LOCUS       NM_031741               2169 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Rattus norvegicus solute carrier family 2 member 5 (Slc2a5), mRNA.
ACCESSION   NM_031741 XM_001075869
VERSION     NM_031741.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2169)
  AUTHORS   Minocha,E., Chaturvedi,C.P. and Nityanand,S.
  TITLE     Renogenic characterization and in vitro differentiation of rat
            amniotic fluid stem cells into renal proximal tubular- and
            juxtaglomerular-like cells
  JOURNAL   In Vitro Cell Dev Biol Anim 55 (2), 138-147 (2019)
   PUBMED   30645697
REFERENCE   2  (bases 1 to 2169)
  AUTHORS   Ebert,K., Ludwig,M., Geillinger,K.E., Schoberth,G.C.,
            Essenwanger,J., Stolz,J., Daniel,H. and Witt,H.
  TITLE     Reassessment of GLUT7 and GLUT9 as Putative Fructose and Glucose
            Transporters
  JOURNAL   J Membr Biol 250 (2), 171-182 (2017)
   PUBMED   28083649
REFERENCE   3  (bases 1 to 2169)
  AUTHORS   Nomura,N., Verdon,G., Kang,H.J., Shimamura,T., Nomura,Y.,
            Sonoda,Y., Hussien,S.A., Qureshi,A.A., Coincon,M., Sato,Y., Abe,H.,
            Nakada-Nakura,Y., Hino,T., Arakawa,T., Kusano-Arai,O., Iwanari,H.,
            Murata,T., Kobayashi,T., Hamakubo,T., Kasahara,M., Iwata,S. and
            Drew,D.
  TITLE     Structure and mechanism of the mammalian fructose transporter GLUT5
  JOURNAL   Nature 526 (7573), 397-401 (2015)
   PUBMED   26416735
  REMARK    GeneRIF: crystal structures of GLUT5 from Rattus norvegicus and Bos
            taurus in open outward- and open inward-facing conformations,
            respectively
REFERENCE   4  (bases 1 to 2169)
  AUTHORS   Patel,C., Douard,V., Yu,S., Gao,N. and Ferraris,R.P.
  TITLE     Transport, metabolism, and endosomal trafficking-dependent
            regulation of intestinal fructose absorption
  JOURNAL   FASEB J 29 (9), 4046-4058 (2015)
   PUBMED   26071406
REFERENCE   5  (bases 1 to 2169)
  AUTHORS   Suzuki,T., Douard,V., Mochizuki,K., Goda,T. and Ferraris,R.P.
  TITLE     Diet-induced epigenetic regulation in vivo of the intestinal
            fructose transporter Glut5 during development of rat small
            intestine
  JOURNAL   Biochem J 435 (1), 43-53 (2011)
   PUBMED   21222652
  REMARK    GeneRIF: investigation of influence of dietary carbohydrates on
            expression of Glut5 in small intestine: Glut5 mRNA increased with
            fructose perfusion and age, a pattern that matched that of Pol II
            binding and histone H3 acetylation at Glut5 promoter
REFERENCE   6  (bases 1 to 2169)
  AUTHORS   Hajduch,E., Litherland,G.J., Turban,S., Brot-Laroche,E. and
            Hundal,H.S.
  TITLE     Insulin regulates the expression of the GLUT5 transporter in L6
            skeletal muscle cells
  JOURNAL   FEBS Lett 549 (1-3), 77-82 (2003)
   PUBMED   12914929
  REMARK    GeneRIF: insulin is capable of increasing the abundance and
            functional activity of GLUT5 in skeletal muscle cells, most likely
            mediated via activation of the GLUT5 promoter
REFERENCE   7  (bases 1 to 2169)
  AUTHORS   Jiang,L., David,E.S., Espina,N. and Ferraris,R.P.
  TITLE     GLUT-5 expression in neonatal rats: crypt-villus location and
            age-dependent regulation
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 281 (3), G666-G674 (2001)
   PUBMED   11518678
REFERENCE   8  (bases 1 to 2169)
  AUTHORS   Darakhshan,F., Hajduch,E., Kristiansen,S., Richter,E.A. and
            Hundal,H.S.
