LOCUS       NM_001412552            3822 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 2 member 3 (Slc2a3),
            transcript variant 2, mRNA.
ACCESSION   NM_001412552 XM_006237295
VERSION     NM_001412552.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3822)
  AUTHORS   Dakic,T., Lakic,I., Zec,M., Takic,M., Stojiljkovic,M. and
            Jevdjovic,T.
  TITLE     Fructose-rich diet and walnut supplementation differently regulate
            rat hypothalamic and hippocampal glucose transporters expression
  JOURNAL   J Sci Food Agric 101 (14), 5984-5991 (2021)
   PUBMED   33856052
  REMARK    GeneRIF: Fructose-rich diet and walnut supplementation differently
            regulate rat hypothalamic and hippocampal glucose transporters
            expression.
REFERENCE   2  (bases 1 to 3822)
  AUTHORS   von Leden,R.E., Moritz,K.E., Bermudez,S., Jaiswal,S., Wilson,C.M.,
            Dardzinski,B.J. and Byrnes,K.R.
  TITLE     Aging alters glucose uptake in the naive and injured rodent spinal
            cord
  JOURNAL   Neurosci Lett 690, 23-28 (2019)
   PUBMED   30296507
  REMARK    GeneRIF: findings show that age alters glucose uptake and GLUT3/4
            expression profiles before and after Spinal Cord Injury.
REFERENCE   3  (bases 1 to 3822)
  AUTHORS   Solis-Maldonado,M., Miro,M.P., Acuna,A.I., Covarrubias-Pinto,A.,
            Loaiza,A., Mayorga,G., Beltran,F.A., Cepeda,C., Levine,M.S.,
            Concha,I.I., Batiz,L.F., Carrasco,M.A. and Castro,M.A.
  TITLE     Altered lactate metabolism in Huntington's disease is dependent on
            GLUT3 expression
  JOURNAL   CNS Neurosci Ther 24 (4), 343-352 (2018)
   PUBMED   29582588
  REMARK    GeneRIF: Study found no differences in mRNA or protein levels of
            neuronal monocarboxylate transporters (MCTs). Functional analyses
            revealed that neuronal MCT2 had high catalytic efficiency in
            Huntington's disease (HD) cells. Ascorbic acid did not stimulate
            lactate uptake in HD cells; and was unable to inhibit glucose
            transport in HD cells because they exhibit decreased expression of
            the neuronal glucose transporter GLUT3.
REFERENCE   4  (bases 1 to 3822)
  AUTHORS   Pearson-Leary,J. and McNay,E.C.
  TITLE     Novel Roles for the Insulin-Regulated Glucose Transporter-4 in
            Hippocampally Dependent Memory
  JOURNAL   J Neurosci 36 (47), 11851-11864 (2016)
   PUBMED   27881773
REFERENCE   5  (bases 1 to 3822)
  AUTHORS   Deng,D., Sun,P., Yan,C., Ke,M., Jiang,X., Xiong,L., Ren,W.,
            Hirata,K., Yamamoto,M., Fan,S. and Yan,N.
  TITLE     Molecular basis of ligand recognition and transport by glucose
            transporters
  JOURNAL   Nature 526 (7573), 391-396 (2015)
   PUBMED   26176916
REFERENCE   6  (bases 1 to 3822)
  AUTHORS   Campbell,I.W., Dominiczak,A.F., Livingstone,C. and Gould,G.W.
  TITLE     Analysis of the glucose transporter compliment of metabolically
            important tissues from the Milan hypertensive rat
  JOURNAL   Biochem Biophys Res Commun 211 (3), 780-791 (1995)
   PUBMED   7598707
REFERENCE   7  (bases 1 to 3822)
  AUTHORS   Krishnan,S.N. and Haddad,G.G.
  TITLE     Cloning of glucose transporter-3 (GLUT3) cDNA from rat brain
  JOURNAL   Life Sci 56 (14), 1193-1197 (1995)
   PUBMED   7475896
REFERENCE   8  (bases 1 to 3822)
  AUTHORS   Simpson,I.A., Chundu,K.R., Davies-Hill,T., Honer,W.G. and Davies,P.
