LOCUS       NM_138827               2573 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus solute carrier family 2 member 1 (Slc2a1), mRNA.
ACCESSION   NM_138827
VERSION     NM_138827.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2573)
  AUTHORS   Zhang,Y.R., Liu,S.M., Chen,Y., Zhang,L.S., Ji,D.R., Zhao,J.,
            Yu,Y.R., Jia,M.Z., Tang,C.S., Huang,W., Zhou,Y.B., Chai,S.B. and
            Qi,Y.F.
  TITLE     Intermedin alleviates diabetic vascular calcification by inhibiting
            GLUT1 through activation of the cAMP/PKA signaling pathway
  JOURNAL   Atherosclerosis 385, 117342 (2023)
   PUBMED   37879153
  REMARK    GeneRIF: Intermedin alleviates diabetic vascular calcification by
            inhibiting GLUT1 through activation of the cAMP/PKA signaling
            pathway.
REFERENCE   2  (bases 1 to 2573)
  AUTHORS   Li,R.J.W., Chiu,J.F.M., Bruce,K., Zhang,S.Y., Barros,D.R.,
            Yue,J.T.Y. and Lam,T.K.T.
  TITLE     A glucose-sensing mechanism with glucose transporter 1 and pyruvate
            kinase in the area postrema regulates hepatic glucose production in
            rats
  JOURNAL   J Biol Chem 299 (5), 104633 (2023)
   PUBMED   36963496
  REMARK    GeneRIF: A glucose-sensing mechanism with glucose transporter 1 and
            pyruvate kinase in the area postrema regulates hepatic glucose
            production in rats.
REFERENCE   3  (bases 1 to 2573)
  AUTHORS   Maruo,K., Nishiyama,M., Honda,Y., Cao,A.L., Gao,W.Q., Shibata,K.,
            Murata,Y. and Kido,M.A.
  TITLE     Increased GLUT1 expression and localization to Golgi apparatus of
            acinar cells in the parotid gland of Goto-Kakizaki diabetic rats
  JOURNAL   Arch Oral Biol 146, 105601 (2023)
   PUBMED   36521282
  REMARK    GeneRIF: Increased GLUT1 expression and localization to Golgi
            apparatus of acinar cells in the parotid gland of Goto-Kakizaki
            diabetic rats.
REFERENCE   4  (bases 1 to 2573)
  AUTHORS   Ermini,L., Mandala,M., Cresti,L., Passaponti,S., Patrussi,L.,
            Paulesu,L., Thornburg,K. and Ietta,F.
  TITLE     Fetal Myocardial Expression of GLUT1: Roles of BPA Exposure and
            Cord Blood Exosomes in a Rat Model
  JOURNAL   Cells 11 (20), 3195 (2022)
   PUBMED   36291063
  REMARK    GeneRIF: Fetal Myocardial Expression of GLUT1: Roles of BPA
            Exposure and Cord Blood Exosomes in a Rat Model.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2573)
  AUTHORS   Dalal,S., Adhikary,J., Roy,A., Biswas,S.S., Mukhopadhyay,P.K.,
            Acharya,S. and Ghosh,A.
  TITLE     Impact of hyperglycemia on the expression of GLUT1 during oral
            carcinogenesis in rats
  JOURNAL   Mol Biol Rep 49 (9), 8369-8380 (2022)
   PUBMED   35713797
  REMARK    GeneRIF: Impact of hyperglycemia on the expression of GLUT1 during
            oral carcinogenesis in rats.
REFERENCE   6  (bases 1 to 2573)
  AUTHORS   Hebert,D.N. and Carruthers,A.
  TITLE     Glucose transporter oligomeric structure determines transporter
            function. Reversible redox-dependent interconversions of tetrameric
            and dimeric GLUT1
  JOURNAL   J Biol Chem 267 (33), 23829-23838 (1992)
   PUBMED   1429721
REFERENCE   7  (bases 1 to 2573)
  AUTHORS   De Vivo,D.C., Trifiletti,R.R., Jacobson,R.I., Ronen,G.M.,
            Behmand,R.A. and Harik,S.I.
  TITLE     Defective glucose transport across the blood-brain barrier as a
            cause of persistent hypoglycorrhachia, seizures, and developmental
            delay
  JOURNAL   N Engl J Med 325 (10), 703-709 (1991)
   PUBMED   1714544
REFERENCE   8  (bases 1 to 2573)
  AUTHORS   Holman,G.D., Kozka,I.J., Clark,A.E., Flower,C.J., Saltis,J.,
            Habberfield,A.D., Simpson,I.A. and Cushman,S.W.
  TITLE     Cell surface labeling of glucose transporter isoform GLUT4 by
            bis-mannose photolabel. Correlation with stimulation of glucose
            transport in rat adipose cells by insulin and phorbol ester
  JOURNAL   J Biol Chem 265 (30), 18172-18179 (1990)
   PUBMED   2211693
REFERENCE   9  (bases 1 to 2573)
  AUTHORS   Williams,S.A. and Birnbaum,M.J.
