LOCUS       NM_024143               2359 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus solute carrier family 27 member 5 (Slc27a5),
            mRNA.
ACCESSION   NM_024143
VERSION     NM_024143.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2359)
  AUTHORS   Falcon,A., Doege,H., Fluitt,A., Tsang,B., Watson,N., Kay,M.A. and
            Stahl,A.
  TITLE     FATP2 is a hepatic fatty acid transporter and peroxisomal very
            long-chain acyl-CoA synthetase
  JOURNAL   Am J Physiol Endocrinol Metab 299 (3), E384-E393 (2010)
   PUBMED   20530735
REFERENCE   2  (bases 1 to 2359)
  AUTHORS   Hubbard,B., Doege,H., Punreddy,S., Wu,H., Huang,X., Kaushik,V.K.,
            Mozell,R.L., Byrnes,J.J., Stricker-Krongrad,A., Chou,C.J.,
            Tartaglia,L.A., Lodish,H.F., Stahl,A. and Gimeno,R.E.
  TITLE     Mice deleted for fatty acid transport protein 5 have defective bile
            acid conjugation and are protected from obesity
  JOURNAL   Gastroenterology 130 (4), 1259-1269 (2006)
   PUBMED   16618417
REFERENCE   3  (bases 1 to 2359)
  AUTHORS   Doege,H., Baillie,R.A., Ortegon,A.M., Tsang,B., Wu,Q., Punreddy,S.,
            Hirsch,D., Watson,N., Gimeno,R.E. and Stahl,A.
  TITLE     Targeted deletion of FATP5 reveals multiple functions in liver
            metabolism: alterations in hepatic lipid homeostasis
  JOURNAL   Gastroenterology 130 (4), 1245-1258 (2006)
   PUBMED   16618416
REFERENCE   4  (bases 1 to 2359)
  AUTHORS   He,D., Barnes,S. and Falany,C.N.
  TITLE     Rat liver bile acid CoA:amino acid N-acyltransferase: expression,
            characterization, and peroxisomal localization
  JOURNAL   J Lipid Res 44 (12), 2242-2249 (2003)
   PUBMED   12951368
REFERENCE   5  (bases 1 to 2359)
  AUTHORS   Falany,C.N., Xie,X., Wheeler,J.B., Wang,J., Smith,M., He,D. and
            Barnes,S.
  TITLE     Molecular cloning and expression of rat liver bile acid CoA ligase
  JOURNAL   J Lipid Res 43 (12), 2062-2071 (2002)
   PUBMED   12454267
REFERENCE   6  (bases 1 to 2359)
  AUTHORS   Mihalik,S.J., Steinberg,S.J., Pei,Z., Park,J., Kim,D.G.,
            Heinzer,A.K., Dacremont,G., Wanders,R.J., Cuebas,D.A., Smith,K.D.
            and Watkins,P.A.
  TITLE     Participation of two members of the very long-chain acyl-CoA
            synthetase family in bile acid synthesis and recycling
  JOURNAL   J Biol Chem 277 (27), 24771-24779 (2002)
   PUBMED   11980911
REFERENCE   7  (bases 1 to 2359)
  AUTHORS   Steinberg,S.J., Mihalik,S.J., Kim,D.G., Cuebas,D.A. and
            Watkins,P.A.
  TITLE     The human liver-specific homolog of very long-chain acyl-CoA
            synthetase is cholate:CoA ligase
  JOURNAL   J Biol Chem 275 (21), 15605-15608 (2000)
   PUBMED   10749848
REFERENCE   8  (bases 1 to 2359)
  AUTHORS   Steinberg,S.J., Wang,S.J., McGuinness,M.C. and Watkins,P.A.
  TITLE     Human liver-specific very-long-chain acyl-coenzyme A synthetase:
            cDNA cloning and characterization of a second enzymatically active
            protein
  JOURNAL   Mol Genet Metab 68 (1), 32-42 (1999)
   PUBMED   10479480
REFERENCE   9  (bases 1 to 2359)
  AUTHORS   Hirsch,D., Stahl,A. and Lodish,H.F.
  TITLE     A family of fatty acid transporters conserved from mycobacterium to
            man
  JOURNAL   Proc Natl Acad Sci U S A 95 (15), 8625-8629 (1998)
   PUBMED   9671728
REFERENCE   10 (bases 1 to 2359)
  AUTHORS   Wheeler,J.B., Shaw,D.R. and Barnes,S.
