LOCUS       NM_053580               3210 bp    mRNA    linear   ROD 02-FEB-2024
DEFINITION  Rattus norvegicus solute carrier family 27 member 1 (Slc27a1),
            mRNA.
ACCESSION   NM_053580
VERSION     NM_053580.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3210)
  AUTHORS   Ochiai,Y., Uchida,Y., Tachikawa,M., Couraud,P.O. and Terasaki,T.
  TITLE     Amyloid beta25-35 impairs docosahexaenoic acid efflux by
            down-regulating fatty acid transport protein 1 (FATP1/SLC27A1)
            protein expression in human brain capillary endothelial cells
  JOURNAL   J Neurochem 150 (4), 385-401 (2019)
   PUBMED   31091338
REFERENCE   2  (bases 1 to 3210)
  AUTHORS   Ochiai,Y., Uchida,Y., Ohtsuki,S., Tachikawa,M., Aizawa,S. and
            Terasaki,T.
  TITLE     The blood-brain barrier fatty acid transport protein 1
            (FATP1/SLC27A1) supplies docosahexaenoic acid to the brain, and
            insulin facilitates transport
  JOURNAL   J Neurochem 141 (3), 400-412 (2017)
   PUBMED   28035674
REFERENCE   3  (bases 1 to 3210)
  AUTHORS   Arif,A., Terenzi,F., Potdar,A.A., Jia,J., Sacks,J., China,A.,
            Halawani,D., Vasu,K., Li,X., Brown,J.M., Chen,J., Kozma,S.C.,
            Thomas,G. and Fox,P.L.
  TITLE     EPRS is a critical mTORC1-S6K1 effector that influences adiposity
            in mice
  JOURNAL   Nature 542 (7641), 357-361 (2017)
   PUBMED   28178239
REFERENCE   4  (bases 1 to 3210)
  AUTHORS   Holloway,G.P., Chou,C.J., Lally,J., Stellingwerff,T., Maher,A.C.,
            Gavrilova,O., Haluzik,M., Alkhateeb,H., Reitman,M.L. and Bonen,A.
  TITLE     Increasing skeletal muscle fatty acid transport protein 1 (FATP1)
            targets fatty acids to oxidation and does not predispose mice to
            diet-induced insulin resistance
  JOURNAL   Diabetologia 54 (6), 1457-1467 (2011)
   PUBMED   21442160
  REMARK    GeneRIF: Overexpression of Fatp1 in skeletal muscle increased the
            rate of long-chain fatty acid transport and channelled these lipids
            to oxidation, not to intramuscular lipid accumulation.
REFERENCE   5  (bases 1 to 3210)
  AUTHORS   Mitchell,R.W., On,N.H., Del Bigio,M.R., Miller,D.W. and Hatch,G.M.
  TITLE     Fatty acid transport protein expression in human brain and
            potential role in fatty acid transport across human brain
            microvessel endothelial cells
  JOURNAL   J Neurochem 117 (4), 735-746 (2011)
   PUBMED   21395585
REFERENCE   6  (bases 1 to 3210)
  AUTHORS   Hatch,G.M., Smith,A.J., Xu,F.Y., Hall,A.M. and Bernlohr,D.A.
  TITLE     FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and
            down-regulates sphingomyelin and cholesterol metabolism in growing
            293 cells
  JOURNAL   J Lipid Res 43 (9), 1380-1389 (2002)
   PUBMED   12235169
REFERENCE   7  (bases 1 to 3210)
  AUTHORS   Coe,N.R., Smith,A.J., Frohnert,B.I., Watkins,P.A. and Bernlohr,D.A.
  TITLE     The fatty acid transport protein (FATP1) is a very long chain
            acyl-CoA synthetase
  JOURNAL   J Biol Chem 274 (51), 36300-36304 (1999)
   PUBMED   10593920
REFERENCE   8  (bases 1 to 3210)
  AUTHORS   Hirsch,D., Stahl,A. and Lodish,H.F.
  TITLE     A family of fatty acid transporters conserved from mycobacterium to
            man
  JOURNAL   Proc Natl Acad Sci U S A 95 (15), 8625-8629 (1998)
   PUBMED   9671728
REFERENCE   9  (bases 1 to 3210)
  AUTHORS   Schaap,F.G., Hamers,L., Van der Vusse,G.J. and Glatz,J.F.
  TITLE     Molecular cloning of fatty acid-transport protein cDNA from rat
  JOURNAL   Biochim Biophys Acta 1354 (1), 29-34 (1997)
   PUBMED   9375787
REFERENCE   10 (bases 1 to 3210)
  AUTHORS   Schaffer,J.E. and Lodish,H.F.
  TITLE     Expression cloning and characterization of a novel adipocyte long
            chain fatty acid transport protein
  JOURNAL   Cell 79 (3), 427-436 (1994)
   PUBMED   7954810
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC074014.1.
