LOCUS       NM_001143817            2543 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus solute carrier family 26 member 6 (Slc26a6),
            mRNA.
ACCESSION   NM_001143817
VERSION     NM_001143817.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2543)
  AUTHORS   Jiang,H., Gao,X., Gong,J., Yang,Q., Lan,R., Wang,T., Liu,J.,
            Yin,C., Wang,S. and Liu,Z.
  TITLE     Downregulated Expression of Solute Carrier Family 26 Member 6 in
            NRK-52E Cells Attenuates Oxalate-Induced Intracellular Oxidative
            Stress
  JOURNAL   Oxid Med Cell Longev 2018, 1724648 (2018)
   PUBMED   30405874
  REMARK    GeneRIF: reducing the expression of Slc26a6 in the kidney may be a
            potential strategy for preventing stone formation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2543)
  AUTHORS   Yin,K., Lei,Y., Wen,X., Lacruz,R.S., Soleimani,M., Kurtz,I.,
            Snead,M.L., White,S.N. and Paine,M.L.
  TITLE     SLC26A Gene Family Participate in pH Regulation during Enamel
            Maturation
  JOURNAL   PLoS One 10 (12), e0144703 (2015)
   PUBMED   26671068
  REMARK    GeneRIF: Slc26a1, Slc26a6 and Slc26a7 are novel participants in the
            extracellular transport of bicarbonate during enamel maturation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2543)
  AUTHORS   Simao,S., Gomes,P., Pinho,M.J. and Soares-da-Silva,P.
  TITLE     Identification of SLC26A transporters involved in the Cl/HCO
            exchange in proximal tubular cells from WKY and SHR
  JOURNAL   Life Sci 93 (12-14), 435-440 (2013)
   PUBMED   23933130
  REMARK    GeneRIF: Expression of slc26a4, slc26a6 and slc26a9 is increased in
            proximal tubule epithelial cells from spontaneously hypertensive
            rats compared with WKY control rats.
REFERENCE   4  (bases 1 to 2543)
  AUTHORS   Gholami,K., Muniandy,S. and Salleh,N.
  TITLE     In-vivo functional study on the involvement of CFTR, SLC26A6, NHE-1
            and CA isoenzymes II and XII in uterine fluid pH, volume and
            electrolyte regulation in rats under different sex-steroid
            influence
  JOURNAL   Int J Med Sci 10 (9), 1121-1134 (2013)
   PUBMED   23869188
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2543)
  AUTHORS   Gholami,K., Muniandy,S. and Salleh,N.
  TITLE     Progesterone downregulates oestrogen-induced expression of CFTR and
            SLC26A6 proteins and mRNA in rats' uteri
  JOURNAL   J Biomed Biotechnol 2012, 596084 (2012)
   PUBMED   23226939
  REMARK    GeneRIF: Progestore inhibits CFTR and SLC26A6 proteins and mRNA
            expression while oestrogen (E) causes vice versa.
REFERENCE   6  (bases 1 to 2543)
  AUTHORS   Xie,Q., Welch,R., Mercado,A., Romero,M.F. and Mount,D.B.
  TITLE     Molecular characterization of the murine Slc26a6 anion exchanger:
            functional comparison with Slc26a1
  JOURNAL   Am J Physiol Renal Physiol 283 (4), F826-F838 (2002)
   PUBMED   12217875
REFERENCE   7  (bases 1 to 2543)
  AUTHORS   Jiang,Z., Grichtchenko,I.I., Boron,W.F. and Aronson,P.S.
  TITLE     Specificity of anion exchange mediated by mouse Slc26a6
  JOURNAL   J Biol Chem 277 (37), 33963-33967 (2002)
   PUBMED   12119287
REFERENCE   8  (bases 1 to 2543)
  AUTHORS   Wang,Z., Petrovic,S., Mann,E. and Soleimani,M.
  TITLE     Identification of an apical Cl(-)/HCO3(-) exchanger in the small
            intestine
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 282 (3), G573-G579 (2002)
   PUBMED   11842009
REFERENCE   9  (bases 1 to 2543)
  AUTHORS   Knauf,F., Yang,C.L., Thomson,R.B., Mentone,S.A., Giebisch,G. and
            Aronson,P.S.
  TITLE     Identification of a chloride-formate exchanger expressed on the
            brush border membrane of renal proximal tubule cells
  JOURNAL   Proc Natl Acad Sci U S A 98 (16), 9425-9430 (2001)
   PUBMED   11459928
REFERENCE   10 (bases 1 to 2543)
  AUTHORS   Lohi,H., Kujala,M., Kerkela,E., Saarialho-Kere,U., Kestila,M. and
            Kere,J.
