LOCUS       NM_053863               2401 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus solute carrier family 28 member 1 (Slc28a1),
            mRNA.
ACCESSION   NM_053863
VERSION     NM_053863.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2401)
  AUTHORS   Cano-Soldado,P., Gorraitz,E., Errasti-Murugarren,E., Casado,F.J.,
            Lostao,M.P. and Pastor-Anglada,M.
  TITLE     Functional analysis of the human concentrative nucleoside
            transporter-1 variant hCNT1S546P provides insight into the
            sodium-binding pocket
  JOURNAL   Am J Physiol Cell Physiol 302 (1), C257-C266 (2012)
   PUBMED   21998139
REFERENCE   2  (bases 1 to 2401)
  AUTHORS   Rodriguez-Mulero,S., Errasti-Murugarren,E., Ballarin,J., Felipe,A.,
            Doucet,A., Casado,F.J. and Pastor-Anglada,M.
  TITLE     Expression of concentrative nucleoside transporters SLC28 (CNT1,
            CNT2, and CNT3) along the rat nephron: effect of diabetes
  JOURNAL   Kidney Int 68 (2), 665-672 (2005)
   PUBMED   16014043
  REMARK    GeneRIF: Diabetes increased CNT1 and CNT3 expression in the
            glomerulus and insulin treatment decreased it
REFERENCE   3  (bases 1 to 2401)
  AUTHORS   Duflot,S., Calvo,M., Casado,F.J., Enrich,C. and Pastor-Anglada,M.
  TITLE     Concentrative nucleoside transporter (rCNT1) is targeted to the
            apical membrane through the hepatic transcytotic pathway
  JOURNAL   Exp Cell Res 281 (1), 77-85 (2002)
   PUBMED   12441131
REFERENCE   4  (bases 1 to 2401)
  AUTHORS   Valdes,R., Casado,F.J. and Pastor-Anglada,M.
  TITLE     Cell-cycle-dependent regulation of CNT1, a concentrative nucleoside
            transporter involved in the uptake of cell-cycle-dependent
            nucleoside-derived anticancer drugs
  JOURNAL   Biochem Biophys Res Commun 296 (3), 575-579 (2002)
   PUBMED   12176019
  REMARK    GeneRIF: Cell-cycle-dependent regulation of CNT1 protein levels in
            a rat hepatoma cell line.
REFERENCE   5  (bases 1 to 2401)
  AUTHORS   Felipe,A., Valdes,R., Santo,B., Lloberas,J., Casado,J. and
            Pastor-Anglada,M.
  TITLE     Na+-dependent nucleoside transport in liver: two different isoforms
            from the same gene family are expressed in liver cells
  JOURNAL   Biochem J 330 (Pt 2) (Pt 2), 997-1001 (1998)
   PUBMED   9480921
REFERENCE   6  (bases 1 to 2401)
  AUTHORS   Crawford,C.R., Cass,C.E., Young,J.D. and Belt,J.A.
  TITLE     Stable expression of a recombinant sodium-dependent,
            pyrimidine-selective nucleoside transporter (CNT1) in a
            transport-deficient mouse leukemia cell line
  JOURNAL   Biochem Cell Biol 76 (5), 843-851 (1998)
   PUBMED   10353719
REFERENCE   7  (bases 1 to 2401)
  AUTHORS   Huang,Q.Q., Yao,S.Y., Ritzel,M.W., Paterson,A.R., Cass,C.E. and
            Young,J.D.
