LOCUS       NM_133611               6235 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus solute carrier family 2 member 13 (Slc2a13),
            mRNA.
ACCESSION   NM_133611 XM_347239
VERSION     NM_133611.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6235)
  AUTHORS   Edamatsu,M., Kondo,Y. and Ando,M.
  TITLE     Differential localizations of the myo-inositol transporters HMIT
            and SMIT1 in the cochlear stria vascularis
  JOURNAL   Neurosci Lett 674, 88-93 (2018)
   PUBMED   29551423
  REMARK    GeneRIF: Results indicate that H(+)/myo-inositol cotransporter
            (HMIT) is expressed in marginal cells and basal cells of the stria
            vascularis, while Na(+)/myo-inositol cotransporter 1 (SMIT1)
            expression is enriched in basal cells. Study speculates that HMIT
            and SMIT1 may play important roles in the homeostasis of cochlear
            fluids.
REFERENCE   2  (bases 1 to 6235)
  AUTHORS   Teranishi,Y., Inoue,M., Yamamoto,N.G., Kihara,T., Wiehager,B.,
            Ishikawa,T., Winblad,B., Schedin-Weiss,S., Frykman,S. and
            Tjernberg,L.O.
  TITLE     Proton myo-inositol cotransporter is a novel gamma-secretase
            associated protein that regulates Abeta production without
            affecting Notch cleavage
  JOURNAL   FEBS J 282 (17), 3438-3451 (2015)
   PUBMED   26094765
  REMARK    Review article
REFERENCE   3  (bases 1 to 6235)
  AUTHORS   Di Daniel,E., Mok,M.H., Mead,E., Mutinelli,C., Zambello,E.,
            Caberlotto,L.L., Pell,T.J., Langmead,C.J., Shah,A.J., Duddy,G.,
            Kew,J.N. and Maycox,P.R.
  TITLE     Evaluation of expression and function of the H+/myo-inositol
            transporter HMIT
  JOURNAL   BMC Cell Biol 10, 54 (2009)
   PUBMED   19607714
  REMARK    GeneRIF: HMIT is primarily a neuronal transporter widely expressed
            in the rat and human brain, with particularly high levels in the
            hippocampus and cortex, as shown by immunohistochemistry.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6235)
  AUTHORS   Uldry,M., Steiner,P., Zurich,M.G., Beguin,P., Hirling,H., Dolci,W.
            and Thorens,B.
  TITLE     Regulated exocytosis of an H+/myo-inositol symporter at synapses
            and growth cones
  JOURNAL   EMBO J 23 (3), 531-540 (2004)
   PUBMED   14749729
  REMARK    GeneRIF: HMIT is expressed in a vesicular compartment involved in
            activity-dependent regulation of myo-inositol uptake in neurons
REFERENCE   5  (bases 1 to 6235)
  AUTHORS   Uldry,M., Ibberson,M., Horisberger,J.D., Chatton,J.Y.,
            Riederer,B.M. and Thorens,B.
  TITLE     Identification of a mammalian H(+)-myo-inositol symporter expressed
            predominantly in the brain
  JOURNAL   EMBO J 20 (16), 4467-4477 (2001)
   PUBMED   11500374
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1, AJ315643.1 and FQ117644.1.
            
            On Aug 3, 2012 this sequence version replaced NM_133611.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ315643.1, SRR26643287.19080.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-313               JAXUCZ010000007.1  124605834-124606146 c
            314-1398            AJ315643.1         322-1406
            1399-1491           JAXUCZ010000007.1  124330739-124330831 c
            1492-2141           AJ315643.1         1500-2149
            2142-5565           JAXUCZ010000007.1  124279536-124282959 c
            5566-6235           FQ117644.1         12-681              c
FEATURES             Location/Qualifiers
     source          1..6235
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q35"
     gene            1..6235
