctggtgt ccacaagccc ctcatcatcg gcatttgcct catggtcttc cagcagctgt
      841 caggggtcaa cgccatcatg ttctatgcca acaccatctt tgaggaggcc aagttcaagg
      901 acagcagcct ggcctcggtc actgtgggca tcatccaggt tctgttcact gctgtggcgg
      961 ccctcatcat ggacagagca gggcgaaaac tgcttctggc cttgtcgggt gtgatcatgg
     1021 ttttcagcat gagcgccttt ggtacctact tcaaactgac ccagagtggc cccagcaact
     1081 cctcccatgt aggcctcctg gtgcccatct ccgcagagcc tgctgatgtt cacctggggc
     1141 tggcctggct ggctgtaggc agcatgtgcc tcttcatcgc tggttttgca gtaggctggg
     1201 gacccatccc ctggctcctc atgtcagaga tcttccctct gcacatcaag ggtgtggcta
     1261 ccggcgtctg tgtcctcacc aactggttca tggcctttct ggtgaccaaa gagtttaaca
     1321 gcatcatgga gatcctcaga ccctacggcg ccttctggct caccgctgcc ttctgtatcc
     1381 tcagcgtcct tttcacgctc acctttgtcc ctgagactaa aggcaggact ctggaacaaa
     1441 tcacagccca tttcgaggga cggtgacgga ccctttctgt gactggcagc cctgagctga
     1501 gctggcttcg ggtttcaaaa ggagtggagt ggcctcagtg accacagttt gagcccaggg
     1561 gccccctgac tcctcagatc tccgggccag ctttgtccag atctcaaccc agatccacac
     1621 catgagcttc accagattct gaggctctgc agcctgctgc acacacaaca catctgcgga
     1681 gccatgcagt ctcgcctaac ccacgggtct ccttcctaag actaaagcaa ctgacgagac
     1741 tgcgggctcc tggctctagt gctctggctg ggcatctttg gggtgcttgg tcctaagcaa
     1801 ctgcccatac ctcacttgac tgggggatga gaaagggact tagccacata agatttgggc
     1861 tcagaaacaa ggtcaggtga gtccaggaag aaaagagaat gttcttgtct tgtcaaccaa
     1921 gtccttctca gagtgcccag agacctccgg attcaccttg gggttagcca gcttacccat
     1981 cacttacagg ttctctccag ctcttccctg gtctcagtgt cctggatcat tagtcaccag
     2041 gtcttgttga gtttcagaaa ataaaaggcc tctttccgtt caactttaaa aaaaaaaaaa
     2101 aaaaa
//
