LOCUS       NM_031736               2961 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus solute carrier family 27 member 2 (Slc27a2),
            mRNA.
ACCESSION   NM_031736 XM_346669
VERSION     NM_031736.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2961)
  AUTHORS   Khan,S., Cabral,P.D., Schilling,W.P., Schmidt,Z.W., Uddin,A.N.,
            Gingras,A., Madhavan,S.M., Garvin,J.L. and Schelling,J.R.
  TITLE     Kidney Proximal Tubule Lipoapoptosis Is Regulated by Fatty Acid
            Transporter-2 (FATP2)
  JOURNAL   J Am Soc Nephrol 29 (1), 81-91 (2018)
   PUBMED   28993506
  REMARK    GeneRIF: We conclude that FATP2 is a major apical proximal tubule
            NEFA transporter that regulates lipoapoptosis and may be an
            amenable target for the prevention of CKD progression.
REFERENCE   2  (bases 1 to 2961)
  AUTHORS   Ohkuni,A., Ohno,Y. and Kihara,A.
  TITLE     Identification of acyl-CoA synthetases involved in the mammalian
            sphingosine 1-phosphate metabolic pathway
  JOURNAL   Biochem Biophys Res Commun 442 (3-4), 195-201 (2013)
   PUBMED   24269233
REFERENCE   3  (bases 1 to 2961)
  AUTHORS   Melton,E.M., Cerny,R.L., Watkins,P.A., DiRusso,C.C. and Black,P.N.
  TITLE     Human fatty acid transport protein 2a/very long chain acyl-CoA
            synthetase 1 (FATP2a/Acsvl1) has a preference in mediating the
            channeling of exogenous n-3 fatty acids into phosphatidylinositol
  JOURNAL   J Biol Chem 286 (35), 30670-30679 (2011)
   PUBMED   21768100
REFERENCE   4  (bases 1 to 2961)
  AUTHORS   Krammer,J., Digel,M., Ehehalt,F., Stremmel,W., Fullekrug,J. and
            Ehehalt,R.
  TITLE     Overexpression of CD36 and acyl-CoA synthetases FATP2, FATP4 and
            ACSL1 increases fatty acid uptake in human hepatoma cells
  JOURNAL   Int J Med Sci 8 (7), 599-614 (2011)
   PUBMED   22022213
REFERENCE   5  (bases 1 to 2961)
  AUTHORS   Falcon,A., Doege,H., Fluitt,A., Tsang,B., Watson,N., Kay,M.A. and
            Stahl,A.
  TITLE     FATP2 is a hepatic fatty acid transporter and peroxisomal very
            long-chain acyl-CoA synthetase
  JOURNAL   Am J Physiol Endocrinol Metab 299 (3), E384-E393 (2010)
   PUBMED   20530735
REFERENCE   6  (bases 1 to 2961)
  AUTHORS   Smith,B.T., Sengupta,T.K. and Singh,I.
  TITLE     Intraperoxisomal localization of very-long-chain fatty acyl-CoA
            synthetase: implication in X-adrenoleukodystrophy
  JOURNAL   Exp Cell Res 254 (2), 309-320 (2000)
   PUBMED   10640429
REFERENCE   7  (bases 1 to 2961)
  AUTHORS   Steinberg,S.J., Wang,S.J., Kim,D.G., Mihalik,S.J. and Watkins,P.A.
  TITLE     Human very-long-chain acyl-CoA synthetase: cloning, topography, and
            relevance to branched-chain fatty acid metabolism
  JOURNAL   Biochem Biophys Res Commun 257 (2), 615-621 (1999)
   PUBMED   10198260
REFERENCE   8  (bases 1 to 2961)
  AUTHORS   Hirsch,D., Stahl,A. and Lodish,H.F.
  TITLE     A family of fatty acid transporters conserved from mycobacterium to
            man
  JOURNAL   Proc Natl Acad Sci U S A 95 (15), 8625-8629 (1998)
   PUBMED   9671728
REFERENCE   9  (bases 1 to 2961)
  AUTHORS   Pirard,M., Collet,J.F., Matthijs,G. and Van Schaftingen,E.
  TITLE     Comparison of PMM1 with the phosphomannomutases expressed in rat
            liver and in human cells
  JOURNAL   FEBS Lett 411 (2-3), 251-254 (1997)
   PUBMED   9271215
REFERENCE   10 (bases 1 to 2961)
  AUTHORS   Uchiyama,A., Aoyama,T., Kamijo,K., Uchida,Y., Kondo,N., Orii,T. and
            Hashimoto,T.