                     /gene="Slc2a13"
                     /gene_synonym="Hmit"
                     /note="solute carrier family 2 member 13"
                     /db_xref="GeneID:171147"
                     /db_xref="RGD:621814"
     exon            1..602
                     /gene="Slc2a13"
                     /gene_synonym="Hmit"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1993
                     /gene="Slc2a13"
                     /gene_synonym="Hmit"
                     /note="h(+)-myo-inositol symporter; h(+)-myo-inositol
                     cotransporter; proton myo-inositol symporter; solute
                     carrier family 2 (facilitated glucose transporter), member
                     13"
                     /codon_start=1
                     /product="proton myo-inositol cotransporter"
                     /protein_id="NP_598295.2"
                     /db_xref="GeneID:171147"
                     /db_xref="RGD:621814"
                     /translation="MSRKASEDVEYTLRSLSSLMGERRRRQPEPGAPGGERSLLAAES
                     AASLQGAELERAARRQFQRDETPAFVYAAAAFSALGGFLFGYDTGVVSGAMLLLRRQM
                     RLGAMWQELLVSGAVGAAAVAALAGGALNGALGRRSAILLASALCTVGSAVLAAAANK
                     ETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGA
                     FSYLQKDGWRYMLGLAAIPAVIQFLGFLFLPESPRWLIQKGQTQKARRILSQMRGNQT
                     IDEEYDSIRNSIEEEEKEASAAGPIICRMLSYPPTRRALAVGCGLQMFQQLSGINTIM
                     YYSATILQMSGVEDDRLAIWLASITAFTNFIFTLVGVWLVEKVGRRKLTFGSLAGTTV
                     ALTILALGFLLSAQVSPRVTFRPTAPSGQNATCTEYSYCNECMLDPDCGFCYKINSSA
                     VIDSSCVPVNKASTNEAAWGRCENETKFKAEDVHWAYSFCPTPYSWTALVGLVLYLVF
                     FAPGMGPMPWTVNSEIYPLWARSTGNACSAGINWIFNVLVSLTFLHTAEYLTYYGAFF
                     LYAGFAAVGLLFVYGCLPETKGKKLEEIESLFDHRLCTCGTADSDEGRYIEYIRVKGS
                     NYHLSDNDASDVE"
     exon            603..762
                     /gene="Slc2a13"
                     /gene_synonym="Hmit"
                     /inference="alignment:Splign:2.1.0"
     exon            763..971
                     /gene="Slc2a13"
                     /gene_synonym="Hmit"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1080
                     /gene="Slc2a13"
                     /gene_synonym="Hmit"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1244
                     /gene="Slc2a13"
                     /gene_synonym="Hmit"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1365
                     /gene="Slc2a13"
                     /gene_synonym="Hmit"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1491
                     /gene="Slc2a13"
                     /gene_synonym="Hmit"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1613
                     /gene="Slc2a13"
                     /gene_synonym="Hmit"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1766
                     /gene="Slc2a13"
                     /gene_synonym="Hmit"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..6220
                     /gene="Slc2a13"
                     /gene_synonym="Hmit"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggctcagc agctggcagc gagtgcgcgg cgccccacgg aacttccccg cagccgcccg
       61 ggcggcgtcc gtctgtccca tgtcccgcaa ggcgagcgag gacgtggagt acacgctgcg
      121 cagcctgagc agcctgatgg gcgagaggcg ccgccggcag ccggagcccg gggcgccggg
      181 cggggagcgc agcctcctgg ccgccgagtc ggccgccagc ctgcagggcg cggagctgga
      241 gcgcgcggcg cgcaggcagt tccagcgcga cgagaccccc gccttcgtgt acgcggccgc
      301 cgccttctcc gcgctcggcg gcttcctgtt cggctacgac accggcgtgg tgtcgggggc
      361 catgctgctg ctgcggcgcc agatgcgcct gggcgcgatg tggcaggagc tgctggtgtc