  TITLE     Purification and characterization of a rat liver bile acid coenzyme
            A ligase from rat liver microsomes
  JOURNAL   Arch Biochem Biophys 348 (1), 15-24 (1997)
   PUBMED   9390170
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF242189.1.
            
            On Aug 31, 2012 this sequence version replaced NM_024143.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF242189.1, BC091147.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2359              AF242189.1         2-2360
FEATURES             Location/Qualifiers
     source          1..2359
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2359
                     /gene="Slc27a5"
                     /gene_synonym="BAL; rBAL-1"
                     /note="solute carrier family 27 member 5"
                     /db_xref="GeneID:79111"
                     /db_xref="RGD:708535"
     exon            1..738
                     /gene="Slc27a5"
                     /gene_synonym="BAL; rBAL-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..2123
                     /gene="Slc27a5"
                     /gene_synonym="BAL; rBAL-1"
                     /EC_number="6.2.1.3"
                     /EC_number="6.2.1.7"
                     /note="bile acyl-CoA synthetase; BACS; FATP-5; VLACSR;
                     BA-CoA ligase; solute carrier family 27 (fatty acid
                     transporter), member 5; VLACS-related; cholate--CoA
                     ligase; bile acid-CoA ligase; fatty acid transport protein
                     5; very long-chain acyl-CoA synthetase-related protein;
                     long-chain-fatty-acid--CoA ligase"
                     /codon_start=1
                     /product="long-chain fatty acid transport protein 5"
                     /protein_id="NP_077057.1"
                     /db_xref="GeneID:79111"
                     /db_xref="RGD:708535"
                     /translation="MGVWKKLTFLLLSLLLLVGLGQPLWPAATALALRWFLGDPTCFV
                     LLGLAFLGRPWISSWIPHWLSLAAAALTLSLLPPRPPPELRWLHKDVAFAFKLLFYGL
                     NLRRRLNRHPPELFVDALEQQAQARPDQVALVCTGSEGCSITNRELNAKACQAAWALK
                     AKLKEATIQEDKGATAILVLPSKSISALSVFLGLAKLGCPVAWINPHSRGMPLLHSVQ
                     SSGASVLIVDPDLQENLEEVLPKLLAENIRCFYLGHSSPTPGVEALGAALDAAPSDPV
                     PAKLRANIKWKSPAIFIYTSGTTGLPKPAILSHERVIQMSNVLSFCGRTADDVVYNVL
                     PLYHSMGLVLGVLGCLQLGATCVLAPKFSASRYWAECRQYSVTVVLYVGEVLRYLCNV
                     PGQPEDKKHTVRFALGNGLRADVWENFQQRFGPIQIWELYGSTEGNVGLMNYVGHCGA
                     VGKTSCFIRMLTPLELVQFDIETAEPVRDKQGFCIPVETGKPGLLLTKIRKNQPFLGY
                     RGSQDETKRKLVANVRQVGDLYYNTGDVLALDQEGFFYFRDRLGDTFRWKGENVSTRE
                     VEGVLSILDFLEEVNVYGVTVPGCEGKVGMAAVKLAPGKTFDGQKLYQHVRSWLPAYA
                     TPHFIRIQDSLEITNTYKLVKSQLAREGFDVGVIADPLYILDNKAETFRSLMPDVYQA
                     VCEGTWKL"
     exon            739..948
                     /gene="Slc27a5"
                     /gene_synonym="BAL; rBAL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1107
                     /gene="Slc27a5"
                     /gene_synonym="BAL; rBAL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1232
                     /gene="Slc27a5"
                     /gene_synonym="BAL; rBAL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1427
                     /gene="Slc27a5"
                     /gene_synonym="BAL; rBAL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1518
                     /gene="Slc27a5"
                     /gene_synonym="BAL; rBAL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1717