            
            [WARNING] On Mar 19, 2024 this sequence was replaced by
            NM_053580.3.
            
            On Jul 8, 2004 this sequence version replaced NM_053580.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC074014.1, U89529.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3210
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3210
                     /gene="Slc27a1"
                     /gene_synonym="FATP"
                     /note="solute carrier family 27 member 1"
                     /db_xref="GeneID:94172"
                     /db_xref="RGD:620927"
     exon            1..176
                     /gene="Slc27a1"
                     /gene_synonym="FATP"
                     /inference="alignment:Splign:2.1.0"
     exon            177..344
                     /gene="Slc27a1"
                     /gene_synonym="FATP"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..2118
                     /gene="Slc27a1"
                     /gene_synonym="FATP"
                     /EC_number="6.2.1.3"
                     /EC_number="6.2.1.15"
                     /note="solute carrier family 27 (fatty acid transporter),
                     member 1; FATP-1; fatty acid transport protein 1;
                     arachidonate--CoA ligase; long-chain-fatty-acid--CoA
                     ligase; very long-chain acyl-CoA synthetase"
                     /codon_start=1
                     /product="long-chain fatty acid transport protein 1"
                     /protein_id="NP_446032.2"
                     /db_xref="GeneID:94172"
                     /db_xref="RGD:620927"
                     /translation="MRTPGAGTASVASLGLLWLLGLPWTWSAAAAFGVYVGSGGWRFL
                     RIVCKTARRDLFGLSVLIRVRLELRRHRRAGDTIPRIFQAVAQRQPERLALVDASSGI
                     CWTFAQLDTYSNAVANLFLQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNV
                     NLRREPLAFCLGTSAAKALIYGGEMAAAVAEVSEQLGKSLLKFCSGDLGPESVLPDTQ
                     LLDPMLAEAPTTPLAQAPGKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHS
                     YSMRANDVLYDCLPLYHSAGNIMGVGQCIIYGLTVVLRKKFSASRFWDDCVKYNCTVV
                     QYIGEICRYLLRQPVRDVERRHHVRLAVGNGLRPAIWEEFTQRFGVRQIGEFYGATEC
                     NCSIANMDGKVGSCGFNSRILTHVYPIRLVKVNEDTMEPLRDSQGLCIPCQPGEPGLL
                     VGQINQQDPLRRFDGYVSDSATNKKIAHSVFRKGDSAYLSGDVLVMDELGYMYFRDRS
                     GDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPGVEGKAGMAAIADPHNQLDPN
                     SMYQELQKVLASYAQPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQTSDRLFFLDLK
                     QGRYLPLDERVHARICAGDFSL"
     exon            345..739
                     /gene="Slc27a1"
                     /gene_synonym="FATP"
                     /inference="alignment:Splign:2.1.0"
     exon            740..901
                     /gene="Slc27a1"
                     /gene_synonym="FATP"
                     /inference="alignment:Splign:2.1.0"
     exon            902..971
                     /gene="Slc27a1"
                     /gene_synonym="FATP"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1063
                     /gene="Slc27a1"
                     /gene_synonym="FATP"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1173
                     /gene="Slc27a1"
                     /gene_synonym="FATP"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1383
                     /gene="Slc27a1"
                     /gene_synonym="FATP"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1510
                     /gene="Slc27a1"
                     /gene_synonym="FATP"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1648
                     /gene="Slc27a1"
                     /gene_synonym="FATP"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1813
                     /gene="Slc27a1"
                     /gene_synonym="FATP"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1960
                     /gene="Slc27a1"
                     /gene_synonym="FATP"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..3187
                     /gene="Slc27a1"