  TITLE     Mapping of five new putative anion transporter genes in human and
            characterization of SLC26A6, a candidate gene for pancreatic anion
            exchanger
  JOURNAL   Genomics 70 (1), 102-112 (2000)
   PUBMED   11087667
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.24353.1,
                                           SRR26643298.46730.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                JAXUCZ010000008.1  118438188-118438239
            53-218              JAXUCZ010000008.1  118439785-118439950
            219-358             JAXUCZ010000008.1  118440031-118440170
            359-469             JAXUCZ010000008.1  118440339-118440449
            470-618             JAXUCZ010000008.1  118440720-118440868
            619-783             JAXUCZ010000008.1  118440990-118441154
            784-936             JAXUCZ010000008.1  118441240-118441392
            937-1019            JAXUCZ010000008.1  118441690-118441772
            1020-1167           JAXUCZ010000008.1  118441854-118442001
            1168-1281           JAXUCZ010000008.1  118442210-118442323
            1282-1359           JAXUCZ010000008.1  118442495-118442572
            1360-1455           JAXUCZ010000008.1  118442886-118442981
            1456-1562           JAXUCZ010000008.1  118443063-118443169
            1563-1632           JAXUCZ010000008.1  118443341-118443410
            1633-1725           JAXUCZ010000008.1  118444649-118444741
            1726-1830           JAXUCZ010000008.1  118444839-118444943
            1831-1923           JAXUCZ010000008.1  118445791-118445883
            1924-2100           JAXUCZ010000008.1  118446553-118446729
            2101-2155           JAXUCZ010000008.1  118446885-118446939
            2156-2292           JAXUCZ010000008.1  118447659-118447795
            2293-2543           JAXUCZ010000008.1  118448005-118448255
FEATURES             Location/Qualifiers
     source          1..2543
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2543
                     /gene="Slc26a6"
                     /note="solute carrier family 26 member 6"
                     /db_xref="GeneID:301010"
                     /db_xref="RGD:1310197"
     exon            1..52
                     /gene="Slc26a6"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..2307
                     /gene="Slc26a6"
                     /note="solute carrier family 26 (anion exchanger), member
                     6"
                     /codon_start=1
                     /product="solute carrier family 26 member 6"
                     /protein_id="NP_001137289.1"
                     /db_xref="GeneID:301010"
                     /db_xref="RGD:1310197"
                     /translation="MGLPDGSDHGTQQTQALLSATQEMELERRDYHVERPLLNQEQLE
                     DLGHWGPVSKTHPWRTWFRCSRARAKSLLIQHVPVLGWLPRYPVREWLLGDLLSGLSV
                     AIMQLPQGLAYALLAGLPPMFGLYSSFYPVFVYFLFGTSRHISVGTFAVMSVMVGGVT
                     ESLTADEAFVQSLNTTVDGARVQVAYTLSFLVGLFQVGLGLVHFGFVVTYLSEPLVRS
                     YTTAASVQVLVSQLKYVFGIKLNSHSGPLSVIYTVLEVCAQLPKTVPGTVVTAIVAGV
                     VLVLVKLLNEKLRRRLPLPIPGELLTLIGATAISYGVKLNDRFKVDVVGNITTGLIPP
                     VAPKTELFATLVGNAFAIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGG
                     FFQCFPVSCSMSRSLVQESTGGNTQIAGAVSSLFILLIIVKLGELFRDLPKAVLAAVI
                     IVNLKGMMKQFSDICSLWKANRVDLLIWLVTFVATILLNLDIGLAVSIVFSLLLVVIR
                     MQLPHYSVLGQVPDTDIYRDVAEYSGAKEVPGVKVFRSSATMYFANAELYSDSLKKKC
                     GVDVDRLITQKKKRIKKQEMKIKRMNKAKKSQKQAASSKISSVSVNVNTNFEDIKSND
                     VEGSEAKVHQGEELEDVVASNQEDAKPPIMTSLKALGLPQPDFHSLILDLSTVSFVDT
                     VCIKSLKNIFRDFREIEVEVYIAACYSPVVTQLEAGHFFDESITKQHVFASVHDAVTF
                     ALHHRKSGPKSPVLATKL"
     exon            53..218
                     /gene="Slc26a6"
                     /inference="alignment:Splign:2.1.0"
     exon            219..358
                     /gene="Slc26a6"
                     /inference="alignment:Splign:2.1.0"
     exon            359..469
                     /gene="Slc26a6"
                     /inference="alignment:Splign:2.1.0"
     exon            470..618
                     /gene="Slc26a6"
                     /inference="alignment:Splign:2.1.0"
     exon            619..783
                     /gene="Slc26a6"
                     /inference="alignment:Splign:2.1.0"
     exon            784..936
                     /gene="Slc26a6"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1019