      421 gggcgcggtg ggcgcggccg ccgtcgcggc gctggccgga ggggccctga acggcgccct
      481 cggtcggcga agcgccatcc tgctggccag cgccctgtgc accgtgggct ccgccgtgct
      541 ggccgccgcc gccaacaagg agacgctgct ggccggccgc ctggtcgtgg ggctcggcat
      601 cggcatcgca tccatgacag tgcccgtgta catcgccgag gtctctccac ccaacctgag
      661 aggtcgcttg gtcaccatca acaccctctt catcaccggc ggacagttct ttgcgagcgt
      721 tgttgatgga gcctttagtt acctgcagaa ggatggatgg aggtacatgt tgggacttgc
      781 ggccattcca gccgttatac aattcctcgg attcctcttt ttgcccgaaa gtcctcggtg
      841 gctgatacag aaaggacaga ctcagaaggc ccgccgaatt ttgtcccaga tgcgtgggaa
      901 tcagaccatt gacgaggagt atgacagcat caggaacagc atcgaggagg aggagaagga
      961 agccagcgca gctggaccta taatctgcag aatgctgagt taccccccaa ctcgccgagc
     1021 gttagctgtg ggatgtggct tacagatgtt ccagcagctc tcgggcatca acactatcat
     1081 gtactacagc gcgaccatcc tgcagatgtc cggcgtggaa gatgatagac ttgcaatatg
     1141 gctggcttcc attacagcgt tcaccaattt cattttcaca ctggtgggcg tctggctcgt
     1201 ggagaaggtg ggccgcagga agctcacctt tggcagtttg gcaggtacca cagtagcact
     1261 tacaattctt gccttgggat ttctgctctc agctcaggtc tcaccacggg tcactttcag
     1321 accaacggct ccctcgggtc aaaatgccac ctgcacagaa tacagttact gtaatgagtg
     1381 tatgctggat ccagactgtg gtttctgcta caagatcaac agttcggctg tcattgattc
     1441 ctcctgtgtt ccggtgaaca aagcttccac caatgaagca gcctggggca ggtgtgaaaa
     1501 cgaaaccaag ttcaaagcag aagatgttca ctgggcttac agtttctgcc ctaccccata
     1561 ctcctggaca gcactcgtgg gcctggtgtt atatcttgtt ttctttgcac ccggaatggg
     1621 accaatgccc tggaccgtga actctgaaat ctatcctctc tgggcaagaa gtacaggaaa
     1681 tgcgtgctca gctggaataa actggatttt caacgtgctg gtttcactga cctttttaca
     1741 cacagcggag tatcttacat actatggagc gttcttcctc tacgccggat tcgccgctgt
     1801 gggactgctt ttcgtctatg gctgtcttcc tgaaaccaaa gggaaaaaac tagaggaaat
     1861 cgaatcgctc ttcgaccacc ggctgtgcac ctgcggcacc gcggactcgg acgagggcag
     1921 gtacatcgag tacatccgcg tgaagggaag taactaccat ctctccgaca acgacgcctc
     1981 ggacgtggag tgacttccac ccgatggctt tccagttact gaagtgaacg tgtcgggaag
     2041 gccagcggtt ggtcactgcc ctgctcacaa gccgagtctc cccaccgtcc ttgccaatga
     2101 ctccatattc cagaagactt gatgagcaga aaaatacaac tgtggtgatg tttattttca
     2161 tacacagaaa tgctaaaaaa aaaataaata aataaccaca gatttttctt aggcaaatgt
     2221 gtacaagccc ttcccgagac aatctaaaca ctactgttgt acccagcgac ttcagttggg
     2281 gtccctttct ccttaaacca cacataatta gtggcaatac agtcagtgct tacctaggca
     2341 gattatttac gtatatttat aaaggattat ttaaaacgat ctaagaatat ttaatgtcaa
     2401 aacacggcct attgacccta aattttcata tcaggtagtg gcttttctct gatcagtaca
     2461 gagtgaatcc catctaaact tccctccaca aattccggag tcctacgagg acacagctgt
     2521 ccctttcgcc tttggattcc agatgttagc ttctccaaca cagatatgga aattccctca
     2581 gaggctgaat acacaggagc ttttgaacac tatccaaagc gggcctttta agggttattt
     2641 tcgtactctt tttgcatcag tgatgagtat atttgcagag acacgttagc atgttttgat
     2701 aagtatattt tattgtccga gtaagaaaga acagattttt atatgccccg attcgtgagt
     2761 cacttcggaa tgcagtcgta gacgtgaagc agcgccaggc ggtcaactgc gttccagggt
     2821 cggttccacc ccagattctg cattgtcacg cctggctcct gctgttctgt gccttcctgg
     2881 gtgtcgaatg acagctgctg gcacaagagg aaagaagtca gtggcagaga cgttatcgac
     2941 atttaattta aatcctagga cttctttctc caggtgtttt attggttcgt actgaggaca
     3001 ggagcgcacc ccacttctaa ttactttcga tctccccctg aggacgtgag ctactttcta
     3061 atttcgtgtt ctctgctcat tctcaataat ttgctgcaca agcaaaattc gaagctgtgt
     3121 ctgcttcttt atctcagact tggtttggtt tctgtctgga gaaatctcgg tttctccatt
     3181 ggaaaagaag acctagccag gttcttaacg ccacagtcag tattgtgtct ctcaaagtat
     3241 ttgatggttt ctatgttcag tcaaccctga gttcctaatt cttaccaccc tatggagagc
     3301 tatgtgatac gaacaaaatt acttgctcac agacgtcatt tatctgtgtg ttcttctaaa