  TITLE     Biochemical and functional characterization of the GLUT5 fructose
            transporter in rat skeletal muscle
  JOURNAL   Biochem J 336 (Pt 2) (Pt 2), 361-366 (1998)
   PUBMED   9820812
REFERENCE   9  (bases 1 to 2169)
  AUTHORS   Inukai,K., Asano,T., Katagiri,H., Ishihara,H., Anai,M.,
            Fukushima,Y., Tsukuda,K., Kikuchi,M., Yazaki,Y. and Oka,Y.
  TITLE     Cloning and increased expression with fructose feeding of rat
            jejunal GLUT5
  JOURNAL   Endocrinology 133 (5), 2009-2014 (1993)
   PUBMED   8404647
REFERENCE   10 (bases 1 to 2169)
  AUTHORS   Rand,E.B., Depaoli,A.M., Davidson,N.O., Bell,G.I. and Burant,C.F.
  TITLE     Sequence, tissue distribution, and functional characterization of
            the rat fructose transporter GLUT5
  JOURNAL   Am J Physiol 264 (6 Pt 1), G1169-G1176 (1993)
   PUBMED   8333543
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D13871.1.
            
            On Jun 25, 2006 this sequence version replaced XM_001075869.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D13871.1, L05195.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2169
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2169
                     /gene="Slc2a5"
                     /note="solute carrier family 2 member 5"
                     /db_xref="GeneID:65197"
                     /db_xref="RGD:68328"
     exon            1..72
                     /gene="Slc2a5"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1551
                     /gene="Slc2a5"
                     /note="solute carrier family 2 (facilitated glucose
                     transporter), member 5; GLUT-5; fructose transporter;
                     glucose transporter type 5, small intestine; solute
                     carrier family 2 (facilitated glucose/fructose
                     transporter), member 5"
                     /codon_start=1
                     /product="solute carrier family 2, facilitated glucose
                     transporter member 5"
                     /protein_id="NP_113929.1"
                     /db_xref="GeneID:65197"
                     /db_xref="RGD:68328"
                     /translation="MEKEDQEKTGKLTLVLALATFLAAFGSSFQYGYNVAAVNSPSEF
                     MQQFYNDTYYDRNKENIESFTLTLLWSLTVSMFPFGGFIGSLMVGFLVNNLGRKGALL
                     FNNIFSILPAILMGCSKIAKSFEIIIASRLLVGICAGISSNVVPMYLGELAPKNLRGA
                     LGVVPQLFITVGILVAQLFGLRSVLASEEGWPILLGLTGVPAGLQLLLLPFFPESPRY
                     LLIQKKNESAAEKALQTLRGWKDVDMEMEEIRKEDEAEKAAGFISVWKLFRMQSLRWQ
                     LISTIVLMTGQQLSGVNAIYYYADQIYLSAGVKSNDVQYVTAGTGAVNVFMTMVTVFV
                     VELWGRRNLLLIGFSTCLTACIVLTVALALQNTISWMPYVSIVCVIVYVIGHAVGPSP
                     IPALFITEIFLQSSRPSAYMIGGSVHWLSNFIVGLIFPFIQVGLGPYSFIIFAIICLL
                     TSIYIFMVVPETKGRTFVEINQIFAKKNKVSDVYPEKEEKELNDLPPATREQ"
     exon            73..171
                     /gene="Slc2a5"
                     /inference="alignment:Splign:2.1.0"
     exon            172..332
                     /gene="Slc2a5"
                     /inference="alignment:Splign:2.1.0"
     exon            333..457
                     /gene="Slc2a5"
                     /inference="alignment:Splign:2.1.0"
     exon            458..610
                     /gene="Slc2a5"
                     /inference="alignment:Splign:2.1.0"
     exon            611..736