  TITLE     The rat facilitated glucose transporter gene. Transformation and
            serum-stimulated transcription initiate from identical sites
  JOURNAL   J Biol Chem 263 (36), 19513-19518 (1988)
   PUBMED   3198639
REFERENCE   10 (bases 1 to 2573)
  AUTHORS   Birnbaum,M.J., Haspel,H.C. and Rosen,O.M.
  TITLE     Cloning and characterization of a cDNA encoding the rat brain
            glucose-transporter protein
  JOURNAL   Proc Natl Acad Sci U S A 83 (16), 5784-5788 (1986)
   PUBMED   3016720
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 27, 2020 this sequence version replaced NM_138827.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M13979.1, SRR26643298.28632.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               JAXUCZ010000005.1  138002522-138002747
            227-322             JAXUCZ010000005.1  138013690-138013785
            323-483             JAXUCZ010000005.1  138025379-138025539
            484-724             JAXUCZ010000005.1  138025689-138025929
            725-887             JAXUCZ010000005.1  138026618-138026780
            888-1075            JAXUCZ010000005.1  138026872-138027059
            1076-1180           JAXUCZ010000005.1  138027338-138027442
            1181-1282           JAXUCZ010000005.1  138027847-138027948
            1283-1486           JAXUCZ010000005.1  138029178-138029381
            1487-2573           JAXUCZ010000005.1  138029656-138030742
FEATURES             Location/Qualifiers
     source          1..2573
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2573
                     /gene="Slc2a1"
                     /gene_synonym="Glut1; GLUTB; GTG1; Gtg3; RATGTG1"
                     /note="solute carrier family 2 member 1"
                     /db_xref="GeneID:24778"
                     /db_xref="RGD:3704"
     exon            1..226
                     /gene="Slc2a1"
                     /gene_synonym="Glut1; GLUTB; GTG1; Gtg3; RATGTG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..1687
                     /gene="Slc2a1"
                     /gene_synonym="Glut1; GLUTB; GTG1; Gtg3; RATGTG1"
                     /note="GLUT-1; glucose transporter type 1,
                     erythrocyte/brain; Solute carrier family 2 a 1
                     (facilitated glucose transporter) brain; solute carrier
                     family 2 (facilitated glucose transporter), member 1"
                     /codon_start=1
                     /product="solute carrier family 2, facilitated glucose
                     transporter member 1"
                     /protein_id="NP_620182.1"
                     /db_xref="GeneID:24778"
                     /db_xref="RGD:3704"
                     /translation="MEPSSKKVTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFY
                     NQTWNHRYGESIPSTTLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLL
                     AFVSAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLH
                     QLGIVVGILIAQVFGLDSIMGNADLWPLLLSVIFIPALLQCILLPFCPESPRFLLINR
                     NEENRAKSVLKKLRGTADVTRDLQEMKEEGRQMMREKKVTILELFRSPAYRQPILIAV
                     VLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRR
                     TLHLIGLAGMAGCAVLMTIALALLEQLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVA
                     ELFSQGPRPAAVAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFTYF
                     KVPETKGRTFDEIASGFRQGGASQSDKTPEELFHPLGADSQV"
     exon            227..322
                     /gene="Slc2a1"
                     /gene_synonym="Glut1; GLUTB; GTG1; Gtg3; RATGTG1"
                     /inference="alignment:Splign:2.1.0"
     exon            323..483
                     /gene="Slc2a1"
                     /gene_synonym="Glut1; GLUTB; GTG1; Gtg3; RATGTG1"
                     /inference="alignment:Splign:2.1.0"
     exon            484..724
                     /gene="Slc2a1"
                     /gene_synonym="Glut1; GLUTB; GTG1; Gtg3; RATGTG1"
                     /inference="alignment:Splign:2.1.0"
     exon            725..887
                     /gene="Slc2a1"