                     /gene="Slc26a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1167
                     /gene="Slc26a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1281
                     /gene="Slc26a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1359
                     /gene="Slc26a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1455
                     /gene="Slc26a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1562
                     /gene="Slc26a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1632
                     /gene="Slc26a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1725
                     /gene="Slc26a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1830
                     /gene="Slc26a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1923
                     /gene="Slc26a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2100
                     /gene="Slc26a6"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2155
                     /gene="Slc26a6"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2292
                     /gene="Slc26a6"
                     /inference="alignment:Splign:2.1.0"
     exon            2293..2543
                     /gene="Slc26a6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagccgcaca cgagctaccc tctgagggtc atgggactgc ctgatgggtc cgaccacggg
       61 acacagcaga cgcaggctct cctgtctgca acccaagaaa tggagctgga aaggagagac
      121 taccatgtgg aaaggccatt gctgaaccaa gagcagctag aggatctggg gcactggggt
      181 ccagtgtcga agacccaccc gtggcgaact tggtttcgat gctcccgtgc tcgggccaaa
      241 tctcttctga tccagcatgt tccggtcttg ggctggttac cccgatatcc tgtgcgtgag
      301 tggctcttgg gtgacctgtt atccggcctg agtgtggcca tcatgcagct tccacagggc
      361 ttggcctatg ccctcctggc gggattgcct cctatgtttg gcctgtacag ttctttctac
      421 cctgtcttcg tctacttcct gtttggtacc tctagacaca tctctgtggg gacctttgct
      481 gtcatgtctg tgatggtggg cggcgtgaca gaatctctga cagcagatga ggccttcgtg
      541 caaagcttga acaccacagt cgatggtgcc cgtgtgcagg tggcctacac gctcagcttc
      601 ctggttggcc ttttccaggt ggggctgggc ctggtacact tcggttttgt ggtcacctac
      661 ctgtcagagc ctttggtccg cagctatacc acggctgcct ctgtgcaagt cctcgtctcc
      721 cagctcaagt atgtgtttgg catcaaactc aacagtcact ctgggccact gtccgttatc
      781 tatacagtgc tggaggtctg tgcccagctg cctaagactg tgcctggcac cgtggtcaca
      841 gcaatcgtgg caggagtggt gttggtgctg gttaaactgc tgaatgaaaa actgcgccga
      901 cgtctgccct tgcccattcc tggggaacta ctcacgctaa ttggggccac cgctatttcc
      961 tacggtgtga agctgaatga cagattcaag gtggatgtgg tgggcaacat caccacaggg
     1021 ctgatacccc cagtggcacc caagacggag ctgtttgcaa cgcttgtggg aaacgccttc
     1081 gccattgccg tggtgggctt cgccattgcc atctcactgg ggaagatctt tgccctgagg
     1141 catggctacc gtgtggacag caaccaggag ctggtagccc ttggcctcag taacctcatc
     1201 ggaggcttct tccagtgctt tcctgtgagc tgctccatgt ctcggagctt ggtacaggag
     1261 agcacgggag gcaacacgca gattgctgga gccgtatctt ccctctttat actcctaatt
     1321 attgtcaaac ttggggaact cttccgagac ctgcccaagg ccgtcctggc agctgttatc
     1381 attgtgaacc tcaagggtat gatgaagcag ttctctgaca tctgctctct ctggaaggca
     1441 aatcgagtgg acctgctaat ctggctggtg acctttgtgg ccacgatcct gctgaacctg
     1501 gacatcggcc tggcagtctc catagtcttc tccttgctgc tcgtggtgat ccgaatgcag
     1561 ctgccccatt actccgtcct ggggcaggtg ccagatacgg atatttatag agacgtggca
     1621 gaatactcag gggccaagga ggtcccgggt gtgaaagtct tccgttcctc agccaccatg
     1681 tacttcgcca acgctgagct ctacagtgat tcgctgaaaa agaagtgtgg cgtggacgtt
     1741 gaccgcctca tcacccagaa aaagaaacga atcaagaagc aggagatgaa gataaagcga
     1801 atgaacaaag ccaagaagtc ccagaaacag gctgcttctt ccaagatctc ctcagtttct
     1861 gtcaacgtca acaccaactt tgaagacatc aaaagcaatg atgttgaggg ctctgaggcc
     1921 aaggtgcacc aaggggagga gttggaggat gtagtcgcca gcaatcaaga agatgccaag
     1981 cccccaatca tgacctcact gaaggccctg ggcctgcctc agccagactt ccatagcctc
     2041 atcctagact tgagcactgt ctcctttgtg gacactgtgt gcatcaagag cctgaaaaac
     2101 attttccgtg acttccggga gatcgaagtg gaagtatata tcgcagcctg ttacagtcct
     2161 gtggtcaccc agcttgaagc tggacacttc tttgatgagt ctatcactaa gcagcacgtc
     2221 tttgcctctg ttcatgacgc cgtgaccttt gccctccacc accggaagtc tggccctaag
     2281 agccctgttt tggccaccaa actctgactt tgctgcagga gactgcctac ctctggaggt
     2341 tgtgacaggt caccctcatg aacccccctg cctctgagcc acctccaggt gccacctggg
     2401 actccattcc atgtacctgc acatacaact catgggtgga tgccctggga ctccaagttc
     2461 agtgctatag gcctggggca gggtattaca gtcaggctgg ccttggctgg aaaaagctga
     2521 tgtgggttta cagttttggg aat
//