                     /gene="Slc2a5"
                     /inference="alignment:Splign:2.1.0"
     exon            737..924
                     /gene="Slc2a5"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1035
                     /gene="Slc2a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1137
                     /gene="Slc2a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1213
                     /gene="Slc2a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1341
                     /gene="Slc2a5"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..2166
                     /gene="Slc2a5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaggaggtg agccagctgc aggctaccct tgcagagcaa cgatggagaa agaggatcaa
       61 gagaagacag ggaagctgac cctggtcctt gccctggcaa ctttcctagc tgcctttggc
      121 tcctccttcc agtatgggta caacgtggct gctgtcaact cgccctcaga gttcatgcag
      181 cagttctaca atgacaccta ctacgacaga aacaaggaga acattgagtc cttcaccctg
      241 acgctgctgt ggtccctgac tgtctccatg ttcccctttg gaggttttat aggatctctc
      301 atggttggat tcttggtgaa taacttgggc agaaaagggg ccttactgtt caacaacata
      361 ttctccatcc tgccggccat cttgatgggg tgcagcaaaa ttgccaaatc ctttgagata
      421 ataattgctt ccagacttct ggttggaata tgtgcaggta tatcttccaa cgtggtcccc
      481 atgtacttag gggagctagc ccccaaaaac ctgcgagggg ctcttggagt ggttcctcag
      541 ctcttcatca ctgtgggcat ccttgtggcc cagctgtttg gccttcggag tgtcttggca
      601 agcgaggaag gctggccaat cctcctgggt ctgactggag tccctgccgg cctgcagctc
      661 ctcttgctgc ccttctttcc tgagagcccc cgctacctgc tgattcagaa gaaaaatgaa
      721 tcagctgctg agaaagccct tcagaccctt cgaggttgga aagatgtgga catggagatg
      781 gaggaaatcc ggaaggagga tgaggctgag aaggcggcag gcttcatctc tgtgtggaag
      841 ctgttccgca tgcagtccct ccgctggcaa ctcatctcca cgatcgtcct catgaccggc
      901 cagcagctgt caggagtgaa cgcgatttac tactacgctg accagatcta cctcagcgca
      961 ggggtgaaaa gcaacgacgt ccaatatgtg acggctggga ctggggccgt caacgtgttc
     1021 atgaccatgg tcacggtttt tgtggtagag ctttggggac gtcggaatct tctcctcatc
     1081 ggcttctcca cctgcctcac agcttgcata gtgctgacgg tcgcactggc actgcagaac
     1141 accatctcct ggatgcccta tgtcagcatc gtctgtgtca ttgtctacgt cataggacac
     1201 gccgtggggc ccagtcccat ccctgccctg ttcatcaccg agatcttcct gcaatcctct
     1261 cgaccatccg cctacatgat cggaggcagc gtccactggc tctctaactt catcgtgggc
     1321 ctcatcttcc cgttcattca agtgggcctt ggtccttaca gcttcatcat ctttgcgatt
     1381 atatgtctcc tcacctccat ctacatcttc atggtcgtcc cagagaccaa gggcaggacg
     1441 tttgtcgaga tcaaccagat ttttgccaag aagaacaagg tatcggacgt atatccggag
     1501 aaggaggaaa aggagcttaa tgacctccca cctgctaccc gggagcagta gcagagccag
     1561 gccaccaggc agtatggcca gtctgcatgg gcctcctgtc tagactttgg ttctgggttc
     1621 ttagtgtctg tgacactggg agggacacga gcctggcggg gaatggcagc cctccactca
     1681 gtggggacac ctgacgggct ttcgtgcttc cgtgctgtcc ctaaccatag aggccagtca
     1741 cgggctcttg gtcacacaca aagccatacc tggcctttgc tgggttgact gtggcgaggg
     1801 tcttgtaaca ttgcttttct aacaaaaaca gttgccgaga gacaagacgt gacggtccta
     1861 tttttttttt aacttttttt ttctattctt tttttttttt ttttttcgga gctggggatt
     1921 gaacccaggg ccttgcgctt gctaggcaag cgctctacca ctgagccaaa tcccttgtgt
     1981 ggctcctccc atgggcgtgg agagaccact ggcatctgct ggtgattgat gtggtcctct
     2041 ttttctgacc cagccatgtc acaaagctga ggaacaggcc acttggggag acacacggag
     2101 cgtgaattat caactgtcaa cgacagtatt ctgtttagcc aataaaacag atctgatcac
     2161 ttcttaaaa
//
