LOCUS       NM_012879               2484 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus solute carrier family 2 member 2 (Slc2a2), mRNA.
ACCESSION   NM_012879 XM_001063900
VERSION     NM_012879.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2484)
  AUTHORS   Roy,S.C., Sapkota,S., Pasula,M.B., Katakam,S., Shrestha,R. and
            Briski,K.P.
  TITLE     Glucose transporter-2 regulation of VMN GABA neuron metabolic
            sensor and transmitter gene expression
  JOURNAL   Sci Rep 14 (1), 14220 (2024)
   PUBMED   38902332
  REMARK    GeneRIF: Glucose transporter-2 regulation of VMN GABA neuron
            metabolic sensor and transmitter gene expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2484)
  AUTHORS   Samario-Roman,J., Velasco,M., Larque,C., Cardenas-Vazquez,R.,
            Ortiz-Huidobro,R.I. and Hiriart,M.
  TITLE     NGF effects promote the maturation of rat pancreatic beta cells by
            regulating GLUT2 levels and distribution, and glucokinase activity
  JOURNAL   PLoS One 19 (6), e0303934 (2024)
   PUBMED   38875221
  REMARK    GeneRIF: NGF effects promote the maturation of rat pancreatic beta
            cells by regulating GLUT2 levels and distribution, and glucokinase
            activity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2484)
  AUTHORS   Niu,B., Ma,L., Yao,L., Zhang,Y. and Su,H.
  TITLE     HCV affects KATP channels through GnT-IVa-mediated N-glycosylation
            of GLUT2 on the surface of pancreatic beta-cells leading to
            impaired insulin secretion
  JOURNAL   Endocrine 84 (2), 427-440 (2024)
   PUBMED   37962815
  REMARK    GeneRIF: HCV affects KATP channels through GnT-IVa-mediated
            N-glycosylation of GLUT2 on the surface of pancreatic beta-cells
            leading to impaired insulin secretion.
REFERENCE   4  (bases 1 to 2484)
  AUTHORS   Pasula,M.B., Napit,P.R., Alhamyani,A., Roy,S.C., Sylvester,P.W.,
            Bheemanapally,K. and Briski,K.P.
  TITLE     Sex Dimorphic Glucose Transporter-2 Regulation of Hypothalamic
            Astrocyte Glucose and Energy Sensor Expression and Glycogen
            Metabolism
  JOURNAL   Neurochem Res 48 (2), 404-417 (2023)
   PUBMED   36173588
  REMARK    GeneRIF: Sex Dimorphic Glucose Transporter-2 Regulation of
            Hypothalamic Astrocyte Glucose and Energy Sensor Expression and
            Glycogen Metabolism.
REFERENCE   5  (bases 1 to 2484)
  AUTHORS   Salimi,M., Eskandari,F., Khodagholi,F., Abdollahifar,M.A.,
            Hedayati,M., Zardooz,H. and Keyhanmanesh,R.
  TITLE     Perinatal stress exposure induced oxidative stress, metabolism
            disorder, and reduced GLUT-2 in adult offspring of rats
  JOURNAL   Hormones (Athens) 21 (4), 625-640 (2022)
   PUBMED   35843978
  REMARK    GeneRIF: Perinatal stress exposure induced oxidative stress,
            metabolism disorder, and reduced GLUT-2 in adult offspring of rats.
            Erratum:[Hormones (Athens). 2022 Dec;21(4):751-757. doi:
            10.1007/s42000-022-00393-8.. PMID: 35997949]
REFERENCE   6  (bases 1 to 2484)
  AUTHORS   Ferrer,J., Benito,C. and Gomis,R.
  TITLE     Pancreatic islet GLUT2 glucose transporter mRNA and protein
            expression in humans with and without NIDDM
  JOURNAL   Diabetes 44 (12), 1369-1374 (1995)
   PUBMED   7589840
REFERENCE   7  (bases 1 to 2484)
  AUTHORS   Ahn,Y.H., Kim,J.W., Han,G.S., Lee,B.G. and Kim,Y.S.
  TITLE     Cloning and characterization of rat pancreatic beta-cell/liver type
            glucose transporter gene: a unique exon/intron organization
  JOURNAL   Arch Biochem Biophys 323 (2), 387-396 (1995)
   PUBMED   7487103
REFERENCE   8  (bases 1 to 2484)
  AUTHORS   De Vos,A., Heimberg,H., Quartier,E., Huypens,P., Bouwens,L.,
            Pipeleers,D. and Schuit,F.
