LOCUS       NM_001105911            2753 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus solute carrier family 29 member 4 (Slc29a4),
            mRNA.
ACCESSION   NM_001105911 XM_001072979 XM_221940
VERSION     NM_001105911.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2753)
  AUTHORS   Usui,T., Nakazawa,A., Okura,T., Deguchi,Y., Akanuma,S.I., Kubo,Y.
            and Hosoya,K.I.
  TITLE     Histamine elimination from the cerebrospinal fluid across the
            blood-cerebrospinal fluid barrier: involvement of plasma membrane
            monoamine transporter (PMAT/SLC29A4)
  JOURNAL   J Neurochem 139 (3), 408-418 (2016)
   PUBMED   27501284
  REMARK    GeneRIF: These results suggest the elimination of histamine from
            the CSF via plasma membrane monoamine transporter at the
            blood-brain barrier and blood-CSF barrier
REFERENCE   2  (bases 1 to 2753)
  AUTHORS   Wu,K.C., Lu,Y.H., Peng,Y.H., Hsu,L.C. and Lin,C.J.
  TITLE     Effects of lipopolysaccharide on the expression of plasma membrane
            monoamine transporter (PMAT) at the blood-brain barrier and its
            implications to the transport of neurotoxins
  JOURNAL   J Neurochem 135 (6), 1178-1188 (2015)
   PUBMED   26376205
REFERENCE   3  (bases 1 to 2753)
  AUTHORS   Gong,L., Goswami,S., Giacomini,K.M., Altman,R.B. and Klein,T.E.
  TITLE     Metformin pathways: pharmacokinetics and pharmacodynamics
  JOURNAL   Pharmacogenet Genomics 22 (11), 820-827 (2012)
   PUBMED   22722338
  REMARK    Review article
REFERENCE   4  (bases 1 to 2753)
  AUTHORS   Okura,T., Kato,S., Takano,Y., Sato,T., Yamashita,A., Morimoto,R.,
            Ohtsuki,S., Terasaki,T. and Deguchi,Y.
  TITLE     Functional characterization of rat plasma membrane monoamine
            transporter in the blood-brain and blood-cerebrospinal fluid
            barriers
  JOURNAL   J Pharm Sci 100 (9), 3924-3938 (2011)
   PUBMED   21538354
REFERENCE   5  (bases 1 to 2753)
  AUTHORS   Duan,H. and Wang,J.
  TITLE     Selective transport of monoamine neurotransmitters by human plasma
            membrane monoamine transporter and organic cation transporter 3
  JOURNAL   J Pharmacol Exp Ther 335 (3), 743-753 (2010)
   PUBMED   20858707
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474012.1.
            
            [WARNING] On Mar 13, 2025 this sequence was replaced by
            NM_001105911.2.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_001072979.1, XM_221940.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMD00132261, SAMD00132262
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2753
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..2753
                     /gene="Slc29a4"
                     /note="solute carrier family 29 member 4"
                     /db_xref="GeneID:288499"
                     /db_xref="RGD:1310545"
     exon            1..200
                     /gene="Slc29a4"
                     /inference="alignment:Splign:2.1.0"
     exon            201..374
                     /gene="Slc29a4"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..1780
                     /gene="Slc29a4"
                     /note="solute carrier family 29 (nucleoside transporters),
                     member 4; solute carrier family 29 (equilibrative
                     nucleoside transporter), member 4"
                     /codon_start=1
                     /product="equilibrative nucleoside transporter 4"
                     /protein_id="NP_001099381.1"
                     /db_xref="GeneID:288499"
                     /db_xref="RGD:1310545"
                     /translation="MGSIGSQRLKEPCVAATSGQSVVTSFDNFQLETTIEGAQDPGIR
                     VRGVPPFTDSAVDEPVPDDRYHAIYFAMLLAGVGFLLPYNSFITDVDYLHHKYPGTSI
                     VFDMSLTYILVALAAVLLNNVVVERLNLHTRITTGYLLALGPLLFISIFDVWLQLFSH
                     DQAYAINLAAVGTVAFGCTVQQSSFYGYTGLLPKRYTQGVMTGESTAGVMISLSRILT
                     KLLLPDERASTIIFFLVSAGLELLCFLLHLLVRRSRFVLYYTTRPRDSRPVRAGYRVH
                     HDVASGDIHFHQTPALSSSRSPKDSPAHEVTHSNSGVYMRFDVPRPRVKRSWPTFRAL
                     LLHRYVVARVIWADMLSIAVTYFITLCLFPGLESEIRHCVLGEWLPILVMAVFNLSDF
                     VGKILAALPVDWRGTHLLACSCLRVVFIPLFILCVYPTGMPALRHPAWPCVFSLLMGI
                     SNGYFGSVPMILAAGKVSPKQRELAGNTMTVSYMSGLTLGSAVAYCTYSLTRDAHSSC
                     FQTATANDSILVGP"
     exon            375..506
                     /gene="Slc29a4"