                     /gene="Slc27a5"
                     /gene_synonym="BAL; rBAL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1815
                     /gene="Slc27a5"
                     /gene_synonym="BAL; rBAL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1946
                     /gene="Slc27a5"
                     /gene_synonym="BAL; rBAL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2260
                     /gene="Slc27a5"
                     /gene_synonym="BAL; rBAL-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcagagctg agactacccg ctctcagcta cttcacaaag agccagtgcc atgggtgttt
       61 ggaagaaact aaccttcttg ctgctgtcgc tgcttctcct ggttggcctg gggcagcccc
      121 tgtggccagc agctacggct ctggccctgc gttggttcct gggagacccc acgtgctttg
      181 tgctgcttgg cttggcattc ctgggcagac cctggatcag ctcctggata ccccactggc
      241 tgagcctggc agcagcagct ctcacattat ccctattgcc tccacggcca cccccagaac
      301 ttcgctggct gcacaaagat gtggccttcg ccttcaagtt gcttttctat ggcctgaacc
      361 tcaggcgacg ccttaacaga catcctccag aactctttgt ggatgcttta gagcagcaag
      421 cacaggcccg gcctgaccag gtggccttgg tgtgtactgg gtctgagggc tgctcaatca
      481 caaataggga gctgaatgcc aaggcctgtc aagcagcatg ggccctgaaa gcaaagctga
      541 aggaagccac aatccaggag gacaaaggcg ctactgctat tttagtactc ccgtccaagt
      601 ccatttctgc tctgagtgtg tttctgggtt tggccaagtt gggctgccct gtggcctgga
      661 tcaatccaca cagtcgagga atgcccttgc tacactctgt gcagagctct ggggctagtg
      721 tgctgattgt ggatccagac ctccaggaga acctggaaga agtccttccc aagctgctag
      781 ctgagaacat tcgatgcttc taccttggcc acagctcacc cactccgggc gtagaggctc
      841 taggagctgc cctggacgct gcaccttctg acccagtgcc tgccaagctt cgtgctaata
      901 taaagtggaa atccccagcc atattcatct atacttcagg gaccactgga cttccaaagc
      961 cagccatcct atcacatgag cgggtcatac aaatgagtaa cgtgctgtcc ttttgtggga
     1021 gaacagctga tgatgtggtc tacaatgttc tacctctgta ccattcgatg gggcttgtcc
     1081 ttggagtcct cggctgctta caacttggag ccacctgtgt cctggccccc aagttctctg
     1141 cttcccgata ctgggctgag tgccggcagt acagtgtgac agtggtcctg tatgtgggtg
     1201 aagtcctgcg atacttgtgt aatgtcccag ggcaaccaga agacaagaaa catacagtgc
     1261 ggttcgcatt gggcaatgga cttcgggcag acgtgtggga aaacttccag caacgatttg
     1321 gtcccattca gatctgggaa ctctacggct ccacagaggg caacgtgggc ttaatgaact
     1381 atgtggggca ctgcggggct gtgggcaaga ccagctgctt cattcgaatg ctgactcccc
     1441 ttgagcttgt acagtttgac atagagacgg cagagcctgt gagggacaaa cagggttttt
     1501 gcatccctgt ggagacagga aagccaggac ttcttttgac caagattcga aagaaccaac
     1561 ccttcctggg ctaccgtggt tcccaggatg aaaccaagcg gaaactggtt gcgaacgtac
     1621 ggcaagtagg agacctctac tacaacacag gggatgtgct ggccttggac caggaaggct
     1681 tcttctactt ccgagaccgc cttggtgaca ccttccggtg gaagggtgaa aatgtatcca
     1741 ctcgagaggt ggagggtgtg ttgtctatcc tagacttcct agaggaagtc aatgtctatg
     1801 gtgtgactgt gccagggtgt gagggtaagg ttggcatggc tgctgtgaaa ctggctcctg
     1861 ggaagacttt tgatgggcag aagctctacc agcatgtccg ctcctggctc cctgcctatg
     1921 ccacacctca tttcatccgt atccaggact ccctggagat cacaaacacc tacaagctag
     1981 tgaagtcaca actggcgcgt gagggttttg atgtgggggt cattgctgac cctctctaca
     2041 tactggacaa caaggccgaa accttccgga gtctgatgcc agatgtgtac caggctgtgt
     2101 gtgaaggaac ctggaagctc tgatcaccta gccaagtgga aggctatcca aaagtgtgga
     2161 aatcggaaat cgacactagt cagcttcaca aagtggtcag ggttccagat gtccatggcc
     2221 cagtagtact tagagaataa acttgaatgt gtatatagaa aaaaaaaaaa aaaaaaaaaa
     2281 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2341 aaaaaaaaaa aaaaaaaaa
//