  TITLE     Cloning and functional expression of a complementary DNA encoding a
            mammalian nucleoside transport protein
  JOURNAL   J Biol Chem 269 (27), 17757-17760 (1994)
   PUBMED   8027026
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U10279.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U10279.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2401
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..2401
                     /gene="Slc28a1"
                     /gene_synonym="Cnt1"
                     /note="solute carrier family 28 member 1"
                     /db_xref="GeneID:116642"
                     /db_xref="RGD:621223"
     exon            1..140
                     /gene="Slc28a1"
                     /gene_synonym="Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            141..252
                     /gene="Slc28a1"
                     /gene_synonym="Cnt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..2103
                     /gene="Slc28a1"
                     /gene_synonym="Cnt1"
                     /note="concentrative nucleoside transporter 1; CNT 1;
                     sodium-coupled nucleoside transporter 1; Na(+)/nucleoside
                     cotransporter 1; solute carrier family 28 (sodium-coupled
                     nucleoside transporter), member 1; solute carrier family
                     28 (concentrative nucleoside transporter), member 1"
                     /codon_start=1
                     /product="sodium/nucleoside cotransporter 1"
                     /protein_id="NP_446315.1"
                     /db_xref="GeneID:116642"
                     /db_xref="RGD:621223"
                     /translation="MADNTQRQRESISLTPMAHGLENMGAEFLESMEEGRLPHSHSSL
                     PEGEGGLNKAERKAFSRWRSLQPTVQARSFCREHRQLFGWICKGLLSTACLGFLMVAC
                     LLDLQRALALLIITCVVLVFLAYDLLKRLLGSKLRRCVKFQGHSCLSLWLKRGLALAA
                     GVGLILWLSLDTAQRPEQLVSFAGICVFLVLLFAGSKHHRAVSWRAVSWGLGLQFVLG
                     LFVIRTEPGFIAFQWLGDQIQVFLSYTEAGSSFVFGEALVKDVFAFQVLPIIIFFSCV
                     MSVLYYLGLMQWVILKIAWLMQVTMGTSATETLSVAGNIFVSQTEAPLLIRPYLADMT
                     LSEVHVVMTGGYATIAGSLLGAYISFGIDAASLIAASVMAAPCALALSKLVYPEVEES
                     KFRSENGVKLTYGDAQNLLEAASAGAAISVKVVANIAANLIAFLAVLAFVNAALSWLG
                     DMVDIQGLSFQLICSYVLRPVAFLMGVAWEDCPVVAELLGIKFFLNEFVAYQELSQYK
                     QRRLAGAEEWLGDKKQWISVRAEILTTYALCGFANFSSIGIMLGGLTSLVPQRRSDFS
                     QIVLRALITGAFVSLLNACVAGILYVPRGVEVDCVSLLNQTVSSSSFEVYLCCRQVFQ
                     STSSEFSQVALDNCCRFYNHTVCT"
     exon            253..341
                     /gene="Slc28a1"
                     /gene_synonym="Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            342..433
                     /gene="Slc28a1"
                     /gene_synonym="Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            434..617
                     /gene="Slc28a1"
                     /gene_synonym="Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            618..759
                     /gene="Slc28a1"
                     /gene_synonym="Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            760..873
                     /gene="Slc28a1"
                     /gene_synonym="Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            874..951
                     /gene="Slc28a1"
                     /gene_synonym="Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1032
                     /gene="Slc28a1"
                     /gene_synonym="Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1113
                     /gene="Slc28a1"
                     /gene_synonym="Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1239
                     /gene="Slc28a1"
                     /gene_synonym="Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1370
                     /gene="Slc28a1"