  TITLE     Human and rat beta cells differ in glucose transporter but not in
            glucokinase gene expression
  JOURNAL   J Clin Invest 96 (5), 2489-2495 (1995)
   PUBMED   7593639
REFERENCE   9  (bases 1 to 2484)
  AUTHORS   Miyamoto,K., Takagi,T., Fujii,T., Matsubara,T., Hase,K.,
            Taketani,Y., Oka,T., Minami,H. and Nakabou,Y.
  TITLE     Role of liver-type glucose transporter (GLUT2) in transport across
            the basolateral membrane in rat jejunum
  JOURNAL   FEBS Lett 314 (3), 466-470 (1992)
   PUBMED   1468587
REFERENCE   10 (bases 1 to 2484)
  AUTHORS   Thorens,B., Sarkar,H.K., Kaback,H.R. and Lodish,H.F.
  TITLE     Cloning and functional expression in bacteria of a novel glucose
            transporter present in liver, intestine, kidney, and
            beta-pancreatic islet cells
  JOURNAL   Cell 55 (2), 281-290 (1988)
   PUBMED   3048704
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078875.1.
            
            On Dec 8, 2007 this sequence version replaced NM_012879.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078875.1, J03145.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2484
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..2484
                     /gene="Slc2a2"
                     /gene_synonym="Glut2; GTT2"
                     /note="solute carrier family 2 member 2"
                     /db_xref="GeneID:25351"
                     /db_xref="RGD:3705"
     exon            1..48
                     /gene="Slc2a2"
                     /gene_synonym="Glut2; GTT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1602
                     /gene="Slc2a2"
                     /gene_synonym="Glut2; GTT2"
                     /note="GLUT-2; glucose transporter type 2, liver; solute
                     carrier family 2 (facilitated glucose transporter), member
                     2; Solute carrier family 2 A2 (glucose transporter, type
                     2)"
                     /codon_start=1
                     /product="solute carrier family 2, facilitated glucose
                     transporter member 2"
                     /protein_id="NP_037011.2"
                     /db_xref="GeneID:25351"
                     /db_xref="RGD:3705"
                     /translation="MSEDKITGTLAFTVFTAVLGSFQFGYDIGVINAPQEVIISHYRH
                     VLGVPLDDRRATINYDINGTDTPLIVTPAHTTPDAWEEETEGSAHIVTMLWSLSVSSF
                     AVGGMVASFFGGWLGDKLGRIKAMLAANSLSLTGALLMGCSKFGPAHALIIAGRSVSG
                     LYCGLISGLVPMYIGEIAPTTLRGALGTLHQLALVTGILISQIAGLSFILGNQDYWHI
                     LLGLSAVPALLQCLLLLFCPESPRYLYLKLEEEVRAKKSLKRLRGTEDVTKDINEMRK
                     EKEEASTEQKVSVIQLFTDPNYRQPIVVALMLHLAQQFSGINGIFYYSTSIFQTAGIS
                     QPVYATIGVGAINMIFTAVSVLLVEKAGRRTLFLAGMIGMFFCAVFMSLGLVLLDKFT
                     WMSYVSMTAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPTALALAAFSNWVCNFIIAL
                     CFQYIADFLGPYVFFLFAGVVLIFTLFTFFKVPETKGKSFDEIAAEFRKKSGSAPPRK
                     AAVQMEFLGSSETV"
     exon            49..141
                     /gene="Slc2a2"
                     /gene_synonym="Glut2; GTT2"
                     /inference="alignment:Splign:2.1.0"
     exon            142..398
                     /gene="Slc2a2"
                     /gene_synonym="Glut2; GTT2"
                     /inference="alignment:Splign:2.1.0"
     exon            399..523
                     /gene="Slc2a2"
                     /gene_synonym="Glut2; GTT2"
                     /inference="alignment:Splign:2.1.0"
     exon            524..639
                     /gene="Slc2a2"
                     /gene_synonym="Glut2; GTT2"
                     /inference="alignment:Splign:2.1.0"
     exon            640..802
                     /gene="Slc2a2"
                     /gene_synonym="Glut2; GTT2"
                     /inference="alignment:Splign:2.1.0"
