LOCUS       NM_031684               2142 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus solute carrier family 29 member 1 (Slc29a1),
            mRNA.
ACCESSION   NM_031684 XM_001065180 XM_001065357 XM_001065410 XM_001065464
            XM_001065529 XM_001065589
VERSION     NM_031684.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2142)
  AUTHORS   Zhou,X., Chen,Q., Huang,H., Zhang,J., Wang,J., Chen,Y., Peng,Y.,
            Zhang,H., Zeng,J., Feng,Z. and Xu,Z.
  TITLE     Inhibition of p38 MAPK regulates epileptic severity by decreasing
            expression levels of A1R and ENT1
  JOURNAL   Mol Med Rep 22 (6), 5348-5357 (2020)
   PUBMED   33174009
  REMARK    GeneRIF: Inhibition of p38 MAPK regulates epileptic severity by
            decreasing expression levels of A1R and ENT1.
REFERENCE   2  (bases 1 to 2142)
  AUTHORS   Zhang,D., Jin,W., Liu,H., Liang,T., Peng,Y., Zhang,J. and Zhang,Y.
  TITLE     ENT1 inhibition attenuates apoptosis by activation of
            cAMP/pCREB/Bcl2 pathway after MCAO in rats
  JOURNAL   Exp Neurol 331, 113362 (2020)
   PUBMED   32445645
  REMARK    GeneRIF: ENT1 inhibition attenuates apoptosis by activation of
            cAMP/pCREB/Bcl2 pathway after MCAO in rats.
REFERENCE   3  (bases 1 to 2142)
  AUTHORS   Nishimura,T., Sano,Y., Takahashi,Y., Noguchi,S., Uchida,Y.,
            Takagi,A., Tanaka,T., Katakura,S., Nakashima,E., Tachikawa,M.,
            Maruyama,T., Terasaki,T. and Tomi,M.
  TITLE     Quantification of ENT1 and ENT2 Proteins at the Placental Barrier
            and Contribution of These Transporters to Ribavirin Uptake
  JOURNAL   J Pharm Sci 108 (12), 3917-3922 (2019)
   PUBMED   31520644
  REMARK    GeneRIF: Quantification of ENT1 and ENT2 Proteins at the Placental
            Barrier and Contribution of These Transporters to Ribavirin Uptake.
REFERENCE   4  (bases 1 to 2142)
  AUTHORS   Chen,X.T., Wang,X.G., Xie,L.Y., Huang,J.W., Zhao,W., Wang,Q.,
            Yao,L.M. and Li,W.R.
  TITLE     Effects of Xingnaojing Injection on Adenosinergic Transmission and
            Orexin Signaling in Lateral Hypothalamus of Ethanol-Induced Coma
            Rats
  JOURNAL   Biomed Res Int 2019, 2389485 (2019)
   PUBMED   31346513
  REMARK    GeneRIF: Based on these results, we suggest that XNJI promotes
            arousal by inhibiting adenosine neurotransmission via reducing
            adenosine level and the expression of A1R and ENT1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2142)
  AUTHORS   Klein,D.M., Harding,M.C., Crowther,M.K. and Cherrington,N.J.
  TITLE     Localization of nucleoside transporters in rat epididymis
  JOURNAL   J Biochem Mol Toxicol 31 (8) (2017)
   PUBMED   28322028
  REMARK    GeneRIF: The purpose of this study is to determine the localization
            of nucleoside transporters expressed within rat epididymis to
            demonstrate the potential of epididymal reabsorption. Using
            immunohistochemistry, we determined that equilibrative nucleoside
            transporter 1 (ENT1) is localized to the basolateral membrane of
            epithelial cells, ENT2 is expressed in the nucleus of the
            epithelium and CNT2 is expressed by basal cells.
REFERENCE   6  (bases 1 to 2142)
  AUTHORS   Kiss,A., Farah,K., Kim,J., Garriock,R.J., Drysdale,T.A. and
            Hammond,J.R.
  TITLE     Molecular cloning and functional characterization of
            inhibitor-sensitive (mENT1) and inhibitor-resistant (mENT2)
            equilibrative nucleoside transporters from mouse brain
  JOURNAL   Biochem J 352 Pt 2 (Pt 2), 363-372 (2000)
   PUBMED   11085929
REFERENCE   7  (bases 1 to 2142)
  AUTHORS   Kobayashi,S., Zimmermann,H. and Millhorn,D.E.
  TITLE     Chronic hypoxia enhances adenosine release in rat PC12 cells by
            altering adenosine metabolism and membrane transport
  JOURNAL   J Neurochem 74 (2), 621-632 (2000)
   PUBMED   10646513
REFERENCE   8  (bases 1 to 2142)
  AUTHORS   Griffiths,M., Yao,S.Y., Abidi,F., Phillips,S.E., Cass,C.E.,
            Young,J.D. and Baldwin,S.A.