  TITLE     Decreased concentrations of GLUT1 and GLUT3 glucose transporters in
            the brains of patients with Alzheimer's disease
  JOURNAL   Ann Neurol 35 (5), 546-551 (1994)
   PUBMED   8179300
REFERENCE   9  (bases 1 to 3822)
  AUTHORS   Nagamatsu,S., Sawa,H., Kamada,K., Nakamichi,Y., Yoshimoto,K. and
            Hoshino,T.
  TITLE     Neuron-specific glucose transporter (NSGT): CNS distribution of
            GLUT3 rat glucose transporter (RGT3) in rat central neurons
  JOURNAL   FEBS Lett 334 (3), 289-295 (1993)
   PUBMED   8243635
REFERENCE   10 (bases 1 to 3822)
  AUTHORS   Colville,C.A., Seatter,M.J., Jess,T.J., Gould,G.W. and Thomas,H.M.
  TITLE     Kinetic analysis of the liver-type (GLUT2) and brain-type (GLUT3)
            glucose transporters in Xenopus oocytes: substrate specificities
            and effects of transport inhibitors
  JOURNAL   Biochem J 290 (Pt 3) (Pt 3), 701-706 (1993)
   PUBMED   8457197
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Oct 5, 2022 this sequence version replaced XM_006237295.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1820582.1,
                                           SRR26360181.3318918.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               JAXUCZ010000004.1  157697266-157697413 c
            149-226             JAXUCZ010000004.1  157694206-157694283 c
            227-319             JAXUCZ010000004.1  157644116-157644208 c
            320-480             JAXUCZ010000004.1  157643585-157643745 c
            481-721             JAXUCZ010000004.1  157641184-157641424 c
            722-884             JAXUCZ010000004.1  157640723-157640885 c
            885-1072            JAXUCZ010000004.1  157639716-157639903 c
            1073-1177           JAXUCZ010000004.1  157637927-157638031 c
            1178-1279           JAXUCZ010000004.1  157637537-157637638 c
            1280-1483           JAXUCZ010000004.1  157636607-157636810 c
            1484-3822           JAXUCZ010000004.1  157632887-157635225 c
FEATURES             Location/Qualifiers
     source          1..3822
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..3822
                     /gene="Slc2a3"
                     /gene_synonym="GLUT3"
                     /note="solute carrier family 2 member 3"
                     /db_xref="GeneID:25551"
                     /db_xref="RGD:3706"
     exon            1..148
                     /gene="Slc2a3"
                     /gene_synonym="GLUT3"
                     /inference="alignment:Splign:2.1.0"
     exon            149..226
                     /gene="Slc2a3"
                     /gene_synonym="GLUT3"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1693
                     /gene="Slc2a3"
                     /gene_synonym="GLUT3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     GLUT-3; glucose transporter type 3, brain; solute carrier
                     family 2, facilitated glucose transporter member 3-like;
                     solute carrier family 2 (facilitated glucose transporter),
                     member 3; solute carrier family 2, member 2; Solute
                     carrier family 2 A3 (neuron glucose transporter)"
                     /codon_start=1
                     /product="solute carrier family 2, facilitated glucose
                     transporter member 3 isoform 2"
                     /protein_id="NP_001399481.1"
                     /db_xref="GeneID:25551"