     exon            803..990
                     /gene="Slc2a2"
                     /gene_synonym="Glut2; GTT2"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1095
                     /gene="Slc2a2"
                     /gene_synonym="Glut2; GTT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1197
                     /gene="Slc2a2"
                     /gene_synonym="Glut2; GTT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1401
                     /gene="Slc2a2"
                     /gene_synonym="Glut2; GTT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..2462
                     /gene="Slc2a2"
                     /gene_synonym="Glut2; GTT2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacctggatt gagacaacaa ctccgcacgc aacatgtcag aagacaagat caccggaacc
       61 ttggctttca ctgtcttcac tgcagtgctg ggttccttcc agttcggata tgacatcggt
      121 gtgatcaatg cacctcaaga ggtaataata tcccattatc gacatgtttt gggtgttcct
      181 ctggatgacc gaagagctac cattaactat gacatcaatg gcacagacac cccactcata
      241 gtcacaccag cacatacgac accagacgcc tgggaagaag agactgaagg atctgctcac
      301 atagtcacta tgctctggtc tctgtctgtg tccagctttg cagtaggcgg aatggtcgcc
      361 tcgttctttg gtgggtggct tggggacaaa ctcggaagga tcaaagccat gttggctgca
      421 aacagcctct cgttgactgg agccctcttg atggggtgtt ccaaatttgg accggcacat
      481 gctctcatca ttgctggaag aagcgtatca ggactgtact gtgggctaat ttcaggactg
      541 gttccaatgt acattggcga gattgctcca accacactca ggggtgccct gggcactctt
      601 caccaactgg ctcttgtcac aggcattctt attagtcaga ttgctggcct cagcttcatt
      661 ctgggcaatc aggattactg gcacatccta cttggcctat ctgctgtacc agctctcctg
      721 cagtgtctgc tactgctctt ctgtccagaa agccccagat acctttacct aaagttggaa
      781 gaggaagtca gggcaaagaa aagcttgaaa agactaaggg gcactgagga cgtcaccaaa
      841 gatattaatg agatgaggaa agaaaaggaa gaggcgtcga ctgagcagaa ggtctccgtg
      901 atccagctct tcacggatcc gaattatcgg cagcccattg tggtggcact gatgctacac
      961 ttggctcagc agttctctgg aatcaatggg atattttact attcaaccag catttttcag
     1021 acagctggca tcagccagcc tgtgtatgca accatcggcg ttggtgccat caacatgatc
     1081 ttcacggctg tctctgtgct gcttgtggag aaagcggggc ggcggaccct gttcctggcc
     1141 gggatgattg gcatgttttt ctgtgccgtc ttcatgtcgc tgggactggt gttgctggat
     1201 aagttcacct ggatgagtta tgtgagcatg acggccatct tcctcttcgt cagtttcttt
     1261 gagattgggc caggtccaat cccttggttc atggttgctg aatttttcag ccaaggaccc
     1321 cgtcccacgg ctctggcact ggctgccttc agcaactggg tctgcaattt catcatcgcc
     1381 ctctgcttcc agtacattgc ggacttcctc gggccttacg tgttcttcct ttttgctggg
     1441 gtggtcctga tcttcaccct gttcacattt tttaaagttc cagaaaccaa aggaaagtct
     1501 tttgacgaaa ttgctgcaga attccggaag aagagtggtt cggccccacc acgcaaagcc
     1561 gctgtacaaa tggaattcct ggggtcttca gagactgtgt gaggatgagc tgcctaaaat
     1621 ccaggaacag accagaaggg aaccatgcgc tccctcttaa ctcgaatcct tcatgagtgt
     1681 aggactacac ccaggaggat catttattcc ttttgaagaa tttgtacaga ctccgattag
     1741 aaacgtcaac atatatcatt accaaagaaa gtattttttt aacttagaga atctattttg
     1801 gatggtaaaa ctcttcagta aaccagaggc tgctctgctt ctctacaggg aaagcacgtt
     1861 ataagcttcc tcgcctggtt ctactgaaat tggagagctt tcaacatatc actgctctta
     1921 aaagcacgtg actaagaaat ctgaagctac aactgatatc tatatattta aatataattc
     1981 cattggaatt ttcttagcca cagatctgat gctgaaggac ctatggctgg caaggctcac
     2041 actcaaactg acgtctctgt tacccacctc ggtttctctc acatgtacta gactttgtgt
     2101 tttgttttaa actatttttc tgcattttta tagagaactc ctgagtatgt taagctatat
     2161 ttgtaatgaa aagcctcttc tctatagcta ccaaaatctt catgtagtga gagaaaacgt
     2221 ttcagtttct ttgatgtata ttgtaaggtt aaacgctcga gtttttccta gccattgagt
     2281 ctagattatc agttaatatt agcatctaaa ccatgttagt tactctccat ttcagtcctt
     2341 tgtattgtac ttttacttgt tttttttttt aattgcccat ggcacacact taaaaccatc
     2401 aggagtcagg cattttgcat attgcctcca aaatctaata aactggacca atcacaggga
     2461 aaaaaaaaaa aaaaaaaaaa aaaa
//