  TITLE     Molecular cloning of cDNA encoding rat very long-chain acyl-CoA
            synthetase
  JOURNAL   J Biol Chem 271 (48), 30360-30365 (1996)
   PUBMED   8939997
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_031736.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D85100.1, BC081766.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1270              JAXUCZ010000003.1  134258101-134259370
            1271-1480           JAXUCZ010000003.1  134268137-134268346
            1481-1639           JAXUCZ010000003.1  134271431-134271589
            1640-1764           JAXUCZ010000003.1  134273976-134274100
            1765-1959           JAXUCZ010000003.1  134282921-134283115
            1960-2050           JAXUCZ010000003.1  134285304-134285394
            2051-2249           JAXUCZ010000003.1  134286266-134286464
            2250-2347           JAXUCZ010000003.1  134289011-134289108
            2348-2478           JAXUCZ010000003.1  134293554-134293684
            2479-2961           JAXUCZ010000003.1  134295099-134295581
FEATURES             Location/Qualifiers
     source          1..2961
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..2961
                     /gene="Slc27a2"
                     /note="solute carrier family 27 member 2"
                     /db_xref="GeneID:65192"
                     /db_xref="RGD:71103"
     exon            1..1270
                     /gene="Slc27a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             793..2655
                     /gene="Slc27a2"
                     /EC_number="6.2.1.3"
                     /EC_number="6.2.1.7"
                     /EC_number="6.2.1.15"
                     /EC_number="6.2.1.24"
                     /note="very long-chain acyl-CoA synthetase; VLCS; VLACS;
                     FATP-2; THCA-CoA ligase; phytanate--CoA ligase;
                     arachidonate--CoA ligase; fatty acid transport protein 2;
                     long-chain-fatty-acid--CoA ligase; solute carrier family
                     27 (fatty acid transporter), member 2; very
                     long-chain-fatty-acid-CoA ligase; fatty-acid-coenzyme A
                     ligase, very long-chain 1; solute carrier family 27 (fatty
                     acid transporter), member 32"
                     /codon_start=1
                     /product="long-chain fatty acid transport protein 2"
                     /protein_id="NP_113924.2"
                     /db_xref="GeneID:65192"
                     /db_xref="RGD:71103"
                     /translation="MLPVLYTGLAGLLLLPLLLTCCCPYLLQDVRFFLQLANMARQVR
                     SYRQRRPVRTILHVFLEQARKTPHKPFLLFRDETLTYAQVDRRSNQVARALHDHLGLR
                     QGDCVALFMGNEPAYVWLWLGLLKLGCPMACLNYNIRAKSLLHCFQCCGAKVLLASPE
                     LHEAVEEVLPTLKKEGMSVFYVSRTSNTNGVDTVLDKVDGVSADPIPESWRSEVTFTT
                     PAVYIYTSGTTGLPKAATINHHRLWYGTSLALRSGIKAHDVIYTTMPLYHSAALMIGL
                     HGCIVVGATFALRSKFSASQFWDDCRKYNATVIQYIGELLRYLCNTPQKPNDRDHKVK
                     IALGNGLRGDVWREFIKRFGDIHIYEFYASTEGNIGFMNYPRKIGAVGRENYLQKKVV
                     RHELIKYDVEKDEPVRDANGYCIKVPKGEVGLLICKITELTPFFGYAGGKTQTEKKKL
                     RDVFKKGDVYFNSGDLLMIDRENFIYFHDRVGDTFRWKGENVATTEVADIVGLVDFVE
                     EVNVYGVPVPGHEGRIGMASIKMKENYEFNGKKLFQHISEYLPSYSRPRFLRIQDTIE
                     ITGTFKHRKVTLMEEGFNPSVIKDTLYFMDDAEKTYVPMTEDIYNAIIDKTLKL"
     exon            1271..1480
                     /gene="Slc27a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1639
                     /gene="Slc27a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1764
                     /gene="Slc27a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1959
                     /gene="Slc27a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2050
                     /gene="Slc27a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2249
                     /gene="Slc27a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2347