                     /gene_synonym="FATP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggacggaca gggcagaggc acgcaggggc gcagtgagaa gcgcctagga ctttgcaaag
       61 ggctcatccc ctgaagggac ccaccagcta ggcccgagct cagaagttcc cactccagac
      121 ttctgcgaga acccgtgagg aagcagcgag aaccgggggt ttgcaagcca gagaaggatg
      181 cggactccgg gagcaggaac agcctctgtg gcctcattgg ggctgctttg gcttctggga
      241 cttccgtgga cctggagcgc ggcggcggcg ttcggtgtgt acgtgggtag cggtggctgg
      301 cgctttctgc gtatcgtctg caagacggcg aggcgagacc tctttggcct ctctgttctg
      361 atccgcgtgc ggctagagct acgacgacac cggcgagcag gagacacgat cccacgcatc
      421 ttccaggccg tggcccagcg acagccggag cgcctggcgc tggtagatgc gagtagcggt
      481 atctgctgga ccttcgcaca gctagacacc tactccaatg ctgtggccaa tctgttcctc
      541 cagctgggct ttgcgccagg cgatgtggtg gctgtgttcc tggaaggccg gcccgagttc
      601 gtgggactgt ggctgggcct ggccaaggcc ggtgtagtgg ctgcgcttct caatgtcaac
      661 ctgaggcggg agccccttgc cttctgcttg ggcacatcag ctgccaaggc cctcatttat
      721 ggcggggaga tggcagcggc ggtggcggag gtgagtgagc agctggggaa gagcctgctc
      781 aagttctgct ctggagatct ggggcctgag agcgtcctgc ctgacacgca gcttctggac
      841 cccatgcttg ctgaggcgcc caccacaccc ctggcacagg ccccaggcaa gggcatggat
      901 gatcggctat tttacatcta tacttctggg accaccggac ttcctaaggc ggccattgtg
      961 gtgcacagca ggtactaccg cattgcagcc ttcggccacc attcctacag catgcgggcc
     1021 aacgatgtgc tctatgactg cctacctctc taccactcag cagggaacat catgggcgtg
     1081 ggacagtgta tcatctacgg gttaacggtg gtactgcgca agaagttctc cgccagccgc
     1141 ttctgggacg actgtgtcaa atataattgc acggtagtgc agtacatcgg tgaaatatgc
     1201 cgctacctgc taaggcagcc ggttcgcgat gtagagcggc ggcaccacgt gcgcctggcc
     1261 gtgggtaacg gactgcggcc agccatctgg gaggagttca cgcagcgttt cggtgtgcga
     1321 cagattggcg agttctacgg cgccaccgag tgcaactgca gcattgccaa catggacggc
     1381 aaggtcggct cctgcggctt caacagccgt atcctcacgc atgtgtaccc catccgtctg
     1441 gtcaaggtca acgaggacac gatggagcca ctgagggact cccaaggcct ctgcatcccg
     1501 tgccagcccg gggaacctgg ccttctcgtg ggccagatca accagcaaga ccctctgcgg
     1561 cgcttcgatg gctatgttag tgacagcgcc accaacaaga agattgccca cagcgtgttc
     1621 cgaaaggggg acagcgccta cctttcaggt gacgtgctag tgatggacga gctggggtac
     1681 atgtacttcc gtgaccgcag cggggatacc ttccgatggc gcggcgagaa cgtatccacc
     1741 acggaggtgg aagccgtgct gagccgcctg ttgggccaga cggacgtggc tgtgtatgga
     1801 gtggctgtgc caggagtgga ggggaaagcc ggcatggcgg ccattgcaga cccccacaac
     1861 cagctggacc ctaactcaat gtaccaggaa ttgcagaagg ttcttgcatc ctatgcccag
     1921 cccatcttcc tgcgtcttct gccccaagtg gatacaacag gcaccttcaa gatccagaag
     1981 acccggctac agcgtgaagg ctttgacccc cgccagacct cagaccggct cttctttcta
     2041 gacctgaaac agggacgcta cctacccctg gatgagagag tccatgcccg catctgcgca
     2101 ggcgacttct cactctgagc ctggtgagtg ggatggccct ggacttgtga gaccagggag
     2161 ccggacaccc ctgttcaggt gtttctcctg cctggccacg tggccagcag cacctgtggg
     2221 tgcaggaaac tggaacctga gtggccgggt gtccctttcc tacaacccac tatgcacaca
     2281 tctagcctct gccttggtct ttttctccat ctctttcctc cgtgcccagc aggagcccca
     2341 cagacacatt ggctgctgtg tcctgcagtg ggaccggtgt ctaggggtcc atgctgcagg
     2401 ctgtgacccg cactggtgcc cacctccctt ccccattgtg ccttaggttc ctccactgtt
     2461 tgccggtgaa gcaagtgggg acccacatag ctgttgtccc tgctgagggt tggtagcaaa
     2521 tgcaccctca tgtcagctgg gagacacatg cagtctccca ctgaccccca atcaactgaa
     2581 gatactgttt tgtattattg ttttgagata gggtctcact gtggaggcca agctggcctc
     2641 aggctcacca ctctactgcc tccgggcacc agcctgcagt ttgatgacat gtatgcacta
     2701 ttgttctaag ggtcttctga gtccctgctt tcccctcatg tcctaaaacc ttccagaact
     2761 gactctgatc acttggatgt agctagtgtt ggccctgccc acgtgtgtca attcaggggt
     2821 ccccaggcat catctctgga ggccctaacc ttggcaaagc ttggatgtcc tcacatcaca
     2881 gcaggagacc caggaaggtt gctgtggtgt tctcttgggc accccctggc ggcagccctg
     2941 gacatgcttc cctgctgtgg atagcccaaa ccgttgccta tgacatttga ggtctaccct
     3001 tctggctccc atggtcccca ttgagatctt tggtgactca cctcagccac caagccaggc
     3061 ctctgccttc cttcagctct aagggcatga agggtgtgga cagagcagcc acaggctgcc
     3121 cacagtcacc cacatgcaag tgttatttcc ttgtttgttt taaaaaaata aacatgctga
     3181 gccttgaaaa aaaaaaaaaa aaaaaaaaaa
//