  TITLE     Molecular cloning and characterization of a
            nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside
            transporter from human placenta
  JOURNAL   Biochem J 328 (Pt 3) (Pt 3), 739-743 (1997)
   PUBMED   9396714
REFERENCE   9  (bases 1 to 2142)
  AUTHORS   Yao,S.Y., Ng,A.M., Muzyka,W.R., Griffiths,M., Cass,C.E.,
            Baldwin,S.A. and Young,J.D.
  TITLE     Molecular cloning and functional characterization of
            nitrobenzylthioinosine (NBMPR)-sensitive (es) and NBMPR-insensitive
            (ei) equilibrative nucleoside transporter proteins (rENT1 and
            rENT2) from rat tissues
  JOURNAL   J Biol Chem 272 (45), 28423-28430 (1997)
   PUBMED   9353301
REFERENCE   10 (bases 1 to 2142)
  AUTHORS   Griffiths,M., Beaumont,N., Yao,S.Y., Sundaram,M., Boumah,C.E.,
            Davies,A., Kwong,F.Y., Coe,I., Cass,C.E., Young,J.D. and
            Baldwin,S.A.
  TITLE     Cloning of a human nucleoside transporter implicated in the
            cellular uptake of adenosine and chemotherapeutic drugs
  JOURNAL   Nat Med 3 (1), 89-93 (1997)
   PUBMED   8986748
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078789.1.
            
            [WARNING] On Aug 3, 2024 this sequence was replaced by NM_031684.3.
            
            On or before Jun 25, 2006 this sequence version replaced
            XM_001065180.1, XM_001065357.1, XM_001065410.1, XM_001065464.1,
            XM_001065529.1, XM_001065589.1, NM_031684.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078789.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2142
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..2142
                     /gene="Slc29a1"
                     /gene_synonym="ENT1; rENT1"
                     /note="solute carrier family 29 member 1"
                     /db_xref="GeneID:63997"
                     /db_xref="RGD:61899"
     exon            1..73
                     /gene="Slc29a1"
                     /gene_synonym="ENT1; rENT1"
                     /inference="alignment:Splign:2.1.0"
     exon            74..162
                     /gene="Slc29a1"
                     /gene_synonym="ENT1; rENT1"
                     /inference="alignment:Splign:2.1.0"
     exon            163..264
                     /gene="Slc29a1"
                     /gene_synonym="ENT1; rENT1"
                     /inference="alignment:Splign:2.1.0"
     exon            265..347
                     /gene="Slc29a1"
                     /gene_synonym="ENT1; rENT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             319..1692
                     /gene="Slc29a1"
                     /gene_synonym="ENT1; rENT1"
                     /note="solute carrier family 29 (equilibrative nucleoside
                     transporter), member 1; nucleoside transporter, es-type;
                     equilibrative nitrobenzylmercaptopurine riboside-sensitive
                     nucleoside transporter; NBMPR-sensitive equilibrative
                     nucleoside transporter; solute carrier family 29
                     (nucleoside transporters), member 1; equilibrative
                     NBMPR-sensitive nucleoside transporter"
                     /codon_start=1
                     /product="equilibrative nucleoside transporter 1"
                     /protein_id="NP_113872.1"
                     /db_xref="GeneID:63997"
                     /db_xref="RGD:61899"
                     /translation="MTTSHQPQDRYKAVWLIFFVLGLGTLLPWNFFITATQYFTSRLN
                     TSQNISLVTNQSCESTEALADPSVSLPARSSLSAIFNNVMTLCAMLPLLIFTCLNSFL
                     HQKVSQSLRILGSLLAILLVFLVTATLVKVQMDALSFFIITMIKIVLINSFGAILQAS
                     LFGLAGVLPANYTAPIMSGQGLAGFFTSVAMICAVASGSKLSESAFGYFITACAVVIL
                     AILCYLALPWMEFYRHYLQLNLAGPAEQETKLDLISEGEEPRGGREESGVPGPNSLPA
                     NRNQSIKAILKSIWVLALSVCFIFTVTIGLFPAVTAEVESSIAGTSPWKNCYFIPVAC
                     FLNFNVFDWLGRSLTAICMWPGQDSRWLPVLVACRVVFIPLLMLCNVKQHHYLPSLFK
                     HDVWFITFMAAFAFSNGYLASLCMCFGPKKVKPAEAETAGNIMSFFLCLGLALGAVLS
                     FLLRALV"
     exon            348..429
                     /gene="Slc29a1"
                     /gene_synonym="ENT1; rENT1"