                     /gene="Slc27a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2478
                     /gene="Slc27a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2479..2961
                     /gene="Slc27a2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacagtactg ccgatgttgg acagaggatc gcttaacaga acgaaatctc aaaacaaatt
       61 aacaggaccc ggttgcttga tttcccaaat caggaaaggc tcgaaatgtc tagaggggct
      121 gactgatgca gcggtgaccc ggactggaga cagttggacg cgatcatctc tggtgctttt
      181 gttcaacctt gaaaccttcg ccacaggaga cttgcctgag cagagaagca aacgtggaga
      241 aacaaagaga gatctagcga aaagcctctg ggaccaagga ggggaggtgg gactctgggt
      301 tggcggtggc acctgctgcc ggctattaat aatagggtcg cggtgcgttt ataaggtgtt
      361 tgattaaaca aagactctat gagagaagaa taactagcaa cagccccacg tctgagtcgc
      421 cgcctccgac ctttttcaac gtgggttctt tgggccgagc gtcgtttgcc gagaactaga
      481 tctcacctga ccccagacgc tgaaaacaag cgctgtggca tcctgggcca cccaagctga
      541 caagggcgcg ccccctgagc acacgaggtg ccccacgagg gggcgggacc cacagccgtc
      601 ccgcccgcac cgcggtgtcc gctgcgggca cctgcagccg agccgccacc cgcagtcgca
      661 gcgcgtccgg cggccgaacc cggtcgtcag ctcgtcagca cctgctctgc ttctctcccg
      721 cccgccgccg cgctgcacgc ctcgagcgct ccctcggccc cggcggggac cggggacccc
      781 gcagccaccg ccatgctgcc agtgctctac accggcctgg cggggctgct gctgctgcct
      841 ctgctgctca cctgctgctg cccctacctc ctccaggacg tgcggttctt cctgcaactg
      901 gccaacatgg cccggcaggt gcgcagctac cggcagcggc gacccgtgcg caccatcctg
      961 catgtcttct tggagcaagc gcgcaagacc ccgcacaagc ccttcctgct gtttcgcgac
     1021 gagacgctta cctacgccca ggtagaccgg cgcagcaacc aagtagcgcg ggcgctgcat
     1081 gatcacctgg gactgcggca gggggattgc gtggccctct tcatgggcaa tgagccggcc
     1141 tacgtgtggc tctggctggg actgctcaaa ctgggctgtc ccatggcgtg cctcaactac
     1201 aacatccgtg ccaagtctct gctacactgc tttcagtgct gcggggcgaa ggtgctgctg
     1261 gcctccccag agctacacga agctgtcgag gaggttcttc caaccctgaa aaaggagggc
     1321 atgtccgtct tctacgtaag cagaacttct aacactaatg gcgtggacac agtactggac
     1381 aaagtagacg gggtgtcggc ggaccccatc ccggagtcgt ggaggtctga agtcacgttc
     1441 accacacccg cagtctacat atatacttcg ggcaccacag gtcttccaaa ggctgcaacc
     1501 attaatcacc atcgcctctg gtatgggacc agccttgccc tgagatccgg aattaaggct
     1561 catgacgtca tctacaccac catgcccctg taccacagcg cggcgctcat gattggcctc
     1621 cacggatgca ttgtggttgg ggctacattt gctttgcgga gcaaattttc agccagccag
     1681 ttttgggacg actgcaggaa atacaacgcc actgtcattc agtacatcgg tgaactgctt
     1741 cggtacctct gcaacacgcc ccagaaacca aatgaccggg accacaaagt gaaaatagca
     1801 ctaggaaatg gcttacgagg agatgtgtgg agagagttca tcaagagatt tggggacatt
     1861 cacatttatg agttctacgc ttccactgaa ggcaacattg gatttatgaa ctatccaaga
     1921 aaaatcggag ctgttggaag agaaaattac ctacaaaaaa aagttgtaag gcacgagctg
     1981 atcaagtatg acgtggagaa ggatgagccc gtccgtgatg caaatggata ttgcatcaaa
     2041 gtccccaaag gtgaggttgg actcttgatt tgcaaaatca cagagctcac accatttttt
     2101 ggctatgctg gaggaaagac ccagacagag aagaaaaagc tcagagatgt ttttaagaaa
     2161 ggagacgtct acttcaacag tggcgatctc ctgatgatcg accgtgaaaa tttcatctat
     2221 tttcacgaca gagttggaga caccttccgg tggaaaggag agaatgtagc taccacggaa
     2281 gtcgctgaca ttgtgggact ggtagatttt gttgaagaag tgaatgttta cggtgtgccc
     2341 gtgccaggtc atgaaggtcg catcgggatg gcctcgatca agatgaaaga aaactacgag
     2401 ttcaatggaa agaaactctt tcagcacatc tcggagtacc tgcccagtta ctcgaggcct
     2461 cggttcctga gaatacaaga taccattgag atcaccggga cttttaaaca ccgcaaagtg
     2521 accctgatgg aagagggctt taacccctca gtcatcaaag ataccttgta tttcatggat
     2581 gacgcagaaa aaacatacgt gcccatgact gaggacattt ataatgccat aattgataag
     2641 actctgaagc tctgaatgtt gcctggctcc taacacttcc agaaagaaac acaataggcc
     2701 tagcatagcc ccttcacatg tgtaatccaa ctttaacttg attaaaggtt ataggtgtga
     2761 tttttcctag gaaattattc atttaaagga caattgtttg tttgtttgtt tgttttttat
     2821 taattacacc agaacgtttg caagtaaaaa gatttaaagt cacttatttt tcaatgtgca
     2881 cctgccattt gtccttgcaa acttagcttc ttggagagag ggccttattt ttttaaagac
     2941 ataataaact atgtaaacac t
//