                     /gene_synonym="Glut1; GLUTB; GTG1; Gtg3; RATGTG1"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1075
                     /gene="Slc2a1"
                     /gene_synonym="Glut1; GLUTB; GTG1; Gtg3; RATGTG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1180
                     /gene="Slc2a1"
                     /gene_synonym="Glut1; GLUTB; GTG1; Gtg3; RATGTG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1282
                     /gene="Slc2a1"
                     /gene_synonym="Glut1; GLUTB; GTG1; Gtg3; RATGTG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1486
                     /gene="Slc2a1"
                     /gene_synonym="Glut1; GLUTB; GTG1; Gtg3; RATGTG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..2573
                     /gene="Slc2a1"
                     /gene_synonym="Glut1; GLUTB; GTG1; Gtg3; RATGTG1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgcgggcc aatggcggcg gtcctataaa aaggcagctc cgcgcgctct cttcctaaga
       61 acacaagaat cccttgtgga gtgtcggttt aggttacagg gtcttaagtg agtcagggcg
      121 cggaggtccg gcgggagacg catagtcaca gcacgtccat tctccgtttc acagcccgca
      181 cagcttgagc ctcgagcgca gcgcggccat ggagcccagc agcaagaagg tgacgggccg
      241 ccttatgttg gccgtgggag gggcagtgct cggatccctg cagtttggct ataacaccgg
      301 tgtcatcaac gccccccaga aggtaattga ggagttctac aatcaaacat ggaaccaccg
      361 ctatggagag tccatcccat ccaccacact caccacactc tggtctctct ccgtggccat
      421 cttctctgtc gggggcatga ttggttcctt ctctgtgggc ctctttgtta atcgctttgg
      481 caggcggaac tccatgctga tgatgaacct gttggccttt gtgtctgccg tgcttatggg
      541 tttctccaaa ctgggcaagt cctttgagat gctgatcctg ggccgcttca tcattggagt
      601 gtactgtggc ctgaccaccg gctttgtgcc catgtatgtg ggggaggtgt cacccacagc
      661 tcttcgtgga gccctgggca ccctgcacca gctgggcatc gtcgttggga tccttattgc
      721 ccaggtgttc ggcttagact ccatcatggg caatgcagac ttgtggcctc tactgctcag
      781 tgtcatcttc atcccagccc tgctacagtg tatcctgttg cccttctgcc ctgagagccc
      841 ccgcttcctg ctcatcaatc gtaacgagga gaaccgggcc aagagtgtgc tgaaaaagct
      901 tcgagggaca gccgatgtga cccgagacct gcaggagatg aaagaagagg gtcggcagat
      961 gatgcgggag aagaaggtca ccatcttgga gctgttccgc tcacccgcct accgccagcc
     1021 catcctcatc gccgtggtgc tgcagctgtc ccagcagctg tcgggcatca atgctgtgtt
     1081 ctactactca acgagcatct tcgagaaggc aggtgtgcag cagcctgtgt atgccaccat
     1141 cggctcgggt atcgtcaaca cggccttcac tgtggtgtcg ctgttcgtcg tggagcgagc
     1201 tggccgtcgg accctgcacc tcattggtct ggctggcatg gcgggctgtg ctgtgctcat
     1261 gaccatcgcc ctggccctgc tggagcagct gccctggatg tcctatctga gtatcgtggc
     1321 catctttggc tttgtggcct tctttgaagt aggccccggt cctattccat ggttcattgt
     1381 ggccgagctg ttcagccagg ggccccgacc tgctgctgtt gctgtggctg gcttctctaa
     1441 ctggacctca aacttcatcg tgggcatgtg cttccaatat gtggagcaac tgtgtggccc
     1501 ctacgtcttc atcatcttca cggtgctgct ggtactcttc ttcatcttca cctacttcaa
     1561 agttcctgag accaaaggcc ggaccttcga tgagatcgct tccggcttcc ggcagggggg
     1621 tgccagccag agcgacaaga cacctgagga gctcttccac cctctggggg ctgactccca
     1681 agtgtgagga gcccacagcc agccccgcct gctcccagca gccccgagga tctctctgga
     1741 gcacaggcag ctagatgaga cctcttccaa actgacagat ctcgggagag ccgggcctgg
     1801 gcacctttct tcagtcagca atgaagtcca gaagaatatt caggactttg atggctccag
     1861 aatttttaat gaaagcaaga ctgttgctca gatctattca gataagcagc agattttata
     1921 atttttttat tactgatttt gttattattt tttttttatc agccactctc ctatctccac
     1981 actgtagtct tcaccttgat tggcctagtg cctgagggtg gagaccacgc cctgtccaga
     2041 cacatgcctt ctttgccaag ctaatctgta gggctggacc tttggccaag gacacactaa
     2101 tactgaacaa tgagctagga ggctttaccg caggaggcgg tagctgccac ccacttctgc
     2161 aggcctggat ctcgacacca taggggtcca ggctccattt aggattcgcc cattcctgtc
     2221 tcttccaact caaccaacca ctcgattaat ctttccttgc ctgagaccag ttgaaagcac
     2281 tggagtgcag ggaggagagg gaagggccag gctgggctgc caggttcagg tctcctgtgc
     2341 actgagggcc agacaaacac catgagaagg acctcggagg ctgagaactt actgctgaag
     2401 acacggacac tcctgccctg ctgtgtatag atggaagata tttatatatt ttttggttgt
     2461 caatattaaa tacagacact aagttatagt atatatctgg acaaacccac ttgtaaatac
     2521 accaacaaac tcctgtaact ttacctaagc agatataaat ggctggtttt tag
//