                     /inference="alignment:Splign:2.1.0"
     exon            430..632
                     /gene="Slc29a1"
                     /gene_synonym="ENT1; rENT1"
                     /inference="alignment:Splign:2.1.0"
     exon            633..772
                     /gene="Slc29a1"
                     /gene_synonym="ENT1; rENT1"
                     /inference="alignment:Splign:2.1.0"
     exon            773..907
                     /gene="Slc29a1"
                     /gene_synonym="ENT1; rENT1"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1005
                     /gene="Slc29a1"
                     /gene_synonym="ENT1; rENT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1084
                     /gene="Slc29a1"
                     /gene_synonym="ENT1; rENT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1182
                     /gene="Slc29a1"
                     /gene_synonym="ENT1; rENT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1291
                     /gene="Slc29a1"
                     /gene_synonym="ENT1; rENT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1380
                     /gene="Slc29a1"
                     /gene_synonym="ENT1; rENT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1580
                     /gene="Slc29a1"
                     /gene_synonym="ENT1; rENT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..2116
                     /gene="Slc29a1"
                     /gene_synonym="ENT1; rENT1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggcggcta ctctcgctcg ccctgtgcca gagactggtc ggctccggcc ttggcagcgg
       61 cccccacccc aagtgcctag gaggatgctt ggctgacaca cagagaacct cagctaatac
      121 tccttgaaac caacagaagg aaccttctgc tttcatctgg aggacccagc gttctgcctg
      181 agcgtgagct aggacccccc tcccagggaa cgcccaggtg ccttgggctt tcgccctcct
      241 gccaacatcg agtctccaag ttcgcaagag ccagagggaa ggagctgcca accaggcaca
      301 gcggagaaca ctggaaccat gacaaccagt caccagcctc aggacaggta taaggctgtc
      361 tggctcatct tctttgtcct gggtctgggg acactgctcc cctggaattt ttttataaca
      421 gcaacccagt atttcacaag ccgcctgaac acgtcccaga atatatcctt ggtcaccaac
      481 caatcatgcg aaagcaccga ggccttggct gacccctcag tgtccttgcc agcccggagt
      541 tctctcagtg ccatcttcaa caatgtcatg accctgtgtg ccatgttgcc cttgctgatc
      601 ttcacctgcc tcaactcttt cctgcatcag aaggtgtctc agtcccttcg gatcttgggc
      661 agcctgctgg ctatcctgtt ggtgttcctc gtcactgcca ccctggtgaa ggtgcagatg
      721 gatgccctgt ccttcttcat catcaccatg atcaagattg tgctcattaa ctcatttggt
      781 gccattttgc aagccagcct tttcggtctg gcaggcgtcc tgccggccaa ctacacagcc
      841 cccatcatga gtggccaggg cctggctggc ttcttcacct ctgttgccat gatctgtgcc
      901 gtcgccagtg gctctaagct gtcagaaagt gcttttggtt acttcatcac ggcctgtgca
      961 gttgtcattc tggccatact gtgttacctg gccctgcctt ggatggaatt ctaccgacat
     1021 tacctgcagc tcaaccttgc ggggcctgca gagcaggaga ccaagttgga tctcatcagt
     1081 gaaggagagg agccaagagg aggaagagag gaatctgggg tgccaggccc caactctcta
     1141 cccgccaaca gaaaccaatc catcaaagcc atactgaaga gtatctgggt cctggctctg
     1201 tctgtctgtt tcatcttcac agtcaccatt gggttgttcc ctgctgtgac tgctgaggtg
     1261 gaatccagca tcgcaggcac aagtccctgg aaaaactgct acttcatccc tgtggcctgc
     1321 ttcctgaatt tcaatgtctt tgactggcta ggccggagcc tcacagctat ttgcatgtgg
     1381 cctggtcagg acagccgctg gttgccggtc ctggtcgcct gcagggttgt gtttatcccc
     1441 ctgctgatgc tctgcaatgt gaagcagcac cactacctgc cctccctctt taagcatgat
     1501 gtctggttca tcaccttcat ggccgccttt gccttctcca atggctacct cgccagcctc
     1561 tgcatgtgct tcgggcccaa gaaagtcaaa ccggctgagg cagagactgc cggaaacatc
     1621 atgtccttct ttctgtgtct gggcctggct ctgggagctg tgttgtcctt cttgttaagg
     1681 gcacttgtgt gagcgaccct gtgtggacag aggaactaca ctgcctgctt cctgctcact
     1741 tccttcgctg ttagggacga gcaggggtcc agagggctgc tcttctgctt tcctccggtg
     1801 ctgggcccag atgtccagga acaaaggagg gagcctctga ggatggactt gggattgggg
     1861 gtcagagtgg tagggggaca atggtctctg acggacagct ctgactgatc cctgcctaag
     1921 ccaagcacaa gagactccac aaggatgggg tggagacaga tggctgactg tgtatcatga
     1981 tctgatgtcc cttgcccttc tttcttctgt gcctgttcca ggtccccgat ccttgtcatt
     2041 ttactgcctt ttttatactg acagaaacca ggtgccttca gaggccatct gattaaataa
     2101 acattttttt cctccaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