                     /gene_synonym="Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1539
                     /gene="Slc28a1"
                     /gene_synonym="Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1737
                     /gene="Slc28a1"
                     /gene_synonym="Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1819
                     /gene="Slc28a1"
                     /gene_synonym="Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1918
                     /gene="Slc28a1"
                     /gene_synonym="Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2030
                     /gene="Slc28a1"
                     /gene_synonym="Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2401
                     /gene="Slc28a1"
                     /gene_synonym="Cnt1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctgacgctg ccttctcact gcagataagt gagtagtaca ggaccctctc ccctctctat
       61 gcagccctgt gtctgtgagt gcccagggag caggcattta ccaggtctgg tggctgcgtg
      121 ttccacacgt cctcatgagg ctgaagagcc aagcacatgg cagacaacac acagaggcaa
      181 agagagtcca tttccctcac gcctatggcc cacggcctgg agaacatggg ggcagaattc
      241 ctggaaagca tggaggaagg ccgactccct cacagtcact caagcctgcc ggagggtgaa
      301 ggtggcctga acaaagcaga gcggaaggcc ttctcccgat ggaggagtct gcagccgact
      361 gtgcaagcga gaagcttctg cagggagcac cggcagctgt ttggatggat ctgcaaaggc
      421 ctgctctcta ctgcatgtct tggcttcttg atggtcgcct gcctcctgga cctccagagg
      481 gccctagcac tgttgatcat cacctgtgtg gttctcgtct ttctggccta tgatctgcta
      541 aagaggcttc tggggtccaa gctgaggagg tgtgtgaagt ttcaaggcca ttcttgcctg
      601 agcctctggc tgaaaagagg tctagccctt gctgctggtg tgggcctgat cttgtggcta
      661 tctctggaca ccgcccagcg gcctgaacag ctggtgtcct ttgcagggat ctgtgtgttc
      721 cttgtccttc tctttgctgg ctcaaagcat caccgtgcgg tgtcatggcg agctgtgtcc
      781 tggggccttg ggctgcagtt tgtgcttggg ctcttcgtca tcagaacaga accagggttc
      841 attgcattcc agtggctagg ggatcagatc caggtcttcc tgagttacac cgaggcaggc
      901 tccagcttcg tcttcggaga ggctctggtg aaggatgtct ttgcctttca ggttttgccc
      961 atcatcatct tcttcagctg cgtcatgtct gttctgtact atctgggcct catgcagtgg
     1021 gtgatcctga agattgcctg gttgatgcag gtcaccatgg gcacctcagc caccgagaca
     1081 ctgagtgtgg cgggaaacat ctttgtgagc cagactgaag ctcctctgct gatccggccc
     1141 tatctggcag acatgacact ctctgaagtt cacgttgtca tgactggagg ctatgctacc
     1201 attgctggca gcctcctggg cgcctacatc tcctttggga tcgacgctgc ttccttaatc
     1261 gcagcctctg tcatggccgc cccttgtgcg ttggctctct ccaagctggt ctacccagag
     1321 gtggaggagt ccaagttccg gagtgagaat ggcgtgaagc tgacctatgg agacgctcag
     1381 aacctcttgg aagcagccag tgctggggct gccatctcag tgaaggtcgt tgccaacatt
     1441 gctgccaatc tgattgcctt cctggctgta ctagccttcg tcaatgctgc cctctcctgg
     1501 ctaggggaca tggtggacat ccagggactc agcttccagc tcatctgctc ctacgtcctg
     1561 cggcctgtgg ccttcttgat gggtgtggcc tgggaggact gtccggtagt ggctgagttg
     1621 ctgggcatca agttctttct gaatgagttt gtggcctatc aagagctttc ccagtacaag
     1681 caacgacgcc tggcaggggc tgaggagtgg cttggtgaca agaaacagtg gatctctgtc
     1741 agagcagaaa tcctgactac atacgccctc tgtggatttg ccaacttcag ctccatcggc
     1801 atcatgttgg gaggcctgac ctccctagtc ccccagcgga ggagcgactt ctcccagatt
     1861 gtactccggg cactgatcac aggggctttc gtgtccctgc taaacgcctg tgtggcaggg
     1921 atcctctatg tacccagggg ggtcgaggtg gactgcgtgt cccttctgaa ccaaactgtc
     1981 agcagcagca gctttgaggt ttacctgtgc tgccgccaag tcttccagag cactagctcg
     2041 gagttcagcc aagtggcact ggacaactgc tgtcgatttt acaaccacac agtctgcaca
     2101 tagctgggac ggagcatctt cctagcctca gggctcatcc agcccagaga ggccgtggga
     2161 ctcgtcacta cctccatccc acaattggga agggtgcaac ggtcatcgct gctcccatgt
     2221 ctgcctctcc aagtacgagt tcccagagtc tggtctgctc tcctgccctt tgggagccaa
     2281 cattctggtc ctcttgagtc ctctttcctt gggaacctca tgtgcaccag ccaaaagcct
     2341 cctccctgct ccctcccaag cacccagctt gttgggtatc cccccaaaag ctgtctctag
     2401 a
//