                     /db_xref="RGD:3706"
                     /translation="MESNKQNVTPSLVFAVTVATIGSFQFGYNTGVINAPETIIKDFL
                     NYTLEERLEDLPSEGLLTTLWSLCVAIFSVGGMIGSFSVGLFVNRFGRRNSMLLVNLI
                     AILGGCLMGFAKIAESVEMLILGRLIIGIFCGLCTGFVPMYIGEVSPTALRGAFGTLN
                     QLGIVVGILVAQVFGLDFILGSEELWPGLLGLTIIPAILQSAALPFCPESPRFLLINR
                     KEEDQATEILQRLWGTPDVIQEIQEMKDESIRMSQEKQVTVLELFKSPSYFQPLLISV
                     VLQLSQQFSGINAVFYYSTGIFQDAGVQEPIYATIGAGVVNTIFTVVSLFLVERAGRR
                     TLHMIGLGGMAVCSVFMTISLLLKDEYEAMSFVCIVAILVYVAFFEIGPGPIPWFIVA
                     ELFSQGPRPAAMAVAGCSNWTSNFLVGMFFPSAAAYLGAYVFIIFAAFLVFFLIFTFF
                     KVPETKGRTFEDITRAFEGQAQSGKGSAGVELNSMQPVKETPGNA"
     exon            227..319
                     /gene="Slc2a3"
                     /gene_synonym="GLUT3"
                     /inference="alignment:Splign:2.1.0"
     exon            320..480
                     /gene="Slc2a3"
                     /gene_synonym="GLUT3"
                     /inference="alignment:Splign:2.1.0"
     exon            481..721
                     /gene="Slc2a3"
                     /gene_synonym="GLUT3"
                     /inference="alignment:Splign:2.1.0"
     exon            722..884
                     /gene="Slc2a3"
                     /gene_synonym="GLUT3"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1072
                     /gene="Slc2a3"
                     /gene_synonym="GLUT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1177
                     /gene="Slc2a3"
                     /gene_synonym="GLUT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1279
                     /gene="Slc2a3"
                     /gene_synonym="GLUT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1483
                     /gene="Slc2a3"
                     /gene_synonym="GLUT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..3822
                     /gene="Slc2a3"
                     /gene_synonym="GLUT3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaaagtggg ctggcgacgg cgcggggcta acggctgaga cggtggcggc ggtggtgctg
       61 tcactccggc gctacgcccg cccggagcag agcggggctg ccaagcgggc ggttgggcgg
      121 aactcggcac cgggcagctg cggggatgga agctgtgcct tgaaaagaaa tttgaagaag
      181 gatcaaatct tgctacgata gagagatgga gagcaacaaa cagaacgtga ccccatctct
      241 ggtgttcgct gttactgttg ccacaatcgg ttctttccag tttggctaca acaccggagt
      301 catcaatgcg cctgagacaa tcattaagga ctttcttaac tacacgttgg aagagcggtt
      361 ggaagaccta ccaagcgagg ggctgctgac cacgctctgg tcgttatgtg tggccatctt
      421 ctccgttggg ggcatgattg gctctttttc tgtcggactc tttgtcaacc gctttggcag
      481 acgcaactcc atgcttctag tcaacctgat tgccatcctt gggggttgcc ttatgggctt
      541 cgccaagata gcggagtcgg ttgaaatgct gatcctgggc cgcctgatta ttggcatctt
      601 ctgtggtctg tgcacgggct ttgtgccgat gtacattgga gaggtgtctc ccactgccct
      661 acggggtgca tttggcacgc taaaccagct gggcatcgtt gttgggatcc ttgtggctca
      721 ggtctttggt ttggacttta ttctgggctc tgaggagctg tggcctggac tactgggctt
      781 aaccatcatt ccagctatcc tacagagcgc agcccttccg ttttgccccg agagtccaag
      841 gttcttgctc attaacagaa aggaggaaga ccaagcgacg gagatcctcc agcggttgtg
      901 gggcaccccg gatgtgatcc aggagatcca ggagatgaaa gacgagagta tcaggatgtc
      961 acaggagaag caggtcactg tgctggagct cttcaagtct cctagctact tccagcccct
     1021 tctcatctcc gttgtcctcc agttgtctca gcagttctct gggatcaatg ctgtgttcta