                     /inference="alignment:Splign:2.1.0"
     exon            507..620
                     /gene="Slc29a4"
                     /inference="alignment:Splign:2.1.0"
     exon            621..749
                     /gene="Slc29a4"
                     /inference="alignment:Splign:2.1.0"
     exon            750..824
                     /gene="Slc29a4"
                     /inference="alignment:Splign:2.1.0"
     exon            825..1069
                     /gene="Slc29a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1208
                     /gene="Slc29a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1396
                     /gene="Slc29a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1637
                     /gene="Slc29a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..2753
                     /gene="Slc29a4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggcggggc gtgagccggg ctagctcgcc gcagctgctg cgcccctcgc acgcgctcgc
       61 ggacccgggc ccgcggaccg ggacaccaag gaggacgccc gccgcgcccg gcccaagcct
      121 cgaagaacgg ggcacagcgc aaagggtccg ggcgcgggcg gcgggcagcc accgaggatc
      181 ccagcctggg gccggccgag tgtgaactgc catgggctcc attggaagcc agcgcctcaa
      241 ggagccctgt gtggcagcca catctggcca gagtgtggtg acaagctttg acaactttca
      301 gctggagacg acaatcgagg gggctcagga tccaggcatc agagtcaggg gcgtcccccc
      361 tttcacagac tctgcggtag acgagcctgt gccggacgac cgctaccatg ccatctactt
      421 tgccatgctg ctggctggcg tgggcttcct actgccctac aacagtttta tcaccgatgt
      481 ggactatctt caccacaagt acccaggaac ctccatcgtg tttgacatga gcctcaccta
      541 tatcttggtg gcactggcag ccgtgctcct caacaacgtt gtggtggaga ggttgaacct
      601 gcacactagg atcaccacag gttacctcct ggccttgggt cccttgctct ttatcagcat
      661 ctttgatgtg tggcttcagc tcttctctca cgaccaggct tacgccatca acctggccgc
      721 cgtgggcact gtggcctttg gctgcacagt gcagcaatct agcttctacg gctacacagg
      781 attactgccc aagaggtaca cgcagggggt gatgactgga gagagcacgg caggggtgat
      841 gatctctctg agccgaatcc tcactaagct gctgctcccg gatgagcggg ccagcaccat
      901 catcttcttc ctggtctctg ctggcttgga gctcctgtgc ttcctgctgc acttgctggt
      961 gcgacgcagc cgttttgtgc tctactacac cactcggcct cgtgacagcc gccctgtccg
     1021 ggcaggctac cgagtgcacc atgatgtcgc gtcaggagac atccactttc accaaactcc
     1081 agccctgtcc agcagcaggt ccccaaagga cagcccagcc catgaggtga cccacagcaa
     1141 cagcggcgtc tacatgcgtt ttgatgtgcc ccggccacga gtcaaacgga gctggcccac
     1201 cttcagagcc ctgctgctgc accgatacgt cgtggcgcgg gtcatctggg ccgacatgct
     1261 atccattgcg gtaacttact tcattacgct ctgcctgttt cctggcctgg agtccgagat
     1321 ccgccactgc gtgctgggcg agtggctgcc catcctggtc atggccgtgt tcaacctgtc
     1381 agactttgtg ggcaagatcc tggcagccct acccgtggac tggaggggta cccatctgct
     1441 tgcctgctct tgccttcgtg tggtcttcat ccccctcttc atcctgtgtg tgtaccccac
     1501 tggtatgcct gccctccgtc accctgcctg gccctgtgtc ttctcactgc taatgggcat
     1561 cagcaatggc tactttggca gcgtgcccat gatcctggca gctggaaaag tgagccccaa
     1621 gcagcgggag ctggcaggga acaccatgac tgtgtcctat atgtcggggt tgaccctggg
     1681 ctctgctgtg gcctattgca cctacagcct cacccgtgac gcccacagca gctgctttca
     1741 aacagccacc gccaacgact ccatccttgt tggcccctga gccaggccca cccgatcctg
     1801 ccacctgccc aggaagggct gctcgggcca gataccccaa ggcctgagga ccctcccacc
     1861 cctgcctcag tgcctgcggg gtcctggccg cctcctaagc cactaacgcc accttgctac
     1921 cttgttccag tcgcacactg cagttggagc atcaccaccc agggcaccac ctcctcgtgt
     1981 ctgggttggg tcggacacct gcccttcacc ctctatgtcc agaggctcca cgtttgtcac
     2041 catggtgggg ttattcagcc actcggaatg gctgaccaca atctgagttg acttccttca
     2101 ctgtgacccc actgtgcggt cccatgacgg tcttcaatgt agttttcatt tactggacgg
     2161 gggggggggc acctcctcat gagtatgaga gatcttggag gcaagtcccc aaccccgttc
     2221 tgtccccttc ttgttcttac acacttcttc acaaccctcc ccgagctccc acatacataa
     2281 aggattaaga ctcattccta cgtctacaca ggcctcctgt agtcatagca acagagctga
     2341 cctgggtgca cccaccttag gtggaggacc cccaagccct cagagcacag gctaagggcc
     2401 acacccaaca gatgtcccat ttcctccccg gctccattca atttatccat aatgcaggga
     2461 cagctgagat ccactgtgac ctacgtcgcc ccactcccat ccactgagag tcaagcagtg
     2521 acacatcaca cctgaacccc tggcaagtag cgggcaaggt gaggagtgga gtcctgggag
     2581 ccaggactgg ctgtaggacc tcctgccaga gagagctttg gctgaaccac gacacttgcc
     2641 tctccacaca tctggcccca gctgtgacca ccttgtacca atccctgctg tgtcctgtct
     2701 acctgtgtgt tctctgacta ccgcactggc cattaaagat ggcagagact gcc
//