     3361 gctaaggctg aatctaaggg ccagttggga caaatcagtt tgatgctgca cgtgatctaa
     3421 gcatctgatt gagttacata cccaggtgaa tgatgactag tgacacacga agaaaagctt
     3481 cctgccgatc tccaaaacgg ttattcttgc ttcttctcac cgtaattacc aagcacagac
     3541 tgtagcagag gaagttaccc tccggtcacc agagttacct acactgtcaa ctttgtgccc
     3601 tacagatcct tcagccaaaa gacgacattc tctctgtttg attatttaac gttattaaaa
     3661 aaaactaaca taatattttg gaaaggtttc cctcaaatta ggtgctttga aatttattat
     3721 agagaatatt agtactgatt tttctctaga gcagaagata ttatgtaata ggatgtgtta
     3781 ttcgatattt ctgatctctt aaggcgtttc ttaacagcat tttatgagat caaatgtggt
     3841 gtcgttagca tattatggga agaaaaagat aagcaagtgc tccttttaag atatattttt
     3901 ccaatttctc caacccgttg cctcaattct tcttcccttt gaggtctgcg tggccttaag
     3961 cacacacagg tatctcagca gagctggcca ggaaaccttt ctaacgggac aacttgagtc
     4021 cttagtgctg aaagctgggt atgtgtgacc cattcttgct aacaaaaaca agtatgttct
     4081 cagcttcatg tccataaatt aacatgatat tgttaattta ttaggaaatt gtccacgtac
     4141 ttcttgccct gtccccttca tttctaaaaa tcttttgtta tcgatacagt aacaggagtc
     4201 catcccttta acatacagca cagcgctgta catgtaagac ttatttataa cttgtaaaaa
     4261 gcaacttgaa aaggaaccct ctaaaatcca gatatgattt tcagatttgc cgaacattta
     4321 gaatgcatta aattctcaga cttttattct cttagacacc ttctatgctc ttagtgtctt
     4381 tgaccacagc tgtcaacttg gaaaaccacc cacgtgaaat catcaaacat ctatattttg
     4441 taggacaatt tcgatatgat atgacatgac atgacgtgac ctgacatgtt aaaatagacg
     4501 tattaagcaa atgtacttgc tacagcaatg ttagctttct ttccaaacgc gttccaaatc
     4561 cgatacaggt gtatttcagt tgggaacatt gggtgaagaa ggtcacgacc atgcctgaaa
     4621 tctagctggg tggctaacgt gcaggagaat gaagaatgca tcattgtgta tccatgtaag
     4681 cacaatctgt tgaaaatgat gtcaaaagga ctcgctgtcg cggtcagtgg atatggttca
     4741 gtggtggagc accggcctgg aaaagatccc atcttaatat ttttcttctg tgtaaacatc
     4801 tgtaataatt tcaatggtca tacctacact cagtcatcct ctaaaacatg gctttgaatg
     4861 tacatgtaga aggtctaaat gaaaggtatt tccaggagaa aacccaccag aatcttttca
     4921 accgtttacc aatgaaacac actccaggat ccagtcctaa cacacgtcac tcactctaac
     4981 gtgggagacc agtgaaagca cagaattgat gggtcttggc tgtccgctag acagagagaa
     5041 agactggggg gaaaactgac gcttggccca tttggttttt aagagcaatg tatggttaat
     5101 aacagttcaa aagtagctac tgcctataaa agactcagaa ttgttctctg ggttaatttt
     5161 taacaccctt cggcctatta atttctacca gtcccagcct cgagcacagc aaggttcatt
     5221 cagttctcca aggcgccccg tagcgctgcc cccttgggaa acagcagtta caaatgccac
     5281 acagccaacc aactgctcat ctctgccttg tgtgctgttt ggggaagaaa atacacacgt
     5341 gctgataatc ttcagagaga tgcttcacaa atattcacgt ccagaactac caggaagtat
     5401 tttatcatta ccataatgtg cttgtgaggt cagaagagta tacttctcta aatcttcaca
     5461 cgtgtacagt acagtctctc acacttcagt aattcagtca acgggccttc gttgactctg
     5521 tttacaggta atattcatat tctagacagt taggctcaca ggattgagtt ttgtcctatc
     5581 catataaata aggaacggac tactgtgcag ataatcagta ctcaaagtta cgagccaaca
     5641 ctttataaag ttttaagatt ttgctaaatt caacatccca tttcacttaa agtctagaca
     5701 atatactatt gactctagcc aaagtagaaa tccatgacct acacccatgt ccagattctc
     5761 tggtggctcc tgcactatgc ctcacttgat gttacgattc tgtttgtgct aagtgttcca
     5821 atttctattt aggaactcta aatacacatc tctatccgat caggagtttc tcgctgttag
     5881 aggtgtacgt attttgaact gtatttagtt ttctagtgca tgtttcctac tgtttaatac
     5941 ttgacaaacc ttggcgaatt tagtctttcc attcctacct gtgacataca gaatctctct
     6001 tgaaaactgc cactgtccca tttaccaaat catgctagcc tacactgtat caaaagtacg
     6061 gtatatttta tggagactta gtgatacaca cgtcaatgtt ttttaggtta ttttatcgaa
     6121 cttcagtatt tacatgaagt tataatcctt ttttttttaa agaaagtgtc agtgccagac
     6181 ctgtataaga aaacaatcaa ataaaagtaa agataactca aaaaaaaaaa aaaaa
//