     1081 ttactcgacg ggaatcttcc aggatgcggg tgtccaggag cccatctatg ccacgattgg
     1141 agcgggtgtg gtcaacacta tcttcactgt agtctctctg ttcctggtgg agcgggcagg
     1201 aaggagaacc ctgcacatga taggcctggg aggcatggct gtttgctccg ttttcatgac
     1261 gatttctctg ttactgaagg atgaatatga agccatgagc tttgtctgta ttgtggctat
     1321 cttggtctac gtggccttct ttgagattgg ccctggcccc attccctggt ttattgtggc
     1381 tgaactcttc agccagggcc cccgaccagc tgccatggct gtggctggct gttctaactg
     1441 gacctccaac tttttggtgg gaatgttctt cccctcggct gcggcctact tgggagccta
     1501 cgtttttatc atcttcgctg ccttcctcgt tttcttccta atcttcacct tcttcaaagt
     1561 cccagagacc aaaggcagga ctttcgagga tattacccgg gccttcgagg ggcaggcgca
     1621 gtctgggaaa ggctctgctg gtgtggagtt gaacagcatg cagcctgtca aggagacccc
     1681 tggcaatgcc tgagccggac ctcctccctc acctccctcc actgtggaaa gcaacctccc
     1741 ctgaagtggg gagacctcat caggatgaac caggactgct tctgagcgct gctattcaca
     1801 ccccacacac tccatgaaaa ctcagctgca cccaatgctg gggttggtca aatcgccaat
     1861 ggcttttaag tgtttgatct gggggatact tctcttgtaa tcgggagaga ccaagtaagc
     1921 ctaccttcat attgggaggg gaggggccac agctcccctt aggttctaaa acctgctcat
     1981 taagacaact agggagtagg agggggggca gcactccccc caccaccacc ttagcttgcc
     2041 aggaaacaga tcttcataac cagtgtggag ggccctgggg attgaacaag ggagccctcc
     2101 tcacttgata cagctctgca cagcaaaata acttgagttt tatttatttt atcttcaggt
     2161 tgaattgcat aaatatttat ttttttaagt gtaattttac caaataatga aagagtgacg
     2221 aaattgaggt tggagggagg tgttttaaag gaggttctgg aggaaagaaa gtttggtgct
     2281 ggagagagag agagagagag ggtacaacag ggagggagga tggatgttta ctggtggcct
     2341 gtgagccacc accattgtta atggagggag gctctccctt gttatttctc agaagactga
     2401 atgtctgtac caaaaggctc atggctttct ctgggccttt ccatttaagg ttatagtttt
     2461 ttatgtagtg ttactaaaat ctaggcttgt tactaaagtg ggctttgtag ttattggtat
     2521 cggtggattt ttatgttact tggagtccag aacagggaga gctcaccaca aacctctcct
     2581 ttccctggac caaacaccct ctctgtcctg tgaactcacc ttttcttctc tgtgggtcac
     2641 tcccattacc acactggtga gcgagccaaa tggatgagag acacaaagac cgtagttctt
     2701 gagagacatt atttttttca actttgtttt ttaagagatt ttatgtgttg atttgttttg
     2761 gtttggttta aagggattca tagctaactt ggatttttgt tacctcagct ctgggagagg
     2821 atttttgctg aatgactatt aattacctga gcattgttgc tctgaggtca tggcatgcta
     2881 gcctatgtct gttacagtct caggctgccc ttgtttcctc gttcctgtgc tattgtgcta
     2941 cacgctcaag gggccttgac tctgcttaca cacattaggg gcagtgtgag taaatgtgca
     3001 gtgtccacac ttgaggacat gaatgtctgc actgtcactt tgctctgggt gtgaagtccc
     3061 tggtcccctt gctcctgtag ctttcttttg atcgactact ggaactcaac cctgtgtaca
     3121 agagcagcac tgcctctggt gggtggtgtt tgcagccagg attagatgcc agtcctcggg
     3181 ttccctggcc ttgttggaaa ggtgtgcttc cttgaggtct gagaatggaa ggctctgcct
     3241 cactctagct aggaggcgca atgggaaagt atgagttcag ggcgtcaggg cagtggctcc
     3301 tgaagagcca gctgtggaca gagggagtga ggctttattt aaagtgacag gaagaaacat
     3361 ggcgttttgg tatattggga gcaatgccaa gattccctcc tgccctacat aggtcacaga
     3421 caccttccca accatcccct cctccacttc cataaatgaa gacagccctg atgaccctca
     3481 ccccttttgc ataggtcact ggatcccact gtccttcctc ggtgcttaca cactttacag
     3541 accctttagg cgagcccttg catagagcgt tatctcagtg ctccattcca gtcctgactc
     3601 cctgtggcca ttgagacttt ggatttaaga actcacattg ctagggagag gggctttgct
     3661 gggaaaggtg actcctctgt aacctagcct cttgtgctcc tccatgacag aaatgctggg
     3721 tggagtttta catttgccaa tggccagctt gtgaatatct tcatatacac tttctattca
     3781 tgttactgta gtttctgttt tgaaataaaa cttctgaatg ta
//
